DK1303307T3 - Kombinationsterapi mod tumorer omfattende substituerede acryloyldistamycinderivater og alkyleringsmidler - Google Patents

Kombinationsterapi mod tumorer omfattende substituerede acryloyldistamycinderivater og alkyleringsmidler

Info

Publication number: DK1303307T3
Authority: DK; Denmark
Prior art keywords: combination therapy; alkylating agents; against tumors; therapy against; distamycin derivatives
Prior art date: 2000-06-23

Application number

DK01960355T

Other languages

English (en)

Inventor

Maria Cristina Rosa Geroni

Paolo Cozzi

Italo Beria

Original Assignee

Nerviano Medical Sciences Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-06-20

Publication date

2007-07-16

2001-06-20 Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl

2007-07-16 Application granted granted Critical

2007-07-16 Publication of DK1303307T3 publication Critical patent/DK1303307T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK01960355T 2000-06-23 2001-06-20 Kombinationsterapi mod tumorer omfattende substituerede acryloyldistamycinderivater og alkyleringsmidler DK1303307T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0015447.6A GB0015447D0 (en)	2000-06-23	2000-06-23	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
PCT/EP2001/007064 WO2001097790A2 (en)	2000-06-23	2001-06-20	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents

Publications (1)

Publication Number	Publication Date
DK1303307T3 true DK1303307T3 (da)	2007-07-16

Family

ID=9894288

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01960355T DK1303307T3 (da)	2000-06-23	2001-06-20	Kombinationsterapi mod tumorer omfattende substituerede acryloyldistamycinderivater og alkyleringsmidler

Country Status (28)

Country	Link
US (1)	US8642580B2 (da)
EP (1)	EP1303307B1 (da)
JP (1)	JP2003535891A (da)
KR (1)	KR100869037B1 (da)
CN (1)	CN100479860C (da)
AT (1)	ATE362365T1 (da)
AU (2)	AU2001281867B2 (da)
BR (1)	BR0111740A (da)
CA (1)	CA2410160C (da)
CY (1)	CY1106713T1 (da)
CZ (1)	CZ301053B6 (da)
DE (1)	DE60128472T2 (da)
DK (1)	DK1303307T3 (da)
EA (1)	EA008502B1 (da)
EE (1)	EE05300B1 (da)
ES (1)	ES2284674T3 (da)
GB (1)	GB0015447D0 (da)
HK (1)	HK1054335B (da)
HU (1)	HUP0301234A2 (da)
IL (2)	IL152956A0 (da)
MX (1)	MXPA02012209A (da)
NO (1)	NO329782B1 (da)
NZ (1)	NZ522999A (da)
PL (1)	PL202053B1 (da)
PT (1)	PT1303307E (da)
SK (1)	SK18342002A3 (da)
WO (1)	WO2001097790A2 (da)
ZA (1)	ZA200209836B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003055522A1 (en) *	2002-01-02	2003-07-10	Pharmacia Italia Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
NZ535700A (en) *	2002-04-02	2007-06-29	Nerviano Medical Sciences Srl	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
MD36Z (ro) *	2008-12-02	2010-01-31	Василе ЖОВМИР	Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD23Z (ro) *	2008-12-02	2010-01-31	Василе ЖОВМИР	Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD24Z (ro) *	2008-12-02	2010-01-31	Василе ЖОВМИР	Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) *	2008-12-02	2010-01-31	Василе ЖОВМИР	Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
CN107011358B (zh) *	2012-04-05	2020-05-05	内尔维阿诺医学科学有限公司	新的烷化剂

Family Cites Families (24)

