DK1245564T3 - Benzamidinderivater - Google Patents
BenzamidinderivaterInfo
- Publication number
- DK1245564T3 DK1245564T3 DK00970070T DK00970070T DK1245564T3 DK 1245564 T3 DK1245564 T3 DK 1245564T3 DK 00970070 T DK00970070 T DK 00970070T DK 00970070 T DK00970070 T DK 00970070T DK 1245564 T3 DK1245564 T3 DK 1245564T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- optionally substituted
- hydrogen atom
- alkyl group
- halogen atom
- Prior art date
Links
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000003937 benzamidines Chemical class 0.000 abstract 1
- 208000015294 blood coagulation disease Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Manufacture Of Alloys Or Alloy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30719299 | 1999-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1245564T3 true DK1245564T3 (da) | 2006-08-14 |
Family
ID=17966162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00970070T DK1245564T3 (da) | 1999-10-28 | 2000-10-25 | Benzamidinderivater |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US6555556B1 (da) |
| EP (1) | EP1245564B1 (da) |
| KR (1) | KR100642953B1 (da) |
| CN (2) | CN1572882A (da) |
| AT (1) | ATE322479T1 (da) |
| AU (1) | AU776193B2 (da) |
| BR (1) | BR0015120A (da) |
| CA (1) | CA2389156C (da) |
| CY (1) | CY1106116T1 (da) |
| CZ (1) | CZ20021432A3 (da) |
| DE (1) | DE60027204T2 (da) |
| DK (1) | DK1245564T3 (da) |
| ES (1) | ES2261248T3 (da) |
| HK (1) | HK1047431B (da) |
| HU (1) | HUP0203161A3 (da) |
| IL (2) | IL149306A0 (da) |
| MX (1) | MXPA02004218A (da) |
| NO (1) | NO323147B1 (da) |
| NZ (1) | NZ518581A (da) |
| PL (1) | PL354619A1 (da) |
| PT (1) | PT1245564E (da) |
| RU (1) | RU2222529C2 (da) |
| TR (1) | TR200201654T2 (da) |
| TW (1) | TWI226886B (da) |
| WO (1) | WO2001030756A1 (da) |
| ZA (1) | ZA200203278B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1245564T3 (da) * | 1999-10-28 | 2006-08-14 | Sankyo Co | Benzamidinderivater |
| HUP0400384A3 (en) * | 2001-04-05 | 2008-08-28 | Sankyo Co | Benzamidine derivative and pharmaceutical compositions containing them and their use |
| WO2002089803A1 (en) * | 2001-05-07 | 2002-11-14 | Sankyo Company, Limited | Composition for iontophoresis |
| KR100969847B1 (ko) * | 2002-03-15 | 2010-07-13 | 깃세이 야쿠힌 고교 가부시키가이샤 | 5-히드록시카르밤이미도일-2-히드록시벤젠술폰아미드유도체의 신규한 결정 |
| KR101047042B1 (ko) * | 2004-11-23 | 2011-07-06 | 동화약품주식회사 | 생체이용율을 향상시킨 경구용 제제 |
| CN103159620A (zh) * | 2013-03-28 | 2013-06-19 | 广西师范大学 | 一种2-羟基间苯二甲酸的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| ES2193202T3 (es) | 1994-12-02 | 2003-11-01 | Yamanouchi Pharma Co Ltd | Nuevo derivado de amidinonaftilo o sal de este. |
| DE69628856T2 (de) * | 1996-01-02 | 2004-05-06 | Aventis Pharmaceuticals Inc. | Substituierte n-[(aminoiminomethyl oder aminomethyl)phenyl]propylamide |
| CN1234798A (zh) * | 1996-09-12 | 1999-11-10 | 舍林股份公司 | 环状氨基酸和环状羟基羧酸衍生物取代的苄脒衍生物和它们用作抗凝剂的用途 |
| TW542822B (en) | 1997-01-17 | 2003-07-21 | Ajinomoto Kk | Benzamidine derivatives |
| AU3857300A (en) * | 1999-02-11 | 2000-08-29 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| US6350761B1 (en) * | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
| DK1245564T3 (da) * | 1999-10-28 | 2006-08-14 | Sankyo Co | Benzamidinderivater |
-
2000
- 2000-10-25 DK DK00970070T patent/DK1245564T3/da active
- 2000-10-25 CN CNA2004100634713A patent/CN1572882A/zh active Pending
- 2000-10-25 WO PCT/JP2000/007469 patent/WO2001030756A1/ja active IP Right Grant
- 2000-10-25 PT PT00970070T patent/PT1245564E/pt unknown
- 2000-10-25 IL IL14930600A patent/IL149306A0/xx active IP Right Grant
- 2000-10-25 CN CNB008178003A patent/CN1293052C/zh not_active Expired - Fee Related
- 2000-10-25 ES ES00970070T patent/ES2261248T3/es not_active Expired - Lifetime
- 2000-10-25 EP EP00970070A patent/EP1245564B1/en not_active Expired - Lifetime
- 2000-10-25 TR TR2002/01654T patent/TR200201654T2/xx unknown
- 2000-10-25 MX MXPA02004218A patent/MXPA02004218A/es active IP Right Grant
- 2000-10-25 CZ CZ20021432A patent/CZ20021432A3/cs unknown
- 2000-10-25 AU AU79574/00A patent/AU776193B2/en not_active Ceased
- 2000-10-25 CA CA002389156A patent/CA2389156C/en not_active Expired - Fee Related
- 2000-10-25 AT AT00970070T patent/ATE322479T1/de not_active IP Right Cessation
- 2000-10-25 BR BR0015120-3A patent/BR0015120A/pt not_active Application Discontinuation
- 2000-10-25 PL PL00354619A patent/PL354619A1/xx unknown
- 2000-10-25 DE DE60027204T patent/DE60027204T2/de not_active Expired - Lifetime
- 2000-10-25 KR KR1020027005382A patent/KR100642953B1/ko not_active IP Right Cessation
- 2000-10-25 HU HU0203161A patent/HUP0203161A3/hu unknown
- 2000-10-25 NZ NZ518581A patent/NZ518581A/en unknown
- 2000-10-25 RU RU2002111343/04A patent/RU2222529C2/ru not_active IP Right Cessation
- 2000-10-27 TW TW089122706A patent/TWI226886B/zh not_active IP Right Cessation
-
2002
- 2002-04-23 IL IL149306A patent/IL149306A/en not_active IP Right Cessation
- 2002-04-24 ZA ZA200203278A patent/ZA200203278B/en unknown
- 2002-04-25 US US10/132,042 patent/US6555556B1/en not_active Expired - Fee Related
- 2002-04-26 NO NO20021990A patent/NO323147B1/no not_active IP Right Cessation
- 2002-11-06 US US10/288,838 patent/US20040010009A1/en not_active Abandoned
- 2002-12-05 HK HK02108844.9A patent/HK1047431B/zh not_active IP Right Cessation
-
2003
- 2003-11-07 US US10/704,355 patent/US20040248981A1/en not_active Abandoned
-
2006
- 2006-07-04 CY CY20061100927T patent/CY1106116T1/el unknown
Also Published As
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