DK1492579T3 - Medicinske proteseindretninger med forbedret bioforligelighed - Google Patents
Medicinske proteseindretninger med forbedret bioforligelighedInfo
- Publication number
- DK1492579T3 DK1492579T3 DK03717853T DK03717853T DK1492579T3 DK 1492579 T3 DK1492579 T3 DK 1492579T3 DK 03717853 T DK03717853 T DK 03717853T DK 03717853 T DK03717853 T DK 03717853T DK 1492579 T3 DK1492579 T3 DK 1492579T3
- Authority
- DK
- Denmark
- Prior art keywords
- medical prosthetic
- prosthetic devices
- improved biocompatibility
- hydroxide
- titanium
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 239000007769 metal material Substances 0.000 abstract 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 1
- 239000000956 alloy Substances 0.000 abstract 1
- 229910045601 alloy Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- LLZRNZOLAXHGLL-UHFFFAOYSA-J titanic acid Chemical compound O[Ti](O)(O)O LLZRNZOLAXHGLL-UHFFFAOYSA-J 0.000 abstract 1
- 239000010936 titanium Substances 0.000 abstract 1
- 229910052719 titanium Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Dental Preparations (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200200515 | 2002-04-09 | ||
PCT/SE2003/000575 WO2003086495A1 (en) | 2002-04-09 | 2003-04-08 | Medical prosthetic devices having improved biocompatibility |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1492579T3 true DK1492579T3 (da) | 2009-01-19 |
Family
ID=29225534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03717853T DK1492579T3 (da) | 2002-04-09 | 2003-04-08 | Medicinske proteseindretninger med forbedret bioforligelighed |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1492579B1 (da) |
JP (2) | JP4945772B2 (da) |
KR (1) | KR101020026B1 (da) |
CN (1) | CN1313165C (da) |
AT (1) | ATE407709T1 (da) |
AU (1) | AU2003222551B2 (da) |
BR (1) | BRPI0309068B8 (da) |
CA (1) | CA2481488C (da) |
DE (1) | DE60323475D1 (da) |
DK (1) | DK1492579T3 (da) |
ES (1) | ES2312765T3 (da) |
RU (1) | RU2313370C2 (da) |
WO (1) | WO2003086495A1 (da) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10232139A1 (de) | 2002-07-04 | 2004-01-22 | Technische Universität Dresden | Mit Nukleinsäuren und Nukleinsäurederivaten beschichteter metallischer Gegenstand, Verfahren zu dessen Herstellung und dessen Verwendung |
US8298292B2 (en) | 2003-04-16 | 2012-10-30 | Howmedica Osteonics Corp. | Craniofacial implant |
WO2004093743A1 (en) | 2003-04-16 | 2004-11-04 | Porex Surgical, Inc. | Craniofacial implant |
JP5026004B2 (ja) * | 2005-06-28 | 2012-09-12 | 江崎グリコ株式会社 | リン酸化糖を含有するチタンインプラント材 |
ATE518494T1 (de) * | 2006-02-28 | 2011-08-15 | Straumann Holding Ag | Aufbau mit hydroxylierter oberfläche |
ATE519445T1 (de) * | 2006-02-28 | 2011-08-15 | Straumann Holding Ag | Einteiliges implantat mit hydroxylierter kontaktoberfläche für weiches gewebe |
CA2657522A1 (en) * | 2006-07-28 | 2008-01-31 | Med-El Elektro-Medizinische Gerate Gesellschaft M.B.H. | Layered electrode array and cable |
JP5179815B2 (ja) * | 2007-09-11 | 2013-04-10 | 昭男 田中 | 骨形成剤および骨形成方法 |
JP5207480B2 (ja) * | 2008-05-30 | 2013-06-12 | 株式会社ナントー精密 | インプラント体及びその製造方法並びに歯科用インプラント |
MX2011007080A (es) * | 2008-12-31 | 2011-10-17 | Kci Licensing Inc | Sistema para inducir el flujo de fluido para estimular el crecimiento de tejido. |
