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DK0941318T3 - Håndvægtformede konstruerede ekspressionssystemer til genterapi - Google Patents

Håndvægtformede konstruerede ekspressionssystemer til genterapi

Info

Publication number
DK0941318T3
DK0941318T3 DK97949949T DK97949949T DK0941318T3 DK 0941318 T3 DK0941318 T3 DK 0941318T3 DK 97949949 T DK97949949 T DK 97949949T DK 97949949 T DK97949949 T DK 97949949T DK 0941318 T3 DK0941318 T3 DK 0941318T3
Authority
DK
Denmark
Prior art keywords
expression
dumbbell
construct
shaped gene
gene expression
Prior art date
Application number
DK97949949T
Other languages
English (en)
Other versions
DK0941318T5 (da
Inventor
Burghardt Wittig
Claas Junghans
Original Assignee
Soft Gene Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Soft Gene Gmbh filed Critical Soft Gene Gmbh
Application granted granted Critical
Publication of DK0941318T3 publication Critical patent/DK0941318T3/da
Publication of DK0941318T5 publication Critical patent/DK0941318T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y10S977/916—Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK97949949T 1996-11-13 1997-11-13 Håndvægtformede konstruerede ekspressionssystemer til genterapi DK0941318T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19648625A DE19648625A1 (de) 1996-11-13 1996-11-13 Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer
PCT/DE1997/002704 WO1998021322A1 (de) 1996-11-13 1997-11-13 Design-prinzip für die konstruktion von expressionskonstrukten für die gentherapie

Publications (2)

Publication Number Publication Date
DK0941318T3 true DK0941318T3 (da) 2001-05-21
DK0941318T5 DK0941318T5 (da) 2002-02-18

Family

ID=7812619

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97949949T DK0941318T5 (da) 1996-11-13 1997-11-13 Håndvægtformede konstruerede ekspressionssystemer til genterapi

Country Status (9)

