DK1040349T3 - Positionering og elektrofysiologisk karakterisering af individuelle celler og rekonstituerede membransystemer på bærere med mikrostruktur - Google Patents
Positionering og elektrofysiologisk karakterisering af individuelle celler og rekonstituerede membransystemer på bærere med mikrostrukturInfo
- Publication number
- DK1040349T3 DK1040349T3 DK98932469T DK98932469T DK1040349T3 DK 1040349 T3 DK1040349 T3 DK 1040349T3 DK 98932469 T DK98932469 T DK 98932469T DK 98932469 T DK98932469 T DK 98932469T DK 1040349 T3 DK1040349 T3 DK 1040349T3
- Authority
- DK
- Denmark
- Prior art keywords
- positioning
- microstructure
- carriers
- individual cells
- membrane systems
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH290397 | 1997-12-17 | ||
PCT/IB1998/001150 WO1999031503A1 (de) | 1997-12-17 | 1998-07-28 | Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1040349T3 true DK1040349T3 (da) | 2002-01-28 |
DK1040349T4 DK1040349T4 (da) | 2013-02-25 |
Family
ID=4244210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98932469.4T DK1040349T4 (da) | 1997-12-17 | 1998-07-28 | Positionering og elektrofysisk karakterisering af individuelle celler og rekonstituerede membransystemer på bærere med mikrostruktur |
Country Status (11)
Country | Link |
---|---|
US (3) | US6758961B1 (da) |
EP (1) | EP1040349B2 (da) |
JP (1) | JP3486171B2 (da) |
AT (1) | ATE205300T1 (da) |
AU (1) | AU746580B2 (da) |
CA (1) | CA2316966C (da) |
DE (1) | DE59801410D1 (da) |
DK (1) | DK1040349T4 (da) |
ES (1) | ES2163284T3 (da) |
HK (1) | HK1028450A1 (da) |
WO (1) | WO1999031503A1 (da) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU9786798A (en) * | 1997-10-10 | 1999-05-03 | Biosepra Inc. | Aligned multiwell multiplate stack and method for processing biological/chemicalsamples using the same |
US7244349B2 (en) * | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
US20020144905A1 (en) * | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
ES2163284T3 (es) | 1997-12-17 | 2002-01-16 | Ecole Polytech | Posicionamiento y caracterizacion electrofisiologica de celulas individuales y sistemas de membranas reconstituidos sobre soportes microestructurados. |
GB9812783D0 (en) | 1998-06-12 | 1998-08-12 | Cenes Ltd | High throuoghput screen |
US6682649B1 (en) | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
CN1204404C (zh) * | 1999-10-01 | 2005-06-01 | 索菲昂生物科学有限公司 | 电生理学性质的测定组件及其构照方法 |
WO2001034764A2 (en) * | 1999-11-08 | 2001-05-17 | Cytion S.A. | Apparatus and methods for positioning and analyzing biological membranous objects |
US6692952B1 (en) | 1999-11-10 | 2004-02-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
WO2001035071A2 (en) * | 1999-11-10 | 2001-05-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
GB9930719D0 (en) * | 1999-12-24 | 2000-02-16 | Central Research Lab Ltd | Apparatus for and method of making electrical measurements on an object in a m edium |
GB9930718D0 (en) * | 1999-12-24 | 2000-02-16 | Central Research Lab Ltd | Apparatus for and method of making electrical measurements on objects |
AU2001234996A1 (en) | 2000-02-11 | 2001-08-20 | Yale University | Planar patch clamp electrodes |
US20040168912A1 (en) * | 2000-02-11 | 2004-09-02 | James Klemic | Planar patch clamp electrodes |
AU7189801A (en) * | 2000-07-07 | 2002-01-21 | Bristol Myers Squibb Co | Electrophysiology configuration suitable for high throughput screening of compounds for drug discovery |
EP1178315A1 (de) * | 2000-07-31 | 2002-02-06 | Albrecht Dr.med. Priv.Doz. Lepple-Wienhues | Verfahren und Vorrichtung zur Untersuchung von Zellen mit Hilfe der Patch Clamp-Methode |
US7067046B2 (en) * | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
US7270730B2 (en) * | 2000-08-04 | 2007-09-18 | Essen Instruments, Inc. | High-throughput electrophysiological measurement system |
WO2002024862A2 (en) * | 2000-09-19 | 2002-03-28 | Cytion S.A. | Sample positioning and analysis system |
US6932893B2 (en) | 2000-10-02 | 2005-08-23 | Sophion Bioscience A/S | System for electrophysiological measurements |
IL155182A0 (en) * | 2000-10-02 | 2003-11-23 | Sophion Bioscience As | System for electrophysiological measurements |
DE50115872D1 (de) | 2000-12-06 | 2011-06-16 | Ecole Polytech | Verfahren zur herstellung eines bioanalytischen reagenzes, nachweisverfahren beruhend auf der verwendung des bioanalytischen reagenz, sowie dessen verwendung |
