DK1056449T3 - 20-HETE-antagonister og -agonister - Google Patents

20-HETE-antagonister og -agonister

Info

Publication number: DK1056449T3
Authority: DK; Denmark
Prior art keywords: hete; agonists; antagonists; acid; hydroxyeicosa
Prior art date: 1998-02-26

Application number

DK99908425T

Other languages

English (en)

Inventor

Richard J Roman

John R Falck

Magdalena Alonso-Galicia

Elizabeth R Jacobs

David R Harder

Original Assignee

Univ Texas

Mcw Res Found Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

1999-02-24

Publication date

2003-08-11

1999-02-24 Application filed by Univ Texas, Mcw Res Found Inc filed Critical Univ Texas

2003-08-11 Application granted granted Critical

2003-08-11 Publication of DK1056449T3 publication Critical patent/DK1056449T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

DK99908425T 1998-02-26 1999-02-24 20-HETE-antagonister og -agonister DK1056449T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7609198P	1998-02-26	1998-02-26
PCT/US1999/004020 WO1999043310A2 (en)	1998-02-26	1999-02-24	20-hete antagonists and agonists

Publications (1)

Publication Number	Publication Date
DK1056449T3 true DK1056449T3 (da)	2003-08-11

Family

ID=22129876

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99908425T DK1056449T3 (da)	1998-02-26	1999-02-24	20-HETE-antagonister og -agonister

Country Status (13)

Country	Link
US (3)	US6395781B1 (da)
EP (1)	EP1056449B1 (da)
JP (1)	JP3921583B2 (da)
KR (1)	KR100390312B1 (da)
CN (1)	CN1148179C (da)
AT (1)	ATE237321T1 (da)
AU (1)	AU750579B2 (da)
CA (1)	CA2320706C (da)
DE (1)	DE69906944T2 (da)
DK (1)	DK1056449T3 (da)
ES (1)	ES2194444T3 (da)
PT (1)	PT1056449E (da)
WO (1)	WO1999043310A2 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6395781B1 (en) *	1998-02-26	2002-05-28	Mcw Research Foundation	20-HETE antagonists and agonists
US7214711B2 (en) *	1998-12-23	2007-05-08	Neurotherapeutics Pharma Llc	Method of treating migraine headache without aura
US8008283B2 (en) *	1998-12-23	2011-08-30	Neurotherapeutics Pharma, Inc.	Methods and compositions for the treatment of neuropsychiatric disorders
US8722668B2 (en) *	1998-12-23	2014-05-13	Daryl W. Hochman	Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
ATE315932T1 (de)	1999-11-01	2006-02-15	Taisho Pharmaceutical Co Ltd	Hemmer für das 20-hete-produzierende enzym
AU2001288798B2 (en)	2000-11-03	2006-11-02	Mcw Research Foundation, Inc.	Use of 20-HETE synthesizing enzyme inhibitors as therapy for cerebral vascular diseases
US20020151734A1 (en) *	2001-01-02	2002-10-17	Schwartzman Michal Laniado	12-HETrE analogs and methods of use thereof
CN1272313C (zh) *	2001-04-26	2006-08-30	大正制药株式会社	20－羟基二十碳四烯酸生成抑制剂
US6818662B2 (en) *	2002-05-28	2004-11-16	Taisho Pharmaceutical Co., Ltd.	Pharmaceutical composition
US6825232B2 (en)	2002-06-14	2004-11-30	Alcon, Inc.	Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
CN101507720A (zh) *	2003-11-14	2009-08-19	Mcw研究基金会股份有限公司	调节血管生成和癌细胞增殖的方法
US20080306155A1 (en) *	2004-09-16	2008-12-11	Roman Richard J	Method for treating renal disease
US20070004802A1 (en) *	2004-09-16	2007-01-04	Roman Richard J	Method for treating renal disease
US20060063836A1 (en) *	2004-09-16	2006-03-23	Roman Richard J	Method for treating renal disease
EP1951702A2 (en) *	2005-10-17	2008-08-06	NeuroTherapeutics Pharma, Inc.	Diuretic-like compound analogs useful for regulation of central nervous system disorders
US8846764B2 (en) *	2006-09-13	2014-09-30	The Medical College Of Wisconsin, Inc.	Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases
US20090069418A1 (en) *	2007-04-25	2009-03-12	Alkayed Nabil J	Compositions and Methods for the Treatment of Disorders Associated with Aberrant Vasodilation
EP2208720A1 (en) *	2009-01-13	2010-07-21	Max-Delbrück-Centrum für Molekulare Medizin (MDC)	Novel eicosanoid derivatives
ES2732310T3 (es) *	2013-12-10	2019-11-21	Univ California	Diagnóstico diferencial de enfermedad hepática
MX368689B (es)	2014-01-22	2019-10-11	Max Delbrueck Centrum Fuer Molekulare Medizin	Derivados de citocromo p450 (cyp)-eicosanoide novedosos.
US11690825B2 (en)	2016-03-09	2023-07-04	Board Of Regents, The University Of Texas System	20-HETE receptor (GPR75) antagonists and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5334736A (en)	1991-05-16	1994-08-02	University Of Texas System Board Of Regents	Functionalizing carbohydrate derivatives by base-induced β-eliminatiom forming bioactive derivatives containing hydroxy-diene subunits
US5502226A (en) *	1994-11-14	1996-03-26	Elizabeth Arden Co., Division Of Conopco, Inc.	Process of preparing ω-hydroxy acids
US5753702A (en)	1996-05-22	1998-05-19	University Of Vermont	Arachidonic acid metabolite, 16-hete
US6395781B1 (en) *	1998-02-26	2002-05-28	Mcw Research Foundation	20-HETE antagonists and agonists

