FI873609A0 - Kemiluminoivia akridiinijohdannaisia, niiden valmistus ja niiden käyttö luminesenssi-immunoanalyyseissä - Google Patents
Kemiluminoivia akridiinijohdannaisia, niiden valmistus ja niiden käyttö luminesenssi-immunoanalyyseissäInfo
- Publication number
- FI873609A0 FI873609A0 FI873609A FI873609A FI873609A0 FI 873609 A0 FI873609 A0 FI 873609A0 FI 873609 A FI873609 A FI 873609A FI 873609 A FI873609 A FI 873609A FI 873609 A0 FI873609 A0 FI 873609A0
- Authority
- FI
- Finland
- Prior art keywords
- group
- preparation
- luminescence immunoassays
- acridine derivatives
- hydrogen
- Prior art date
Links
- 238000003018 immunoassay Methods 0.000 title abstract 2
- 238000004020 luminiscence type Methods 0.000 title abstract 2
- 125000000641 acridinyl group Chemical class C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 title 1
- 229940027998 antiseptic and disinfectant acridine derivative Drugs 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3628573A DE3628573C2 (de) | 1986-08-22 | 1986-08-22 | Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays |
| DE3628573 | 1986-08-22 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI873609A0 true FI873609A0 (fi) | 1987-08-20 |
| FI873609A FI873609A (fi) | 1988-02-23 |
| FI90542B FI90542B (fi) | 1993-11-15 |
| FI90542C FI90542C (fi) | 1994-02-25 |
Family
ID=6307971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI873609A FI90542C (fi) | 1986-08-22 | 1987-08-20 | Kemiluminoivia akridiinijohdannaisia, niiden valmistus ja niiden käyttö luminesenssi-immunoanalyyseissä |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP0257541B1 (fi) |
| JP (2) | JPH0699401B2 (fi) |
| AT (2) | ATE223903T1 (fi) |
| CA (1) | CA1341402C (fi) |
| DE (4) | DE3645292C2 (fi) |
| DK (1) | DK171437B1 (fi) |
| ES (2) | ES2182835T3 (fi) |
| FI (1) | FI90542C (fi) |
| GR (1) | GR3019470T3 (fi) |
| IE (1) | IE74678B1 (fi) |
| NO (1) | NO171725C (fi) |
| PT (1) | PT85563B (fi) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
| US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| DE3750503T2 (de) * | 1986-10-22 | 1995-02-09 | Abbott Lab | Chemilumineszierende Acridinium- und Phenantridiniumsalze. |
| NZ227506A (en) * | 1987-12-31 | 1992-06-25 | London Diagnostics Inc | Specific binding assays using chemiluminescent compounds |
| FR2625565A1 (fr) * | 1987-12-31 | 1989-07-07 | London Diagnostics Inc | Esters, thioesters et amides chimioluminescents perfectionnes, et analyses les utilisant |
| US6002007A (en) * | 1988-02-20 | 1999-12-14 | Dade Behring Marburg Gmbh | Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays |
| DE3844954C2 (de) * | 1988-02-20 | 1998-07-16 | Hoechst Ag | Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays |
| US4950613A (en) * | 1988-02-26 | 1990-08-21 | Gen-Probe Incorporated | Proteted chemiluminescent labels |
| US5227489A (en) * | 1988-08-01 | 1993-07-13 | Ciba Corning Diagnostics Corp. | Stable hydrophilic acridinium esters suitable for liposome encapsulation |
| AU634716B2 (en) * | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
| US5663074A (en) * | 1988-09-26 | 1997-09-02 | Chiron Diagnostics Corporation | Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof |
| US5241070A (en) * | 1988-09-26 | 1993-08-31 | Ciba Corning Diagnostics Corp. | Nucleophilic polysubstituted aryl acridinium esters and uses thereof |
| EP0511366A1 (en) * | 1990-11-21 | 1992-11-04 | Beckman Instruments, Inc. | Chemiluminescent compounds |
| DE4041080A1 (de) | 1990-12-21 | 1992-06-25 | Behringwerke Ag | Verfahren zur bestimmung eines analyten |
| DE4228839A1 (de) | 1992-08-29 | 1994-03-03 | Behringwerke Ag | Verfahren zum Nachweis und zur Bestimmung von Mediatoren |
| US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
| BE1008216A4 (fr) * | 1994-01-25 | 1996-02-20 | Biocode Sa | Derives chemoluminescents heterocycliques. |
| MX9606598A (es) * | 1994-06-24 | 1997-05-31 | Behringwerke Ag | Procedimiento para la estabilizacion de moleculas, o partes de moleculas, sensibles a la hidrolisis. |
| AU2775395A (en) * | 1994-07-15 | 1996-02-16 | Abbott Laboratories | Chemiluminescent signal enhancement |
| WO1996027785A1 (en) * | 1995-03-03 | 1996-09-12 | Abbott Laboratories | Article and method for conducting chemiluminescent reaction |
