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DK1521752T3 - Makrocykliske forbindelser til behandling af cancer - Google Patents

Makrocykliske forbindelser til behandling af cancer

Info

Publication number
DK1521752T3
DK1521752T3 DK03763870T DK03763870T DK1521752T3 DK 1521752 T3 DK1521752 T3 DK 1521752T3 DK 03763870 T DK03763870 T DK 03763870T DK 03763870 T DK03763870 T DK 03763870T DK 1521752 T3 DK1521752 T3 DK 1521752T3
Authority
DK
Denmark
Prior art keywords
cancer
treatment
macrocyclic compounds
macrocyclic
compounds
Prior art date
Application number
DK03763870T
Other languages
English (en)
Inventor
Gerhard Hoefle
Wolfgang Richter
Original Assignee
Helmholtz Infektionsforschung
Wolfgang Richter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10232094A external-priority patent/DE10232094A1/de
Priority claimed from DE10255660A external-priority patent/DE10255660A1/de
Application filed by Helmholtz Infektionsforschung, Wolfgang Richter filed Critical Helmholtz Infektionsforschung
Application granted granted Critical
Publication of DK1521752T3 publication Critical patent/DK1521752T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26Radicals substituted by sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D327/00Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK03763870T 2002-07-15 2003-07-15 Makrocykliske forbindelser til behandling af cancer DK1521752T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10232094A DE10232094A1 (de) 2002-07-15 2002-07-15 5-Thiaepothilone und 15-disubstituierte Epothilone
DE10255660A DE10255660A1 (de) 2002-11-28 2002-11-28 Neue Makrocyclen zur Behandlung von Krebserkrankungen
PCT/EP2003/007664 WO2004007492A1 (en) 2002-07-15 2003-07-15 Novel macrocycles for the treatment of cancer

Publications (1)

Publication Number Publication Date
DK1521752T3 true DK1521752T3 (da) 2009-06-22

Family

ID=30116646

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03763870T DK1521752T3 (da) 2002-07-15 2003-07-15 Makrocykliske forbindelser til behandling af cancer

Country Status (10)

Country Link
US (1) US7553859B2 (da)
EP (1) EP1521752B1 (da)
JP (1) JP4597667B2 (da)
AT (1) ATE423780T1 (da)
AU (1) AU2003252540B2 (da)
CA (1) CA2491943C (da)
DE (1) DE60326348D1 (da)
DK (1) DK1521752T3 (da)
ES (1) ES2323956T3 (da)
WO (1) WO2004007492A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003296242A1 (en) * 2002-11-28 2004-06-18 Wolfgang Richter Thia-epothilone derivatives for the treatment of cancer
HRP20140783T1 (hr) 2008-04-24 2014-09-12 Bristol-Myers Squibb Company Uporaba epotilona d u lijeäśenju tau-povezanih bolesti ukljuäśujuä†i alzheimerovu bolest
EP2394640A1 (en) 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
EP2708243A1 (en) 2012-09-17 2014-03-19 OntoChem GmbH Receptor ligand linked cytotoxic molecules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064650A2 (en) * 2000-03-01 2001-09-07 Sloan-Kettering Institute For Cancer Research Center Synthesis of epothilones, intermediates thereto and analogues thereof
AU2001271639A1 (en) * 2000-06-28 2002-01-08 Teva Pharmaceutical Industries Ltd. Carvedilol
AU2003296242A1 (en) * 2002-11-28 2004-06-18 Wolfgang Richter Thia-epothilone derivatives for the treatment of cancer

Also Published As

Publication number Publication date
JP4597667B2 (ja) 2010-12-15
EP1521752A1 (en) 2005-04-13
US20060004065A1 (en) 2006-01-05
CA2491943C (en) 2012-06-19
US7553859B2 (en) 2009-06-30
AU2003252540A1 (en) 2004-02-02
WO2004007492A1 (en) 2004-01-22
ES2323956T3 (es) 2009-07-28
JP2005537263A (ja) 2005-12-08
EP1521752B1 (en) 2009-02-25
CA2491943A1 (en) 2004-01-22
DE60326348D1 (de) 2009-04-09
AU2003252540B2 (en) 2008-11-20
ATE423780T1 (de) 2009-03-15

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