DE69907495D1 - (7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5-(10)-en-20-yn-3-on als reine verbindung - Google Patents

(7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5-(10)-en-20-yn-3-on als reine verbindung

Info

Publication number: DE69907495D1
Authority: DE; Germany
Prior art keywords: 7alpha; 17alpha; pregn; hydroxy; methyl
Prior art date: 1998-10-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Revoked

Application number

DE69907495T

Other languages

English (en)

Other versions

DE69907495T2 (de

Inventor

Huub Kirchholtes

Arnoud Sas

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Organon NV

Original Assignee

Akzo Nobel NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-11

Publication date

2003-06-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8234220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69907495(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-10-11 Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV

2003-06-05 Publication of DE69907495D1 publication Critical patent/DE69907495D1/de

2004-05-06 Application granted granted Critical

2004-05-06 Publication of DE69907495T2 publication Critical patent/DE69907495T2/de

2019-10-12 Anticipated expiration legal-status Critical

Status Revoked legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Immunology (AREA)
Biophysics (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DE69907495T 1998-10-16 1999-10-11 (7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5-(10)-en-20-yn-3-on als reine verbindung Revoked DE69907495T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP98203460		1998-10-16
EP98203460		1998-10-16
PCT/EP1999/007768 WO2000023460A1 (en)	1998-10-16	1999-10-11	HIGH PURITY COMPOSITION COMPRISING (7α,17α)- 17-HYDROXY- 7-METHYL- 19-NOR-17-PREGN- 5(10)-EN-20-YN-3-ONE

Publications (2)

Publication Number	Publication Date
DE69907495D1 true DE69907495D1 (de)	2003-06-05
DE69907495T2 DE69907495T2 (de)	2004-05-06

Family

ID=8234220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69907495T Revoked DE69907495T2 (de)	1998-10-16	1999-10-11	(7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5-(10)-en-20-yn-3-on als reine verbindung

Country Status (30)

Country	Link
US (3)	US6969708B1 (de)
EP (2)	EP1121375B1 (de)
JP (1)	JP2002527525A (de)
KR (3)	KR20050003358A (de)
CN (2)	CN100432093C (de)
AR (1)	AR020832A1 (de)
AT (1)	ATE239032T1 (de)
AU (1)	AU763232B2 (de)
BR (1)	BR9914441A (de)
CA (1)	CA2344686C (de)
CO (1)	CO5160271A1 (de)
CZ (1)	CZ298703B6 (de)
DE (1)	DE69907495T2 (de)
DK (1)	DK1121375T3 (de)
ES (1)	ES2197677T3 (de)
HK (1)	HK1039620B (de)
HU (1)	HUP0104206A3 (de)
ID (1)	ID28463A (de)
IL (1)	IL141850A (de)
NO (1)	NO317427B1 (de)
NZ (1)	NZ510501A (de)
PE (1)	PE20001377A1 (de)
PL (1)	PL197870B1 (de)
PT (1)	PT1121375E (de)
RU (1)	RU2220975C2 (de)
SK (1)	SK284569B6 (de)
TR (2)	TR200101083T2 (de)
TW (2)	TW577893B (de)
WO (1)	WO2000023460A1 (de)
ZA (1)	ZA200101952B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL356465A1 (en) *	2002-10-04	2004-04-05	ANPHARM Przedsiębiorstwo Farmaceutyczne S.A.	METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE
TW200418525A (en) *	2002-11-20	2004-10-01	Akzo Nobel Nv	Coated pharmaceutical tablets containing Tibolone
GB0304927D0 (en)	2003-03-04	2003-04-09	Resolution Chemicals Ltd	Process for the production of tibolone
WO2005117899A1 (en) *	2004-06-02	2005-12-15	Cipla Limited	Pharmaceutical composition comprising tibolone and process for procuding the same
DK1848727T3 (da)	2005-02-01	2015-07-20	Hoffmann La Roche	Ibandronat polymorf b
LT2662380T (lt)	2005-02-01	2019-03-12	Atnahs Pharma Uk Limited	Ibandronato polimorfo a medicininis panaudojimas
WO2006125453A1 (en) *	2005-05-23	2006-11-30	Newchem S.P.A.	Process for the preparation of pure crystalline tibolone
CZ300465B6 (cs) *	2007-07-25	2009-05-27	Zentiva, A. S.	Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu
ITMI20130120A1 (it) *	2013-01-25	2014-07-26	Ind Chimica Srl	Processo per la preparazione in forma cristallina di tibolone, (7alfa,17alfa)-17-idrossi-7-metil-19-norpregn-5(10)-en-20-in-3-one
EP3897181A4 (de) *	2018-12-17	2022-08-24	Société des Produits Nestlé S.A.	Formulierungen für orale ei-immuntherapie, herstellungsverfahren und behandlungen für ei-allergien
CN114409717B (zh) *	2021-12-17	2023-03-17	湖南科益新生物医药有限公司	替勃龙中间体醚化物和替勃龙的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE665514A (de) *	1964-06-16
CH488682A (de) *	1965-07-30	1970-04-15	Ciba Geigy	Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
NL146838B (nl) *	1966-06-24	1975-08-15	Organon Nv	Werkwijze voor het bereiden van (delta)5(10)-3- keto-19-norsteroiden.
US3515719A (en) *	1967-03-15	1970-06-02	Upjohn Co	7-methyl-6,19-epoxy steroids of the androstane series
US4701450A (en) *	1984-03-21	1987-10-20	Akzo N.V.	Steroids for use as immunomodulators
EP0406279A1 (de) *	1988-03-25	1991-01-09	Akzo N.V.	Pharmazeutische zubereitung mit gehalt an einem fluoridsalz
IE63051B1 (en) *	1989-03-18	1995-03-22	Akzo Nv	Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
ZA941464B (en) *	1993-03-05	1994-09-27	Akzo Nv	Use of pregnane derivative
IL115445A (en) *	1994-10-17	1999-08-17	Akzo Nobel Nv	Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation
TW448049B (en) *	1997-03-05	2001-08-01	Akzo Nobel Nv	Use of a 7Α-methyl-17Α-ethynyl-estrane derivative for the treatment of atherosclerosis
IL123984A (en) *	1997-04-22	2004-09-27	Akzo Nobel Nv	Pharmacological dosage units containing tibolone and carrier pharmacy are acceptable

1999
- 1999-10-11 ID IDW20010850A patent/ID28463A/id unknown
- 1999-10-11 JP JP2000577186A patent/JP2002527525A/ja not_active Withdrawn
- 1999-10-11 WO PCT/EP1999/007768 patent/WO2000023460A1/en active IP Right Grant
- 1999-10-11 NZ NZ510501A patent/NZ510501A/en not_active IP Right Cessation
- 1999-10-11 PT PT99948994T patent/PT1121375E/pt unknown
- 1999-10-11 DE DE69907495T patent/DE69907495T2/de not_active Revoked
- 1999-10-11 TW TW088117530A patent/TW577893B/zh not_active IP Right Cessation
- 1999-10-11 KR KR10-2004-7016210A patent/KR20050003358A/ko not_active Withdrawn
- 1999-10-11 TR TR2001/01083T patent/TR200101083T2/xx unknown
- 1999-10-11 KR KR1020017004639A patent/KR100635018B1/ko not_active Expired - Fee Related
- 1999-10-11 US US09/787,215 patent/US6969708B1/en not_active Expired - Fee Related
- 1999-10-11 CN CNB2005101186668A patent/CN100432093C/zh not_active Expired - Fee Related
- 1999-10-11 AT AT99948994T patent/ATE239032T1/de not_active IP Right Cessation
- 1999-10-11 RU RU2001113281/04A patent/RU2220975C2/ru not_active IP Right Cessation
- 1999-10-11 CZ CZ20010976A patent/CZ298703B6/cs not_active IP Right Cessation
- 1999-10-11 SK SK493-2001A patent/SK284569B6/sk not_active IP Right Cessation
- 1999-10-11 EP EP99948994A patent/EP1121375B1/de not_active Revoked
- 1999-10-11 BR BR9914441-7A patent/BR9914441A/pt not_active Application Discontinuation
- 1999-10-11 TR TR2005/04091T patent/TR200504091T2/xx unknown
- 1999-10-11 IL IL14185099A patent/IL141850A/xx not_active IP Right Cessation
- 1999-10-11 KR KR1020067011204A patent/KR20060071897A/ko not_active Ceased
- 1999-10-11 DK DK99948994T patent/DK1121375T3/da active
- 1999-10-11 PL PL347264A patent/PL197870B1/pl not_active IP Right Cessation
- 1999-10-11 AU AU62029/99A patent/AU763232B2/en not_active Expired
- 1999-10-11 TW TW092128164A patent/TW200403251A/zh unknown
- 1999-10-11 CA CA002344686A patent/CA2344686C/en not_active Expired - Fee Related
- 1999-10-11 EP EP02022689A patent/EP1275379A3/de not_active Withdrawn
- 1999-10-11 CN CNB99811734XA patent/CN100378116C/zh not_active Expired - Fee Related
- 1999-10-11 HU HU0104206A patent/HUP0104206A3/hu unknown
- 1999-10-11 ES ES99948994T patent/ES2197677T3/es not_active Expired - Lifetime
- 1999-10-15 CO CO99065751A patent/CO5160271A1/es unknown
- 1999-10-15 PE PE1999001042A patent/PE20001377A1/es not_active Application Discontinuation
- 1999-10-15 AR ARP990105229A patent/AR020832A1/es unknown
2001
- 2001-03-08 ZA ZA200101952A patent/ZA200101952B/en unknown
- 2001-04-03 NO NO20011664A patent/NO317427B1/no not_active IP Right Cessation
2002
- 2002-01-18 HK HK02100410.0A patent/HK1039620B/zh not_active IP Right Cessation
2004
- 2004-07-08 US US10/887,397 patent/US20040248870A1/en not_active Abandoned
2005
- 2005-07-07 US US11/176,842 patent/US20050245496A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL347264A1 (en)	2002-03-25
US20050245496A1 (en)	2005-11-03
CO5160271A1 (es)	2002-05-30
WO2000023460A1 (en)	2000-04-27
KR20050003358A (ko)	2005-01-10
DK1121375T3 (da)	2003-08-04
TW577893B (en)	2004-03-01
NZ510501A (en)	2003-10-31
HK1039620B (zh)	2003-08-22
PE20001377A1 (es)	2000-12-09
KR20010080133A (ko)	2001-08-22
NO20011664L (no)	2001-04-03
TR200101083T2 (tr)	2001-08-21
HK1039620A1 (en)	2002-05-03
US6969708B1 (en)	2005-11-29
ES2197677T3 (es)	2004-01-01
NO317427B1 (no)	2004-10-25
JP2002527525A (ja)	2002-08-27
ATE239032T1 (de)	2003-05-15
AR020832A1 (es)	2002-05-29
TR200504091T2 (tr)	2006-05-22
EP1121375A1 (de)	2001-08-08
CN100432093C (zh)	2008-11-12
BR9914441A (pt)	2001-06-26
TW200403251A (en)	2004-03-01
PL197870B1 (pl)	2008-05-30
EP1275379A3 (de)	2003-03-26
CN1769293A (zh)	2006-05-10
CZ2001976A3 (cs)	2001-08-15
EP1121375B1 (de)	2003-05-02
EP1275379A2 (de)	2003-01-15
KR100635018B1 (ko)	2006-10-17
AU763232B2 (en)	2003-07-17
SK4932001A3 (en)	2001-12-03
CN1322210A (zh)	2001-11-14
ID28463A (id)	2001-05-24
NO20011664D0 (no)	2001-04-03
RU2220975C2 (ru)	2004-01-10
AU6202999A (en)	2000-05-08
DE69907495T2 (de)	2004-05-06
IL141850A (en)	2005-11-20
HUP0104206A3 (en)	2002-06-28
SK284569B6 (sk)	2005-06-02
HUP0104206A2 (hu)	2002-04-29
US20040248870A1 (en)	2004-12-09
CZ298703B6 (cs)	2007-12-27
CN100378116C (zh)	2008-04-02
KR20060071897A (ko)	2006-06-27
CA2344686A1 (en)	2000-04-27
ZA200101952B (en)	2002-06-10
CA2344686C (en)	2009-04-28
PT1121375E (pt)	2003-07-31
IL141850A0 (en)	2002-03-10

