DK100685A - Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater - Google Patents

Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater Download PDF

Info

Publication number: DK100685A
Authority: DK; Denmark
Prior art keywords: antipsycotic; fluorphenyl; pyrimidinyl; butyl; piperazine derivatives
Prior art date: 1984-03-06

Application number

DK100685A

Other languages

English (en)

Other versions

DK166149C (da

DK166149B (da

DK100685D0 (da

Inventor

Joseph P Yevich

Jr Walter G Lobeck

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-06

Filing date

1985-03-05

Publication date

1985-09-07

1985-03-05 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1985-03-05 Publication of DK100685D0 publication Critical patent/DK100685D0/da

1985-09-07 Publication of DK100685A publication Critical patent/DK100685A/da

1993-03-15 Publication of DK166149B publication Critical patent/DK166149B/da

1993-08-09 Application granted granted Critical

1993-08-09 Publication of DK166149C publication Critical patent/DK166149C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Legs For Furniture In General (AREA)
Plural Heterocyclic Compounds (AREA)

DK100685A 1984-03-06 1985-03-05 Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater, farmaceutiske praeparater indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne DK166149C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US58658084A	1984-03-06	1984-03-06
US58658084		1984-03-06
US06/683,309 US4605655A (en)	1984-03-06	1984-12-18	Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US68330984		1984-12-18

Publications (4)

Publication Number	Publication Date
DK100685D0 DK100685D0 (da)	1985-03-05
DK100685A true DK100685A (da)	1985-09-07
DK166149B DK166149B (da)	1993-03-15
DK166149C DK166149C (da)	1993-08-09

Family

ID=27079753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK100685A DK166149C (da)	1984-03-06	1985-03-05	Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater, farmaceutiske praeparater indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne

Country Status (27)

Country	Link
US (1)	US4605655A (da)
KR (3)	KR920005113B1 (da)
AT (1)	AT390951B (da)
AU (1)	AU576555B2 (da)
BE (1)	BE901880A (da)
CA (1)	CA1256871A (da)
CH (1)	CH663022A5 (da)
CY (1)	CY1545A (da)
DE (1)	DE3507983A1 (da)
DK (1)	DK166149C (da)
ES (1)	ES8607254A1 (da)
FI (1)	FI84478C (da)
FR (1)	FR2560878B1 (da)
GB (1)	GB2155925B (da)
GR (1)	GR850561B (da)
HK (1)	HK82890A (da)
HU (1)	HU193949B (da)
IE (1)	IE58338B1 (da)
IT (1)	IT1183483B (da)
LU (1)	LU85796A1 (da)
MX (1)	MX9203177A (da)
MY (1)	MY102240A (da)
NL (1)	NL8500628A (da)
PT (1)	PT80058B (da)
SE (1)	SE462429B (da)
SG (1)	SG35590G (da)
ZA (1)	ZA851486B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668687A (en) *	1984-07-23	1987-05-26	Bristol-Myers Company	Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4677104A (en) *	1985-05-06	1987-06-30	Bristol-Myers Company	Antipsychotic fused-ring pyridinylpiperazine derivatives
US4766215A (en) *	1987-02-27	1988-08-23	American Home Products Corporation	Histamine H1 -receptor antagonists
SE8701375D0 (sv) *	1987-04-02	1987-04-02	Leo Ab	Novel pyridyl- and pyrimidyl derivatives
US4826844A (en) *	1987-09-30	1989-05-02	American Home Products Corporation	Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
MX173180B (es) *	1987-10-26	1994-02-07	Pfizer	Procedimiento para preparar agentes ansioliticos
US4882432A (en) *	1989-01-09	1989-11-21	American Home Products Corporation	Polycyclic-carbamic acid piperazinoalkyl esters and amides
GB8909209D0 (en) *	1989-04-22	1989-06-07	Wyeth John & Brother Ltd	Piperazine derivatives
IE64038B1 (en) *	1989-04-22	1995-06-28	Wyeth John & Brother Ltd	Tertiary alkyl functionalized piperazine derivatives
US4994460A (en) *	1989-06-01	1991-02-19	Bristol-Myers Squibb Co.	Agents for treatment of brain ischemia
US5055470A (en) *	1989-06-01	1991-10-08	Bristol-Myers Squibb Co.	Method of treatment of ischemia in brain
FR2672052B1 (fr) *	1991-01-28	1995-05-24	Esteve Labor Dr	Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5681956A (en) *	1990-12-28	1997-10-28	Neurogen Corporation	4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5646281A (en) *	1990-12-28	1997-07-08	Neurogen Corporation	Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands
US5512584A (en) *	1991-04-16	1996-04-30	Basf Aktiengesellschaft	1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
EP0538693A3 (en) *	1991-10-23	1994-08-17	Squibb & Sons Inc	Stereoselective preparation of halophenyl alcohols
TW217382B (da) *	1991-10-24	1993-12-11	Bristol Myers Squibb Co
SE9201239D0 (sv) *	1992-04-21	1992-04-21	Kabi Pharmacia Ab	Agents for treating substance abuse disorders
US5324662A (en) *	1992-05-15	1994-06-28	E. R. Squibb & Sons, Inc.	Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
DE4219973A1 (de) *	1992-06-19	1993-12-23	Basf Ag	N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4243287A1 (de) *	1992-06-19	1993-12-23	Basf Ag	N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
ES2074946B1 (es) *	1993-07-19	1996-06-16	Ferrer Int	Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
EP0757040A4 (en) *	1994-04-18	1997-07-16	Asahi Chemical Ind	ADAMANTANE DERIVATIVE, PROCESS FOR PRODUCTION AND USE OF SAID DERIVATIVE
US5607936A (en) *	1994-09-30	1997-03-04	Merck & Co., Inc.	Substituted aryl piperazines as neurokinin antagonists
ES2104509B1 (es) *	1995-06-13	1998-07-01	Ferrer Int	Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina.
US6166205A (en) *	1998-09-02	2000-12-26	Neurogen Corporation	2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
PT2155736E (pt) *	2007-05-14	2012-03-28	Sk Biopharmaceuticals Co Ltd	Novo composto carbamoiloxiarilalcanoilarilpiperazina, composições farmacêuticas compreendendo este composto e método para tratamento da dor, ansiedade e depressão pela administração do composto
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
EP4153209A1 (en)	2020-05-20	2023-03-29	The Board of Trustees of the University of Illinois	Method for treating lysosomal storage diseases with histatin peptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2973360A (en) *	1959-10-12	1961-02-28	Paul A J Janssen	Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines
US2979508A (en) *	1959-10-12	1961-04-11	Paul A J Janssen	Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2985657A (en) *	1959-10-12	1961-05-23	Paul A J Janssen	1-(aroylalkyl)-4-heterocyclylpiperazines
NL127996C (da) *	1963-11-19
GB1259685A (en) *	1969-04-03	1972-01-12	Soc D Etudes Prod Chimique	Amino-pyrimidine derivatives
BE758380A (fr) *	1969-11-04	1971-04-16	Sumitomo Chemical Co	Procede de preparation de derives d'aryl-cetones
GB1307256A (en) *	1970-09-15	1973-02-14	Science Union & Cie	Piperazine derivatives and a process for their preparation
BE882836A (fr) *	1979-05-15	1980-08-18	Soc D Etudes Prod Chimique	Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique
US4316899A (en) *	1979-08-24	1982-02-23	Beecham Group Limited	Chromanone derivatives, a process for their preparation and compositions containing them
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

1984
- 1984-12-18 US US06/683,309 patent/US4605655A/en not_active Expired - Lifetime
1985
- 1985-02-27 ZA ZA851486A patent/ZA851486B/xx unknown
- 1985-03-01 FI FI850850A patent/FI84478C/fi not_active IP Right Cessation
- 1985-03-04 AU AU39449/85A patent/AU576555B2/en not_active Expired
- 1985-03-04 ES ES540901A patent/ES8607254A1/es not_active Expired
- 1985-03-05 LU LU85796A patent/LU85796A1/fr unknown
- 1985-03-05 BE BE0/214607A patent/BE901880A/fr not_active IP Right Cessation
- 1985-03-05 DK DK100685A patent/DK166149C/da not_active IP Right Cessation
- 1985-03-05 CH CH991/85A patent/CH663022A5/de not_active IP Right Cessation
- 1985-03-05 FR FR8503220A patent/FR2560878B1/fr not_active Expired
- 1985-03-05 GB GB08505662A patent/GB2155925B/en not_active Expired
- 1985-03-05 GR GR850561A patent/GR850561B/el not_active IP Right Cessation
- 1985-03-05 HU HU85831A patent/HU193949B/hu unknown
- 1985-03-05 PT PT80058A patent/PT80058B/pt unknown
- 1985-03-05 IT IT19773/85A patent/IT1183483B/it active
- 1985-03-05 AT AT0064985A patent/AT390951B/de not_active IP Right Cessation
- 1985-03-05 IE IE54685A patent/IE58338B1/en not_active IP Right Cessation
- 1985-03-05 SE SE8501067A patent/SE462429B/sv not_active IP Right Cessation
- 1985-03-06 KR KR1019850001414A patent/KR920005113B1/ko not_active IP Right Cessation
- 1985-03-06 DE DE19853507983 patent/DE3507983A1/de not_active Ceased
- 1985-03-06 NL NL8500628A patent/NL8500628A/nl active Search and Examination
- 1985-03-06 CA CA000475878A patent/CA1256871A/en not_active Expired
1987
- 1987-10-01 MY MYPI87002690A patent/MY102240A/en unknown
1990
- 1990-05-19 SG SG355/90A patent/SG35590G/en unknown
- 1990-10-11 HK HK828/90A patent/HK82890A/xx not_active IP Right Cessation
1991
- 1991-03-22 CY CY1545A patent/CY1545A/xx unknown
1992
- 1992-05-09 KR KR1019920007854A patent/KR920005114B1/ko not_active IP Right Cessation
- 1992-05-09 KR KR1019920007855A patent/KR920005694B1/ko not_active IP Right Cessation
- 1992-06-23 MX MX9203177A patent/MX9203177A/es unknown

