DK1273304T4 - Anvendelse af interleukin-15 - Google Patents
Anvendelse af interleukin-15Info
- Publication number
- DK1273304T4 DK1273304T4 DK02014656T DK02014656T DK1273304T4 DK 1273304 T4 DK1273304 T4 DK 1273304T4 DK 02014656 T DK02014656 T DK 02014656T DK 02014656 T DK02014656 T DK 02014656T DK 1273304 T4 DK1273304 T4 DK 1273304T4
- Authority
- DK
- Denmark
- Prior art keywords
- antibodies
- alpha
- inhibiting
- compounds
- receptor
- Prior art date
Links
- 102000003812 Interleukin-15 Human genes 0.000 title abstract 4
- 108090000172 Interleukin-15 Proteins 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 108010053727 Interleukin-15 Receptor alpha Subunit Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 abstract 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 abstract 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 abstract 1
- 108010017535 Interleukin-15 Receptors Proteins 0.000 abstract 1
- 102000004556 Interleukin-15 Receptors Human genes 0.000 abstract 1
- 239000000074 antisense oligonucleotide Substances 0.000 abstract 1
- 238000012230 antisense oligonucleotides Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97200515 | 1997-02-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1273304T3 DK1273304T3 (da) | 2005-09-12 |
| DK1273304T4 true DK1273304T4 (da) | 2009-08-31 |
Family
ID=8228040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02014656T DK1273304T4 (da) | 1997-02-21 | 1998-02-23 | Anvendelse af interleukin-15 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6344192B1 (es) |
| EP (2) | EP0971728B1 (es) |
| AT (2) | ATE295736T1 (es) |
| AU (1) | AU6726698A (es) |
| DE (2) | DE69810091T2 (es) |
| DK (1) | DK1273304T4 (es) |
| ES (1) | ES2187946T3 (es) |
| WO (1) | WO1998036768A1 (es) |
| ZA (1) | ZA981478B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192935B1 (en) | 1993-03-08 | 2007-03-20 | Amgen Inc. | Polynucleotides encoding epithelium-derived T-cell factor and uses thereof |
| IL126919A0 (en) * | 1998-11-05 | 1999-09-22 | Univ Ben Gurion | Antisense oligomer |
| US5985663A (en) * | 1998-11-25 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of interleukin-15 expression |
| EP1927657A3 (en) * | 2000-05-11 | 2008-10-22 | Baylor Research Institute | Compositions and methods for producing antigen-presenting cells |
| MXPA03002278A (es) * | 2000-09-14 | 2004-12-03 | Beth Israel Hospital | Modulacion de respuestas de la celula t mediadas por il-2 e il-15. |
| US7041302B2 (en) * | 2001-01-09 | 2006-05-09 | Biother Corporation | Therapeutic modulation of the tumor inflammatory response |
| US7329405B2 (en) | 2001-08-23 | 2008-02-12 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
| US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
| RS51829B (sr) | 2001-08-23 | 2012-02-29 | Genmab A/S. | Ljudska antitela specifična za interleukin 15 (il-15) |
| CU23093A1 (es) * | 2002-10-09 | 2005-10-19 | Ct Ingenieria Genetica Biotech | Composición vacunal que comprende interleucina-15 (il-15) |
| PL1606318T3 (pl) | 2003-03-26 | 2010-01-29 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Ulepszone białka fuzyjne FC |
| DE602004031681D1 (de) | 2003-07-21 | 2011-04-14 | Transgene Sa | Multifunktionelle Cytokine |
| CU23472A1 (es) * | 2004-09-17 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la interleucina-15 |
| DK1809321T3 (da) | 2004-10-08 | 2012-06-25 | Us Gov Health & Human Serv | Adoptiv immunterapi med forøget T-lymfocytoverlevelse |
| EP1899364B2 (en) | 2005-05-17 | 2024-10-30 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| US20070160578A1 (en) * | 2005-12-14 | 2007-07-12 | The Gov. Of The Usa As Represented By The Secretary Of The Dep. Of Health And Human Services | Expansion of natural killer and CD8 T-cells with IL-15R/ligand activator complexes |
| EP1984505B1 (en) | 2006-01-13 | 2019-12-25 | The Government of the U.S.A., as repr. by the Secretary, Dept. of Health & Human Services, the Nat. Inst. of Health | Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells |
| US20080131415A1 (en) * | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| ES2518393T3 (es) | 2007-05-11 | 2014-11-05 | Altor Bioscience Corporation | Moléculas de fusión y variantes de IL-15 |
| WO2009002562A2 (en) | 2007-06-27 | 2008-12-31 | Marine Polymer Technologies, Inc. | Complexes of il-15 and il-15ralpha and uses thereof |
