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DK168443B1 - Pyrimid-2-on-1-yl-forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåde til fremstilling af forbindelserne - Google Patents

Pyrimid-2-on-1-yl-forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåde til fremstilling af forbindelserne Download PDF

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Publication number
DK168443B1
DK168443B1 DK696988A DK696988A DK168443B1 DK 168443 B1 DK168443 B1 DK 168443B1 DK 696988 A DK696988 A DK 696988A DK 696988 A DK696988 A DK 696988A DK 168443 B1 DK168443 B1 DK 168443B1
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DK
Denmark
Prior art keywords
compound
formula
compounds
group
compound according
Prior art date
Application number
DK696988A
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Danish (da)
English (en)
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DK696988D0 (da
DK696988A (da
Inventor
Roelf Datema
Zsuzanna Maria Ilona Kovacs
Karl Nils Gunnar Johansson
Bjoern Gunnar Lindborg
Goeran Bertil Stening
Bo Fredrik Oeberg
Original Assignee
Medivir Ab
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Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of DK696988D0 publication Critical patent/DK696988D0/da
Publication of DK696988A publication Critical patent/DK696988A/da
Application granted granted Critical
Publication of DK168443B1 publication Critical patent/DK168443B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK696988A 1987-04-16 1988-12-15 Pyrimid-2-on-1-yl-forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåde til fremstilling af forbindelserne DK168443B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
SE8701605 1987-04-16
SE8701605A SE8701605D0 (sv) 1987-04-16 1987-04-16 Novel medicinal compounds
PCT/SE1988/000169 WO1988008001A1 (en) 1987-04-16 1988-04-06 Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
SE8800169 1988-04-06
CA000580141A CA1336088C (en) 1987-04-16 1988-10-14 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and uracil
CA580141 1988-10-14

Publications (3)

Publication Number Publication Date
DK696988D0 DK696988D0 (da) 1988-12-15
DK696988A DK696988A (da) 1989-01-31
DK168443B1 true DK168443B1 (da) 1994-03-28

Family

ID=25672174

Family Applications (3)

Application Number Title Priority Date Filing Date
DK696988A DK168443B1 (da) 1987-04-16 1988-12-15 Pyrimid-2-on-1-yl-forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåde til fremstilling af forbindelserne
DK108491A DK108491A (da) 1987-04-16 1991-06-07 Nucleosider og nucleosidanaloge samt farmaceutiske praeparater indeholdende disse forbindelser
DK104994A DK104994A (da) 1987-04-16 1994-09-13 Anvendelse af beta-anomere forbindelser til fremstilling af farmaceutiske præparater til behandling eller forebyggelse af HIV eller hepatitis B Virus

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK108491A DK108491A (da) 1987-04-16 1991-06-07 Nucleosider og nucleosidanaloge samt farmaceutiske praeparater indeholdende disse forbindelser
DK104994A DK104994A (da) 1987-04-16 1994-09-13 Anvendelse af beta-anomere forbindelser til fremstilling af farmaceutiske præparater til behandling eller forebyggelse af HIV eller hepatitis B Virus

Country Status (9)

Country Link
JP (1) JPH01503069A (ja)
AT (1) ATE115958T1 (ja)
AU (1) AU614082B2 (ja)
CA (1) CA1336088C (ja)
DE (1) DE3852531T2 (ja)
DK (3) DK168443B1 (ja)
HU (1) HU211547A9 (ja)
SE (1) SE8701605D0 (ja)
WO (1) WO1988008001A1 (ja)