Also Published As

Publication number	Publication date
US4605655A (en)	1986-08-12
DK166149C (da)	1993-08-09
FI850850L (fi)	1985-09-07
SE8501067L (sv)	1985-09-07
ATA64985A (de)	1990-01-15
FI850850A0 (fi)	1985-03-01
ES540901A0 (es)	1986-05-16
SG35590G (en)	1990-07-13
GB8505662D0 (en)	1985-04-03
NL8500628A (nl)	1985-10-01
MY102240A (en)	1992-05-15
KR850006402A (ko)	1985-10-05
HUT37781A (en)	1986-02-28
FR2560878A1 (fr)	1985-09-13
CY1545A (en)	1991-03-22
KR920005694B1 (ko)	1992-07-13
FR2560878B1 (fr)	1988-10-14
DE3507983A1 (de)	1985-09-12
HK82890A (en)	1990-10-19
FI84478C (fi)	1991-12-10
MX9203177A (es)	1992-07-01
SE462429B (sv)	1990-06-25
KR920005113B1 (ko)	1992-06-26
PT80058A (en)	1985-04-01
IT1183483B (it)	1987-10-22
GB2155925B (en)	1987-11-25
AU3944985A (en)	1985-09-12
DK166149B (da)	1993-03-15
KR920005114B1 (ko)	1992-06-26
PT80058B (pt)	1987-10-20
CH663022A5 (de)	1987-11-13
IT8519773A0 (it)	1985-03-05
IE850546L (en)	1985-09-06
SE8501067D0 (sv)	1985-03-05
GR850561B (da)	1985-07-03
ES8607254A1 (es)	1986-05-16
LU85796A1 (fr)	1985-12-12
AT390951B (de)	1990-07-25
DK100685D0 (da)	1985-03-05
ZA851486B (en)	1985-11-27
BE901880A (fr)	1985-09-05
AU576555B2 (en)	1988-09-01
FI84478B (fi)	1991-08-30
GB2155925A (en)	1985-10-02
IE58338B1 (en)	1993-09-08
CA1256871A (en)	1989-07-04
HU193949B (en)	1987-12-28

Publication	Publication Date	Title
DK100685D0 (da)	1985-03-05	Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater
DK268285A (da)	1985-12-17	Dialkoxypyridinderivater
DK35785A (da)	1985-07-26	Tetrahydrocarbazolonderivater
DK378085D0 (da)	1985-08-20	Heterocycliske derivater
DK243985A (da)	1985-12-02	Aminoalkylphenoxyderivater
DE3463503D1 (de)	1987-06-11	Sulfonamido-benzamide derivatives
DK552685D0 (da)	1985-11-28	Heterocycliske forbindelser
DK108585A (da)	1985-09-14	Piperazinderivater
DK162485A (da)	1985-10-12	Heterocykliske forbindelser
DK327985A (da)	1986-01-20	Pyrimidinderivater
DE3566887D1 (de)	1989-01-26	Flavanon derivatives
DK524585D0 (da)	1985-11-13	Cholecalciferolderivater
DK443685D0 (da)	1985-09-30	Pirimidinderivater
DK460785D0 (da)	1985-10-08	Substituerede furanylderivater
DK320585A (da)	1986-01-14	Fluorallylaminderivater
DK333785D0 (da)	1985-07-22	Mevalonolactonderivater
DE3588103D1 (de)	1996-05-30	5-Fluorouracil-Derivate
DK514585A (da)	1986-05-09	Aminoethylanilinderivater
DK496885D0 (da)	1985-10-29	Heterocycliske forbindelser
DE3565100D1 (de)	1988-10-27	Cycloalkane-indene-carboximidamide derivatives
DK267190D0 (da)	1990-11-07	13-substitueret-5-ketomilbemycinderivater
DK397786D0 (da)	1986-08-20	Piperazinderivater
ES532341A0 (es)	1985-11-16	Derivados de piperazina
DK54085A (da)	1985-08-09	Phenylpropargylaminderivater
DK552585D0 (da)	1985-11-28	Piperazinderivater

Legal Events

Date	Code	Title	Description
2005-03-21	PUP	Patent expired