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DK1070077T3 - 15-Leddede ketolid-lactamer med antibakteriel virkning - Google Patents

15-Leddede ketolid-lactamer med antibakteriel virkning

Info

Publication number
DK1070077T3
DK1070077T3 DK99911955T DK99911955T DK1070077T3 DK 1070077 T3 DK1070077 T3 DK 1070077T3 DK 99911955 T DK99911955 T DK 99911955T DK 99911955 T DK99911955 T DK 99911955T DK 1070077 T3 DK1070077 T3 DK 1070077T3
Authority
DK
Denmark
Prior art keywords
ketolide
lactams
jointed
antibacterial action
antibacterial
Prior art date
Application number
DK99911955T
Other languages
Danish (da)
English (en)
Inventor
Gorjana Lazarevski
Gabrijela Kobrehel
Zeljko Kelneric
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Application granted granted Critical
Publication of DK1070077T3 publication Critical patent/DK1070077T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK99911955T 1998-04-06 1999-04-02 15-Leddede ketolid-lactamer med antibakteriel virkning DK1070077T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (1)

Publication Number Publication Date
DK1070077T3 true DK1070077T3 (da) 2003-09-22

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99911955T DK1070077T3 (da) 1998-04-06 1999-04-02 15-Leddede ketolid-lactamer med antibakteriel virkning

Country Status (26)

Country Link
US (1) US6110965A (ko)
EP (1) EP1070077B1 (ko)
JP (1) JP2002510701A (ko)
KR (1) KR100600463B1 (ko)
CN (1) CN1141312C (ko)
AR (1) AR019261A1 (ko)
AT (1) ATE241638T1 (ko)
AU (1) AU3046499A (ko)
BG (1) BG64600B1 (ko)
BR (1) BR9910115A (ko)
CA (1) CA2327775C (ko)
DE (1) DE69908338T2 (ko)
DK (1) DK1070077T3 (ko)
EE (1) EE04283B1 (ko)
ES (1) ES2200512T3 (ko)
HR (1) HRP980189B1 (ko)
HU (1) HUP0101817A3 (ko)
IL (2) IL138837A0 (ko)
NO (1) NO317982B1 (ko)
PL (1) PL193742B1 (ko)
PT (1) PT1070077E (ko)
RU (1) RU2211222C2 (ko)
SI (1) SI1070077T1 (ko)
SK (1) SK284169B6 (ko)
UA (1) UA70941C2 (ko)
WO (1) WO1999051616A1 (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
DE60138876D1 (de) * 2000-03-28 2009-07-16 Sandoz Ag Geschmackmaskierte granulierte teilchen
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
IL159585A0 (en) * 2001-08-21 2004-06-01 Pfizer Prod Inc Single dose azithromycin for treating respiratory infections
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
CA2476448A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
US20040005641A1 (en) 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003255851B2 (en) 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005030227A1 (en) * 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
JP5036558B2 (ja) 2005-01-13 2012-09-26 グラクソ グループ リミテッド 抗炎症活性を有するマクロライド
US7547679B2 (en) 2005-05-10 2009-06-16 Glaxosmithkline Istrazivacki Center Zagreb D.O.O Ether linked macrolides useful for the treatment of microbial infections
WO2007129646A1 (ja) * 2006-05-01 2007-11-15 Taisho Pharmaceutical Co., Ltd. マクロライド誘導体
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
MX2011008074A (es) * 2009-01-30 2011-08-17 Glaxo Group Ltd Macrolido anti-inflamatorio.
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
US9175031B2 (en) * 2010-12-09 2015-11-03 Wockhardt Limited Ketolide compounds
EP3883647A1 (en) * 2018-11-19 2021-09-29 Zikani Therapeutics, Inc. C10-alkylene substituted 13-membered macrolides and uses thereof
CA3156529A1 (en) * 2019-10-29 2021-05-06 Sudhir Nambiar Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5166967A (en) * 1990-08-27 1992-11-24 Fabian Carl E Markers for dental x-ray film and packets for simplified film mounting
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US5686587A (en) * 1993-05-19 1997-11-11 Pfizer Inc. Intermediate for azithromycin
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
RU2144541C1 (ru) * 1995-12-08 2000-01-20 Руссель Юклаф Производные эритромицина, способ их получения, промежуточный продукт, фармацевтическая композиция

Also Published As

Publication number Publication date
SI1070077T1 (en) 2004-02-29
HK1036457A1 (en) 2002-01-04
BG64600B1 (bg) 2005-08-31
US6110965A (en) 2000-08-29
CN1301268A (zh) 2001-06-27
HUP0101817A3 (en) 2003-07-28
IL138837A0 (en) 2001-10-31
CN1141312C (zh) 2004-03-10
NO20005015D0 (no) 2000-10-05
HRP980189B1 (en) 2004-04-30
KR100600463B1 (ko) 2006-07-13
BR9910115A (pt) 2000-12-26
ATE241638T1 (de) 2003-06-15
NO317982B1 (no) 2005-01-17
AR019261A1 (es) 2002-02-13
EP1070077A1 (en) 2001-01-24
UA70941C2 (uk) 2004-11-15
HUP0101817A2 (hu) 2001-11-28
IL138837A (en) 2006-10-05
PL193742B1 (pl) 2007-03-30
RU2211222C2 (ru) 2003-08-27
EP1070077B1 (en) 2003-05-28
BG104913A (en) 2001-08-31
AU3046499A (en) 1999-10-25
CA2327775A1 (en) 1999-10-14
SK15022000A3 (sk) 2001-03-12
EE04283B1 (et) 2004-04-15
CA2327775C (en) 2007-08-07
WO1999051616A1 (en) 1999-10-14
SK284169B6 (sk) 2004-10-05
EE200000587A (et) 2002-04-15
PL343441A1 (en) 2001-08-13
KR20010034754A (ko) 2001-04-25
HRP980189A2 (en) 2000-12-31
NO20005015L (no) 2000-12-04
DE69908338D1 (de) 2003-07-03
DE69908338T2 (de) 2004-04-08
PT1070077E (pt) 2003-10-31
JP2002510701A (ja) 2002-04-09
ES2200512T3 (es) 2004-03-01

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