| US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| EP0761652A1 (en) * | 1995-08-01 | 1997-03-12 | Mochida Pharmaceutical Co., Ltd. | Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof |
| KR100259761B1 (ko) * | 1996-03-15 | 2000-07-01 | 타이도 나오카타 | 에스에이치기 표지용시약, 그의 제조방법 및 이를 이용한 표지법 |
| PT915851E (pt) * | 1996-07-16 | 2002-09-30 | Staat Nl Verteg Door Min Welzi | Esteres dibenzodihidropiridinecarboxilicos e seu uso no ensaio dos metodos quimiluminiscente |
| BE1011206A4 (fr) * | 1997-06-11 | 1999-06-01 | Biocode Sa | Derives chimioluminescents heterocycliques. |
| EP1496050A1 (en) | 2003-07-08 | 2005-01-12 | Roche Diagnostics GmbH | Novel chemiluminescent compounds and their use |
| EP1658495A1 (en) | 2003-07-30 | 2006-05-24 | Roche Diagnostics GmbH | Novel chemiluminescent compounds and their use |
| ATE471513T1 (de) | 2003-07-30 | 2010-07-15 | Hoffmann La Roche | Neue chemilumineszenzverbindungen und ihre verwendung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1461877A (en) * | 1974-02-12 | 1977-01-19 | Wellcome Found | Assay method utilizing chemiluminescence |
| GB2008247B (en) * | 1977-11-17 | 1982-12-15 | Welsh Nat School Med | Detecting or quantifying substances using labelling techniques |
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
-
1986
- 1986-08-22 DE DE3645292A patent/DE3645292C2/de not_active Expired - Lifetime
- 1986-08-22 DE DE3628573A patent/DE3628573C2/de not_active Expired - Lifetime
-
1987
- 1987-08-19 ES ES94119395T patent/ES2182835T3/es not_active Expired - Lifetime
- 1987-08-19 DE DE3752357T patent/DE3752357D1/de not_active Expired - Lifetime
- 1987-08-19 ES ES87112022T patent/ES2083949T3/es not_active Expired - Lifetime
- 1987-08-19 EP EP87112022A patent/EP0257541B1/de not_active Expired - Lifetime
- 1987-08-19 EP EP94119395A patent/EP0647628B1/de not_active Expired - Lifetime
- 1987-08-19 AT AT94119395T patent/ATE223903T1/de not_active IP Right Cessation
- 1987-08-19 DE DE3751659T patent/DE3751659D1/de not_active Expired - Lifetime
- 1987-08-19 AT AT87112022T patent/ATE132490T1/de not_active IP Right Cessation
- 1987-08-20 FI FI873609A patent/FI90542C/fi not_active IP Right Cessation
- 1987-08-20 PT PT85563A patent/PT85563B/pt unknown
- 1987-08-20 NO NO873520A patent/NO171725C/no not_active IP Right Cessation
- 1987-08-21 IE IE224587A patent/IE74678B1/en not_active IP Right Cessation
- 1987-08-21 CA CA000545036A patent/CA1341402C/en not_active Expired - Lifetime
- 1987-08-21 JP JP62206622A patent/JPH0699401B2/ja not_active Expired - Lifetime
- 1987-08-21 DK DK437187A patent/DK171437B1/da not_active IP Right Cessation
-
1994
- 1994-06-14 JP JP6131617A patent/JP2766780B2/ja not_active Expired - Lifetime
-
1996
- 1996-03-29 GR GR960400849T patent/GR3019470T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE132490T1 (de) | 1996-01-15 |
| FI90542B (fi) | 1993-11-15 |
| FI90542C (fi) | 1994-02-25 |
| EP0257541A2 (de) | 1988-03-02 |
| NO171725C (no) | 1993-04-28 |
| JPH07179428A (ja) | 1995-07-18 |
| CA1341402C (en) | 2002-11-26 |
| PT85563B (pt) | 1990-05-31 |
| JPH0699401B2 (ja) | 1994-12-07 |
| PT85563A (de) | 1987-09-01 |
| DE3751659D1 (de) | 1996-02-15 |
| ES2182835T3 (es) | 2003-03-16 |
| EP0647628A1 (de) | 1995-04-12 |
| JPS6357572A (ja) | 1988-03-12 |
| DE3628573A1 (de) | 1988-02-25 |
| NO873520L (no) | 1988-02-23 |
| DK171437B1 (da) | 1996-10-28 |
| GR3019470T3 (en) | 1996-06-30 |
| JP2766780B2 (ja) | 1998-06-18 |
| DE3752357D1 (de) | 2002-10-17 |
| EP0647628B1 (de) | 2002-09-11 |
| EP0257541B1 (de) | 1996-01-03 |
| DE3628573C2 (de) | 1994-10-13 |
| ATE223903T1 (de) | 2002-09-15 |
| IE872245L (en) | 1988-02-22 |
| EP0257541A3 (en) | 1988-11-30 |
| NO171725B (no) | 1993-01-18 |
| FI873609A (fi) | 1988-02-23 |
| NO873520D0 (no) | 1987-08-20 |
| DE3645292C2 (de) | 1997-12-11 |
| IE74678B1 (en) | 1997-07-30 |
| DK437187A (da) | 1988-02-23 |
| ES2083949T3 (es) | 1996-05-01 |
| DK437187D0 (da) | 1987-08-21 |
| IE960911L (en) | 1988-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| PC | Transfer of assignment of patent |
Owner name: DADE BEHRING MARBURG GMBH |
|
| FG | Patent granted |
Owner name: DADE BEHRING MARBURG GMBH |
|
| MA | Patent expired |