1999
- 1999-02-23 US US09/259,414 patent/US6395781B1/en not_active Expired - Fee Related
- 1999-02-24 ES ES99908425T patent/ES2194444T3/es not_active Expired - Lifetime
- 1999-02-24 EP EP99908425A patent/EP1056449B1/en not_active Expired - Lifetime
- 1999-02-24 KR KR10-2000-7009516A patent/KR100390312B1/ko not_active IP Right Cessation
- 1999-02-24 CN CNB998033693A patent/CN1148179C/zh not_active Expired - Fee Related
- 1999-02-24 CA CA002320706A patent/CA2320706C/en not_active Expired - Fee Related
- 1999-02-24 DE DE69906944T patent/DE69906944T2/de not_active Expired - Lifetime
- 1999-02-24 AT AT99908425T patent/ATE237321T1/de not_active IP Right Cessation
- 1999-02-24 WO PCT/US1999/004020 patent/WO1999043310A2/en active IP Right Grant
- 1999-02-24 PT PT99908425T patent/PT1056449E/pt unknown
- 1999-02-24 AU AU27861/99A patent/AU750579B2/en not_active Ceased
- 1999-02-24 JP JP2000533108A patent/JP3921583B2/ja not_active Expired - Lifetime
- 1999-02-24 DK DK99908425T patent/DK1056449T3/da active
2001
- 2001-12-14 US US10/021,973 patent/US6596769B2/en not_active Expired - Fee Related
- 2001-12-14 US US10/017,409 patent/US6605641B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR100390312B1 (ko)	2003-07-12
CN1148179C (zh)	2004-05-05
KR20010034544A (ko)	2001-04-25
CA2320706C (en)	2007-05-01
DE69906944T2 (de)	2003-12-24
WO1999043310A3 (en)	1999-10-07
WO1999043310A2 (en)	1999-09-02
JP2003522098A (ja)	2003-07-22
EP1056449B1 (en)	2003-04-16
JP3921583B2 (ja)	2007-05-30
DE69906944D1 (de)	2003-05-22
CA2320706A1 (en)	1999-09-02
EP1056449A2 (en)	2000-12-06
PT1056449E (pt)	2003-09-30
US6395781B1 (en)	2002-05-28
US6596769B2 (en)	2003-07-22
ES2194444T3 (es)	2003-11-16
US6605641B2 (en)	2003-08-12
AU2786199A (en)	1999-09-15
CN1291890A (zh)	2001-04-18
US20020072534A1 (en)	2002-06-13
AU750579B2 (en)	2002-07-25
US20020049244A1 (en)	2002-04-25
ATE237321T1 (de)	2003-05-15

Publication	Publication Date	Title
DK1056449T3 (da)	2003-08-11	20-HETE-antagonister og -agonister
DK1104425T3 (da)	2003-06-23	Hidtil ukendte thiazolopyrimidinforbindelser
BR9916896A (pt)	2001-11-20	Diaril aminas substituìdas com 1-heterociclo
CY1108610T1 (el)	2014-04-09	Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
DZ2788A1 (fr)	2003-12-01	Agonistes et antagonistes selectifs à IL-2.
TR200001218T2 (tr)	2001-05-21	İkameli karboksamidotiazoller, bunların üretimi ve bunları içeren farmasötik bileşimler.
RS50485B (sr)	2010-03-02	Terapeutske kombinacije koje sadrže amplodipin i atorvastatin
IT8323205A0 (it)	1983-10-07	Composizioni farmaceutiche adattivita' antiinfiammatoria e/o analgesica, non ulcerogene.
BR9813817A (pt)	2000-10-10	Análogos de hemiasterlina
BG105256A (en)	2001-11-30	Muscarinic agonists and antagonists
DE59006757D1 (de)	1994-09-15	Knochennagel und Werkzeug für denselben.
BG103968A (en)	2000-07-31	Pharmaceutical antiviral composition containing glycirricinic acid and at least one protein with antiviral activity
RS50165B (sr)	2009-05-06	Primena rar selektivnih retinoid antagonista za proizvodnju leka za tretiranje emfizema
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
PT929299E (pt)	2004-02-27	1,2,3,4-tetra-hidro-2-dibenzofuranaminas e 2-aminociclo-hepta ¬b\| benzofuranos substituidos
ATE28188T1 (de)	1987-07-15	Antikonvulsive mittel.
GB9811221D0 (en)	1998-07-22	Bacterial-pheromones and uses therefor
ES2152315T3 (es)	2001-02-01	Xamoneline tartrato.
ATE57526T1 (de)	1990-11-15	P-acylaminobenzamide.
MXPA04005226A (es)	2004-10-11	1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion.
DK1011329T3 (da)	2003-12-22	7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler
ITTO940212V0 (it)	1994-10-27	Attrezzatura per compassi sostitutiva dell'ago.
ATE82855T1 (de)	1992-12-15	2',3'-dideoxypurinnucleosid/purinnucleosidphosphorylase-inhibitor kombinationstherapie und zusammensetzungen dafuer.