DK1121375T3 - (7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-on i høj renhedsgrad - Google Patents

(7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-on i høj renhedsgrad

Info

Publication number: DK1121375T3
Authority: DK; Denmark
Prior art keywords: 7alpha; 17alpha; pregn; hydroxy; methyl
Prior art date: 1998-10-16

Application number

DK99948994T

Other languages

Danish (da)

English (en)

Inventor

Peter Huub Gerard Kirchholtes

Gerard Arnoud Jozef Maria Sas

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-11

Publication date

2003-08-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8234220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1121375(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-10-11 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

2003-08-04 Application granted granted Critical

2003-08-04 Publication of DK1121375T3 publication Critical patent/DK1121375T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Immunology (AREA)
Diabetes (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK99948994T 1998-10-16 1999-10-11 (7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-on i høj renhedsgrad DK1121375T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98203460		1998-10-16
PCT/EP1999/007768 WO2000023460A1 (fr)	1998-10-16	1999-10-11	COMPOSITION A DEGRE ELEVE DE PURETE RENFERMANT (7α,17α)-17-HYDROXY-7-METHYL-19-NOR-17-PREGN-5(10)-EN-20-YN-3-ONE

Publications (1)

Publication Number	Publication Date
DK1121375T3 true DK1121375T3 (da)	2003-08-04

Family

ID=8234220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99948994T DK1121375T3 (da)	1998-10-16	1999-10-11	(7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-on i høj renhedsgrad

Country Status (30)

Country	Link
US (3)	US6969708B1 (fr)
EP (2)	EP1121375B1 (fr)
JP (1)	JP2002527525A (fr)
KR (3)	KR20050003358A (fr)
CN (2)	CN100378116C (fr)
AR (1)	AR020832A1 (fr)
AT (1)	ATE239032T1 (fr)
AU (1)	AU763232B2 (fr)
BR (1)	BR9914441A (fr)
CA (1)	CA2344686C (fr)
CO (1)	CO5160271A1 (fr)
CZ (1)	CZ298703B6 (fr)
DE (1)	DE69907495T2 (fr)
DK (1)	DK1121375T3 (fr)
ES (1)	ES2197677T3 (fr)
HK (1)	HK1039620B (fr)
HU (1)	HUP0104206A3 (fr)
ID (1)	ID28463A (fr)
IL (1)	IL141850A (fr)
NO (1)	NO317427B1 (fr)
NZ (1)	NZ510501A (fr)
PE (1)	PE20001377A1 (fr)
PL (1)	PL197870B1 (fr)
PT (1)	PT1121375E (fr)
RU (1)	RU2220975C2 (fr)
SK (1)	SK284569B6 (fr)
TR (2)	TR200504091T2 (fr)
TW (2)	TW577893B (fr)
WO (1)	WO2000023460A1 (fr)
ZA (1)	ZA200101952B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL356465A1 (en) *	2002-10-04	2004-04-05	ANPHARM Przedsiębiorstwo Farmaceutyczne S.A.	METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE
TW200418525A (en) *	2002-11-20	2004-10-01	Akzo Nobel Nv	Coated pharmaceutical tablets containing Tibolone
GB0304927D0 (en)	2003-03-04	2003-04-09	Resolution Chemicals Ltd	Process for the production of tibolone
WO2005117899A1 (fr) *	2004-06-02	2005-12-15	Cipla Limited	Composition pharmaceutique comprenant de la tibolone et son procede de production
EP2363401A1 (fr)	2005-02-01	2011-09-07	F. Hoffmann-La Roche AG	Polymorphe B d'ibandronate
DK2662380T3 (en) *	2005-02-01	2019-03-18	Atnahs Pharma Uk Ltd	Medical use of Ibandronate polymorph A
WO2006125453A1 (fr) *	2005-05-23	2006-11-30	Newchem S.P.A.	Procede de preparation de tibolone cristalline pure
CZ300465B6 (cs) *	2007-07-25	2009-05-27	Zentiva, A. S.	Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu
ITMI20130120A1 (it) *	2013-01-25	2014-07-26	Ind Chimica Srl	Processo per la preparazione in forma cristallina di tibolone, (7alfa,17alfa)-17-idrossi-7-metil-19-norpregn-5(10)-en-20-in-3-one
AU2019401576A1 (en) *	2018-12-17	2021-06-24	Société des Produits Nestlé S.A.	Formulations for egg oral immunotherapy, methods of manufacture, and treatments for egg allergy
CN114409717B (zh) *	2021-12-17	2023-03-17	湖南科益新生物医药有限公司	替勃龙中间体醚化物和替勃龙的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE665514A (fr)	1964-06-16
CH488682A (de) *	1965-07-30	1970-04-15	Ciba Geigy	Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
NL146838B (nl) *	1966-06-24	1975-08-15	Organon Nv	Werkwijze voor het bereiden van (delta)5(10)-3- keto-19-norsteroiden.
US3515719A (en) *	1967-03-15	1970-06-02	Upjohn Co	7-methyl-6,19-epoxy steroids of the androstane series
US4701450A (en) *	1984-03-21	1987-10-20	Akzo N.V.	Steroids for use as immunomodulators
WO1989009058A1 (fr) *	1988-03-25	1989-10-05	Akzo N.V.	Preparation pharmaceutique contenant un sel de fluorure
IE63051B1 (en) *	1989-03-18	1995-03-22	Akzo Nv	Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
CA2116829C (fr) *	1993-03-05	2004-09-14	Godefridus Hermanus Johanna Deckers	Utilisation d'un derive du pregnane
CA2159419C (fr)	1994-10-17	2006-07-04	Pieter De Haan	Composition pharmaceutique solide renfermant un excipient pouvant fixer l'eau
IL123422A (en) *	1997-03-05	2003-05-29	Akzo Nobel Nv	USE OF 7alpha-METHYL-17alpha-ETHYNYL-ESTRANE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE PROPHYLAXIS OR THE TREATMENT OF ATHEROSCLEROSIS
IL123984A (en) *	1997-04-22	2004-09-27	Akzo Nobel Nv	Pharmacological dosage units containing tibolone and carrier pharmacy are acceptable

