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DE60333546D1 - PyrazoloÄ4,3-DÜpyrimidines, verfahren zur ihre herstellung und deren verwendung - Google Patents

PyrazoloÄ4,3-DÜpyrimidines, verfahren zur ihre herstellung und deren verwendung

Info

Publication number
DE60333546D1
DE60333546D1 DE60333546T DE60333546T DE60333546D1 DE 60333546 D1 DE60333546 D1 DE 60333546D1 DE 60333546 T DE60333546 T DE 60333546T DE 60333546 T DE60333546 T DE 60333546T DE 60333546 D1 DE60333546 D1 DE 60333546D1
Authority
DE
Germany
Prior art keywords
substituted
alkyl
unsubstituted
cycloalkyl
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60333546T
Other languages
English (en)
Inventor
Daniela Moravcova
Libor Havlicek
Vladimir Krystof
Rene Lenobel
Pavla Binarova
Petra Mlejnek
Borek Vojtesek
Stjepan Uldrijan
Thomas Schmuelling
Miroslav Strnad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita Palackeho V Olomouci Olomouci Cz
Institute of Experimental Botany Academy CAS
Original Assignee
Institute of Experimental Botany Academy CAS
Palacky University Olomouc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Experimental Botany Academy CAS, Palacky University Olomouc filed Critical Institute of Experimental Botany Academy CAS
Application granted granted Critical
Publication of DE60333546D1 publication Critical patent/DE60333546D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60333546T 2003-05-06 2003-05-06 PyrazoloÄ4,3-DÜpyrimidines, verfahren zur ihre herstellung und deren verwendung Expired - Lifetime DE60333546D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03010184A EP1475094B8 (de) 2003-05-06 2003-05-06 Pyrazolo[4,3-D]pyrimidines, verfahren zur ihre herstellung und deren verwendung

Publications (1)

Publication Number Publication Date
DE60333546D1 true DE60333546D1 (de) 2010-09-09

Family

ID=32981816

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60333546T Expired - Lifetime DE60333546D1 (de) 2003-05-06 2003-05-06 PyrazoloÄ4,3-DÜpyrimidines, verfahren zur ihre herstellung und deren verwendung

Country Status (8)

Country Link
US (1) US20070167466A1 (de)
EP (1) EP1475094B8 (de)
AT (1) ATE475421T1 (de)
CA (1) CA2524344C (de)
DE (1) DE60333546D1 (de)
DK (1) DK1475094T3 (de)
ES (1) ES2351624T3 (de)
WO (1) WO2004098608A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2295816T3 (es) 2003-01-14 2008-04-16 Arena Pharmaceuticals, Inc. Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia.
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
JP4920410B2 (ja) * 2003-07-14 2012-04-18 アリーナ ファーマシューティカルズ， インコーポレイテッド 代謝モジュレーターとしての縮合アリールおよびヘテロアリール誘導体ならびに代謝に関連する障害の予防および治療
BRPI0412684A (pt) 2003-07-17 2006-10-03 Plexxinko Inc compostos ppar-ativos
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
US7932257B2 (en) * 2005-07-22 2011-04-26 Sunesis Pharmaceuticals, Inc. Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors
KR101565971B1 (ko) * 2007-06-21 2015-11-05 뉴로내슨트, 아이엔씨. 이소티아졸로피리미디논을 사용하는 신경 발생을 자극하고 신경 변성을 억제하는 방법 및 조성물
KR101483215B1 (ko) * 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
CA2812061A1 (en) 2010-09-22 2012-03-29 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2014126580A1 (en) * 2013-02-15 2014-08-21 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
PT3242666T (pt) 2015-01-06 2024-12-09 Arena Pharm Inc Composto para utilização no tratamento de patologias relacionadas com o recetor s1p1
CZ307147B6 (cs) 2015-05-14 2018-02-07 Ústav experimentální botaniky AV ČR, v. v. i. 5-Substituované 7-[4-(2-pyridyl)fenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako léčiva, a farmaceutické přípravky
IL285890B (en) 2015-06-22 2022-07-01 Arena Pharm Inc Crystalline free-plate habit of l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid
US12156866B2 (en) 2018-06-06 2024-12-03 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CN115554303B (zh) * 2021-09-18 2024-07-09 上海科技大学 一种三环类化合物、其制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1530747A (en) * 1922-05-20 1925-03-24 Frank B Wyatt Motion-picture machine
GB1530747A (en) * 1976-04-05 1978-11-01 Massachusetts Inst Technology Pharmaceutical composition
US4282361A (en) * 1978-03-16 1981-08-04 Massachusetts Institute Of Technology Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines
CZ27399A3 (cs) * 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
AU7323000A (en) * 1999-08-26 2001-04-10 Plant Research International B.V. Conditional inhibition of vegetative propagation
DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen

Also Published As

Publication number Publication date
CA2524344C (en) 2012-03-13
EP1475094B8 (de) 2011-01-12
CA2524344A1 (en) 2004-11-18
ATE475421T1 (de) 2010-08-15
EP1475094B1 (de) 2010-07-28
DK1475094T3 (da) 2010-11-22
WO2004098608A1 (en) 2004-11-18
ES2351624T3 (es) 2011-02-08
EP1475094A1 (de) 2004-11-10
US20070167466A1 (en) 2007-07-19

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: UNIVERSITA PALACKEHO V OLOMOUCI, OLOMOUCI, CZ

Owner name: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I. (I, CZ