EP1225216A1 (de) * | 2001-01-08 | 2002-07-24 | Niels Fertig | Vorrichtung zur Untersuchung von Ionenkanälen in Membranen |
US20030113833A1 (en) * | 2001-01-09 | 2003-06-19 | Hiroaki Oka | Device for measuring extracellular potential, method of measuring extracellular potential by using the same and apparatus for quickly screening drug provided therewith |
WO2002059598A1 (en) * | 2001-01-26 | 2002-08-01 | Cytion S.A. | Method and apparatus for the precise positioning of cells and other small objects |
US20050009004A1 (en) * | 2002-05-04 | 2005-01-13 | Jia Xu | Apparatus including ion transport detecting structures and methods of use |
US20050196746A1 (en) * | 2001-03-24 | 2005-09-08 | Jia Xu | High-density ion transport measurement biochip devices and methods |
CA2441366A1 (en) * | 2001-03-24 | 2002-10-03 | Aviva Biosciences Corporation | Biochips including ion transport detecting structures and methods of use |
US20040146849A1 (en) * | 2002-01-24 | 2004-07-29 | Mingxian Huang | Biochips including ion transport detecting structures and methods of use |
US20060029955A1 (en) | 2001-03-24 | 2006-02-09 | Antonio Guia | High-density ion transport measurement biochip devices and methods |
CN1529814A (zh) * | 2001-06-20 | 2004-09-15 | 索菲昂生物科学有限公司 | 一种用于确定和/或监控离子通道电生理学性质的装置和方法 |
EP1423505A2 (en) | 2001-08-06 | 2004-06-02 | Vanderbilt University | Device and methods for monitoring the status of at least one cell |
US7056430B1 (en) | 2002-01-09 | 2006-06-06 | Axon Instruments, Inc. | Detachable cell-delivery system for patch-clamp unit |
DE10202887B4 (de) * | 2002-01-25 | 2004-05-06 | Advalytix Ag | Zellanalyseverfahren |
DE10203686A1 (de) * | 2002-01-31 | 2003-08-07 | Bayer Ag | Verfahren zur Durchführung von elektrischen Messungen an biologischen Membrankörpern |
GB0203053D0 (en) * | 2002-02-08 | 2002-03-27 | Ayanda Biosystems Sarl | Bio-sensors |
JP4511189B2 (ja) | 2002-02-12 | 2010-07-28 | セレクトリコン アーベー | センサーの周囲の溶液環境を迅速に変化させるシステム及び方法 |
US7470518B2 (en) | 2002-02-12 | 2008-12-30 | Cellectricon Ab | Systems and method for rapidly changing the solution environment around sensors |
ATE354635T1 (de) * | 2002-04-17 | 2007-03-15 | Sophion Bioscience As | Substrat und verfahren zum messen elektrophysiologischer eigenschaften von zellmembranen |
GB2398635A (en) | 2003-02-21 | 2004-08-25 | Sophion Bioscience As | A substrate providing a cell gigaseal for a patch clamp |
WO2003093494A2 (en) * | 2002-05-04 | 2003-11-13 | Aviva Biosciences Corporation | Apparatus including ion transport detecting structures and methods of use |
WO2007132769A1 (ja) * | 2006-05-17 | 2007-11-22 | Panasonic Corporation | 細胞電位測定デバイスとそれに用いる基板、細胞電位測定デバイス用基板の製造方法 |
US8202439B2 (en) | 2002-06-05 | 2012-06-19 | Panasonic Corporation | Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm |
JP4552423B2 (ja) | 2003-11-21 | 2010-09-29 | パナソニック株式会社 | 細胞外電位測定デバイスおよびこれを用いた細胞外電位の測定方法 |
WO2006022092A1 (ja) * | 2004-08-25 | 2006-03-02 | Matsushita Electric Industrial Co., Ltd. | 細胞電位測定プローブ |
US7810380B2 (en) | 2003-03-25 | 2010-10-12 | Tearlab Research, Inc. | Systems and methods for collecting tear film and measuring tear film osmolarity |
FR2844052B1 (fr) | 2002-08-28 | 2005-07-01 | Commissariat Energie Atomique | Dispositif de mesure de l'activite electrique d'elements biologiques et ses applications |
EP1569510B1 (en) | 2002-09-27 | 2011-11-02 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
US20040209352A1 (en) * | 2002-10-28 | 2004-10-21 | Nobuhiko Ozaki | Integrated electrode and cell immobilization device equipped with the integrated electrode |
JP4394917B2 (ja) * | 2003-09-19 | 2010-01-06 | 独立行政法人科学技術振興機構 | 人工脂質二重膜を有する電流測定装置 |
EP1712909B1 (en) | 2004-01-21 | 2012-09-19 | Japan Science and Technology Agency | Method of forming planar lipid double membrane for membrane protein analysis and apparatus therefor |
US7501301B2 (en) * | 2004-03-10 | 2009-03-10 | The Board Of Trustees Of The Leland Stanford Junior University | Low cost fabrication of microelectrode arrays for cell-based biosensors and drug discovery methods |
ATE543617T1 (de) | 2004-04-01 | 2012-02-15 | Picodrill Sa | Herstellung und verwendung von mikroperforierten substraten |
DE202005022036U1 (de) * | 2004-09-10 | 2012-08-07 | Molecular Devices, Llc | Paralleles Patch-Clamp-System |
US20060094053A1 (en) * | 2004-11-04 | 2006-05-04 | Dimitrios Stamou | Self-assembled arrays of lipid-bilayer vesicles |