GB0902705D0 (en) | 2009-02-19 | 2009-04-01 | Neoss Ltd | Surface treatment process for implant |
WO2010114827A1 (en) * | 2009-04-01 | 2010-10-07 | Difusion Technologies, Inc. | Regulation of bone growth using zeolite in combination with bone graft substitutes |
DE102009024616A1 (de) * | 2009-06-08 | 2010-12-23 | Telos Gmbh | Sterilisierbare Implantatbeschichtung und Verfahren zu deren Herstellung |
US8979534B2 (en) | 2009-06-17 | 2015-03-17 | The Trustees Of Columbia University In The City Of New York | Tooth scaffolds |
US9492584B2 (en) | 2009-11-25 | 2016-11-15 | Difusion Technologies, Inc. | Post-charging of zeolite doped plastics with antimicrobial metal ions |
BR112012016027B1 (pt) | 2009-12-11 | 2019-01-15 | Difusion Technologies, Inc. | método de produção de implantes antimicrobianos de polieteretercetona |
TWI425961B (zh) * | 2009-12-29 | 2014-02-11 | Metal Ind Res & Dev Ct | Medical equipment and its surface treatment method |
KR101095962B1 (ko) * | 2010-01-04 | 2011-12-19 | 전북대학교산학협력단 | 임플란트 소재표면에서 효과적인 유전자 전달을 위한 표면처리방법 |
CN102205144B (zh) * | 2010-03-31 | 2014-07-16 | 方崇凯 | 医用金属植入材料多孔钽及其制备方法 |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
CA2795836C (en) | 2010-05-07 | 2015-11-17 | Difusion Technologies, Inc. | Medical implant comprising a thermoplastic resin having aluminosilicate particles incorporated therein |
CN102258805B (zh) * | 2010-05-28 | 2016-08-10 | 温州智创科技有限公司 | 医用金属植入材料多孔铌及其制备方法 |
CA2830079C (en) | 2011-04-05 | 2019-02-26 | Northwood Medical Innovation Limited | Ear scaffold |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
CN102579145B (zh) * | 2012-02-23 | 2014-05-14 | 中国人民解放军第四军医大学 | 一种牙科种植体及其制备方法 |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
SE537637C2 (sv) | 2012-09-18 | 2015-09-01 | Corticalis As | Titandioxidscaffold, metod för att producera denna scaffoldsamt medicinskt implantat innefattande denna |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
NZ715203A (en) * | 2013-05-16 | 2019-07-26 | Agency Science Tech & Res | Heparan sulphates |
WO2015017264A1 (en) * | 2013-07-31 | 2015-02-05 | Footmind, Inc. | Surgical systems and methods for assembling and fusing bones |
CN105327398A (zh) * | 2014-08-07 | 2016-02-17 | 北京纳通科技集团有限公司 | 抗菌涂层组合物、包含抗菌涂层的医用植入材料及其制备方法 |
EP3034033A1 (en) | 2014-12-16 | 2016-06-22 | Nobel Biocare Services AG | Dental implant |
WO2017073591A1 (ja) * | 2015-10-27 | 2017-05-04 | 山本 修 | クロム修飾型インプラント及びその製造方法 |
DE202016008737U1 (de) | 2015-12-15 | 2019-04-05 | Neovasc Tiara Inc. | Transseptales Zuführsystem |
CA3007670A1 (en) | 2016-01-29 | 2017-08-03 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
CN106109059A (zh) * | 2016-08-05 | 2016-11-16 | 北京爱康宜诚医疗器材有限公司 | 假体结构 |
EP3287150B1 (en) | 2016-08-22 | 2022-12-14 | WALDEMAR LINK GmbH & Co. KG | Coating for an implant |
CA3042588A1 (en) | 2016-11-21 | 2018-05-24 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
CN107117962B (zh) * | 2017-05-04 | 2019-08-16 | 中山市瑞丰医疗器械有限公司 | 一种基于静电自组装技术的牙科全瓷修复材料的制备方法 |
US10856984B2 (en) | 2017-08-25 | 2020-12-08 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
CN108939158A (zh) * | 2018-07-27 | 2018-12-07 | 吉林大学 | 小肠脱细胞基质膜结合金属网胸壁修补材料 |
WO2020093172A1 (en) | 2018-11-08 | 2020-05-14 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
