DK0729457T3 - Diaminocyclobuten-3,4-dioner som afslapningsmidler for glat muskulatur - Google Patents
Diaminocyclobuten-3,4-dioner som afslapningsmidler for glat muskulaturInfo
- Publication number
- DK0729457T3 DK0729457T3 DK95901739T DK95901739T DK0729457T3 DK 0729457 T3 DK0729457 T3 DK 0729457T3 DK 95901739 T DK95901739 T DK 95901739T DK 95901739 T DK95901739 T DK 95901739T DK 0729457 T3 DK0729457 T3 DK 0729457T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- smooth muscle
- relaxants
- diaminocyclobutene
- dione
- Prior art date
Links
- WUACDRFRFTWMHE-UHFFFAOYSA-N 3,4-diaminocyclobut-3-ene-1,2-dione Chemical compound NC1=C(N)C(=O)C1=O WUACDRFRFTWMHE-UHFFFAOYSA-N 0.000 title 1
- 239000002249 anxiolytic agent Substances 0.000 title 1
- 210000002460 smooth muscle Anatomy 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229920001774 Perfluoroether Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000005596 alkyl carboxamido group Chemical group 0.000 abstract 2
- 125000005422 alkyl sulfonamido group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000005533 aryl carboxamido group Chemical group 0.000 abstract 1
- 125000005421 aryl sulfonamido group Chemical group 0.000 abstract 1
- 125000005362 aryl sulfone group Chemical group 0.000 abstract 1
- -1 chloro, bromo, fluoro, iodo, 1-imidazolyl Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000050 smooth muscle relaxant Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Pyridine Compounds (AREA)
- Pens And Brushes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/153,706 US5354763A (en) | 1993-11-17 | 1993-11-17 | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
| PCT/US1994/012561 WO1995014005A1 (en) | 1993-11-17 | 1994-11-01 | Diaminocyclobutene-3,4-diones as smooth muscle relaxants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0729457T3 true DK0729457T3 (da) | 1999-08-23 |
Family
ID=22548391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95901739T DK0729457T3 (da) | 1993-11-17 | 1994-11-01 | Diaminocyclobuten-3,4-dioner som afslapningsmidler for glat muskulatur |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US5354763A (xx) |
| EP (1) | EP0729457B1 (xx) |
| JP (1) | JPH09505296A (xx) |
| KR (1) | KR960705780A (xx) |
| AT (1) | ATE174907T1 (xx) |
| AU (1) | AU677479B2 (xx) |
| CA (1) | CA2175386A1 (xx) |
| DE (1) | DE69415554T2 (xx) |
| DK (1) | DK0729457T3 (xx) |
| ES (1) | ES2126241T3 (xx) |
| FI (1) | FI962070A0 (xx) |
| GR (1) | GR3029646T3 (xx) |
| HK (1) | HK1011353A1 (xx) |
| HU (1) | HU215603B (xx) |
| IL (1) | IL111529A (xx) |
| LV (1) | LV12258B (xx) |
| NZ (1) | NZ276568A (xx) |
| PH (1) | PH31054A (xx) |
| SG (1) | SG47587A1 (xx) |
| SI (1) | SI0729457T1 (xx) |
| WO (1) | WO1995014005A1 (xx) |
| ZA (1) | ZA948877B (xx) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466712A (en) * | 1994-11-04 | 1995-11-14 | American Home Products Corporation | Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones |
| MX9703375A (es) * | 1994-11-16 | 1997-08-30 | American Home Prod | Diaminociclobuteno-3,4-dionas. |
| US5464867A (en) * | 1994-11-16 | 1995-11-07 | American Home Products Corporation | Diaminocyclobutene-3,4-diones |
| US5872139A (en) * | 1996-06-17 | 1999-02-16 | American Home Products Corporation | Heterocyclymethylamino derivatives of cyclobutene-3,4-diones |