EP1807696B1 (de) * | 2004-11-05 | 2013-01-09 | Universität Osnabrück | Vorrichtung und verfahren zur messung von zelleigenschaften |
JP4679197B2 (ja) * | 2005-03-25 | 2011-04-27 | 株式会社東芝 | 微生物分離装置 |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
CN100526453C (zh) * | 2005-05-20 | 2009-08-12 | 麦克奥迪实业集团有限公司 | 激光显微切割后细胞收集方法 |
JP4254862B2 (ja) * | 2005-06-07 | 2009-04-15 | パナソニック株式会社 | 細胞電気生理測定デバイスおよびその製造方法 |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US7776193B2 (en) | 2005-12-20 | 2010-08-17 | Panasonic Corporation | Cell electrophysiological sensor |
JP4601000B2 (ja) * | 2006-02-03 | 2010-12-22 | セイコーインスツル株式会社 | 特定物質観察装置及び特定物質観察方法 |
JP4858870B2 (ja) * | 2006-02-16 | 2012-01-18 | 財団法人生産技術研究奨励会 | 培養細胞の電気シグナル計測デバイスおよび該デバイスを用いる電気シグナル計測方法 |
GB2436145A (en) * | 2006-03-16 | 2007-09-19 | Sophion Bioscience As | A system for monitoring properties of a single cell |
JP4682884B2 (ja) * | 2006-03-17 | 2011-05-11 | パナソニック株式会社 | 細胞電気生理センサおよびこれを用いた細胞電気生理現象の測定方法 |
JP4670713B2 (ja) * | 2006-04-11 | 2011-04-13 | パナソニック株式会社 | 細胞電気生理センサおよびこれを用いた細胞電気生理現象の測定方法 |
WO2007119772A1 (ja) * | 2006-04-14 | 2007-10-25 | Panasonic Corporation | 細胞電気生理センサおよびその製造方法 |
JP4779782B2 (ja) * | 2006-04-14 | 2011-09-28 | パナソニック株式会社 | 細胞電気生理センサおよびその製造方法 |
CN101038284B (zh) * | 2007-04-25 | 2011-04-27 | 博奥生物有限公司 | 一种提高电阻抗检测装置的电阻抗检测灵敏度的方法 |
WO2009020682A2 (en) | 2007-05-08 | 2009-02-12 | The Trustees Of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
US20090053755A1 (en) * | 2007-05-24 | 2009-02-26 | Todd Aaron Sulchek | Probe based molecular signal delivery for precise control and measurement of single cell responses |
JP5109617B2 (ja) * | 2007-11-21 | 2012-12-26 | パナソニック株式会社 | 細胞の電気生理現象の測定装置 |
CN101556273B (zh) * | 2008-04-08 | 2013-03-20 | 博奥生物有限公司 | 利用电阻抗传感技术分析细胞迁移的方法及其专用装置 |
CN101614729B (zh) * | 2008-06-27 | 2013-04-24 | 博奥生物有限公司 | 用于细胞操作及电生理信号检测的微电极阵列器件及专用装置 |
EP2411194A1 (en) * | 2009-02-27 | 2012-02-01 | PicoDrill SA | A method of generating a hole or recess or well in a substrate, a device for carrying out the method, and a high frequency high voltage source for use in such a device |
WO2011040996A1 (en) | 2009-09-30 | 2011-04-07 | Quantapore, Inc. | Ultrafast sequencing of biological polymers using a labeled nanopore |
US8623496B2 (en) * | 2009-11-06 | 2014-01-07 | Wisconsin Alumni Research Foundation | Laser drilling technique for creating nanoscale holes |
US20130136673A1 (en) | 2010-07-09 | 2013-05-30 | Sophion Bioscience A/S | Chip assembly for use in a microfluidic analysis sytem |
EP2650678B1 (en) * | 2011-01-13 | 2016-09-14 | Panasonic Intellectual Property Management Co., Ltd. | Sensor chip |
CN103477223B (zh) | 2011-03-01 | 2015-01-14 | 索菲昂生物科学有限公司 | 用于电生理学分析的手持装置 |
US10505234B2 (en) | 2011-03-14 | 2019-12-10 | Battelle Memorial Institute | Battery cell and n situ battery electrode analysis method |
US10598609B2 (en) | 2011-03-14 | 2020-03-24 | Battelle Memorial Institute | Universal liquid sample device and process for high resolution transmission electron microscope imaging and multimodal analyses of liquid sample materials |
US9274059B2 (en) * | 2011-03-14 | 2016-03-01 | Battelle Memorial Institute | Microfluidic electrochemical device and process for chemical imaging and electrochemical analysis at the electrode-liquid interface in-situ |
US20140212020A1 (en) * | 2011-08-12 | 2014-07-31 | Bt Imaging Pty Ltd | Photoluminescence imaging of doping variations in semiconductor wafers |
JP6290096B2 (ja) * | 2012-01-09 | 2018-03-07 | ソフィオン・バイオサイエンス・アクティーゼルスカブ | 改良されたパッチエリアの細胞付着性 |
DE102012002459B4 (de) * | 2012-02-08 | 2015-06-25 | Universität Rostock | Elektrophysiologische Messanordnung und elektrophysiologisches Messverfahren |
US9651539B2 (en) | 2012-10-28 | 2017-05-16 | Quantapore, Inc. | Reducing background fluorescence in MEMS materials by low energy ion beam treatment |
DE102013007295B4 (de) * | 2013-04-26 | 2015-06-25 | Universität Rostock | Elektrophysiologische Messanordnung und elektrophysiologisches Messverfahren |
US9862997B2 (en) | 2013-05-24 | 2018-01-09 | Quantapore, Inc. | Nanopore-based nucleic acid analysis with mixed FRET detection |
WO2015060446A1 (ja) * | 2013-10-25 | 2015-04-30 | 凸版印刷株式会社 | 膜小胞回収デバイス、膜小胞回収方法、及び膜小胞分析方法 |
JP6630875B2 (ja) * | 2014-01-30 | 2020-01-15 | アダマンド並木精密宝石株式会社 | 細胞膜観察及び解析装置、細胞膜観察及び解析方法 |
AU2015320685B2 (en) | 2014-09-23 | 2021-01-28 | Tearlab Research, Inc. | Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest |
US9885079B2 (en) | 2014-10-10 | 2018-02-06 | Quantapore, Inc. | Nanopore-based polymer analysis with mutually-quenching fluorescent labels |
CA2964790C (en) | 2014-10-24 | 2023-02-21 | Quantapore, Inc. | Efficient optical analysis of polymers using arrays of nanostructures |
JP2019522983A (ja) | 2016-07-05 | 2019-08-22 | クアンタポール, インコーポレイテッド | 光学ベースのナノポア配列決定 |
DE102017130518B4 (de) | 2017-12-19 | 2024-04-18 | ChanPharm GmbH | Messgerät, Messverfahren, Hochdurchsatz-Testgerät und Messkit für elektrophysiologische Messungen, insbesondere an Zellaggregaten |
BR112020023494A2 (pt) * | 2018-05-17 | 2021-03-30 | Stuart Lindsay | Dispositivo, sistema e método para medição elétrica direta de atividade enzimática, bem como método para sequenciamento |
CN110523447B (zh) * | 2019-08-29 | 2021-05-11 | 苏州大学 | 一种对细胞多角度力学测量的微流控芯片及其制作方法 |
DE102019129042A1 (de) | 2019-10-28 | 2021-04-29 | ChanPharm GmbH | Elektrophysiologisches Messgerät und Messverfahren zur Erfassung mindestens eines elektrischen Messwerts an einer biologischen Zellprobe |
WO2024196827A1 (en) * | 2023-03-17 | 2024-09-26 | Molecular Devices (Austria) GmbH | Automated cell passaging |
Family Cites Families (154)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3856633A (en) * | 1971-01-07 | 1974-12-24 | Foxboro Co | Concentration measurements utilizing coulometric generation of reagents |
US4062750A (en) | 1974-12-18 | 1977-12-13 | James Francis Butler | Thin film electrochemical electrode and cell |
DE2502621C3 (de) | 1975-01-23 | 1978-09-14 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen |
FR2353856A1 (fr) | 1976-06-02 | 1977-12-30 | Chateau Guy | Ruban destine a servir de support a une reaction par exemple chimique ou biochimique, et procede d'analyse le mettant en oeuvre |
DE2741638C3 (de) * | 1977-09-15 | 1980-03-27 | Ernst Dipl.-Phys. Dr. 8000 Muenchen Remy | Präparattrager mit Elektrodenanordnung fur die Zelluntersuchung, sowie seine Herstellung |
US4128456A (en) | 1977-10-11 | 1978-12-05 | Lee Kai S | Suction electrode for intracellular potential measurement |
US4225410A (en) | 1978-12-04 | 1980-09-30 | Technicon Instruments Corporation | Integrated array of electrochemical sensors |
US4456522A (en) * | 1981-09-23 | 1984-06-26 | Critikon, Inc. | Support and anchoring mechanism for membranes in selectively responsive field effect devices |
DE3144003C2 (de) | 1981-11-04 | 1984-11-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Meßanordnung für extrem kleine Ströme |
US4441507A (en) | 1981-11-30 | 1984-04-10 | Morris Steffin | High speed single electrode membrane voltage clamp |
IL68507A (en) | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
US5310674A (en) | 1982-05-10 | 1994-05-10 | Bar-Ilan University | Apertured cell carrier |
US4490216A (en) | 1983-02-03 | 1984-12-25 | Molecular Devices Corporation | Lipid membrane electroanalytical elements and method of analysis therewith |
DE3485462D1 (de) | 1983-11-08 | 1992-02-27 | Scient Diagnostics Inc | System und verfahren fuer zellenauslese. |
US4661451A (en) * | 1984-02-06 | 1987-04-28 | Ortho Diagnostic Systems, Inc. | Methods for immobilizing and translocating biological cells |
US4661321A (en) * | 1984-05-30 | 1987-04-28 | Halliburton Company | Continuous reactor design |
US4952518A (en) | 1984-10-01 | 1990-08-28 | Cetus Corporation | Automated assay machine and assay tray |
JPS61247965A (ja) | 1985-04-25 | 1986-11-05 | Susumu Kogyo Kk | 酵素免疫測定法 |
EP0213825A3 (en) * | 1985-08-22 | 1989-04-26 | Molecular Devices Corporation | Multiple chemically modulated capacitance |
JP2662215B2 (ja) | 1986-11-19 | 1997-10-08 | 株式会社日立製作所 | 細胞保持装置 |
US4911806A (en) | 1987-02-27 | 1990-03-27 | Biotronics | Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields |
US5079600A (en) | 1987-03-06 | 1992-01-07 | Schnur Joel M | High resolution patterning on solid substrates |
US4874500A (en) | 1987-07-15 | 1989-10-17 | Sri International | Microelectrochemical sensor and sensor array |
US5169600A (en) | 1987-07-15 | 1992-12-08 | Fuji Photo Film Co., Ltd. | Biochemical analysis apparatus for incubating and analyzing test sites on a long tape test film |
US4812221A (en) | 1987-07-15 | 1989-03-14 | Sri International | Fast response time microsensors for gaseous and vaporous species |
US5055263A (en) * | 1988-01-14 | 1991-10-08 | Cyberlab, Inc. | Automated pipetting system |