Publication	Publication Date	Title
ID27595A (id)	2001-04-12	SENYAWA-SENYAWA PIROLO (2,3-d) PIRIMIDINA
DZ2569A1 (fr)	2003-02-15	Dérivés 1,2,3,4-tétrahydronaphtalène substitués.
NO20002384L (no)	2000-07-04	Vekselvirkende setteverktøy
DE19581637T1 (de)	1997-05-07	Multifunktionelle, biologisch dispergierende/biozide Zusammensetzungen
DE69524058D1 (de)	2002-01-03	Modulare, turmartige abgabevorrichtung
NO980570L (no)	1998-03-31	Parasitticidale forbindelser
FI4209U1 (fi)	1999-11-10	Uusia yhdisteitä
DK0975623T3 (da)	2002-10-14	Indazolamidforbindelser som sertoninerge midler
ID21413A (id)	1999-06-10	Turunan-turunan 1,3,8,-triaza-spiro (4,5) dekan-4-on
ATE239032T1 (de)	2003-05-15	(7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17- pregn-5-(10)-en-20-yn-3-on als reine verbindung
ID26909A (id)	2001-02-15	Turunan-turunan 1,3,4-oksadiazolon
AUPP347498A0 (en)	1998-06-04	Dragline rigging
DE69902100D1 (de)	2002-08-14	Thiakronenether verbindung
DE69812805D1 (de)	2003-05-08	Fungizide 2,6,6'-Trimethylbenzophenone
ATE234839T1 (de)	2003-04-15	4,5-azolo-oxindole
ID20635A (id)	1999-02-04	Senyawa metalosen
AU5192999A (en)	2000-02-21	All-purpose pressing-bending machine
TR199902114A3 (tr)	2000-04-21	Pantolon patleti sürfile aleti.
ID26368A (id)	2000-12-14	Turunan-turunan 2 deoksi higromisin
TR199600889A2 (tr)	1997-05-21	Fungisit bilesikler (B).
NO994838L (no)	1999-11-30	<pi>-kompleks-forbindelser
AU2017300A (en)	2000-06-26	Wavelength-selective retro-reflector
AU2002361027A1 (en)	2003-06-30	Substituted 1,5-diaminopentan-3-ol compounds
ZA99985B (en)	1999-08-10	New compound.
ZA9811914B (en)	1999-06-30	Fungicidal compounds.

Legal Events

Date	Code	Title	Description
2004-04-22	8363	Opposition against the patent
2007-06-14	8327	Change in the person/name/address of the patent owner	Owner name: N.V. ORGANON, OSS, NL
2009-10-08	8331	Complete revocation
2012-06-19	R082	Change of representative	Ref document number: 1121375 Country of ref document: EP Representative=s name: WUESTHOFF & WUESTHOFF PATENT- UND RECHTSANWAEL, DE