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DK171437B1 - Kemiluminescerende acridinderivater og fremgangsmåde til deres fremstilling - Google Patents

Kemiluminescerende acridinderivater og fremgangsmåde til deres fremstilling Download PDF

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Publication number
DK171437B1
DK171437B1 DK437187A DK437187A DK171437B1 DK 171437 B1 DK171437 B1 DK 171437B1 DK 437187 A DK437187 A DK 437187A DK 437187 A DK437187 A DK 437187A DK 171437 B1 DK171437 B1 DK 171437B1
Authority
DK
Denmark
Prior art keywords
group
general formula
alkyl
ppm
acridinium
Prior art date
Application number
DK437187A
Other languages
Danish (da)
English (en)
Other versions
DK437187A (da
DK437187D0 (da
Inventor
Peter Molz
Hans-Juergen Skrzipczyk
Henning Luebbers
Helmut Strecker
Gerd Schnorr
Tonio Kinkel
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK437187D0 publication Critical patent/DK437187D0/da
Publication of DK437187A publication Critical patent/DK437187A/da
Priority to DK199200684A priority Critical patent/DK173875B1/da
Application granted granted Critical
Publication of DK171437B1 publication Critical patent/DK171437B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Liquid Crystal Substances (AREA)
DK437187A 1986-08-22 1987-08-21 Kemiluminescerende acridinderivater og fremgangsmåde til deres fremstilling DK171437B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK199200684A DK173875B1 (da) 1986-08-22 1992-05-25 Luminescerende forbindelse og luminescensimmunanalyse, hvor den anvendes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3628573A DE3628573C2 (de) 1986-08-22 1986-08-22 Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays
DE3628573 1986-08-22

Publications (3)

Publication Number Publication Date
DK437187D0 DK437187D0 (da) 1987-08-21
DK437187A DK437187A (da) 1988-02-23
DK171437B1 true DK171437B1 (da) 1996-10-28

Family

ID=6307971

Family Applications (1)

Application Number Title Priority Date Filing Date
DK437187A DK171437B1 (da) 1986-08-22 1987-08-21 Kemiluminescerende acridinderivater og fremgangsmåde til deres fremstilling

Country Status (12)

Country Link
EP (2) EP0257541B1 (fr)
JP (2) JPH0699401B2 (fr)
AT (2) ATE223903T1 (fr)
CA (1) CA1341402C (fr)
DE (4) DE3645292C2 (fr)
DK (1) DK171437B1 (fr)
ES (2) ES2182835T3 (fr)
FI (1) FI90542C (fr)
GR (1) GR3019470T3 (fr)
IE (1) IE74678B1 (fr)
NO (1) NO171725C (fr)
PT (1) PT85563B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3279029D1 (en) * 1981-12-11 1988-10-20 Welsh Nat School Med Luminescent labelling materials and procedures
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
DE3750503T2 (de) * 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
FR2625565A1 (fr) * 1987-12-31 1989-07-07 London Diagnostics Inc Esters, thioesters et amides chimioluminescents perfectionnes, et analyses les utilisant
US6002007A (en) * 1988-02-20 1999-12-14 Dade Behring Marburg Gmbh Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays
DE3844954C2 (de) * 1988-02-20 1998-07-16 Hoechst Ag Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
EP0511366A1 (fr) * 1990-11-21 1992-11-04 Beckman Instruments, Inc. Composes chimioluminescents
DE4041080A1 (de) 1990-12-21 1992-06-25 Behringwerke Ag Verfahren zur bestimmung eines analyten
DE4228839A1 (de) 1992-08-29 1994-03-03 Behringwerke Ag Verfahren zum Nachweis und zur Bestimmung von Mediatoren
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
BE1008216A4 (fr) * 1994-01-25 1996-02-20 Biocode Sa Derives chemoluminescents heterocycliques.
MX9606598A (es) * 1994-06-24 1997-05-31 Behringwerke Ag Procedimiento para la estabilizacion de moleculas, o partes de moleculas, sensibles a la hidrolisis.
AU2775395A (en) * 1994-07-15 1996-02-16 Abbott Laboratories Chemiluminescent signal enhancement
WO1996027785A1 (fr) * 1995-03-03 1996-09-12 Abbott Laboratories Article et procede destine a la conduction d'une reaction chimioluminescente
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0761652A1 (fr) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Dérivés d'acridinium à plusieurs groupes luminescents et groupes liants et leur conjugués
KR100259761B1 (ko) * 1996-03-15 2000-07-01 타이도 나오카타 에스에이치기 표지용시약, 그의 제조방법 및 이를 이용한 표지법
PT915851E (pt) * 1996-07-16 2002-09-30 Staat Nl Verteg Door Min Welzi Esteres dibenzodihidropiridinecarboxilicos e seu uso no ensaio dos metodos quimiluminiscente
BE1011206A4 (fr) * 1997-06-11 1999-06-01 Biocode Sa Derives chimioluminescents heterocycliques.
EP1496050A1 (fr) 2003-07-08 2005-01-12 Roche Diagnostics GmbH Composés chimiluminescents et leur utilisation
EP1658495A1 (fr) 2003-07-30 2006-05-24 Roche Diagnostics GmbH Nouveaux composes chemiluminescents et leur usage
ATE471513T1 (de) 2003-07-30 2010-07-15 Hoffmann La Roche Neue chemilumineszenzverbindungen und ihre verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
GB2008247B (en) * 1977-11-17 1982-12-15 Welsh Nat School Med Detecting or quantifying substances using labelling techniques
DE3279029D1 (en) * 1981-12-11 1988-10-20 Welsh Nat School Med Luminescent labelling materials and procedures

Also Published As

Publication number Publication date
FI873609A0 (fi) 1987-08-20
ATE132490T1 (de) 1996-01-15
FI90542B (fi) 1993-11-15
FI90542C (fi) 1994-02-25
EP0257541A2 (fr) 1988-03-02
NO171725C (no) 1993-04-28
JPH07179428A (ja) 1995-07-18
CA1341402C (fr) 2002-11-26
PT85563B (pt) 1990-05-31
JPH0699401B2 (ja) 1994-12-07
PT85563A (de) 1987-09-01
DE3751659D1 (de) 1996-02-15
ES2182835T3 (es) 2003-03-16
EP0647628A1 (fr) 1995-04-12
JPS6357572A (ja) 1988-03-12
DE3628573A1 (de) 1988-02-25
NO873520L (no) 1988-02-23
GR3019470T3 (en) 1996-06-30
JP2766780B2 (ja) 1998-06-18
DE3752357D1 (de) 2002-10-17
EP0647628B1 (fr) 2002-09-11
EP0257541B1 (fr) 1996-01-03
DE3628573C2 (de) 1994-10-13
ATE223903T1 (de) 2002-09-15
IE872245L (en) 1988-02-22
EP0257541A3 (en) 1988-11-30
NO171725B (no) 1993-01-18
FI873609A (fi) 1988-02-23
NO873520D0 (no) 1987-08-20
DE3645292C2 (de) 1997-12-11
IE74678B1 (en) 1997-07-30
DK437187A (da) 1988-02-23
ES2083949T3 (es) 1996-05-01
DK437187D0 (da) 1987-08-21
IE960911L (en) 1988-02-22

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired