DK169965B1 - Fremgangsmåde til fremstilling af 4-substituerede indolin-2-oner, samt mellemprodukter til brug herved - Google Patents

Fremgangsmåde til fremstilling af 4-substituerede indolin-2-oner, samt mellemprodukter til brug herved Download PDF

Info

Publication number: DK169965B1
Authority: DK; Denmark
Prior art keywords: formula; compound; equivalents; chloride; preparation
Prior art date: 1987-06-19

Application number

DK334788A

Other languages

Danish (da)

English (en)

Other versions

DK334788A (da

DK334788D0 (da

Inventor

Joseph M Fortunak

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-19

Filing date

1988-06-17

Publication date

1995-04-18

1988-06-17 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1988-06-17 Publication of DK334788D0 publication Critical patent/DK334788D0/da

1988-12-20 Publication of DK334788A publication Critical patent/DK334788A/da

1995-04-18 Application granted granted Critical

1995-04-18 Publication of DK169965B1 publication Critical patent/DK169965B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
- C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Polyesters Or Polycarbonates (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Glass Compositions (AREA)

DK334788A 1987-06-19 1988-06-17 Fremgangsmåde til fremstilling af 4-substituerede indolin-2-oner, samt mellemprodukter til brug herved DK169965B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8714371		1987-06-19
GB878714371A GB8714371D0 (en)	1987-06-19	1987-06-19	Process

Publications (3)

Publication Number	Publication Date
DK334788D0 DK334788D0 (da)	1988-06-17
DK334788A DK334788A (da)	1988-12-20
DK169965B1 true DK169965B1 (da)	1995-04-18

Family

ID=10619198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK334788A DK169965B1 (da)	1987-06-19	1988-06-17	Fremgangsmåde til fremstilling af 4-substituerede indolin-2-oner, samt mellemprodukter til brug herved

Country Status (25)

Country	Link
US (1)	US4997954A (zh)
EP (1)	EP0300614B1 (zh)
JP (1)	JPH07596B2 (zh)
KR (1)	KR0143088B1 (zh)
CN (1)	CN1019296B (zh)
AT (1)	ATE93521T1 (zh)
AU (1)	AU600582B2 (zh)
CA (1)	CA1326035C (zh)
CY (1)	CY1951A (zh)
DE (1)	DE3883456T2 (zh)
DK (1)	DK169965B1 (zh)
EG (1)	EG18412A (zh)
ES (1)	ES2058285T3 (zh)
FI (1)	FI89264C (zh)
GB (1)	GB8714371D0 (zh)
HK (1)	HK1003226A1 (zh)
HU (4)	HU203723B (zh)
IE (1)	IE62830B1 (zh)
IL (1)	IL86736A (zh)
MY (1)	MY103583A (zh)
NO (1)	NO172577C (zh)
NZ (1)	NZ225072A (zh)
PH (1)	PH24608A (zh)
PT (1)	PT87770B (zh)
ZA (1)	ZA884334B (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9008605D0 (en) *	1990-04-17	1990-06-13	Smith Kline French Lab	Process
MX9304801A (es) *	1992-08-06	1997-06-28	Warner Lambert Co	2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales.
US5278162A (en) *	1992-09-18	1994-01-11	The Du Pont Merck Pharmaceutical Company	3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
GB9300309D0 (en) *	1993-01-08	1993-03-03	Smithkline Beecham Plc	Process
US6218421B1 (en) *	1999-07-01	2001-04-17	Smithkline Beecham P.L.C.	Method of promoting smoking cessation
AR030557A1 (es)	2000-04-14	2003-08-27	Jagotec Ag	Una tableta en multicapa de liberacion controlada y metodo de tratamiento
AU2002222642A1 (en) *	2000-12-14	2002-06-24	Nissan Chemical Industries Ltd.	Method for producing indole derivative
WO2005074387A2 (en) *	2003-12-30	2005-08-18	Sun Pharmaceutical Industries Limited	Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride
US7378439B2 (en) *	2004-01-20	2008-05-27	Usv, Ltd.	Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
WO2005105741A1 (en) *	2004-02-11	2005-11-10	Sun Pharmaceutical Industries Limited	Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride
EP1568689A1 (en) *	2004-02-19	2005-08-31	Helm AG	Process for the preparation of the 2-oxoindole derivative, Ropinirole
WO2005080333A1 (en) *	2004-02-19	2005-09-01	Torrent Pharmaceuticals Ltd	Process for purification of ropinirole
JP5039541B2 (ja)	2004-04-27	2012-10-03	ワイス・エルエルシー	プロゲステロン受容体調節剤の精製
EP2007721B1 (en)	2006-03-29	2011-07-27	Alembic Limited	A process for the purification of ropinirole hydrochloride
US20070254941A1 (en) *	2006-04-21	2007-11-01	Glenmark Pharmaceuticals Limited	Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
CN100457732C (zh) *	2006-05-25	2009-02-04	药源药物化学（上海）有限公司	罗匹尼罗的制备方法
US20110195117A1 (en) *	2008-09-01	2011-08-11	Lupin Limited	Controlled release compositions of ropinirole
ES2513691T3 (es) *	2009-05-21	2014-10-27	Hisamitsu Pharmaceutical Co., Inc.	Preparación transdérmica
EP3640240B1 (en)	2017-06-16	2020-12-09	Zhejiang Huahai Licheng Pharmaceutical Co., Ltd.	Method for purifying ropinirole hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4588740A (en) *	1982-12-07	1986-05-13	Smithkline Beckman Corporation	Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
US4452808A (en) *	1982-12-07	1984-06-05	Smithkline Beckman Corporation	4-Aminoalkyl-2(3H)-indolones
US4761485A (en) *	1987-03-11	1988-08-02	Pfizer Inc.	Synthetic method for indol-2(3H)-ones

1987
- 1987-06-19 GB GB878714371A patent/GB8714371D0/en active Pending
1988
- 1988-06-13 NO NO882588A patent/NO172577C/no not_active IP Right Cessation
- 1988-06-13 CA CA000569292A patent/CA1326035C/en not_active Expired - Lifetime
- 1988-06-13 PH PH37063A patent/PH24608A/en unknown
- 1988-06-14 IL IL86736A patent/IL86736A/xx not_active IP Right Cessation
- 1988-06-15 US US07/207,351 patent/US4997954A/en not_active Expired - Lifetime
- 1988-06-16 DE DE88305510T patent/DE3883456T2/de not_active Expired - Lifetime
- 1988-06-16 ES ES88305510T patent/ES2058285T3/es not_active Expired - Lifetime
- 1988-06-16 AT AT88305510T patent/ATE93521T1/de not_active IP Right Cessation
- 1988-06-16 EP EP88305510A patent/EP0300614B1/en not_active Expired - Lifetime
- 1988-06-16 CN CN88103732A patent/CN1019296B/zh not_active Expired
- 1988-06-17 HU HU893988A patent/HU203723B/hu not_active IP Right Cessation
- 1988-06-17 HU HU906948A patent/HUT55360A/hu unknown
- 1988-06-17 NZ NZ225072A patent/NZ225072A/xx unknown
- 1988-06-17 KR KR1019880007283A patent/KR0143088B1/ko not_active IP Right Cessation
- 1988-06-17 MY MYPI88000674A patent/MY103583A/en unknown
- 1988-06-17 FI FI882919A patent/FI89264C/fi active IP Right Grant
- 1988-06-17 DK DK334788A patent/DK169965B1/da not_active IP Right Cessation
- 1988-06-17 ZA ZA884334A patent/ZA884334B/xx unknown
- 1988-06-17 JP JP63151067A patent/JPH07596B2/ja not_active Expired - Lifetime
- 1988-06-17 PT PT87770A patent/PT87770B/pt not_active IP Right Cessation
- 1988-06-17 AU AU18119/88A patent/AU600582B2/en not_active Expired
- 1988-06-17 HU HU911599A patent/HU205339B/hu not_active IP Right Cessation
- 1988-06-17 IE IE183788A patent/IE62830B1/en not_active IP Right Cessation
- 1988-06-17 HU HU883123A patent/HU202200B/hu unknown
- 1988-06-19 EG EG342/88A patent/EG18412A/xx active
1997
- 1997-05-16 CY CY195197A patent/CY1951A/xx unknown
1998
- 1998-03-19 HK HK98102343A patent/HK1003226A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO172577B (no)	1993-05-03
DK334788A (da)	1988-12-20
PH24608A (en)	1990-08-17
KR890000421A (ko)	1989-03-14
NO882588D0 (no)	1988-06-13
PT87770B (pt)	1992-10-30
IE881837L (en)	1988-12-19
NO882588L (no)	1988-12-20
CA1326035C (en)	1994-01-11
IL86736A (en)	1992-03-29
AU600582B2 (en)	1990-08-16
NO172577C (no)	1993-08-11
ES2058285T3 (es)	1994-11-01
GB8714371D0 (en)	1987-07-22
HU911599D0 (en)	1991-11-28
HUT52043A (en)	1990-06-28
DK334788D0 (da)	1988-06-17
EP0300614B1 (en)	1993-08-25
ATE93521T1 (de)	1993-09-15
HK1003226A1 (en)	1998-10-16
DE3883456D1 (de)	1993-09-30
HU202200B (en)	1991-02-28
HU203723B (en)	1991-09-30
NZ225072A (en)	1990-05-28
EG18412A (en)	1992-12-30
FI89264C (fi)	1993-09-10
HU205339B (en)	1992-04-28
PT87770A (pt)	1989-05-31
CN1030076A (zh)	1989-01-04
EP0300614A1 (en)	1989-01-25
CY1951A (en)	1997-05-16
ZA884334B (en)	1990-04-25
JPS6419065A (en)	1989-01-23
CN1019296B (zh)	1992-12-02
HUT55360A (en)	1991-05-28
KR0143088B1 (ko)	1998-07-15
US4997954A (en)	1991-03-05
FI882919A (fi)	1988-12-20
FI882919A0 (fi)	1988-06-17
MY103583A (en)	1993-08-28
DE3883456T2 (de)	1994-03-17
IE62830B1 (en)	1995-03-08
JPH07596B2 (ja)	1995-01-11
FI89264B (fi)	1993-05-31
HUT48583A (en)	1989-06-28
AU1811988A (en)	1988-12-22