US5111221A (en) * | 1988-05-13 | 1992-05-05 | United States Of America As Represented By The Secretary Of The Navy | Receptor-based sensor |
US5225374A (en) * | 1988-05-13 | 1993-07-06 | The United States Of America As Represented By The Secretary Of The Navy | Method of fabricating a receptor-based sensor |
ATE136119T1 (de) | 1988-08-18 | 1996-04-15 | Au Membrane & Biotech Res Inst | Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren |
FR2637687B1 (fr) | 1988-10-11 | 1991-01-11 | Inst Textile De France | Dispositif a usage unique pour tests biologiques |
EP0770874A3 (en) | 1989-01-27 | 1998-01-21 | Australian Membrane And Biotechnology Research Institute | Receptor membranes and ionophore gating |
US4912060A (en) | 1989-02-17 | 1990-03-27 | World Precision Instruments, Inc. | Method and apparatus for electrical testing of membranes |
US5262128A (en) | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
GB8927377D0 (en) * | 1989-12-04 | 1990-01-31 | Univ Edinburgh | Improvements in and relating to amperometric assays |
US5229163A (en) | 1989-12-21 | 1993-07-20 | Hoffmann-La Roche Inc. | Process for preparing a microtiter tray for immunometric determinations |
US5041266A (en) | 1989-12-21 | 1991-08-20 | Hoffmann-La Roche Inc. | Tray for immunometric determinations |
IL93020A (en) * | 1990-01-09 | 1995-06-29 | Yeda Res & Dev | Biosensors comprising a lipid bilayer doped with ion channels anchored to a recording electrode by bridging molecules |
US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
AU656520B2 (en) | 1990-03-12 | 1995-02-09 | Institut National De La Recherche Agronomique | Process for the artificial stimulation of cells and cyte culture device |
FR2659347B1 (fr) | 1990-03-12 | 1994-09-02 | Agronomique Inst Nat Rech | Dispositif de culture de cellules assurant leur immobilisation. |
DE4115414C2 (de) * | 1991-05-10 | 1995-07-06 | Meinhard Prof Dr Knoll | Verfahren zur Herstellung von miniaturisierten Chemo- und Biosensorelementen mit ionenselektiver Membran sowie von Trägern für diese Elemente |
US5187096A (en) | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5310469A (en) * | 1991-12-31 | 1994-05-10 | Abbott Laboratories | Biosensor with a membrane containing biologically active material |
JP2869246B2 (ja) | 1992-03-26 | 1999-03-10 | 三洋電機株式会社 | 神経モデル素子 |
US5508200A (en) | 1992-10-19 | 1996-04-16 | Tiffany; Thomas | Method and apparatus for conducting multiple chemical assays |
US5810725A (en) | 1993-04-16 | 1998-09-22 | Matsushita Electric Industrial Co., Ltd. | Planar electrode |
US5415747A (en) | 1993-08-16 | 1995-05-16 | Hewlett-Packard Company | Capillary electrophoresis using zwitterion-coated capillary tubes |
US6225059B1 (en) | 1993-11-01 | 2001-05-01 | Nanogen, Inc. | Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics |
US6287517B1 (en) | 1993-11-01 | 2001-09-11 | Nanogen, Inc. | Laminated assembly for active bioelectronic devices |
US6099803A (en) | 1994-07-07 | 2000-08-08 | Nanogen, Inc. | Advanced active electronic devices for molecular biological analysis and diagnostics |
US6068818A (en) | 1993-11-01 | 2000-05-30 | Nanogen, Inc. | Multicomponent devices for molecular biological analysis and diagnostics |
DE4400955C2 (de) | 1993-12-23 | 1999-04-01 | Fraunhofer Ges Forschung | Adhäsionssteuerbare Oberflächenstruktur |
US5563067A (en) | 1994-06-13 | 1996-10-08 | Matsushita Electric Industrial Co., Ltd. | Cell potential measurement apparatus having a plurality of microelectrodes |
US6403367B1 (en) | 1994-07-07 | 2002-06-11 | Nanogen, Inc. | Integrated portable biological detection system |
US6071394A (en) | 1996-09-06 | 2000-06-06 | Nanogen, Inc. | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
AU2788695A (en) | 1994-10-28 | 1996-05-23 | Neurosearch A/S | Patch clamp apparatus and technique having high throughput and low fluid volume requirements |
US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US5955352A (en) | 1994-12-22 | 1999-09-21 | Showa Yakuhin Kako Co., Ltd. | Instruments for chemical and microbiological tests |
US6043037A (en) * | 1995-02-06 | 2000-03-28 | The Regents Of The University Of California | Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization |
US5795782A (en) | 1995-03-17 | 1998-08-18 | President & Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
SE9502258D0 (sv) * | 1995-06-21 | 1995-06-21 | Pharmacia Biotech Ab | Method for the manufacture of a membrane-containing microstructure |