JP2022507228A (ja) | 2018-11-12 | 2022-01-18 | ノベル バイオケア サーヴィシィズ アーゲー | 歯科インプラント、歯科用構成要素、歯科用インプラントシステム、インプラント可能な構成要素またはインプラントの構成要素の表面に保護層を形成するための方法、保護層を有するインプラント可能な構成要素またはインプラントの構成要素、及び保護層の使用 |
CA3132873A1 (en) | 2019-03-08 | 2020-09-17 | Neovasc Tiara Inc. | Retrievable prosthesis delivery system |
CN113811265B (zh) | 2019-04-01 | 2024-11-29 | 内奥瓦斯克迪亚拉公司 | 能够以可控的方式部署的假体瓣膜 |
CN113924065A (zh) | 2019-04-10 | 2022-01-11 | 内奥瓦斯克迪亚拉公司 | 具有自然血流的假体瓣膜 |
EP3972673A4 (en) | 2019-05-20 | 2023-06-07 | Neovasc Tiara Inc. | INTRODUCER DEVICE WITH HEMOSTASIS MECHANISM |
JP7520897B2 (ja) | 2019-06-20 | 2024-07-23 | ニオバスク ティアラ インコーポレイテッド | 薄型人工補綴僧帽弁 |
US20210402052A1 (en) | 2020-06-30 | 2021-12-30 | Difusion, Inc. | Medical Implants And Methods Of Manufacture |
CN113368305B (zh) * | 2021-05-21 | 2022-04-26 | 上海市伤骨科研究所 | 一种骨诱导及免疫双效涂层及制备方法和在骨整合的应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5152993A (en) * | 1988-01-20 | 1992-10-06 | Ellem Bioteknik Ab | Method of preparing an implant body for implantation |
US5211663A (en) * | 1991-06-24 | 1993-05-18 | Smith & Nephew Richards, Inc. | Passivation methods for metallic medical implants |
FI91713C (fi) * | 1992-04-23 | 1994-08-10 | Axidental Oy | Uusia bioaktiivisia pinnotteita ja niiden valmistus ja käyttö |
CA2150036C (en) * | 1993-11-09 | 2001-07-10 | Tadashi Kokubo | A material for a bone substitute and the manufacturing method thereof |
AU726819B2 (en) * | 1996-03-29 | 2000-11-23 | Desmos, Inc. | Cellular attachment to laminin 5-coated trans-epithelial appliances |
WO1999008730A1 (en) * | 1997-08-15 | 1999-02-25 | Children's Medical Center Corporation | Osteopontin coated surfaces and methods of use |
JP2000093498A (ja) * | 1998-09-22 | 2000-04-04 | Kobe Steel Ltd | 骨代替材料及びその製造方法 |
SE9804400L (sv) * | 1998-12-18 | 2000-02-14 | Bofors Ab | Sätt att vid initiering av artilleridrivkrutladdningar bestående av ett flertal efter varandra anordnade drivkrutsmoduler åstadkomma en jämn övertändning mellan dessa samt i enlighet med sättet utformade drivkrutsmoduler och kompletta laddningar |
SE9804536D0 (sv) * | 1998-12-23 | 1998-12-23 | A & Science Invest Ab | Biological implant and method for production thereof |
SE514323C2 (sv) * | 1999-05-31 | 2001-02-12 | Nobel Biocare Ab | Implantat samt förfarande och användning vid implantat |
JP2002035109A (ja) * | 2000-07-21 | 2002-02-05 | Tadashi Kokubo | 抗血栓性材料及びその製造方法 |
ES2223965T3 (es) * | 2000-12-06 | 2005-03-01 | Astra Tech Ab | Protesis e implantes medicos revestidos con hidruros metalicos y biomoleculas que tienen biocompatibilidad mejorada. |
-
2003
- 2003-04-08 EP EP03717853A patent/EP1492579B1/en not_active Expired - Lifetime
- 2003-04-08 RU RU2004132836/15A patent/RU2313370C2/ru active
- 2003-04-08 AU AU2003222551A patent/AU2003222551B2/en not_active Ceased
- 2003-04-08 CA CA2481488A patent/CA2481488C/en not_active Expired - Lifetime
- 2003-04-08 DE DE60323475T patent/DE60323475D1/de not_active Expired - Lifetime
- 2003-04-08 JP JP2003583505A patent/JP4945772B2/ja not_active Expired - Lifetime
- 2003-04-08 BR BRPI0309068A patent/BRPI0309068B8/pt not_active IP Right Cessation
- 2003-04-08 WO PCT/SE2003/000575 patent/WO2003086495A1/en active IP Right Grant
- 2003-04-08 KR KR1020047016094A patent/KR101020026B1/ko active IP Right Grant
- 2003-04-08 DK DK03717853T patent/DK1492579T3/da active