1999
- 1999-10-11 RU RU2001113281/04A patent/RU2220975C2/ru not_active IP Right Cessation
- 1999-10-11 AU AU62029/99A patent/AU763232B2/en not_active Expired
- 1999-10-11 JP JP2000577186A patent/JP2002527525A/ja not_active Withdrawn
- 1999-10-11 EP EP99948994A patent/EP1121375B1/fr not_active Revoked
- 1999-10-11 BR BR9914441-7A patent/BR9914441A/pt not_active Application Discontinuation
- 1999-10-11 PT PT99948994T patent/PT1121375E/pt unknown
- 1999-10-11 NZ NZ510501A patent/NZ510501A/en not_active IP Right Cessation
- 1999-10-11 AT AT99948994T patent/ATE239032T1/de not_active IP Right Cessation
- 1999-10-11 US US09/787,215 patent/US6969708B1/en not_active Expired - Fee Related
- 1999-10-11 TW TW088117530A patent/TW577893B/zh not_active IP Right Cessation
- 1999-10-11 ID IDW20010850A patent/ID28463A/id unknown
- 1999-10-11 PL PL347264A patent/PL197870B1/pl not_active IP Right Cessation
- 1999-10-11 TW TW092128164A patent/TW200403251A/zh unknown
- 1999-10-11 TR TR2005/04091T patent/TR200504091T2/xx unknown
- 1999-10-11 DE DE69907495T patent/DE69907495T2/de not_active Revoked
- 1999-10-11 CN CNB99811734XA patent/CN100378116C/zh not_active Expired - Fee Related
- 1999-10-11 KR KR10-2004-7016210A patent/KR20050003358A/ko not_active Application Discontinuation
- 1999-10-11 WO PCT/EP1999/007768 patent/WO2000023460A1/fr active IP Right Grant
- 1999-10-11 EP EP02022689A patent/EP1275379A3/fr not_active Withdrawn
- 1999-10-11 KR KR1020067011204A patent/KR20060071897A/ko not_active Application Discontinuation
- 1999-10-11 TR TR2001/01083T patent/TR200101083T2/xx unknown
- 1999-10-11 CA CA002344686A patent/CA2344686C/fr not_active Expired - Fee Related
- 1999-10-11 CN CNB2005101186668A patent/CN100432093C/zh not_active Expired - Fee Related
- 1999-10-11 KR KR1020017004639A patent/KR100635018B1/ko not_active IP Right Cessation
- 1999-10-11 DK DK99948994T patent/DK1121375T3/da active
- 1999-10-11 IL IL14185099A patent/IL141850A/xx not_active IP Right Cessation
- 1999-10-11 SK SK493-2001A patent/SK284569B6/sk not_active IP Right Cessation
- 1999-10-11 HU HU0104206A patent/HUP0104206A3/hu unknown
- 1999-10-11 CZ CZ20010976A patent/CZ298703B6/cs not_active IP Right Cessation
- 1999-10-11 ES ES99948994T patent/ES2197677T3/es not_active Expired - Lifetime
- 1999-10-15 CO CO99065751A patent/CO5160271A1/es unknown
- 1999-10-15 PE PE1999001042A patent/PE20001377A1/es not_active Application Discontinuation
- 1999-10-15 AR ARP990105229A patent/AR020832A1/es unknown
2001
- 2001-03-08 ZA ZA200101952A patent/ZA200101952B/en unknown
- 2001-04-03 NO NO20011664A patent/NO317427B1/no not_active IP Right Cessation
2002
- 2002-01-18 HK HK02100410.0A patent/HK1039620B/zh not_active IP Right Cessation
2004
- 2004-07-08 US US10/887,397 patent/US20040248870A1/en not_active Abandoned
2005
- 2005-07-07 US US11/176,842 patent/US20050245496A1/en not_active Abandoned