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JPS56154493A (en) *	1980-04-30	1981-11-30	Shionogi & Co Ltd	Novel platinum complex
AT387013B (de)	1985-07-16	1988-11-25	Erba Farmitalia	Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
CN85103908A (zh) *	1985-07-16	1986-11-05	法米塔利·卡洛·埃尔巴有限公司	制备4′-表多克索红菌素的新方法
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
EP0265719B1 (en)	1986-10-07	1991-03-06	Boehringer Mannheim Italia S.P.A.	Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en)	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja)	1989-09-27	1999-07-19	千寿製薬株式会社	抗腫瘍剤
GB9000644D0 (en) *	1990-01-11	1990-03-14	Erba Carlo Spa	New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1272234B (it)	1994-05-02	1997-06-16	Consiglio Nazionale Ricerche	Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en)	1994-08-08	1994-09-28	Erba Carlo Spa	Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en)	1996-01-04	1999-03-09	Terrapin Techologies, Inc.	Tethered prodrugs
JP2000503999A (ja)	1996-02-02	2000-04-04	フアルマシア・エ・アツプジヨン・エツセ・ピー・アー	ジスタマイシン誘導体、その調製方法、および抗腫瘍および抗ウイルス剤としてのその使用
GB9610079D0 (en)	1996-05-14	1996-07-17	Pharmacia Spa	Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en)	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) *	1996-11-11	1997-01-08	Pharmacia & Upjohn Spa	Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) *	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en)	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en)	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816652D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en)	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en)	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6576612B1 (en) *	2000-10-02	2003-06-10	Pharmacia Italia S.P.A.	Antitumor therapy comprising distamycin derivatives

2000
- 2000-06-23 GB GBGB0015447.6A patent/GB0015447D0/en not_active Ceased
2001
- 2001-06-20 EE EEP200200660A patent/EE05300B1/xx not_active IP Right Cessation
- 2001-06-20 IL IL15295601A patent/IL152956A0/xx unknown
- 2001-06-20 CA CA002410160A patent/CA2410160C/en not_active Expired - Fee Related
- 2001-06-20 CZ CZ20024106A patent/CZ301053B6/cs not_active IP Right Cessation
- 2001-06-20 BR BR0111740-8A patent/BR0111740A/pt not_active Application Discontinuation
- 2001-06-20 AU AU2001281867A patent/AU2001281867B2/en not_active Ceased
- 2001-06-20 DK DK01960355T patent/DK1303307T3/da active
- 2001-06-20 US US10/311,995 patent/US8642580B2/en not_active Expired - Fee Related
- 2001-06-20 JP JP2002503267A patent/JP2003535891A/ja not_active Withdrawn
- 2001-06-20 DE DE60128472T patent/DE60128472T2/de not_active Expired - Lifetime
- 2001-06-20 KR KR1020027017565A patent/KR100869037B1/ko not_active IP Right Cessation
- 2001-06-20 AU AU8186701A patent/AU8186701A/xx active Pending
- 2001-06-20 EP EP01960355A patent/EP1303307B1/en not_active Expired - Lifetime
- 2001-06-20 ES ES01960355T patent/ES2284674T3/es not_active Expired - Lifetime
- 2001-06-20 PL PL365158A patent/PL202053B1/pl not_active IP Right Cessation
- 2001-06-20 HU HU0301234A patent/HUP0301234A2/hu unknown
- 2001-06-20 NZ NZ522999A patent/NZ522999A/en unknown
- 2001-06-20 EA EA200300061A patent/EA008502B1/ru not_active IP Right Cessation
- 2001-06-20 SK SK1834-2002A patent/SK18342002A3/sk unknown
- 2001-06-20 CN CNB018114776A patent/CN100479860C/zh not_active Expired - Fee Related
- 2001-06-20 MX MXPA02012209A patent/MXPA02012209A/es active IP Right Grant
- 2001-06-20 AT AT01960355T patent/ATE362365T1/de not_active IP Right Cessation
- 2001-06-20 WO PCT/EP2001/007064 patent/WO2001097790A2/en active IP Right Grant
- 2001-06-20 PT PT01960355T patent/PT1303307E/pt unknown
2002
- 2002-11-20 IL IL152956A patent/IL152956A/en not_active IP Right Cessation
- 2002-12-04 ZA ZA200209836A patent/ZA200209836B/en unknown
- 2002-12-18 NO NO20026077A patent/NO329782B1/no not_active IP Right Cessation
2003
- 2003-09-22 HK HK03106772.8A patent/HK1054335B/zh not_active IP Right Cessation
2007
- 2007-07-09 CY CY20071100908T patent/CY1106713T1/el unknown