JP3643863B2 (ja) | 1995-08-09 | 2005-04-27 | アークレイ株式会社 | 液体保持具とその製造方法 |
DE19529371C3 (de) | 1995-08-10 | 2003-05-28 | Nmi Univ Tuebingen | Mikroelektroden-Anordnung |
US6762036B2 (en) * | 1995-11-08 | 2004-07-13 | Trustees Of Boston University | Cellular physiology workstations for automated data acquisition and perfusion control |
AU1059997A (en) | 1995-11-08 | 1997-05-29 | Trustees Of Boston University | Cellular physiology workstations for automated data acquisition and perfusion control |
DE19544127C1 (de) | 1995-11-27 | 1997-03-20 | Gimsa Jan Dr | Verfahren und Vorrichtung zur Erzeugung von Resonanzerscheinungen in Partikelsuspensionen und ihre Verwendung |
DE19601054C1 (de) | 1996-01-05 | 1997-04-10 | Inst Bioprozess Analysenmesst | Verfahren und Vorrichtung zur Bestimmung von Parametern von Partikeln in Elektrolyten |
DE19601488C1 (de) * | 1996-01-17 | 1997-05-28 | Itt Ind Gmbh Deutsche | Verfahren zum Herstellen einer Meßeinrichtung sowie danach hergestellte Meßeinrichtung |
US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
US6103479A (en) | 1996-05-30 | 2000-08-15 | Cellomics, Inc. | Miniaturized cell array methods and apparatus for cell-based screening |
WO1997049987A1 (en) | 1996-06-27 | 1997-12-31 | Cellstat Technologies, Inc. | High-throughput screening method and apparatus |
DE19628928A1 (de) | 1996-07-18 | 1998-01-22 | Basf Ag | Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung |
US6008010A (en) * | 1996-11-01 | 1999-12-28 | University Of Pittsburgh | Method and apparatus for holding cells |
DE19646505A1 (de) * | 1996-11-12 | 1998-05-14 | Itt Ind Gmbh Deutsche | Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen |
WO1998022819A1 (de) * | 1996-11-16 | 1998-05-28 | Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts | Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung |
DE19712309A1 (de) | 1996-11-16 | 1998-05-20 | Nmi Univ Tuebingen | Mikroelementenanordnung, Verfahren zum Kontaktieren von in einer flüssigen Umgebung befindlichen Zellen und Verfahren zum Herstellen einer Mikroelementenanordnung |
US6228326B1 (en) | 1996-11-29 | 2001-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Arrays of independently-addressable supported fluid bilayer membranes |
IL129767A0 (en) * | 1996-12-12 | 2000-02-29 | Prolume Ltd | Apparatus and method for detecting and identifying infectious agents |
US5904824A (en) | 1997-03-07 | 1999-05-18 | Beckman Instruments, Inc. | Microfluidic electrophoresis device |
US5958345A (en) | 1997-03-14 | 1999-09-28 | Moxtek, Inc. | Thin film sample support |
US6143496A (en) * | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
DE69836736T2 (de) | 1997-05-01 | 2007-10-04 | Sophion Bioscience A/S | Vorrichtung zur automatischen elektrodenpositionierung |
US5981268A (en) | 1997-05-30 | 1999-11-09 | Board Of Trustees, Leland Stanford, Jr. University | Hybrid biosensors |
GB9712386D0 (en) | 1997-06-14 | 1997-08-13 | Univ Coventry | Biosensor |
US6163719A (en) | 1997-09-09 | 2000-12-19 | Sherman; Adam Jacob | Biological membrane voltage estimator |
US6207031B1 (en) | 1997-09-15 | 2001-03-27 | Whitehead Institute For Biomedical Research | Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device |
JP2001517789A (ja) | 1997-09-19 | 2001-10-09 | アクレイラ バイオサイエンシズ,インコーポレイティド | 液体移送装置および液体移送方法 |
US6106784A (en) * | 1997-09-26 | 2000-08-22 | Applied Chemical & Engineering Systems, Inc. | Thawing station |
DE19744649C2 (de) * | 1997-10-09 | 2003-03-27 | Fraunhofer Ges Forschung | Verfahren zur Messung bioelektrischer Signale von Zellen nach der Patch-Clamp-Methode sowie Verwendung einer Vorrichtung hierzu |
DE19753598C1 (de) | 1997-12-03 | 1999-07-01 | Micronas Intermetall Gmbh | Vorrichtung zum Messen physiologischer Parameter |
ES2163284T3 (es) | 1997-12-17 | 2002-01-16 | Ecole Polytech | Posicionamiento y caracterizacion electrofisiologica de celulas individuales y sistemas de membranas reconstituidos sobre soportes microestructurados. |
US7244349B2 (en) * | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
US20020144905A1 (en) * | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
US6027695A (en) * | 1998-04-01 | 2000-02-22 | Dupont Pharmaceuticals Company | Apparatus for holding small volumes of liquids |
DE19815882A1 (de) | 1998-04-08 | 1999-10-14 | Fuhr Guenther | Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen |
DE19827957C2 (de) | 1998-05-27 | 2000-06-29 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur Messung einer Zustandsgröße |
DE19841337C1 (de) | 1998-05-27 | 1999-09-23 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle |
EP0962524B1 (de) | 1998-05-27 | 2004-11-03 | Micronas GmbH | Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle |
US6787111B2 (en) | 1998-07-02 | 2004-09-07 | Amersham Biosciences (Sv) Corp. | Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis |
US20020119579A1 (en) | 1998-07-14 | 2002-08-29 | Peter Wagner | Arrays devices and methods of use thereof |
US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6132582A (en) | 1998-09-14 | 2000-10-17 | The Perkin-Elmer Corporation | Sample handling system for a multi-channel capillary electrophoresis device |
US6267872B1 (en) | 1998-11-06 | 2001-07-31 | The Regents Of The University Of California | Miniature support for thin films containing single channels or nanopores and methods for using same |
CA2317743A1 (en) * | 1998-12-11 | 2000-06-22 | Paul Mansky | Sensor array-based system and method for rapid materials characterization |
JP4454155B2 (ja) * | 1999-01-08 | 2010-04-21 | アプライド バイオシステムズ, エルエルシー | 化学種を接触させるためのファイバーアレイならびにファイバーアレイを使用および作製する方法 |
US6377057B1 (en) | 1999-02-18 | 2002-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential |
CN1185492C (zh) | 1999-03-15 | 2005-01-19 | 清华大学 | 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用 |
US6927049B2 (en) | 1999-07-21 | 2005-08-09 | The Regents Of The University Of California | Cell viability detection using electrical measurements |
GB2355354A (en) | 1999-08-03 | 2001-04-18 | Axon Instr Inc | Auto-focus method |
US6365129B1 (en) * | 1999-08-04 | 2002-04-02 | Tosk, Inc. | Invivo high throughput toxicology screening method |
US6488829B1 (en) | 1999-08-05 | 2002-12-03 | Essen Instruments Inc | High-throughput electrophysiological measurement apparatus |
US6682649B1 (en) * | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
DE19948473A1 (de) * | 1999-10-08 | 2001-04-12 | Nmi Univ Tuebingen | Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen |
WO2001034291A2 (en) * | 1999-11-09 | 2001-05-17 | Sri International | High-throughput synthesis, screening and characterization of combinatorial libraries |
US6670115B1 (en) * | 1999-11-24 | 2003-12-30 | Biotronic Technologies, Inc. | Devices and methods for detecting analytes using electrosensor having capture reagent |
DE19961951C2 (de) | 1999-12-20 | 2003-09-18 | Univ Dresden Tech | Verfahren zur Herstellung einer biosensorischen Schicht und Vorrichtung zur Messung mit derartigen Schichten |
JP3525837B2 (ja) | 1999-12-24 | 2004-05-10 | 株式会社日立製作所 | 電気生理自動計測装置及び電気生理自動計測方法 |
GB9930719D0 (en) | 1999-12-24 | 2000-02-16 | Central Research Lab Ltd | Apparatus for and method of making electrical measurements on an object in a m edium |
GB2360162B (en) | 2000-01-07 | 2004-06-02 | Axon Instr Inc | Scanning microscope |
AU2001234996A1 (en) * | 2000-02-11 | 2001-08-20 | Yale University | Planar patch clamp electrodes |
DE10008373C2 (de) | 2000-02-23 | 2002-11-28 | Helmut Adelsberger | Verfahren und Vorrichtung zur Bestimmung der Ionenkanalaktivität |
CN1319761A (zh) | 2000-03-15 | 2001-10-31 | 清华大学 | 高通量电旋转检测的装置和方法 |
EP1266218A2 (en) | 2000-03-15 | 2002-12-18 | Aviva Biosciences Corporation | Apparatus and method for high throughput electrorotation analysis |
US20030139336A1 (en) * | 2000-03-21 | 2003-07-24 | Norwood James Henry | Interface patch clamping |
DE10022772C1 (de) | 2000-05-10 | 2001-11-08 | Meinhard Knoll | Durchflußmeßsystem |
US20030129581A1 (en) * | 2000-06-06 | 2003-07-10 | Owen David Geraint | Patch-clamping method and apparatus |
DE10032568A1 (de) * | 2000-07-05 | 2002-01-24 | Nmi Univ Tuebingen | Vorrichtung und Verfahren zum elektrischen Kontaktieren von in einer Flüssigkeit in Suspension befindlichen biologischen Zellen |
EP1178315A1 (de) | 2000-07-31 | 2002-02-06 | Albrecht Dr.med. Priv.Doz. Lepple-Wienhues | Verfahren und Vorrichtung zur Untersuchung von Zellen mit Hilfe der Patch Clamp-Methode |
US7270730B2 (en) | 2000-08-04 | 2007-09-18 | Essen Instruments, Inc. | High-throughput electrophysiological measurement system |
US6613285B1 (en) * | 2000-09-25 | 2003-09-02 | General Electric Company | Reactor plate and method |
DE10047390A1 (de) | 2000-09-26 | 2002-04-11 | Mirsky Vladimir M | Hochdurchsatzverfahren zum Screening von organischen Verbindungen auf einem Array von planaren lipiden Doppelschichten |
