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DK1423115T3 - Nitrogen-substituerede thalidomidanalogers antiangiogenetiske aktivitet - Google Patents

Nitrogen-substituerede thalidomidanalogers antiangiogenetiske aktivitet

Info

Publication number
DK1423115T3
DK1423115T3 DK02757019T DK02757019T DK1423115T3 DK 1423115 T3 DK1423115 T3 DK 1423115T3 DK 02757019 T DK02757019 T DK 02757019T DK 02757019 T DK02757019 T DK 02757019T DK 1423115 T3 DK1423115 T3 DK 1423115T3
Authority
DK
Denmark
Prior art keywords
nitrogen
substituted
thalidomide analogues
antiangiogenetic
activity
Prior art date
Application number
DK02757019T
Other languages
English (en)
Inventor
Jamshed H Shah
Barry P Conner
Glenn M Swartz Jr
Kimberly A Hunsucker
John Rougas
Amato Robert D
Victor Pribluda
Anthony Treston
Original Assignee
Childrens Medical Center
Entremed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, Entremed Inc filed Critical Childrens Medical Center
Application granted granted Critical
Publication of DK1423115T3 publication Critical patent/DK1423115T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02757019T 2001-08-06 2002-08-06 Nitrogen-substituerede thalidomidanalogers antiangiogenetiske aktivitet DK1423115T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31026101P 2001-08-06 2001-08-06
PCT/US2002/025112 WO2003014315A2 (en) 2001-08-06 2002-08-06 Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs

Publications (1)

Publication Number Publication Date
DK1423115T3 true DK1423115T3 (da) 2009-06-15

Family

ID=23201687

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02757019T DK1423115T3 (da) 2001-08-06 2002-08-06 Nitrogen-substituerede thalidomidanalogers antiangiogenetiske aktivitet

Country Status (14)

Country Link
US (2) US7153867B2 (da)
EP (1) EP1423115B9 (da)
JP (1) JP4494013B2 (da)
AT (1) ATE428419T1 (da)
AU (1) AU2002323063B2 (da)
CA (1) CA2457319C (da)
CY (1) CY1110492T1 (da)
DE (1) DE60231989D1 (da)
DK (1) DK1423115T3 (da)
ES (1) ES2325916T3 (da)
NZ (1) NZ531294A (da)
PT (1) PT1423115E (da)
WO (1) WO2003014315A2 (da)
ZA (1) ZA200400924B (da)

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Also Published As

Publication number Publication date
EP1423115A4 (en) 2006-08-16
CA2457319A1 (en) 2003-02-20
CY1110492T1 (el) 2015-04-29
EP1423115A2 (en) 2004-06-02
ES2325916T3 (es) 2009-09-24
US7153867B2 (en) 2006-12-26
US20030139451A1 (en) 2003-07-24
ATE428419T1 (de) 2009-05-15
DE60231989D1 (de) 2009-05-28
CA2457319C (en) 2011-07-05
JP4494013B2 (ja) 2010-06-30
WO2003014315A2 (en) 2003-02-20
ZA200400924B (en) 2006-04-26
EP1423115B1 (en) 2009-04-15
US20070105903A1 (en) 2007-05-10
AU2002323063B2 (en) 2007-11-08
JP2004538322A (ja) 2004-12-24
NZ531294A (en) 2005-11-25
EP1423115B9 (en) 2009-09-02
WO2003014315A3 (en) 2003-04-17
PT1423115E (pt) 2009-07-21

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