DK127182A - Fremgangsmaade til fremstilling af 1,1-dioxopenicillanoyloxymethyl-6-(2-phenylacetamido)penicillanater og mellemprodukter herved - Google Patents

Fremgangsmaade til fremstilling af 1,1-dioxopenicillanoyloxymethyl-6-(2-phenylacetamido)penicillanater og mellemprodukter herved Download PDF

Info

Publication number: DK127182A
Authority: DK; Denmark
Prior art keywords: penicillanates; dioxopenicillanoyloxymethyl; phenylacetamido; intermediates; preparing
Prior art date: 1981-03-23

Application number

DK127182A

Other languages

English (en)

Other versions

DK162392C (da

DK162392B (da

Inventor

Vytautas John Jasys

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-03-23

Filing date

1982-03-22

Publication date

1982-09-24

1982-03-22 Application filed by Pfizer filed Critical Pfizer

1982-09-24 Publication of DK127182A publication Critical patent/DK127182A/da

1991-10-21 Publication of DK162392B publication Critical patent/DK162392B/da

1992-03-09 Application granted granted Critical

1992-03-09 Publication of DK162392C publication Critical patent/DK162392C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
- C07D499/32—Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK127182A 1981-03-23 1982-03-22 Fremgangsmaade til fremstilling af 1,1-dioxopenicillanoyloxymethyl-6-(2-amino-2-phenylacetamido)penicillanat eller 1,1-dioxopenicillanoyloxymethyl-6-oe2-amino-2-(p-hydroxyphenyl)acetamidoaapenicillanat eller farmaceutisk acceptable syreadditionssalte deraf og dihalogensubstituerede derivater af disse forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden DK162392C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24645681A	1981-03-23	1981-03-23
US24645681		1981-03-23

Publications (3)

Publication Number	Publication Date
DK127182A true DK127182A (da)	1982-09-24
DK162392B DK162392B (da)	1991-10-21
DK162392C DK162392C (da)	1992-03-09

Family

ID=22930766

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK127182A DK162392C (da)	1981-03-23	1982-03-22	Fremgangsmaade til fremstilling af 1,1-dioxopenicillanoyloxymethyl-6-(2-amino-2-phenylacetamido)penicillanat eller 1,1-dioxopenicillanoyloxymethyl-6-oe2-amino-2-(p-hydroxyphenyl)acetamidoaapenicillanat eller farmaceutisk acceptable syreadditionssalte deraf og dihalogensubstituerede derivater af disse forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden
DK121491A DK165746C (da)	1981-03-23	1991-06-21	Halogenpenicillansyreestere
DK021892A DK167119B1 (da)	1981-03-23	1992-02-20	Halogenpenicillansyreestere

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK121491A DK165746C (da)	1981-03-23	1991-06-21	Halogenpenicillansyreestere
DK021892A DK167119B1 (da)	1981-03-23	1992-02-20	Halogenpenicillansyreestere

Country Status (32)

Country	Link
EP (1)	EP0061274B1 (da)
JP (3)	JPS57169493A (da)
KR (1)	KR860001368B1 (da)
AU (1)	AU531892B2 (da)
BG (2)	BG37380A3 (da)
CA (1)	CA1213581A (da)
CS (1)	CS227345B2 (da)
DD (1)	DD202163A5 (da)
DE (1)	DE3267505D1 (da)
DK (3)	DK162392C (da)
EG (1)	EG15803A (da)
ES (2)	ES8305768A1 (da)
FI (1)	FI74284C (da)
GB (1)	GB2095250A (da)
GR (1)	GR75935B (da)
GT (1)	GT198274393A (da)
HK (1)	HK52487A (da)
HU (2)	HU187667B (da)
IE (1)	IE52835B1 (da)
IL (1)	IL65308A (da)
IN (1)	IN159362B (da)
MY (1)	MY8700499A (da)
NO (1)	NO159658C (da)
NZ (1)	NZ200066A (da)
PH (1)	PH17602A (da)
PL (3)	PL139261B1 (da)
PT (1)	PT74621B (da)
RO (2)	RO84278B (da)
SG (1)	SG23387G (da)
SU (2)	SU1277897A3 (da)
YU (2)	YU42761B (da)
ZA (1)	ZA821899B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0084730A1 (en) *	1982-01-22	1983-08-03	Beecham Group Plc	Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use
PH20068A (en) *	1982-12-06	1986-09-18	Pfizer	Process and intermediates for sultamicillin and analogs
GB8808701D0 (en) *	1988-04-13	1988-05-18	Erba Carlo Spa	Beta-lactam derivatives
ES2039299B1 (es) *	1991-10-04	1994-05-16	Asturpharma S A	Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.
ES2100125B1 (es) *	1995-06-02	1998-04-01	Asturpharma S A	Procedimiento de preparacion de esteres de metanodiol de acido dioxopenicilanico.
CN112724162B (zh) *	2020-12-28	2022-06-10	华南农业大学	一种阿莫西林-舒巴坦杂合分子的合成方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE49880B1 (en) *	1979-02-13	1986-01-08	Leo Pharm Prod Ltd	Penicillin derivatives
ZA80796B (en) *	1979-02-13	1981-02-25	Leo Pharm Prod Ltd	Chemical compounds
ZA80646B (en) *	1979-03-05	1981-02-25	Pfizer	Process and intermediates for penicillanic acid,1,1-dioxide and esters thereof
SE449103B (sv) *	1979-03-05	1987-04-06	Pfizer	Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
IE50650B1 (en) *	1979-10-11	1986-06-11	Leo Pharm Prod Ltd	Method for producing penicillanic acid derivatives

1982
- 1982-02-09 IN IN102/DEL/82A patent/IN159362B/en unknown
- 1982-03-15 BG BG055782A patent/BG37380A3/xx unknown
- 1982-03-15 BG BG067396A patent/BG38939A3/xx unknown
- 1982-03-15 EP EP82301296A patent/EP0061274B1/en not_active Expired
- 1982-03-15 DE DE8282301296T patent/DE3267505D1/de not_active Expired
- 1982-03-16 GB GB8207695A patent/GB2095250A/en not_active Withdrawn
- 1982-03-17 GT GT198274393A patent/GT198274393A/es unknown
- 1982-03-18 NO NO820898A patent/NO159658C/no not_active IP Right Cessation
- 1982-03-19 DD DD82238305A patent/DD202163A5/de not_active IP Right Cessation
- 1982-03-19 NZ NZ200066A patent/NZ200066A/en unknown
- 1982-03-21 EG EG148/82A patent/EG15803A/xx active
- 1982-03-22 ZA ZA821899A patent/ZA821899B/xx unknown
- 1982-03-22 PT PT74621A patent/PT74621B/pt unknown
- 1982-03-22 RO RO106986A patent/RO84278B/ro unknown
- 1982-03-22 SU SU823408198A patent/SU1277897A3/ru active
- 1982-03-22 SU SU823408198K patent/SU1277898A3/ru active
- 1982-03-22 IL IL65308A patent/IL65308A/xx not_active IP Right Cessation
- 1982-03-22 HU HU82852A patent/HU187667B/hu unknown
- 1982-03-22 FI FI820991A patent/FI74284C/fi not_active IP Right Cessation
- 1982-03-22 KR KR8201223A patent/KR860001368B1/ko active
- 1982-03-22 YU YU619/82A patent/YU42761B/xx unknown
- 1982-03-22 IE IE659/82A patent/IE52835B1/en unknown
- 1982-03-22 GR GR67669A patent/GR75935B/el unknown
- 1982-03-22 DK DK127182A patent/DK162392C/da not_active IP Right Cessation
- 1982-03-22 CA CA000398989A patent/CA1213581A/en not_active Expired
- 1982-03-22 HU HU842661A patent/HU189917B/hu unknown
- 1982-03-22 AU AU81764/82A patent/AU531892B2/en not_active Expired
- 1982-03-22 RO RO82113915A patent/RO87946A/ro unknown
- 1982-03-22 ES ES510655A patent/ES8305768A1/es not_active Expired
- 1982-03-23 PL PL1982240664A patent/PL139261B1/pl unknown
- 1982-03-23 PL PL1982240663A patent/PL138851B1/pl unknown
- 1982-03-23 PL PL1982235578A patent/PL134250B1/pl unknown
- 1982-03-23 JP JP57046185A patent/JPS57169493A/ja active Granted
- 1982-03-23 PH PH27043A patent/PH17602A/en unknown
- 1982-03-23 CS CS822014A patent/CS227345B2/cs unknown
1983
- 1983-01-13 ES ES518970A patent/ES518970A0/es active Granted
1984
- 1984-10-23 YU YU1810/84A patent/YU43585B/xx unknown
1987
- 1987-03-09 SG SG233/87A patent/SG23387G/en unknown
- 1987-07-09 HK HK524/87A patent/HK52487A/xx not_active IP Right Cessation
- 1987-07-28 JP JP62188686A patent/JPS63146886A/ja active Pending
- 1987-07-28 JP JP62188687A patent/JPS6345287A/ja active Pending
- 1987-12-30 MY MY499/87A patent/MY8700499A/xx unknown
1991
- 1991-06-21 DK DK121491A patent/DK165746C/da not_active IP Right Cessation
1992
- 1992-02-20 DK DK021892A patent/DK167119B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL138851B1 (en)	1986-11-29
DK121491A (da)	1991-06-21
DK167119B1 (da)	1993-08-30
YU181084A (en)	1987-06-30
DK121491D0 (da)	1991-06-21
FI74284C (fi)	1988-01-11
JPS57169493A (en)	1982-10-19
PL139261B1 (en)	1987-01-31
DD202163A5 (de)	1983-08-31
JPH0331717B2 (da)	1991-05-08
YU43585B (en)	1989-08-31
DE3267505D1 (en)	1986-01-02
PL134250B1 (en)	1985-08-31
SG23387G (en)	1987-07-10
EP0061274B1 (en)	1985-11-21
GT198274393A (es)	1983-09-08
YU61982A (en)	1985-03-20
PL235578A1 (en)	1983-06-20
AU8176482A (en)	1982-11-04
NO159658B (no)	1988-10-17
RO87946A (ro)	1985-12-20
HUT34985A (en)	1985-05-28
ES8403132A1 (es)	1984-03-01
GB2095250A (en)	1982-09-29
DK162392C (da)	1992-03-09
PT74621B (en)	1984-11-26
RO84278A (ro)	1984-05-23
GR75935B (da)	1984-08-02
IE820659L (en)	1982-09-23
NO159658C (no)	1989-01-25
DK165746B (da)	1993-01-11
HU189917B (en)	1986-08-28
SU1277898A3 (ru)	1986-12-15
DK162392B (da)	1991-10-21
JPS6345287A (ja)	1988-02-26
SU1277897A3 (ru)	1986-12-15
IE52835B1 (en)	1988-03-16
KR830009113A (ko)	1983-12-17
DK21892D0 (da)	1992-02-20
IL65308A (en)	1985-03-31
AU531892B2 (en)	1983-09-08
BG38939A3 (en)	1986-03-14
RO87946B (ro)	1985-12-02
ZA821899B (en)	1983-01-26
JPS63146886A (ja)	1988-06-18
NO820898L (no)	1982-09-24
HU187667B (en)	1986-02-28
RO84278B (ro)	1984-07-30
DK165746C (da)	1993-06-07
NZ200066A (en)	1985-08-16
IN159362B (da)	1987-05-09
ES518970A0 (es)	1984-03-01
CA1213581A (en)	1986-11-04
YU42761B (en)	1988-12-31
FI820991L (fi)	1982-09-24
FI74284B (fi)	1987-09-30
BG37380A3 (en)	1985-05-15
MY8700499A (en)	1987-12-31
IL65308A0 (en)	1982-05-31
ES510655A0 (es)	1983-04-16
ES8305768A1 (es)	1983-04-16
HK52487A (en)	1987-07-17
PH17602A (en)	1984-10-05
PL240663A1 (en)	1983-09-12
PT74621A (en)	1982-04-01
EG15803A (en)	1990-08-30
CS227345B2 (en)	1984-04-16
DK21892A (da)	1992-02-20
KR860001368B1 (ko)	1986-09-17
EP0061274A1 (en)	1982-09-29
PL240664A1 (en)	1983-09-12

Publication	Publication Date	Title
DK137083D0 (da)	1983-03-25	Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholecalciferol og mellemprodukter til brug herved
DK516182A (da)	1983-05-21	Fremgangsmaade til fremstilling af 3-hydroxy-ml-236b derivater, betegnet m-4 og m-4'
DK164684D0 (da)	1984-03-23	4-substituerede-2-azetidinon-forbindelser,fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved
DK149842C (da)	1987-06-15	Fremgangsmaade til fremstilling af d-camphorat af l-carnitinamid og d-camphorat af d-carnitinamid
DK436981A (da)	1981-10-02	Fremgangsmaade til fremstilling af 25-hydroxy26,26,26,27,27,27,-hexafluor-cholecalciferol og mellemprodukter herved
DK172485D0 (da)	1985-04-17	23,23-difluor-1,25-dihydroxycholecalciferol og derivater deraf, fremgangsmaade til fremstilling af disse og mellemprodukter til brug herved
DK214981A (da)	1981-11-20	Fremgangsmaade til fremstilling af substituerede triazoloquinoxalin 4-oner og syreadditionssalte heraf
DK343682A (da)	1983-02-04	Fremgangsmaade til fremstilling af thiazolidinylalkylen-piperazin-derivater
DK32684D0 (da)	1984-01-25	Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholesterol og mellemprodukter til brug herfor
DK565981A (da)	1982-06-23	Kommutator og fremgangsmaade til fremstilling deraf
IS2700A7 (is)	1982-08-06	Efni afleidd af Pyrrolidin og aðferð til framleiðslu þeirra
DK350883A (da)	1984-02-03	Fremgangsmaade til fremstilling af mycaminosyltylonolid og beslaegtede macrolidderivater og mellemprodukter herved
DK165250C (da)	1993-03-22	Fremgangsmaade til fremstilling af 2-amino-6-chlorpurin
DK509882A (da)	1982-11-16	Konstruktionselement og fremgangsmaade til fremstilling af samme
DK479981A (da)	1982-05-01	Fremgangsmaade til fremstilling af 3-aryl-3-hydroxyphthalimidiner
DK127182A (da)	1982-09-24	Fremgangsmaade til fremstilling af 1,1-dioxopenicillanoyloxymethyl-6-(2-phenylacetamido)penicillanater og mellemprodukter herved
DK355584A (da)	1985-01-23	Fremgangsmaade til fremstilling af 3-exomethylen-cephalosporiner
DK343782A (da)	1983-02-04	Fremgangsmaade til fremstilling af spirothiazolidinyl-piperazin-derivater
DK501582A (da)	1983-05-12	Fremgangsmaade til fremstilling af acylcyanider
DK105082A (da)	1982-09-12	Fremgangsmaade til fremstilling af substituerede trifluormethylphenyl-tetrahydropyridiner
DK274882A (da)	1982-12-20	Fremgangsmaade til fremstilling af 4alfa,5alfa-epoxy-3,20-dioxopregnen-2alfa,16alfa-dicarbonitril og mellemprodukt herved
DK326082A (da)	1983-01-22	Heptadecapeptid og fremgangsmaade til fremstilling heraf
DK76482A (da)	1982-08-24	Fremgangsmaade til fremstilling af antibiotikaene ll-b01208alfa og ll-b01208beta
DK161570C (da)	1992-01-27	Fremgangsmaade og apparat til korrugering af metalroer
DK329685D0 (da)	1985-07-19	Fremgangsmaade til fremstilling af alfa-l-aspartyl-l-phenylalaninalkylestere

Legal Events

Date	Code	Title	Description
2002-04-15	PUP	Patent expired