[go: up one dir, main page]

DK150204C - Analogifremgangsmaade til fremstilling af dipeptidyl-agmatiner eller deres hydrochlorider - Google Patents

Analogifremgangsmaade til fremstilling af dipeptidyl-agmatiner eller deres hydrochlorider

Info

Publication number
DK150204C
DK150204C DK023981A DK23981A DK150204C DK 150204 C DK150204 C DK 150204C DK 023981 A DK023981 A DK 023981A DK 23981 A DK23981 A DK 23981A DK 150204 C DK150204 C DK 150204C
Authority
DK
Denmark
Prior art keywords
agmatines
dipeptidyl
hydrochlorides
analogue
preparation
Prior art date
Application number
DK023981A
Other languages
English (en)
Other versions
DK23981A (da
DK150204B (da
Inventor
Sandor Bajusz
Erzsebet Szell
Eva Barabas
Daniel Bagdy
Zsuzsanna Mohai
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK23981A publication Critical patent/DK23981A/da
Publication of DK150204B publication Critical patent/DK150204B/da
Application granted granted Critical
Publication of DK150204C publication Critical patent/DK150204C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK023981A 1979-06-12 1981-01-20 Analogifremgangsmaade til fremstilling af dipeptidyl-agmatiner eller deres hydrochlorider DK150204C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU79GO1449A HU178398B (en) 1979-06-12 1979-06-12 Process for producing new agmatine derivatives of activity against haemagglutination
HU144980 1980-10-07

Publications (3)

Publication Number Publication Date
DK23981A DK23981A (da) 1982-04-08
DK150204B DK150204B (da) 1987-01-05
DK150204C true DK150204C (da) 1987-10-19

Family

ID=10996896

Family Applications (1)

Application Number Title Priority Date Filing Date
DK023981A DK150204C (da) 1979-06-12 1981-01-20 Analogifremgangsmaade til fremstilling af dipeptidyl-agmatiner eller deres hydrochlorider

Country Status (17)

Country Link
US (1) US4346078A (da)
JP (1) JPS5764653A (da)
AT (1) AT384228B (da)
AU (1) AU535688B2 (da)
BE (1) BE887224A (da)
CA (1) CA1158641A (da)
CH (1) CH649561A5 (da)
DE (1) DE3108810A1 (da)
DK (1) DK150204C (da)
FR (1) FR2491463B1 (da)
GB (1) GB2085444B (da)
HU (1) HU178398B (da)
IL (1) IL62018A (da)
IT (1) IT1168107B (da)
NL (1) NL8100391A (da)
SE (1) SE452326B (da)
SU (1) SU1178322A3 (da)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE968808C (de) * 1949-11-01 1958-04-03 Hermann Schilling Dipl Ing Baeuerliches Motorvielfachgeraet mit einachsigem Motorgrundgeraet
US4088040A (en) * 1977-01-03 1978-05-09 Ross Myring Brian 360° Cable actuating lever
IT1219846B (it) * 1988-02-24 1990-05-24 Consiglio Nazionale Ricerche Nuovi derivati guandinici ad attivita' ipotensia,composizione che li contengono e relativo procedimento di estrazione e purificazione da materiale botanico
FR2656608B1 (fr) * 1989-12-28 1992-04-24 Roussel Uclaf Nouvelles polyamines benzoylees, leur procede de preparation et leur application comme fongicides.
US5430023A (en) * 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
US5252566A (en) * 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
SE507295C2 (sv) * 1992-01-18 1998-05-11 Thyssen Nordseewerke Gmbh Värmeisoleringsformkroppar
US5583146A (en) * 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
US6534536B1 (en) 1994-03-16 2003-03-18 Bristol-Myers Squibb Company Alkylsulfonamido heterocyclic thrombin inhibitors
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
WO1994025051A1 (en) * 1993-04-30 1994-11-10 Merck & Co., Inc. Thrombin inhibitors
SE9301912D0 (sv) * 1993-06-03 1993-06-03 Ab Astra Process for the production of aminoalkylguandines
SE9301911D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptide derivatives
SE9900043D0 (sv) * 1999-01-11 1999-01-11 Astra Ab New use
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5780631A (en) * 1993-06-03 1998-07-14 Astra Aktiebolag Starting materials in the synthesis of thrombin and kininogenase inhibitors
GB9318637D0 (en) * 1993-09-08 1993-10-27 Ferring Res Ltd Enzyme inhibitors
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5691356A (en) * 1994-03-21 1997-11-25 Bristol-Myers Squibb Company Disubstituted heterocyclic thrombin inhibitors
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5498724A (en) * 1994-06-28 1996-03-12 Aktiebolaget Astra Pyrazoleamidine compounds
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
EA199700186A1 (ru) * 1995-02-17 1998-02-26 Басф Акциенгезельшафт Новые дипептидные амидины, используемые в качестве ингибиторов тромбина
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
US5811402A (en) * 1996-03-22 1998-09-22 Eli Lilly And Company Antithrombotic diamides
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
CA2258915A1 (en) * 1996-06-25 1997-12-31 Michael Robert Wiley Anticoagulant agents
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
US5798377A (en) * 1996-10-21 1998-08-25 Merck & Co., Inc. Thrombin inhibitors
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
BR9907112A (pt) 1998-01-26 2000-10-24 Basf Ag Composto, medicamento, e, uso de um composto
JP2003529528A (ja) 1998-04-24 2003-10-07 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
ES2295004T3 (es) 1999-01-13 2008-04-16 Astrazeneca Ab Nuevos derivados amidinobencilaminicos y su uso como inhibidores de trombina.
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US6528503B2 (en) 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
AU2002230836A1 (en) 2000-12-18 2002-07-01 Merck & Co., Inc. Benzylamine derivatives and their use as thrombin inhibitors
CA2436176A1 (en) 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
AU2002316604A1 (en) * 2001-07-06 2003-01-21 Oregon Health And Science University Peptides which modulate blood coagulation and methods of use thereof
US7084134B2 (en) * 2002-05-02 2006-08-01 Merk & Co., Inc. Thrombin inhibitors
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
CN102464701B (zh) 2010-11-08 2015-10-21 上海医药工业研究院 一类新型化合物、其制备方法及用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a

