DK1475094T3 - Pyrazolo[4,3-d]pyrimidiner, fremgangsmåde til deres fremstilling samt deres anvendelse - Google Patents
Pyrazolo[4,3-d]pyrimidiner, fremgangsmåde til deres fremstilling samt deres anvendelseInfo
- Publication number
- DK1475094T3 DK1475094T3 DK03010184.4T DK03010184T DK1475094T3 DK 1475094 T3 DK1475094 T3 DK 1475094T3 DK 03010184 T DK03010184 T DK 03010184T DK 1475094 T3 DK1475094 T3 DK 1475094T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- alkyl
- unsubstituted
- cycloalkyl
- arylalkyl
- Prior art date
Links
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- -1 cycloheteroalkyl Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03010184A EP1475094B8 (en) | 2003-05-06 | 2003-05-06 | Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1475094T3 true DK1475094T3 (da) | 2010-11-22 |
Family
ID=32981816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03010184.4T DK1475094T3 (da) | 2003-05-06 | 2003-05-06 | Pyrazolo[4,3-d]pyrimidiner, fremgangsmåde til deres fremstilling samt deres anvendelse |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20070167466A1 (da) |
| EP (1) | EP1475094B8 (da) |
| AT (1) | ATE475421T1 (da) |
| CA (1) | CA2524344C (da) |
| DE (1) | DE60333546D1 (da) |
| DK (1) | DK1475094T3 (da) |
| ES (1) | ES2351624T3 (da) |
| WO (1) | WO2004098608A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004205642C1 (en) | 2003-01-14 | 2012-01-12 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| BRPI0412689A (pt) * | 2003-07-14 | 2006-10-03 | Arena Pharm Inc | derivados de heteroarila e arila fundida como moduladores de metabolismo e a profilaxia e tratamento de distúrbios relacionados a ele |
| RU2356889C2 (ru) | 2003-07-17 | 2009-05-27 | Плекссикон, Инк. | Соединения, являющиеся активными по отношению к рецепторам, активируемым пролифератором пероксисом |
| MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
| EP1915377A1 (en) * | 2005-07-22 | 2008-04-30 | Sunesis Pharmaceuticals, Inc. | Pyrazolo pyrimidines useful as aurora kinase inhibitors |
| PL2170340T3 (pl) | 2007-06-21 | 2016-06-30 | Neuronascent Inc | Sposoby i kompozycje stymulacji neurogenezy i hamowania degeneracji neuronów z wykorzystaniem izotiazolopirymidonów |
| KR101483215B1 (ko) | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
| CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2014126580A1 (en) * | 2013-02-15 | 2014-08-21 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| MX386419B (es) | 2015-01-06 | 2025-03-18 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
| CZ307147B6 (cs) * | 2015-05-14 | 2018-02-07 | Ústav experimentální botaniky AV ČR, v. v. i. | 5-Substituované 7-[4-(2-pyridyl)fenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako léčiva, a farmaceutické přípravky |
| MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
| KR102859841B1 (ko) | 2018-06-06 | 2025-09-12 | 아레나 파마슈티칼스, 인크. | S1p1 수용체와 관련된 병태의 치료 방법 |
| CN115554303B (zh) * | 2021-09-18 | 2024-07-09 | 上海科技大学 | 一种三环类化合物、其制备方法及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1530747A (en) * | 1922-05-20 | 1925-03-24 | Frank B Wyatt | Motion-picture machine |
| GB1530747A (en) * | 1976-04-05 | 1978-11-01 | Massachusetts Inst Technology | Pharmaceutical composition |
| US4282361A (en) * | 1978-03-16 | 1981-08-04 | Massachusetts Institute Of Technology | Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines |
| CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| AU7323000A (en) * | 1999-08-26 | 2001-04-10 | Plant Research International B.V. | Conditional inhibition of vegetative propagation |
| DE10060388A1 (de) * | 2000-12-05 | 2002-06-06 | Merck Patent Gmbh | Verwendung von Pyrazolo [4,3-d]pyrimidinen |
-
2003
- 2003-05-06 DK DK03010184.4T patent/DK1475094T3/da active
- 2003-05-06 DE DE60333546T patent/DE60333546D1/de not_active Expired - Lifetime
- 2003-05-06 ES ES03010184T patent/ES2351624T3/es not_active Expired - Lifetime
- 2003-05-06 AT AT03010184T patent/ATE475421T1/de not_active IP Right Cessation
- 2003-05-06 EP EP03010184A patent/EP1475094B8/en not_active Expired - Lifetime
-
2004
- 2004-05-06 CA CA2524344A patent/CA2524344C/en not_active Expired - Fee Related
- 2004-05-06 US US10/555,528 patent/US20070167466A1/en not_active Abandoned
- 2004-05-06 WO PCT/EP2004/004855 patent/WO2004098608A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60333546D1 (de) | 2010-09-09 |
| EP1475094A1 (en) | 2004-11-10 |
| EP1475094B1 (en) | 2010-07-28 |
| US20070167466A1 (en) | 2007-07-19 |
| EP1475094B8 (en) | 2011-01-12 |
| CA2524344A1 (en) | 2004-11-18 |
| WO2004098608A1 (en) | 2004-11-18 |
| CA2524344C (en) | 2012-03-13 |
| ATE475421T1 (de) | 2010-08-15 |
| ES2351624T3 (es) | 2011-02-08 |
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