Also Published As

Publication number	Publication date
KR100869037B1 (ko)	2008-11-17
IL152956A (en)	2010-06-30
CN100479860C (zh)	2009-04-22
HK1054335A1 (en)	2003-11-28
ATE362365T1 (de)	2007-06-15
GB0015447D0 (en)	2000-08-16
CZ20024106A3 (cs)	2003-05-14
HK1054335B (zh)	2010-06-11
CA2410160A1 (en)	2001-12-27
EE200200660A (et)	2004-06-15
CN1437485A (zh)	2003-08-20
DE60128472D1 (de)	2007-06-28
CA2410160C (en)	2009-06-02
HUP0301234A2 (hu)	2003-08-28
EE05300B1 (et)	2010-06-15
EP1303307A2 (en)	2003-04-23
US20030180383A1 (en)	2003-09-25
JP2003535891A (ja)	2003-12-02
SK18342002A3 (sk)	2003-06-03
BR0111740A (pt)	2003-07-08
NZ522999A (en)	2004-10-29
ES2284674T3 (es)	2007-11-16
EA200300061A1 (ru)	2003-04-24
EA008502B1 (ru)	2007-06-29
NO20026077D0 (no)	2002-12-18
AU8186701A (en)	2002-01-02
AU2001281867B2 (en)	2006-02-23
WO2001097790A3 (en)	2002-05-16
US8642580B2 (en)	2014-02-04
PT1303307E (pt)	2007-07-04
WO2001097790A2 (en)	2001-12-27
ZA200209836B (en)	2003-12-04
KR20030011105A (ko)	2003-02-06
DE60128472T2 (de)	2008-01-24
PL365158A1 (en)	2004-12-27
CY1106713T1 (el)	2012-05-23
PL202053B1 (pl)	2009-05-29
MXPA02012209A (es)	2003-06-04
NO20026077L (no)	2002-12-18
CZ301053B6 (cs)	2009-10-21
IL152956A0 (en)	2003-06-24
NO329782B1 (no)	2010-12-13
EP1303307B1 (en)	2007-05-16

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GB0005251D0 (en)	2000-04-26	Therapeutic compounds
CY1106697T1 (el)	2012-05-23	Ν-υποκατεστημενες υδρομορφονες και η χρηση αυτων
TW200626572A (en)	2006-08-01	Heterocyclic derivatives and their use as therapeutic agents
TW200626139A (en)	2006-08-01	Heterocyclic derivatives and their use as therapeutic agents
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
BRPI0409959A (pt)	2006-04-25	uso de derivados de azetidinacarboxamida em terapia
DK1303307T3 (da)	2007-07-16	Kombinationsterapi mod tumorer omfattende substituerede acryloyldistamycinderivater og alkyleringsmidler
SE9902267D0 (sv)	1999-06-16	New compounds
DK1206444T3 (da)	2004-03-15	Forbindelser der hæmmer tryptaseaktivitet
PT1280527E (pt)	2005-10-31	Utilizacao de derivados de acriloil distamicina no tratamento de tumores associados a niveis de glutationa elevados
ATE306267T1 (de)	2005-10-15	Kombinationsbehandlung bei akutem myokardinfarkt
AU2002211493A1 (en)	2002-05-15	Indole derivatives as pde5-inhibitors
EP1110960A4 (en)	2001-12-12	AGENTS INDUCING APOPTOSIS
SE0004827D0 (sv)	2000-12-22	Therapeutic compounds
GB0522908D0 (en)	2005-12-21	Therapeutic agents
NO940109D0 (no)	1994-01-12	Ketorolac-derivater med betydelig redusert gastrointestinal irrit asjon og ulcerasjon
DE60022047D1 (de)	2005-09-22	Antivirale therapie