| NZ714757A (en) | 2009-08-14 | 2018-07-27 | Us Gov Health & Human Services | Use of il-15 to increase thymic output and to treat lymphopenia |
| KR20140020228A (ko) | 2010-09-21 | 2014-02-18 | 알토 바이오사이언스 코포레이션 | 다량체성 아이엘 15 용해성 융합 분자 및 그의 제조 및 사용 방법 |
| US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| CA2909576C (en) | 2013-04-19 | 2023-07-18 | Cytune Pharma | Cytokine derived treatment with reduced vascular leak syndrome |
| CN106659775B (zh) | 2014-06-30 | 2021-08-06 | 阿尔托生物科学有限公司 | 基于il-15的分子及其方法和用途 |
| JP7492336B2 (ja) | 2016-10-21 | 2024-05-29 | アルター・バイオサイエンス・コーポレーション | 多量体il-15に基づく分子 |
| WO2023086772A1 (en) | 2021-11-12 | 2023-05-19 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
| WO2024102636A1 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and mica/b |
| US20250243279A1 (en) | 2023-10-17 | 2025-07-31 | Xencor, Inc. | Bispecific antibodies that bind to nkp46 and mica/b |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747024A (en) * | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
| US5574138A (en) * | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| US5591630A (en) * | 1994-05-06 | 1997-01-07 | Immunex Corporation | Monoclonal antibodies that bind interleukin-15 receptors |
| DK0789588T3 (da) * | 1994-11-17 | 2005-05-30 | Univ South Florida | Metode til fremstilling af et medikament til behandling af sekundær immundefekt |
| US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| WO1997014433A1 (en) * | 1995-10-17 | 1997-04-24 | Wayne State University | Chicken interleukin-15 and uses thereof |
| US5870759A (en) * | 1996-10-09 | 1999-02-09 | Oracle Corporation | System for synchronizing data between computers using a before-image of data |
| US6065018A (en) * | 1998-03-04 | 2000-05-16 | International Business Machines Corporation | Synchronizing recovery log having time stamp to a remote site for disaster recovery of a primary database having related hierarchial and relational databases |
| US6356917B1 (en) * | 1998-07-17 | 2002-03-12 | Ncr Corporation | Monitoring and raising alerts for database jobs |
| US6553392B1 (en) * | 1999-02-04 | 2003-04-22 | Hewlett-Packard Development Company, L.P. | System and method for purging database update image files after completion of associated transactions |
| US6728879B1 (en) * | 1999-06-02 | 2004-04-27 | Microsoft Corporation | Transactional log with multi-sector log block validation |
-
1998
- 1998-02-23 AT AT02014656T patent/ATE295736T1/de not_active IP Right Cessation
- 1998-02-23 DE DE69810091T patent/DE69810091T2/de not_active Expired - Lifetime
- 1998-02-23 US US09/380,049 patent/US6344192B1/en not_active Expired - Lifetime
- 1998-02-23 DE DE69830257T patent/DE69830257T3/de not_active Expired - Lifetime
- 1998-02-23 DK DK02014656T patent/DK1273304T4/da active
- 1998-02-23 ZA ZA981478A patent/ZA981478B/xx unknown
- 1998-02-23 EP EP98912417A patent/EP0971728B1/en not_active Expired - Lifetime
- 1998-02-23 AU AU67266/98A patent/AU6726698A/en not_active Abandoned
- 1998-02-23 ES ES98912417T patent/ES2187946T3/es not_active Expired - Lifetime
- 1998-02-23 WO PCT/EP1998/001127 patent/WO1998036768A1/en not_active Ceased
- 1998-02-23 AT AT98912417T patent/ATE229342T1/de active
- 1998-02-23 EP EP02014656A patent/EP1273304B2/en not_active Expired - Lifetime
-
2001
- 2001-10-18 US US10/045,185 patent/US20020182178A1/en not_active Abandoned
-
2007
- 2007-02-08 US US11/703,974 patent/US20070134718A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1273304A2 (en) | 2003-01-08 |
| US6344192B1 (en) | 2002-02-05 |
| EP1273304B1 (en) | 2005-05-18 |
| EP1273304B2 (en) | 2009-07-15 |
| WO1998036768A1 (en) | 1998-08-27 |
| ES2187946T3 (es) | 2003-06-16 |
| DE69810091T2 (de) | 2003-10-09 |
| DE69810091D1 (de) | 2003-01-23 |
| ZA981478B (en) | 1998-08-24 |
| ATE295736T1 (de) | 2005-06-15 |
| EP0971728B1 (en) | 2002-12-11 |
| DE69830257T2 (de) | 2006-02-02 |
| ATE229342T1 (de) | 2002-12-15 |
| EP1273304A3 (en) | 2003-04-23 |
| US20070134718A1 (en) | 2007-06-14 |
| DE69830257T3 (de) | 2009-10-15 |
| EP0971728A1 (en) | 2000-01-19 |
| DK1273304T3 (da) | 2005-09-12 |
| DE69830257D1 (de) | 2005-06-23 |
| US20020182178A1 (en) | 2002-12-05 |
| AU6726698A (en) | 1998-09-09 |
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