CN1325909C (zh) | 2000-09-27 | 2007-07-11 | 清华大学 | 用于微粒操纵与微粒导向的装置及其使用方法 |
WO2002030562A1 (en) | 2000-10-10 | 2002-04-18 | Aviva Biosciences Corporation | An integrated biochip system for sample preparation and analysis |
GB2371626B (en) | 2000-10-11 | 2005-03-16 | Axon Instr Inc | Parallel electrode assembly and method of positioning cells for electrophysiological testing |
US6814843B1 (en) | 2000-11-01 | 2004-11-09 | Roche Diagnostics Corporation | Biosensor |
DE10061347A1 (de) | 2000-12-07 | 2002-06-13 | Univ Schiller Jena | Verfahren zur elektrophysiologischen Messung von Ionenströmen an einer einzelnen Zelle unter Bedingungen der Ischämie und/oder der autokrinen bzw. parakrinen Stimulation |
JP2002174610A (ja) | 2000-12-08 | 2002-06-21 | Nec Corp | バイオセンサ及びバイオセンサを用いた液体試料の測定方法 |
US6461860B2 (en) | 2001-01-25 | 2002-10-08 | Axon Instruments, Inc. | Alignment mechanism for two-electrode voltage-clamp perfusion chamber for electrophysiological testing of oocytes |
US20020108869A1 (en) * | 2001-02-09 | 2002-08-15 | Alex Savtchenko | Device and technique for multiple channel patch clamp recordings |
CA2441366A1 (en) | 2001-03-24 | 2002-10-03 | Aviva Biosciences Corporation | Biochips including ion transport detecting structures and methods of use |
US6899800B2 (en) * | 2001-06-20 | 2005-05-31 | Axon Instruments, Inc. | Polymeric electrode for electrophysiological testing |
EP2156879A3 (en) | 2001-10-11 | 2010-07-07 | Aviva Biosciences Corporation | Methods, compositions and automated systems for separating rare cells from fluid samples |
JP2005528081A (ja) * | 2001-11-30 | 2005-09-22 | ブリストル−マイヤーズ スクイブ カンパニー | 細胞電気特性計測用のピペット形態及びそのアレイ |
MXPA04005035A (es) * | 2001-11-30 | 2004-08-11 | Bristol Myers Squibb Co | Configuraciones de interfaz liquida para registro de pinzamiento zonal automatizado. |
US20030104512A1 (en) * | 2001-11-30 | 2003-06-05 | Freeman Alex R. | Biosensors for single cell and multi cell analysis |
DE10203686A1 (de) | 2002-01-31 | 2003-08-07 | Bayer Ag | Verfahren zur Durchführung von elektrischen Messungen an biologischen Membrankörpern |
JP2003307481A (ja) | 2002-04-17 | 2003-10-31 | Canon Inc | マルチチャネルバイオセンサ |
DE10218325B4 (de) | 2002-04-24 | 2008-09-18 | Siemens Ag | Verfahren zum Betreiben einer Chip-Anordnung |
US7201875B2 (en) * | 2002-09-27 | 2007-04-10 | Becton Dickinson And Company | Fixed mounted sorting cuvette with user replaceable nozzle |
DE20220299U1 (de) | 2002-12-20 | 2003-05-28 | ATTO-TEC GmbH, 57076 Siegen | Biochip-Reader |
US20040251145A1 (en) * | 2003-02-21 | 2004-12-16 | Robertson Janet Kay | High throughput screening (HTS) method and apparatus for monitoring ion channels |
-
1998
- 1998-07-28 ES ES98932469T patent/ES2163284T3/es not_active Expired - Lifetime
- 1998-07-28 US US09/581,837 patent/US6758961B1/en not_active Expired - Fee Related
- 1998-07-28 AU AU82379/98A patent/AU746580B2/en not_active Ceased
- 1998-07-28 WO PCT/IB1998/001150 patent/WO1999031503A1/de active IP Right Grant
- 1998-07-28 DK DK98932469.4T patent/DK1040349T4/da active
- 1998-07-28 DE DE59801410T patent/DE59801410D1/de not_active Expired - Lifetime
- 1998-07-28 EP EP98932469A patent/EP1040349B2/de not_active Expired - Lifetime
- 1998-07-28 JP JP2000539350A patent/JP3486171B2/ja not_active Expired - Fee Related
- 1998-07-28 AT AT98932469T patent/ATE205300T1/de not_active IP Right Cessation
- 1998-07-28 CA CA002316966A patent/CA2316966C/en not_active Expired - Lifetime
-
2000
- 2000-12-08 HK HK00107915A patent/HK1028450A1/xx not_active IP Right Cessation
-
2001
- 2001-09-14 US US09/952,461 patent/US20020104757A1/en not_active Abandoned
-
2008
- 2008-06-17 US US12/141,048 patent/US20090153153A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090153153A1 (en) | 2009-06-18 |
EP1040349B1 (de) | 2001-09-05 |
JP2002508516A (ja) | 2002-03-19 |
AU746580B2 (en) | 2002-05-02 |
CA2316966A1 (en) | 1999-06-24 |
DE59801410D1 (de) | 2001-10-11 |
HK1028450A1 (en) | 2001-02-16 |
ES2163284T3 (es) | 2002-01-16 |
AU8237998A (en) | 1999-07-05 |
ATE205300T1 (de) | 2001-09-15 |
JP3486171B2 (ja) | 2004-01-13 |
CA2316966C (en) | 2008-04-08 |
EP1040349A1 (de) | 2000-10-04 |
WO1999031503A1 (de) | 1999-06-24 |
DK1040349T4 (da) | 2013-02-25 |
US20020104757A1 (en) | 2002-08-08 |
US6758961B1 (en) | 2004-07-06 |
EP1040349B2 (de) | 2012-12-19 |
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