| WO1997048682A1 (en) * | 1996-06-17 | 1997-12-24 | American Home Products Corporation | Heterocyclylmethylamino derivatives of cyclobutene-3,4-diones as potassium channel modulators |
| US5780505A (en) * | 1996-07-17 | 1998-07-14 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones |
| US5750574A (en) * | 1996-07-17 | 1998-05-12 | American Home Products Corporation | Fluorinated N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5763474A (en) * | 1996-07-17 | 1998-06-09 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5846999A (en) * | 1996-07-17 | 1998-12-08 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5840764A (en) * | 1997-01-30 | 1998-11-24 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
| AU6250298A (en) * | 1997-01-30 | 1998-08-25 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
| US6376555B1 (en) | 1998-12-04 | 2002-04-23 | American Home Products Corporation | 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers |
| WO2000034230A1 (en) * | 1998-12-04 | 2000-06-15 | American Home Products Corporation | 4-3-substituted-amino-cyclobut-3-ene-1,2-diones and use for influencing smooth muscle contraction |
| WO2001038329A1 (fr) * | 1999-11-24 | 2001-05-31 | Sumika Fine Chemicals Co., Ltd. | Cristaux de mirtazapine anhydre et leur procede d'obtention |
| US20030204085A1 (en) * | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| US6495576B2 (en) | 2001-02-07 | 2002-12-17 | Abbott Laboratories | Aminal diones as potassium channel openers |
| US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| MY149050A (en) * | 2001-04-16 | 2013-07-15 | Merck Sharp & Dohme | 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands |
| MXPA04003439A (es) * | 2001-10-12 | 2004-07-08 | Schering Corp | Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc. |
| US6878709B2 (en) * | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| NZ535314A (en) * | 2002-03-18 | 2007-08-31 | Schering Corp | Combination treatments for chemokine-mediated diseases |
| JP4664074B2 (ja) * | 2002-10-09 | 2011-04-06 | シェーリング コーポレイション | Ｃｘｃ−ケモカインレセプターリガンドおよびｃｃ−ケモカインレセプターリガンドとしてのチアジアゾールジオキシドおよびチアジアゾールオキシド |
| WO2005066147A1 (en) * | 2003-12-19 | 2005-07-21 | Schering Corporation | Thiadiazoles as cxc- and cc- chemokine receptor ligands |
| CA2550540A1 (en) * | 2003-12-22 | 2005-07-28 | Schering Corporation | Isothiazole dioxides as cxc- and cc- chemokine receptor ligands |
| ES2327840T3 (es) | 2004-12-23 | 2009-11-04 | Gpc Biotech Ag | Derivados de acido escuarico con actividad antiproliferativa. |
| DE602006017849D1 (de) * | 2005-06-29 | 2010-12-09 | Schering Corp | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors |
| CN101253165A (zh) * | 2005-06-29 | 2008-08-27 | 先灵公司 | 作为cxc－化学活素受体配体的二取代的二唑 |
| JP5437061B2 (ja) * | 2006-05-26 | 2014-03-12 | アッヴィ・インコーポレイテッド | ポロ様キナーゼの阻害薬 |
| CA2657051A1 (en) * | 2006-07-07 | 2008-01-10 | Schering Corporation | 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands |
| US8450348B2 (en) | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
| RU2529468C2 (ru) | 2008-06-24 | 2014-09-27 | Топотаргет А/С | Производные 1, 2-дигидроциклобутендиона в качестве ингибиторов фосфорибозилтрансферазы никотинамида |
| UA103198C2 (xx) * | 2008-08-04 | 2013-09-25 | Новартис Аг | Похідні сквараміду як антагоністи cxcr2$производные скварамида как антагонисты cxcr2 |