Also Published As

Publication number Publication date
HU178398B (en) 1982-04-28
DK23981A (da) 1982-04-08
US4346078A (en) 1982-08-24
DE3108810A1 (de) 1982-05-19
JPS5764653A (en) 1982-04-19
CH649561A5 (en) 1985-05-31
IL62018A0 (en) 1981-02-27
IL62018A (en) 1984-03-30
AT384228B (de) 1987-10-12
SU1178322A3 (ru) 1985-09-07
GB2085444A (en) 1982-04-28
IT1168107B (it) 1987-05-20
NL8100391A (nl) 1982-05-03
DK150204B (da) 1987-01-05
IT8120107A0 (it) 1981-03-04
GB2085444B (en) 1984-02-15
AU6672581A (en) 1982-04-22
FR2491463A1 (da) 1982-04-09
FR2491463B1 (da) 1984-08-17
BE887224A (fr) 1981-07-27
SE452326B (sv) 1987-11-23
SE8100302L (sv) 1982-04-08
ATA43681A (de) 1987-03-15
AU535688B2 (en) 1984-03-29
CA1158641A (en) 1983-12-13

Similar Documents

Publication Publication Date Title
DK150204C (da) Analogifremgangsmaade til fremstilling af dipeptidyl-agmatiner eller deres hydrochlorider
DK156434C (da) Analogifremgangsmaade til fremstilling af sulfonylurinstoffer eller deres fysiologisk acceptable salte
DK154940C (da) Analogifremgangsmaade til fremstilling af tetra- eller pentapeptider
DK154553C (da) Analogifremgangsmaade til fremstilling af ether- eller thioethermercaptoacylproliner
DK153787C (da) Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved
DK155665C (da) Analogifremgangsmaade til fremstilling af carbostyrilforbindelser
DK160866C (da) Analogifremgangsmaade til fremstilling af phenoletherforbindelser
DK155048C (da) Analogifremgangsmaade til fremstilling af 1,8-naphthyridinforbindelser
DK148141C (da) Analogifremgangsmaade til fremstilling af phosphonylacetylproliner
DK148477C (da) Analogifremgangsmaade til fremstilling af tetrahydropyridinylindolderivater eller additionssalte deraf
DK158269C (da) Analogifremgangsmaade til fremstilling af morpholinyldaunorubicin- eller morpholinyldoxorubicinderivater
DK156001C (da) Analogifremgangsmaade til fremstilling af mercaptosubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner
DK145260C (da) Analogifremgangsmaade til fremstilling af 4-acylamino-phenyl-ethanolaminer eller syreadditionssalte heraf
DK157193C (da) Analogifremgangsmaade til fremstilling af carbostyrilforbindelser
DK344280A (da) Fremgangsmaade til fremstilling af aminopropoxyarylderivater
DK140480A (da) Fremgangsmaade til fremstilling af mercaptoacyldipeptider
DK229980A (da) Fremgangsmaade til fremstilling af n-heterocyclyl-thienamyciner
DK158658C (da) Analogifremgangsmaade til fremstilling af 9-aminoalkylfluorener eller farmaceutisk acceptable salte deraf
DK158460C (da) Analogifremgangsmaade til fremstilling af substituerede oxocarboxylsyrer
DK159851C (da) Fremgangsmaade til fremstilling af riboflavin
DK405780A (da) Analogifremgangsmaade til fremstilling af 2-amino-3-benzoylphenylacetamider og deres cycliske homologe
DK159153C (da) Analogifremgangsmaade til fremstilling af penicillinforbindelser
DK149026C (da) Analogifremgangsmaade til fremstilling af adeninnucleosidderivater
DK455980A (da) Analogifremgangsmaade til fremstilling af spiroimidazolonforbindelser eller syreaddiionssalte deraf
DK145666C (da) Fremgangsmaade til fremstilling af 17alfa-(3-jodbenzoyloxy)-9alfa-chlor-4-pregnen-3,20-dioner eller deres d-homoanaloge

Legal Events

Date Code Title Description
PBP Patent lapsed