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ATE362365T1 - Kombinierte tumortherapie auf der basis von distamycin-acryloylderivaten und alkylierungsmitteln - Google Patents

Kombinierte tumortherapie auf der basis von distamycin-acryloylderivaten und alkylierungsmitteln

Info

Publication number
ATE362365T1
ATE362365T1 AT01960355T AT01960355T ATE362365T1 AT E362365 T1 ATE362365 T1 AT E362365T1 AT 01960355 T AT01960355 T AT 01960355T AT 01960355 T AT01960355 T AT 01960355T AT E362365 T1 ATE362365 T1 AT E362365T1
Authority
AT
Austria
Prior art keywords
distamycin
alkylating agents
tumor therapy
therapy based
acryloyl derivatives
Prior art date
Application number
AT01960355T
Other languages
English (en)
Inventor
Maria Geroni
Paolo Cozzi
Italo Beria
Original Assignee
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Application granted granted Critical
Publication of ATE362365T1 publication Critical patent/ATE362365T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01960355T 2000-06-23 2001-06-20 Kombinierte tumortherapie auf der basis von distamycin-acryloylderivaten und alkylierungsmitteln ATE362365T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0015447.6A GB0015447D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents

Publications (1)

Publication Number Publication Date
ATE362365T1 true ATE362365T1 (de) 2007-06-15

Family

ID=9894288

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01960355T ATE362365T1 (de) 2000-06-23 2001-06-20 Kombinierte tumortherapie auf der basis von distamycin-acryloylderivaten und alkylierungsmitteln

Country Status (28)

Country Link
US (1) US8642580B2 (de)
EP (1) EP1303307B1 (de)
JP (1) JP2003535891A (de)
KR (1) KR100869037B1 (de)
CN (1) CN100479860C (de)
AT (1) ATE362365T1 (de)
AU (2) AU2001281867B2 (de)
BR (1) BR0111740A (de)
CA (1) CA2410160C (de)
CY (1) CY1106713T1 (de)
CZ (1) CZ301053B6 (de)
DE (1) DE60128472T2 (de)
DK (1) DK1303307T3 (de)
EA (1) EA008502B1 (de)
EE (1) EE05300B1 (de)
ES (1) ES2284674T3 (de)
GB (1) GB0015447D0 (de)
HK (1) HK1054335B (de)
HU (1) HUP0301234A2 (de)
IL (2) IL152956A0 (de)
MX (1) MXPA02012209A (de)
NO (1) NO329782B1 (de)
NZ (1) NZ522999A (de)
PL (1) PL202053B1 (de)
PT (1) PT1303307E (de)
SK (1) SK18342002A3 (de)
WO (1) WO2001097790A2 (de)
ZA (1) ZA200209836B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055522A1 (en) * 2002-01-02 2003-07-10 Pharmacia Italia Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
NZ535700A (en) * 2002-04-02 2007-06-29 Nerviano Medical Sciences Srl Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
CN107011358B (zh) * 2012-04-05 2020-05-05 内尔维阿诺医学科学有限公司 新的烷化剂

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56154493A (en) * 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
AT387013B (de) 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
EP0265719B1 (de) 1986-10-07 1991-03-06 Boehringer Mannheim Italia S.P.A. Pharmazeutische Zusammensetzungen mit antineoplastischer Wirkung
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
JP2000503999A (ja) 1996-02-02 2000-04-04 フアルマシア・エ・アツプジヨン・エツセ・ピー・アー ジスタマイシン誘導体、その調製方法、および抗腫瘍および抗ウイルス剤としてのその使用
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816652D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Also Published As

Publication number Publication date
KR100869037B1 (ko) 2008-11-17
IL152956A (en) 2010-06-30
CN100479860C (zh) 2009-04-22
HK1054335A1 (en) 2003-11-28
GB0015447D0 (en) 2000-08-16
CZ20024106A3 (cs) 2003-05-14
HK1054335B (zh) 2010-06-11
CA2410160A1 (en) 2001-12-27
EE200200660A (et) 2004-06-15
CN1437485A (zh) 2003-08-20
DE60128472D1 (de) 2007-06-28
CA2410160C (en) 2009-06-02
DK1303307T3 (da) 2007-07-16
HUP0301234A2 (hu) 2003-08-28
EE05300B1 (et) 2010-06-15
EP1303307A2 (de) 2003-04-23
US20030180383A1 (en) 2003-09-25
JP2003535891A (ja) 2003-12-02
SK18342002A3 (sk) 2003-06-03
BR0111740A (pt) 2003-07-08
NZ522999A (en) 2004-10-29
ES2284674T3 (es) 2007-11-16
EA200300061A1 (ru) 2003-04-24
EA008502B1 (ru) 2007-06-29
NO20026077D0 (no) 2002-12-18
AU8186701A (en) 2002-01-02
AU2001281867B2 (en) 2006-02-23
WO2001097790A3 (en) 2002-05-16
US8642580B2 (en) 2014-02-04
PT1303307E (pt) 2007-07-04
WO2001097790A2 (en) 2001-12-27
ZA200209836B (en) 2003-12-04
KR20030011105A (ko) 2003-02-06
DE60128472T2 (de) 2008-01-24
PL365158A1 (en) 2004-12-27
CY1106713T1 (el) 2012-05-23
PL202053B1 (pl) 2009-05-29
MXPA02012209A (es) 2003-06-04
NO20026077L (no) 2002-12-18
CZ301053B6 (cs) 2009-10-21
IL152956A0 (en) 2003-06-24
NO329782B1 (no) 2010-12-13
EP1303307B1 (de) 2007-05-16

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