| US9178235B2 (en) | 2009-09-04 | 2015-11-03 | Lg Fuel Cell Systems, Inc. | Reducing gas generators and methods for generating a reducing gas |
| US9140220B2 (en) | 2011-06-30 | 2015-09-22 | Lg Fuel Cell Systems Inc. | Engine systems and methods of operating an engine |
| US8668752B2 (en) * | 2009-09-04 | 2014-03-11 | Rolls-Royce Fuel Cell Systems (Us) Inc. | Apparatus for generating a gas which may be used for startup and shutdown of a fuel cell |
| US9083020B2 (en) | 2009-09-04 | 2015-07-14 | Lg Fuel Cell Systems Inc. | Reducing gas generators and methods for generating reducing gas |
| US9874158B2 (en) | 2009-09-04 | 2018-01-23 | Lg Fuel Cell Systems, Inc | Engine systems and methods of operating an engine |
| US9118048B2 (en) | 2009-09-04 | 2015-08-25 | Lg Fuel Cell Systems Inc. | Engine systems and methods of operating an engine |
| US8597841B2 (en) | 2009-09-04 | 2013-12-03 | Lg Fuel Cell Systems Inc. | Method for generating a gas which may be used for startup and shutdown of a fuel cell |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| WO2019036374A1 (en) | 2017-08-14 | 2019-02-21 | Allergan, Inc. | 3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND THEIR USE |
| UA128700C2 (uk) | 2018-09-21 | 2024-10-02 | Пфайзер Інк. | N-заміщені діоксоциклобутеніламіно-3-гідроксипіколінаміди, прийнятні як інгібітори ccr6 |
| CN116947756B (zh) * | 2023-08-02 | 2025-02-07 | 中国药科大学 | 环丁烯二酮基喹啉类化合物及其制备方法、药物组合物和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4390701A (en) * | 1981-05-18 | 1983-06-28 | Bristol-Myers Company | 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione |
| JPS60255756A (ja) * | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
| US5011837A (en) * | 1988-08-09 | 1991-04-30 | E. R. Squibb & Sons, Inc. | Aryl cyanoguanidines: potassium channel activators and method of making same |
| ES2088895T3 (es) * | 1988-09-16 | 1996-10-01 | Beecham Group Plc | Derivados de benzopirano con actividad antihipertensora. |
| GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
| US5212283A (en) * | 1992-03-03 | 1993-05-18 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Polyimides containing the cyclobutene-3, 4-dione moiety |
| JPH0692915A (ja) * | 1992-07-28 | 1994-04-05 | Sumitomo Metal Ind Ltd | １，２−ジアミノシクロブテン−３，４−ジオン誘導体及びその用途 |
-
1993
- 1993-11-17 US US08/153,706 patent/US5354763A/en not_active Expired - Lifetime
-
1994
- 1994-06-13 US US08/259,049 patent/US5401753A/en not_active Expired - Lifetime
- 1994-06-13 US US08/259,210 patent/US5403853A/en not_active Expired - Lifetime
- 1994-06-13 US US08/259,220 patent/US5397790A/en not_active Expired - Lifetime
- 1994-06-13 US US08/259,212 patent/US5403854A/en not_active Expired - Lifetime
- 1994-11-01 JP JP7514471A patent/JPH09505296A/ja not_active Ceased
- 1994-11-01 DE DE69415554T patent/DE69415554T2/de not_active Expired - Fee Related
- 1994-11-01 SG SG1996002966A patent/SG47587A1/en unknown
- 1994-11-01 CA CA002175386A patent/CA2175386A1/en not_active Abandoned
- 1994-11-01 AU AU10866/95A patent/AU677479B2/en not_active Ceased
- 1994-11-01 WO PCT/US1994/012561 patent/WO1995014005A1/en active IP Right Grant
- 1994-11-01 AT AT95901739T patent/ATE174907T1/de not_active IP Right Cessation
- 1994-11-01 EP EP95901739A patent/EP0729457B1/en not_active Expired - Lifetime