Country Link
US (2) US6451593B1 (da)
EP (1) EP0941318B9 (da)
AT (1) ATE198767T1 (da)
AU (1) AU5308698A (da)
DE (3) DE19648625A1 (da)
DK (1) DK0941318T5 (da)
ES (1) ES2155702T4 (da)
HK (1) HK1024714A1 (da)
WO (1) WO1998021322A1 (da)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19648625A1 (de) * 1996-11-13 1998-05-14 Soft Gene Gmbh Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer
DE19753182A1 (de) * 1997-11-21 1999-07-29 Claas Junghans Topologisch fixierte matrixgebundene Nukleinsäure
DE19826758C1 (de) * 1998-06-15 1999-10-21 Soft Gene Gmbh Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte
JP2002540772A (ja) * 1999-03-24 2002-12-03 ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム 線状および環状発現エレメント
DE19935756A1 (de) * 1999-07-27 2001-02-08 Mologen Forschungs Entwicklung Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
GB9924981D0 (en) * 1999-10-21 1999-12-22 Univ Manchester Gene therapy
DE10025920A1 (de) * 2000-05-27 2001-12-06 Mologen Forschungs Entwicklung Verfahren und Mittel zur Behandlung von Immunreaktionen am Auge
DE10119005A1 (de) * 2001-04-18 2002-10-24 Roche Diagnostics Gmbh Verfahren zur Proteinexpression ausgehend von stabilisierter linearer kurzer DNA in zellfreien in vitro-Transkription/Translations-Systemen mit Exonuklease-haltigen Lysaten oder in einem zellulären System enthaltend Exonukleasen
US8216585B2 (en) * 2001-05-25 2012-07-10 The Trustees Of The University Of Pennsylvania Targeted particles and methods of using the same
US20150050317A1 (en) * 2013-08-19 2015-02-19 Mologen Ag Means for Eliciting an Immune Response and a Method Therefor
PT1432805E (pt) * 2001-10-02 2005-10-31 Mologen Ag Estrutura de expressao do dna para tratamento de infeccoes de leishmaniose
CN1310676C (zh) * 2001-10-02 2007-04-18 莫洛根股份公司 提高免疫应答的方法
EP1507540A4 (en) * 2001-10-10 2006-12-06 Centocor Inc NUCLEIC ACID VACCINES USING NUCLEIC ACIDS ENCODING A TUMOR ANTIGEN AND A NUCLEIC ACID ENCODING A CYTOKINE ADJUVANT
ITMN20020013A1 (it) 2002-04-04 2003-10-06 Amfag Spa Doccia estraibile da cucina
DE50306394D1 (de) * 2002-07-19 2007-03-15 Mologen Ag Dna-expressionskonstrukt zur multiplen genexpression
ES2343518T3 (es) * 2002-09-09 2010-08-03 Hanall Biopharma Co., Ltd. Polipeptidos interferon alfa modificados resistentes a proteasas.
DE10393824D2 (de) * 2002-09-23 2005-08-11 Mologen Ag Impfstoff gegen Infektionen mit Onkoviren, wie dem felinen Leukosevirus der Katze
WO2004096238A1 (en) * 2003-04-01 2004-11-11 Centocor, Inc. Nucleic acid compositions and methods for use
DK1631672T3 (da) * 2003-06-10 2007-01-02 Mologen Ag Cirkulært ekspressionskonstrukt til genterapeutiske anvendelser
US20050137156A1 (en) * 2003-08-09 2005-06-23 Johnston Stephen A. Methods and compositions for generating an immune response
DK1615663T3 (da) 2003-10-24 2008-03-31 Mologen Ag Middel til behandling af Leishmania-infektioner
PL1699480T3 (pl) 2003-12-30 2011-11-30 Mologen Ag Allogeniczny przeciwnowotworowy czynnik terapeutyczny
US7613295B2 (en) * 2004-02-18 2009-11-03 Harris Corporation Cryptographic device and associated methods
EP1716234B1 (de) 2004-02-20 2013-10-02 Mologen AG Substituiertes, nicht-kodierendes nukleinsäuremolekül zur therapeutischen und prophylaktischen immunstimulation in menschen und höheren tieren
US20090004703A1 (en) * 2004-05-28 2009-01-01 Mologen Ag Method for the Production of Suitable Dna Constructs for Specific Inhibition of Gene Expression by Rna Interference
ES2364663T3 (es) * 2004-08-12 2011-09-08 Cedars-Sinai Medical Center Terapia génica combinada para el tratamiento de gliomas macroscópicos.
CA2622584C (en) 2005-09-15 2015-08-11 Novosom Ag Improvements in or relating to amphoteric liposomes
WO2007059760A1 (de) * 2005-11-25 2007-05-31 Mologen Ag Dna-konstrukte zur spezifischen hemmung der genexpression durch rna-interferenz
EP2094238A2 (en) 2006-10-13 2009-09-02 Novosom AG Improvements in or relating to amphoteric liposomes
WO2008095027A2 (en) * 2007-01-30 2008-08-07 Cedars-Sinai Medical Center Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene
DE102007029471A1 (de) 2007-06-20 2008-12-24 Novosom Ag Neue fakultativ kationische Sterole
GB0901593D0 (en) 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
EP2823810B9 (en) 2009-07-09 2019-10-30 Novosom Verwaltungs GmbH Amphoteric liposomes comprising imino lipids
GB201013153D0 (en) * 2010-08-04 2010-09-22 Touchlight Genetics Ltd Primer for production of closed linear DNA
GB2483462A (en) * 2010-09-08 2012-03-14 Mologen Ag Use of a dumbbell-shaped DNA construct for the treatment of cancer through jet-injection administration
GB201021873D0 (en) * 2010-12-23 2011-02-02 Mologen Ag DNA expression construct
WO2013014451A1 (en) 2011-07-25 2013-01-31 Oxford Nanopore Technologies Limited Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
WO2013034687A1 (en) 2011-09-09 2013-03-14 Universität Bern Verwaltungsdirektion Avibacterium paragallinarum rtx toxin
SG11201507138RA (en) 2013-03-08 2015-10-29 Oxford Nanopore Tech Ltd Enzyme stalling method
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
GB201418159D0 (en) * 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
US10612077B2 (en) * 2014-10-23 2020-04-07 Ricardo Mancebo Reagents and methods for isothermal chain reaction
ES2856844T3 (es) 2014-12-31 2021-09-28 Checkmate Pharmaceuticals Inc Inmunoterapia antitumoral combinada
GB201509578D0 (en) * 2015-06-03 2015-07-15 Univ Singapore Vectors
LU92821B1 (en) 2015-09-09 2017-03-20 Mologen Ag Combination comprising immunostimulatory oligonucleotides
GB2542425A (en) 2015-09-21 2017-03-22 Mologen Ag Means for the treatment of HIV
EP3436066A1 (en) 2016-04-01 2019-02-06 Checkmate Pharmaceuticals, Inc. Fc receptor-mediated drug delivery
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
WO2019160866A2 (en) 2018-02-13 2019-08-22 Checkmate Pharmaceuticals, Inc. Compositions and methods for tumor immunotherapy
JP7511478B2 (ja) 2018-04-09 2024-07-05 チェックメイト ファーマシューティカルズ ウイルス様粒子中へのオリゴヌクレオチドのパッケージ化
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
MA52709A (fr) 2018-05-23 2021-03-31 Modernatx Inc Administration d'adn
EP3854419A1 (en) * 2020-01-24 2021-07-28 Univerzita Karlova, Lekarska fakulta v Plzni Dna conjugate and method of transformation of genes into cells
GB202014772D0 (en) 2020-09-18 2020-11-04 Lightbio Ltd Nucleic acid construct
US20240263195A1 (en) 2021-05-11 2024-08-08 Modernatx, Inc. Non-viral delivery of dna for prolonged polypeptide expression in vivo
GB202204112D0 (en) 2022-03-23 2022-05-04 Lightbio Ltd Linear construct