- 2003-04-08 CN CNB038133199A patent/CN1313165C/zh not_active Expired - Fee Related
- 2003-04-08 ES ES03717853T patent/ES2312765T3/es not_active Expired - Lifetime
- 2003-04-08 AT AT03717853T patent/ATE407709T1/de active
-
2011
- 2011-08-26 JP JP2011184497A patent/JP2012024591A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2003222551A1 (en) | 2003-10-27 |
DE60323475D1 (de) | 2008-10-23 |
JP4945772B2 (ja) | 2012-06-06 |
BR0309068B1 (pt) | 2014-12-09 |
EP1492579A1 (en) | 2005-01-05 |
KR20040101420A (ko) | 2004-12-02 |
BR0309068A (pt) | 2005-02-01 |
JP2012024591A (ja) | 2012-02-09 |
ATE407709T1 (de) | 2008-09-15 |
CA2481488A1 (en) | 2003-10-23 |
RU2313370C2 (ru) | 2007-12-27 |
EP1492579B1 (en) | 2008-09-10 |
CN1658914A (zh) | 2005-08-24 |
ES2312765T3 (es) | 2009-03-01 |
BRPI0309068B8 (pt) | 2021-06-22 |
AU2003222551B2 (en) | 2006-02-23 |
KR101020026B1 (ko) | 2011-03-09 |
CN1313165C (zh) | 2007-05-02 |
CA2481488C (en) | 2012-01-24 |
RU2004132836A (ru) | 2005-04-20 |
WO2003086495A1 (en) | 2003-10-23 |
JP2005533532A (ja) | 2005-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1492579T3 (da) | Medicinske proteseindretninger med forbedret bioforligelighed | |
ATE448812T1 (de) | Beschichtung von stents mit verzögerter wirkstofffreisetzung | |
DE602004019938D1 (de) | Beschichtete implantate und beschichtungsverfahren | |
EP3238665A3 (en) | Diffusion-hardened medical implant | |
EP1493123A4 (en) | MODIFICATION OF THE PROCEDURE OF THE NORMALIZED DIFFERENCES FOR OPTICAL REAL-TIME TOMOGRAPHY | |
ATE272650T1 (de) | Analoge des magensaft inhibierenden peptides und ihre verwendung für die behandlung von diabetes | |
AU2003299791A1 (en) | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity | |
EP2526957A3 (en) | Proliferation of MUC1 expressing cells | |
EP2191794A3 (en) | Medical devices | |
EA200501562A1 (ru) | Медицинские имплантаты, содержащие биосовместимые покрытия | |
HK1087103A1 (en) | Anilinopyrazole derivatives useful for the treatment of diabetes | |
AU2003298060A1 (en) | Abutment for a dental implant, dental implant comprising such an abutment, and method for the production of dentures by means of said dental implant | |
DE60234429D1 (de) | Verfahren zur verbesserung der anhaftung von weichteilgewebe und implantate, die gebrauch von diesem verfahen machen | |
NO20052474L (no) | Amort form av esomeprazolsalter | |
MXPA06013039A (es) | El tratamiento de enfermedad respiratoria. | |
AU2003290059A1 (en) | Use of cd137 antagonists for the treatment of tumors | |
DE60015508T2 (de) | C-16 ungesätigte fp-selektive prostaglandin analoge | |
ATE423578T1 (de) | Medizinprodukt mit einem biologischen wirkstoff | |
PT1539261E (pt) | Implante metalico revestido sob concentracao reduzida de oxigenio com proteina osteoindutiva | |
DE602006007592D1 (de) | Aluminiumoxid-beschichtete Implantate und Komponente | |
NO20043674L (no) | Fremgangsmate for behandling av karbonholdige stoffer | |
ITMI20022704A1 (it) | Procedimento per la produzione di mesitilene e durene. | |
AU2003214145A1 (en) | Medical use of ras antagonists for the treatment of capillary malformation | |
AU2003217196A1 (en) | Methods of enhancing the biocompatibility of an implantable medi cal device | |
AU2003258529A1 (en) | Use of lignans for prevening or treating the sings of ageing of the skin |