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GB8629892D0 (en) * 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US4950758A (en) * 1988-01-20 1990-08-21 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
WO1989008115A1 (fr) * 1988-02-24 1989-09-08 Institut De Recherches Chimiques Et Biologiques Ap NOUVEAUX DERIVES DE LA DEOXY-2'-URIDINE SUBSTITUEE EN POSITION 5, 3' ou 5' PAR DES GROUPEMENTS alpha-AMINO ACYLES, PROCEDE POUR LEUR OBTENTION ET MEDICAMENTS LES CONTENANT
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
US5198539A (en) * 1988-08-19 1993-03-30 Burroughs Wellcome Co. 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
FI95384C (fi) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
FR2648045B1 (fr) * 1989-06-13 1991-09-27 Centre Nat Rech Scient Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
EP0491793B1 (en) * 1989-09-15 2005-11-30 Southern Research Institute 2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents
US5591722A (en) * 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US6069252A (en) 1990-02-01 2000-05-30 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
DE69122264T2 (de) * 1990-11-13 1997-02-06 Biochem Pharma Inc., Laval, Quebec Substituierte 1,3-oxathiolane mit antiviralen eigenschaften
US6369066B1 (en) 1990-11-13 2002-04-09 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes with antiviral properties
US6228860B1 (en) 1990-11-13 2001-05-08 Biochem Pharma Inc. Substituted 1,3-oxathiolanes with antiviral properties
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
DE637965T1 (de) * 1991-11-26 1995-12-14 Gilead Sciences Inc Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen.
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
WO1995032983A1 (en) * 1994-05-31 1995-12-07 Medivir Ab Post exposure prevention of hiv
US5612319A (en) * 1994-05-31 1997-03-18 Medivir Ab Postexposure prevention of HIV infection or seroconversion
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
EP0831852B1 (en) 1995-06-07 2006-11-29 Emory University Nucleosides with anti-hepatitis b virus activity
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
JP2002504558A (ja) 1998-02-25 2002-02-12 エモリー ユニバーシテイ ２’−フルオロヌクレオシド
CA2426187C (en) 2000-10-18 2011-08-16 Pharmasset Limited Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation
MX2009003452A (es) 2006-10-10 2009-04-14 Medivir Ab Inhibidores nucleosidicos del vhc.
WO2014109384A1 (ja) * 2013-01-10 2014-07-17 塩野義製薬株式会社 架橋型核酸誘導体の製造方法

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DD75084A (ja) *
US3116282A (en) * 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
FR2040177A1 (en) * 1969-01-31 1971-01-22 Robugen Gmbh 2-deoxyribosyl-uracil derivs
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
DE2918260A1 (de) * 1979-05-07 1980-11-27 Robugen Gmbh Anwendung von 5-alkyl-2'-desoxyuridinen
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
DE2930904A1 (de) * 1979-07-30 1981-02-19 Kailash Kumar Dr Gauri Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel
DE3045375A1 (de) * 1980-12-02 1982-07-01 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen
DE3229169A1 (de) * 1982-08-05 1984-02-09 Robugen GmbH Pharmazeutische Fabrik, 7300 Esslingen Verwendung von 5-alkylpyrimidinnukleosiden und deren derivate als zytostatika
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
PH24388A (en) * 1985-03-16 1990-06-13 Wellcome Foundation Ltd N W I Antiviral nucleosides
EP0199451B1 (en) * 1985-03-16 1996-03-06 The Wellcome Foundation Limited Therapeutic nucleosides
GR861255B (en) * 1985-05-15 1986-09-16 Wellcome Found Therapeutic nucleosides
DE3650741T2 (de) * 1985-09-17 2000-10-12 The Wellcome Foundation Ltd., Greenford Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.

Also Published As

Publication number Publication date
SE8701605D0 (sv) 1987-04-16
WO1988008001A1 (en) 1988-10-20
ATE115958T1 (de) 1995-01-15
DK696988D0 (da) 1988-12-15
DK696988A (da) 1989-01-31
JPH01503069A (ja) 1989-10-19
CA1336088C (en) 1995-06-27
DK108491D0 (da) 1991-06-07
DK108491A (da) 1991-06-07
AU614082B2 (en) 1991-08-22
DE3852531T2 (de) 1995-08-10
AU1689988A (en) 1988-11-04
DE3852531D1 (de) 1995-02-02
DK104994A (da) 1994-09-13
HU211547A9 (en) 1995-12-28

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed