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TR200201654T2 - Benzamidin türevleri. - Google Patents

Benzamidin türevleri.

Info

Publication number
TR200201654T2
TR200201654T2 TR2002/01654T TR200201654T TR200201654T2 TR 200201654 T2 TR200201654 T2 TR 200201654T2 TR 2002/01654 T TR2002/01654 T TR 2002/01654T TR 200201654 T TR200201654 T TR 200201654T TR 200201654 T2 TR200201654 T2 TR 200201654T2
Authority
TR
Turkey
Prior art keywords
relates
treatment
prevention
blood clotting
clotting disorder
Prior art date
Application number
TR2002/01654T
Other languages
English (en)
Inventor
Asai Fumitoshi
Matsuhashi Hayao
Fujimoto Koichi
Original Assignee
Sankyo Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Company Limited filed Critical Sankyo Company Limited
Publication of TR200201654T2 publication Critical patent/TR200201654T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Manufacture Of Alloys Or Alloy Compounds (AREA)

Abstract

Bu bulus, faktör Xa'ya karsi üstün inhibitör aktivitesi olan benzamidin türevleriyle ve farmasötik olarak kabul edilebilir tuzlariyla ilgilidir. Bulus ayrica, kan pihtilasmasiyla ilgili bir bozuklugun önlenmesi veya tedavisi için söz konusu bilesimlerin aktif madde olarak içeren farmasötik terkiplerle de ilgilidir. Bulus, ilaveten kan pihtilasmasiyla ilgili bir bozuklugun önlenmesi veya tedavisi için bir ilacin hazirlanmasinda söz konusu bilesimlerin kullanimiyla da ilgilidir. Ayrica bulus, kan pihtilasmasiyla ilgili bir bozuklugun önlenmesi veya tedavisi için, böyle bir tedaviye ihtiyaci olan bir sicak-kanli hayvana söz konusu birlesimlerden farmasötik olarak etkili bir miktarda verilmesini içeren bir yöntemle ilgilidir. Ayrica, bulus söz konusu bilesimlerin hazirlanmasi için bir prosesle de ilgilidir.
TR2002/01654T 1999-10-28 2000-10-25 Benzamidin türevleri. TR200201654T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30719299 1999-10-28

Publications (1)

Publication Number Publication Date
TR200201654T2 true TR200201654T2 (tr) 2002-12-23

Family

ID=17966162

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01654T TR200201654T2 (tr) 1999-10-28 2000-10-25 Benzamidin türevleri.

Country Status (26)

Country Link
US (3) US6555556B1 (tr)
EP (1) EP1245564B1 (tr)
KR (1) KR100642953B1 (tr)
CN (2) CN1293052C (tr)
AT (1) ATE322479T1 (tr)
AU (1) AU776193B2 (tr)
BR (1) BR0015120A (tr)
CA (1) CA2389156C (tr)
CY (1) CY1106116T1 (tr)
CZ (1) CZ20021432A3 (tr)
DE (1) DE60027204T2 (tr)
DK (1) DK1245564T3 (tr)
ES (1) ES2261248T3 (tr)
HK (1) HK1047431B (tr)
HU (1) HUP0203161A3 (tr)
IL (2) IL149306A0 (tr)
MX (1) MXPA02004218A (tr)
NO (1) NO323147B1 (tr)
NZ (1) NZ518581A (tr)
PL (1) PL354619A1 (tr)
PT (1) PT1245564E (tr)
RU (1) RU2222529C2 (tr)
TR (1) TR200201654T2 (tr)
TW (1) TWI226886B (tr)
WO (1) WO2001030756A1 (tr)
ZA (1) ZA200203278B (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1245564E (pt) * 1999-10-28 2006-06-30 Sankyo Co Derivados de benzamidina.
KR20030087056A (ko) * 2001-04-05 2003-11-12 상꾜 가부시키가이샤 벤즈아미딘 유도체
WO2002089803A1 (en) * 2001-05-07 2002-11-14 Sankyo Company, Limited Composition for iontophoresis
MXPA04009007A (es) 2002-03-15 2005-07-01 Kissei Pharmaceutical Nuevos cristales de derivado de 5-hidroxicarbamimidoil-2-hidroxi-bencenosulfonamida.
ES2333739T3 (es) * 2004-11-23 2010-02-26 Dong Wha Pharmaceutical Co., Ltd. Sal de n-hidroxi-4-(5-(4-(5-isopropil-2-metil-1,3-tiazol-4-il)fenoxi) pentoxi)benzamidina con acido 2-metanosulfonico.
CN103159620A (zh) * 2013-03-28 2013-06-19 广西师范大学 一种2-羟基间苯二甲酸的制备方法
CN120239617A (zh) 2022-11-22 2025-07-01 康诺亚生物医药科技（成都）有限公司 稠环类化合物及其偶联物和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57209270A (en) * 1981-06-19 1982-12-22 Chugai Pharmaceut Co Ltd Proline derivative
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
CN1087736C (zh) * 1994-12-02 2002-07-17 山之内制药株式会社 新型的脒基萘基衍生物或其盐
DE4443390A1 (de) * 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
SI0906094T1 (en) * 1996-01-02 2003-12-31 Aventis Pharmaceuticals Inc. Substituted n- (aminoiminomethyl or aminomethyl)phenyl)propyl amides
IL128691A (en) * 1996-09-12 2007-07-24 Bayer Schering Pharma Ag History of enzamidine converted by annular amino acid and history of annular hydroxy acid and their use against coagulation
TW542822B (en) * 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
US6399627B1 (en) * 1999-02-11 2002-06-04 Cor Therapeutics, Inc. Inhibitors of factor Xa
US6350761B1 (en) * 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
PT1245564E (pt) * 1999-10-28 2006-06-30 Sankyo Co Derivados de benzamidina.

Also Published As

Publication number Publication date
PT1245564E (pt) 2006-06-30
KR100642953B1 (ko) 2006-11-10
CA2389156A1 (en) 2001-05-03
EP1245564A1 (en) 2002-10-02
DE60027204D1 (en) 2006-05-18
CN1572882A (zh) 2005-02-02
IL149306A (en) 2007-07-04
TWI226886B (en) 2005-01-21
NO20021990D0 (no) 2002-04-26
HK1047431B (en) 2006-07-14
CN1293052C (zh) 2007-01-03
HK1047431A1 (en) 2003-02-21
US6555556B1 (en) 2003-04-29
NZ518581A (en) 2004-11-26
RU2222529C2 (ru) 2004-01-27
BR0015120A (pt) 2002-06-25
NO20021990L (no) 2002-06-25
EP1245564A4 (en) 2003-03-05
DE60027204T2 (de) 2006-11-23
PL354619A1 (en) 2004-02-09
CN1413189A (zh) 2003-04-23
ATE322479T1 (de) 2006-04-15
EP1245564B1 (en) 2006-04-05
CA2389156C (en) 2009-05-12
CZ20021432A3 (cs) 2002-10-16
US20040010009A1 (en) 2004-01-15
HUP0203161A2 (hu) 2002-12-28
CY1106116T1 (el) 2011-06-08
HUP0203161A3 (en) 2003-12-29
US20040248981A1 (en) 2004-12-09
AU776193B2 (en) 2004-09-02
ZA200203278B (en) 2003-08-26
NO323147B1 (no) 2007-01-08
KR20020092347A (ko) 2002-12-11
AU7957400A (en) 2001-05-08
WO2001030756A1 (fr) 2001-05-03
ES2261248T3 (es) 2006-11-16
MXPA02004218A (es) 2002-10-17
IL149306A0 (en) 2002-11-10
DK1245564T3 (da) 2006-08-14

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