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DK1471074T3 - Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler - Google Patents

Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler

Info

Publication number
DK1471074T3
DK1471074T3 DK04103238T DK04103238T DK1471074T3 DK 1471074 T3 DK1471074 T3 DK 1471074T3 DK 04103238 T DK04103238 T DK 04103238T DK 04103238 T DK04103238 T DK 04103238T DK 1471074 T3 DK1471074 T3 DK 1471074T3
Authority
DK
Denmark
Prior art keywords
recombinant protein
purification
recombinant
conformation
proteins
Prior art date
Application number
DK04103238T
Other languages
English (en)
Inventor
Geert Maertens
Joost Louwagie
Alfons Bosman
Erwin Sablon
Maan Zrein
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8237028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1471074(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of DK1471074T3 publication Critical patent/DK1471074T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
DK04103238T 1998-04-17 1999-04-15 Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler DK1471074T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98870087 1998-04-17
PCT/EP1999/002547 WO1999054735A1 (en) 1998-04-17 1999-04-15 Improved immunodiagnostic assays using reducing agents

Publications (1)

Publication Number Publication Date
DK1471074T3 true DK1471074T3 (da) 2008-11-17

Family

ID=8237028

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04103238T DK1471074T3 (da) 1998-04-17 1999-04-15 Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler
DK99920678T DK1071955T4 (da) 1998-04-17 1999-04-15 Forbedrede immundiagnostiske assays, som anvender reduktionsmidler

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK99920678T DK1071955T4 (da) 1998-04-17 1999-04-15 Forbedrede immundiagnostiske assays, som anvender reduktionsmidler

Country Status (22)

Country Link
US (1) US7935490B2 (da)
EP (2) EP1471074B1 (da)
JP (2) JP2002512370A (da)
KR (1) KR20010042807A (da)
CN (1) CN1305589A (da)
AT (2) ATE278960T1 (da)
AU (1) AU751362B2 (da)
BR (1) BRPI9909678B8 (da)
CA (2) CA2324970C (da)
CY (1) CY1108424T1 (da)
CZ (1) CZ298268B6 (da)
DE (2) DE69939132D1 (da)
DK (2) DK1471074T3 (da)
ES (2) ES2230851T5 (da)
HK (1) HK1036653A1 (da)
HU (1) HUP0101719A3 (da)
IL (1) IL138791A0 (da)
PL (1) PL343469A1 (da)
PT (2) PT1471074E (da)
TR (4) TR200101648T2 (da)
WO (1) WO1999054735A1 (da)
ZA (1) ZA200005445B (da)