Also Published As

Publication number	Publication date
TR200101083T2 (tr)	2001-08-21
DE69907495T2 (de)	2004-05-06
NO20011664D0 (no)	2001-04-03
HUP0104206A2 (hu)	2002-04-29
SK284569B6 (sk)	2005-06-02
HK1039620B (zh)	2003-08-22
KR20060071897A (ko)	2006-06-27
CO5160271A1 (es)	2002-05-30
EP1121375B1 (fr)	2003-05-02
KR20010080133A (ko)	2001-08-22
NZ510501A (en)	2003-10-31
NO20011664L (no)	2001-04-03
PE20001377A1 (es)	2000-12-09
US20040248870A1 (en)	2004-12-09
AU6202999A (en)	2000-05-08
KR100635018B1 (ko)	2006-10-17
JP2002527525A (ja)	2002-08-27
CA2344686C (fr)	2009-04-28
US6969708B1 (en)	2005-11-29
CN100432093C (zh)	2008-11-12
US20050245496A1 (en)	2005-11-03
TW577893B (en)	2004-03-01
EP1275379A2 (fr)	2003-01-15
HK1039620A1 (en)	2002-05-03
ID28463A (id)	2001-05-24
BR9914441A (pt)	2001-06-26
IL141850A0 (en)	2002-03-10
CZ2001976A3 (cs)	2001-08-15
HUP0104206A3 (en)	2002-06-28
NO317427B1 (no)	2004-10-25
PL197870B1 (pl)	2008-05-30
ZA200101952B (en)	2002-06-10
CZ298703B6 (cs)	2007-12-27
TR200504091T2 (tr)	2006-05-22
TW200403251A (en)	2004-03-01
ATE239032T1 (de)	2003-05-15
AR020832A1 (es)	2002-05-29
WO2000023460A1 (fr)	2000-04-27
EP1121375A1 (fr)	2001-08-08
SK4932001A3 (en)	2001-12-03
CN100378116C (zh)	2008-04-02
IL141850A (en)	2005-11-20
CN1322210A (zh)	2001-11-14
EP1275379A3 (fr)	2003-03-26
PL347264A1 (en)	2002-03-25
PT1121375E (pt)	2003-07-31
KR20050003358A (ko)	2005-01-10
AU763232B2 (en)	2003-07-17
DE69907495D1 (de)	2003-06-05
CA2344686A1 (fr)	2000-04-27
ES2197677T3 (es)	2004-01-01
CN1769293A (zh)	2006-05-10
RU2220975C2 (ru)	2004-01-10

Publication	Publication Date	Title
PT1114031E (pt)	2005-09-30	4-carboxiamino-1,2,3,4-tetradhiroquinolinas substituidas em posicao 2
ID29241A (id)	2001-08-16	Turunan-turunan kinolin teranelasi-1,2
DE69933287D1 (de)	2006-11-02	12,13-modifizierte epothilon-derivate
PT993456E (pt)	2005-01-31	4,5-diaril-imidazoles 2-substituidos
PT1015467E (pt)	2004-05-31	Derivados de eritromicina em ponte 6,9-
ID21413A (id)	1999-06-10	Turunan-turunan 1,3,8,-triaza-spiro (4,5) dekan-4-on
DE69917327D1 (de)	2004-06-17	3,3-biarylpiperidin- und 3,3-biarylmorpholinderivate
DE59909387D1 (de)	2004-06-09	Elektrokardiogramm-Anordnung
DK1121375T3 (da)	2003-08-04	(7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-on i høj renhedsgrad
NO20003825L (no)	2000-07-26	1,3,4 - oxadiazolonderivater
DE60025958D1 (de)	2006-04-20	14,15-beta-methylen substituierte androgene
DE69521515D1 (de)	2001-08-02	Quantenkryptographie
DK1149106T3 (da)	2003-07-14	4,5-azolo-oxindoler
NO20004167L (no)	2000-10-19	Kaspase-8 interagerende proteiner
ATE234302T1 (de)	2003-03-15	Di- oder triazaspiro(4,5)decanderivate
DE69926606D1 (de)	2005-09-15	Plazentaprotein 13
FI980759A0 (fi)	1998-04-02	Taetningskonstruktion foer suglaodan i en sugvals
DE69934804D1 (de)	2007-02-22	Supraleiter
ID26368A (id)	2000-12-14	Turunan-turunan 2 deoksi higromisin
DK1068200T3 (da)	2005-06-20	2,4,4-trisubstituerede-1,3-dioxolanfungicider
DE69915055D1 (de)	2004-04-01	Antitumorale 1,5-diazaanthraquinone
DE69908923D1 (de)	2003-07-24	1,3,4-thiadiazolylazofarbstoffe-enthaltende tintenzusammensetzungen
ITPS990017V0 (it)	1999-05-19	Leeran 1 (lorean)
BR7400300U (pt)	1995-10-24	Disposição construtiva em extensão elétrica
BR7700791U (pt)	1998-12-22	Disposição construtiva em roupeiro