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
PT690732E (pt) 1994-01-21 2003-06-30 Powderject Vaccines Inc Instrumento de administracao de genes accionado por gas
DE4416784A1 (de) * 1994-05-09 1995-11-30 Soft Gene Gmbh Methode zur Anreicherung von Zellen, die durch ballistischen Transfer modifiziert wurden
FR2731014B1 (fr) 1995-02-23 1997-03-28 Rhone Poulenc Rorer Sa Molecules d'adn, preparation et utilisation en therapie genique
DE19510696A1 (de) 1995-03-14 1996-09-19 Soft Gene Gmbh Vorrichtung zur Druckverteilung im Kopfstück einer Apparatur zum ballistischen Transfer von Zellen
FR2732971B1 (fr) * 1995-04-13 1997-07-04 Genset Sa Oligonucleotide sens inhibiteur de virus herpes simplex (hsv) a structure en haltere
DE19648625A1 (de) * 1996-11-13 1998-05-14 Soft Gene Gmbh Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer

Also Published As

Publication number Publication date
EP0941318B1 (de) 2001-01-17
EP0941318A1 (de) 1999-09-15
DK0941318T5 (da) 2002-02-18
EP0941318B9 (de) 2001-12-19
US20030054392A1 (en) 2003-03-20
WO1998021322A1 (de) 1998-05-22
ATE198767T1 (de) 2001-02-15
DE19781276D2 (de) 1999-09-30
ES2155702T4 (es) 2002-12-16
ES2155702T3 (es) 2001-05-16
US6451593B1 (en) 2002-09-17
DE19648625A1 (de) 1998-05-14
DE59702936D1 (de) 2001-02-22
US7074772B2 (en) 2006-07-11
AU5308698A (en) 1998-06-03
HK1024714A1 (en) 2000-10-20

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