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US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
EP1947185B1 (en) * 2000-08-17 2011-07-20 Tripep Ab HCV NS3/4A encoding nucleic acid
WO2002085932A2 (en) 2001-04-24 2002-10-31 Innogenetics N.V. Constructs and methods for expression of recombinant hcv envelope proteins
JP2004108914A (ja) * 2002-09-18 2004-04-08 Kudo Norio コラーゲンの測定方法
JP2006516955A (ja) * 2002-11-08 2006-07-13 イノジェネティックス・ナムローゼ・フェンノートシャップ Ｅ１ペプチド及びｎｓ３ペプチドを含むｈｃｖワクチン組成物
US20050014136A1 (en) * 2003-05-28 2005-01-20 Innogenetics N.V. Modified HCV NS5
CA2544185C (en) * 2003-10-28 2010-09-28 Advanced Life Science Institute, Inc. Method of detecting hepatitis c virus
US20090209737A1 (en) * 2006-07-07 2009-08-20 Pall Corporation Use of denaturing agents during affinity capture
JP2010533491A (ja) * 2007-07-16 2010-10-28 ファイザー・インク 乳生産動物および乳業産物のゲノムマーカー指数を改善する方法
AU2008300011A1 (en) * 2007-09-12 2009-03-19 Pfizer, Inc. Methods of using genetic markers and related epistatic interactions
BRPI0818300A2 (pt) * 2007-10-03 2017-05-09 Pfizer marcadores genéticos para gado com chifres e sem chifres e processos relacionados
CN101952718A (zh) * 2007-12-17 2011-01-19 美国辉瑞有限公司 改善产乳动物和产品的遗传图谱的方法
JP5476376B2 (ja) * 2008-07-16 2014-04-23 ラジオメーター・メディカル・アー・ペー・エス 高性能固相
CN102081018A (zh) * 2009-11-30 2011-06-01 希森美康株式会社 样品的预处理方法及hcv的免疫测定方法
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
KR102441636B1 (ko) 2014-10-29 2022-09-13 아보트 러보러터리즈 Ns3 포획 펩타이드를 사용한 대상체 항-hcv 항체 검출 검정
CN109870581B (zh) * 2017-12-04 2021-05-04 厦门万泰凯瑞生物技术有限公司 一种定量检测HBsAg的试剂盒及方法
CN109678954B (zh) * 2018-12-29 2022-01-07 山东莱博生物科技有限公司 一对能够特异性识别hcv ns3蛋白的单克隆抗体及其应用
CN110988362B (zh) * 2019-12-20 2023-11-14 迈克生物股份有限公司 抗组蛋白抗体测定试剂、试剂盒及其使用方法
CN112225783B (zh) * 2020-09-16 2021-08-31 东莞市朋志生物科技有限公司 Hcv重组抗原及其突变体
CN112285361B (zh) * 2020-09-27 2023-12-05 中国人民解放军空军军医大学 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
CN113219169B (zh) * 2021-05-22 2021-12-17 北京金诺百泰生物技术有限公司 生物检测用封闭剂及其制备方法、包被板及应用该包被板的试剂盒
CN115112897B (zh) * 2021-12-10 2024-11-01 中山大学附属第八医院（深圳福田） 一种用于鉴别抗体检测生物学假阳性的方法

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Also Published As

Publication number Publication date
CZ298268B6 (cs) 2007-08-08
EP1071955B2 (en) 2009-02-18
DE69939132D1 (de) 2008-08-28
PT1471074E (pt) 2008-10-23
HK1036653A1 (en) 2002-01-11
EP1471074B1 (en) 2008-07-16
WO1999054735A1 (en) 1999-10-28
JP2002512370A (ja) 2002-04-23
BRPI9909678B8 (pt) 2021-05-25
JP3974620B2 (ja) 2007-09-12
CY1108424T1 (el) 2014-04-09
DE69920895D1 (de) 2004-11-11
PT1071955E (pt) 2005-02-28
ES2230851T5 (es) 2009-06-25
BR9909678B1 (pt) 2013-11-12
HUP0101719A3 (en) 2006-05-29
TR200003024T2 (tr) 2000-12-21
ATE278960T1 (de) 2004-10-15
BR9909678A (pt) 2000-12-19
US20060263854A1 (en) 2006-11-23
DE69920895T3 (de) 2009-09-03
CA2658218A1 (en) 1999-10-28
ZA200005445B (en) 2003-01-06
TR200101647T2 (tr) 2002-06-21
EP1071955B1 (en) 2004-10-06
AU3817199A (en) 1999-11-08
CZ20003819A3 (cs) 2001-10-17
HUP0101719A2 (hu) 2001-09-28
AU751362B2 (en) 2002-08-15
CA2658218C (en) 2014-10-28
EP1471074A2 (en) 2004-10-27
DK1071955T3 (da) 2005-02-07
ES2230851T3 (es) 2005-05-01
CN1305589A (zh) 2001-07-25
TR200101648T2 (tr) 2002-06-21
DK1071955T4 (da) 2009-06-15
EP1071955A1 (en) 2001-01-31
EP1471074A3 (en) 2004-11-10
DE69920895T2 (de) 2005-10-13
ES2310701T3 (es) 2009-01-16
CA2324970A1 (en) 1999-10-28
US7935490B2 (en) 2011-05-03
CA2324970C (en) 2009-06-30
KR20010042807A (ko) 2001-05-25
IL138791A0 (en) 2001-10-31
TR200202213T2 (tr) 2002-11-21
ATE401340T1 (de) 2008-08-15
PL343469A1 (en) 2001-08-13
JP2005185285A (ja) 2005-07-14

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