Publication	Publication Date	Title
DK169965B1 (da)	1995-04-18	Fremgangsmåde til fremstilling af 4-substituerede indolin-2-oner, samt mellemprodukter til brug herved
SU685151A3 (ru)	1979-09-05	Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
US4110338A (en)	1978-08-29	Product and preparation of 1H-tetrazole-5-thiol derivatives
SK280466B6 (sk)	2000-02-14	5,6-disubstituované-3-pyridylmetylamóniumhalogenid
JP2846042B2 (ja)	1999-01-13	インドールカルボン酸誘導体の製造法
DK2468716T3 (en)	2017-10-02	PROCEDURE FOR THE PREPARATION OF BENDAMUSTIN ALKYL ESTERS, BENDAMUSTIN AND DERIVATIVES OF SAME
KR20180116371A (ko)	2018-10-24	4-알콕시-3-히드록시피콜린산의 제조 방법
EP0008446B1 (en)	1982-09-22	Process for the preparation of carbazoles and novel carbazole derivatives utilized therein
EP0273321B1 (en)	1992-04-22	7-bromo-beta-carboline compound and method for producing same
CA1332948C (en)	1994-11-08	Process for the preparation of substituted quinolines
JP5640283B2 (ja)	2014-12-17	ピリミジン誘導体の調製プロセス
DK156391B (da)	1989-08-14	Analogifremgangsmaade til fremstilling af 3-aminopyrrolderivater
SU999967A3 (ru)	1983-02-23	Способ получени 6-N-замещенных 6-амино-3-пиридазинилгидразинов или их солей
US5973169A (en)	1999-10-26	Ipriflavone preparation process
JPH07121931B2 (ja)	1995-12-25	ベンゾ〔ｂ〕フラン誘導体
US3230234A (en)	1966-01-18	Process for the preparation of 2, 3-dihydro-1h-cyclohepta [b] pyrrole-2, 8-dione derivatives and products thereof
NO116853B (zh)	1969-06-02
US7238719B2 (en)	2007-07-03	Process for producing 1,2,3-Triazole compounds
Deady et al.	1986	Nucleophilic-Substitution Reactions in Benzo [C][1, 8] Naphthyridines
SU455104A1 (ru)	1974-12-30	Способ получени 2-метил-3-( -алкил -бензимидазолил-2")-этилиндолов
US4185020A (en)	1980-01-22	5-(4-Nitrophenyl)-2-furanmethanamines derivatives
HU207042B (en)	1993-03-01	Process for producing substituted indolinone derivatives
SU730298A3 (ru)	1980-04-25	Способ получени производных имидазола или их солей, или их комплексов с сол ми металлов
IT202100020609A1 (it)	2023-01-30	Metodo di preparazione di agente adatto per il trattamento dell'anemia
GB1570912A (en)	1980-07-09	Aromatic sulphonamido derivatives and process for their manufacture

Legal Events

Date	Code	Title	Description
1995-04-18	B1	Patent granted (law 1993)
2008-07-07	PUP	Patent expired