- 1994-11-01 ES ES95901739T patent/ES2126241T3/es not_active Expired - Lifetime
- 1994-11-01 SI SI9430213T patent/SI0729457T1/xx unknown
- 1994-11-01 NZ NZ276568A patent/NZ276568A/en unknown
- 1994-11-01 DK DK95901739T patent/DK0729457T3/da active
- 1994-11-01 KR KR1019960702542A patent/KR960705780A/ko not_active Abandoned
- 1994-11-01 HU HU9601310A patent/HU215603B/hu not_active IP Right Cessation
- 1994-11-04 IL IL11152994A patent/IL111529A/xx active IP Right Grant
- 1994-11-09 ZA ZA948877A patent/ZA948877B/xx unknown
- 1994-11-16 PH PH49383A patent/PH31054A/en unknown
-
1996
- 1996-05-15 FI FI962070A patent/FI962070A0/fi unknown
-
1998
- 1998-11-24 HK HK98112276A patent/HK1011353A1/xx not_active IP Right Cessation
-
1999
- 1999-02-15 LV LVP-99-23A patent/LV12258B/en unknown
- 1999-03-09 GR GR990400737T patent/GR3029646T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE174907T1 (de) | 1999-01-15 |
| HU215603B (hu) | 1999-01-28 |
| ZA948877B (en) | 1996-05-09 |
| NZ276568A (en) | 1996-11-26 |
| CA2175386A1 (en) | 1995-05-26 |
| DE69415554D1 (de) | 1999-02-04 |
| EP0729457B1 (en) | 1998-12-23 |
| FI962070L (fi) | 1996-05-15 |
| US5401753A (en) | 1995-03-28 |
| FI962070A0 (fi) | 1996-05-15 |
| SG47587A1 (en) | 1998-04-17 |
| KR960705780A (ko) | 1996-11-08 |
| GR3029646T3 (en) | 1999-06-30 |
| HUT75655A (en) | 1997-05-28 |
| US5354763A (en) | 1994-10-11 |
| LV12258B (en) | 1999-09-20 |
| AU677479B2 (en) | 1997-04-24 |
| JPH09505296A (ja) | 1997-05-27 |
| AU1086695A (en) | 1995-06-06 |
| EP0729457A1 (en) | 1996-09-04 |
| ES2126241T3 (es) | 1999-03-16 |
| IL111529A (en) | 1999-08-17 |
| LV12258A (lv) | 1999-04-20 |
| WO1995014005A1 (en) | 1995-05-26 |
| HU9601310D0 (en) | 1996-07-29 |
| US5403854A (en) | 1995-04-04 |
| HK1011353A1 (en) | 1999-07-09 |
| IL111529A0 (en) | 1995-01-24 |
| DE69415554T2 (de) | 1999-05-12 |
| US5403853A (en) | 1995-04-04 |
| US5397790A (en) | 1995-03-14 |
| SI0729457T1 (en) | 1999-04-30 |
| PH31054A (en) | 1998-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0729457T3 (da) | Diaminocyclobuten-3,4-dioner som afslapningsmidler for glat muskulatur | |
| NZ296442A (en) | N-aryl and N-heteroaryl-1,2-diaminocyclobutene-3,4-diones and use as muscle relaxants | |
| CA2088840A1 (en) | 4-benzoyl isoxazole herbicides | |
| TR27253A (tr) | Yeni 4-benzoyl isoxazole türevleri, bunlari iceren bilesimler ve bunlarin herbisid olarak kullanimi. | |
| DE69507639D1 (de) | Diaminocyclobuten-3,4-dione | |
| FI970668A0 (fi) | 2,3-dihydro-1-(2,2,2-trifluorietyyli)-2-okso-5-fenyyli-1H-1,4-bentsodiatsepiinejä | |
| TR21379A (tr) | N-fenilpirazol t*revleri | |
| IL92341A0 (en) | 2-(2',3',4'-trisubstituted benzoyl)-1,3-cyclohexanediones and their use as herbicides | |
| FI935307A0 (fi) | Joderade aromatiska foereningar | |
| ES2193385T3 (es) | Inhibidores tiadiazol amida de la metaloproteasa. | |
| SE8006143L (sv) | 5-(klorofenyl)-6h-1,3,4-tiadiazin-2-aminer | |
| AU8036782A (en) | Mixtures of optical brighteners | |
| SE8302824D0 (sv) | New herbicidal compounds | |
| DK428087A (da) | Dihydropyridin-5-phosphonsyre-cyclopropylenester | |
| AR011771A1 (es) | Derivados de aminofenil cetona y procedimientos para la preparacion de los mismos | |
| AU3634489A (en) | Aminomethylphenols and fungicides containing these compounds |