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ES2088895T3 - Derivados de benzopirano con actividad antihipertensora. - Google Patents

Derivados de benzopirano con actividad antihipertensora.

Info

Publication number
ES2088895T3
ES2088895T3 ES89309272T ES89309272T ES2088895T3 ES 2088895 T3 ES2088895 T3 ES 2088895T3 ES 89309272 T ES89309272 T ES 89309272T ES 89309272 T ES89309272 T ES 89309272T ES 2088895 T3 ES2088895 T3 ES 2088895T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
group
optionally substituted
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89309272T
Other languages
English (en)
Inventor
Geoffrey Stemp
Gordon Burrell
David Glynn Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888821826A external-priority patent/GB8821826D0/en
Priority claimed from GB898907394A external-priority patent/GB8907394D0/en
Priority claimed from GB898917176A external-priority patent/GB8917176D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2088895T3 publication Critical patent/ES2088895T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
    • C07C255/67—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and azido groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Abstract

LOS COMPONENTES DE FORMULA (I) Y SALES FARMACEUTICAMENTE ACEPTABLES DE ELLOS: DONDE A Y LO FORMAN JUNTOS UN ENLACE M -O O -CH2-; BIEN Y ES N Y R2 ES HIDROGENO; O Y ES C-R1 DONDE BIEN UNO DE R1 Y R2 ES HIDROGENO Y EL OTRO ES NITRO, CIANO, HALO, CF3, FORMIL, ALDOXIMO, CF3O, NO2-CH=CH-, NC-CH=CH- UN GRUPO RXX- DONDE RX ES C1-6 ALQUILO, ARILO O HETEROARILO, QUE PUEDE SER SUSTITUIDO POR UNO, DOS O TRES DE LOS C1-4 ALQUILO, C1-4 ALCOXI, NITRO, HALO, CF3 Y CIANO; Y X ES C==, O.C=O, C=O.O, CHOH, SO, SO2, O.SO, O.SO2, CONH, O.CONH, C=S, O.C=S, C=S.O, CH.SH, SONH, SO2NH, O.SO_NH, O.SO2NH, CO-CH=CH, C=NHOH, C=NNH2; O UN GRUPO RYRZNZ- EN EL QUE RY Y RZ SON INDEPENDIENTEMENTE HIDROGENO O C1-6 ALQUILO Y Z ES C=O, SO O SO2; O R1 ES UN GRUPO C3-8 CICLOALQUILO O UN GRUPO C1-6 ALQUILO OPCIONALMENTE SUSTITUIDO POR UN GRUPO QUE ES HIDROXI, C1-6 ALCOXI, AMINO OPCIONALMENTE SUSTITUIDO POR UNO O DOS GRUPOS C1-6 ALQUILO, C1-7 ALCANOILAMINO, C3-8 CICLOALQUILAMINO; Y R2 ES HIDROGENO O NO DE R1 Y R2 ES NITRO,CIANO O C1-3 ALQUILCARBONIL Y EL OTRO ES UN GRUPO DIFERENTE ELEGIDO DE NITRO, CIANO, HALO, C1-3 ALQUILCARBONIL, METOXI O AMINO OPCIONALMENTE SUSTITUIDO POR UNO O DOS C1-6ALQUILO O POR C2-7 ALCANOIL; BIEN UNO DE R3 Y R4 ES HIDROGENO O C1-4 ALQUILO O EL OTRO ES C1-4 ALQUILO; O R3 Y R4 SON C2-5 POLIMETILENO; BIEN R5 ES HIDROGENO, HIDROXI, C1-6 ALCOXI O C1-7 ACILOXI; Y R6 ES HIDROGENO O R5 Y R6 SON UN ENLACE; BIEN R7 ES HIDROGENO, HIDROXI, C1-6 ALQUILO, C3-6 CICLOALQUILO, C2-6 ALQUENILO O C2-6 ALQUINILO; Y R8 ES HIDROGENO O C1-6 ALQUILO; O R7 Y R8 SON C2-4 POLIMETILENO; R9 ES CN, NO2, COR10 O SOSR10 DOPNDE R10 ES C1-3 ALQUILO, NH2, NH (C1-3 ALQUILO), CF3 O FENILO OPCIONALMENTE SUSTITUIDO COMO DEFINE RX; Y EL COMPLEJO R8N(NR9) NHR7 ES TRANSFERIDO AL GRUPO R5 CUANDO R5 ES HIDROXI, C1-6 ALCOXI O C1-7 ACILOXI; QUE TIENE UNA ACTIVIDAD ANTIHIPERTENSIVA Y/O BRONCODILATADORA, PROCESO PARA SU PREPARACION Y SU USO COMO FARMACEUTICO.
ES89309272T 1988-09-16 1989-09-12 Derivados de benzopirano con actividad antihipertensora. Expired - Lifetime ES2088895T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888821826A GB8821826D0 (en) 1988-09-16 1988-09-16 Novel compounds
GB898907394A GB8907394D0 (en) 1989-04-01 1989-04-01 Novel compounds
GB898917176A GB8917176D0 (en) 1989-07-28 1989-07-28 Novel compounds

Publications (1)

Publication Number Publication Date
ES2088895T3 true ES2088895T3 (es) 1996-10-01

Family

ID=27264088

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89309272T Expired - Lifetime ES2088895T3 (es) 1988-09-16 1989-09-12 Derivados de benzopirano con actividad antihipertensora.

Country Status (12)

Country Link
US (1) US5053427A (es)
EP (1) EP0359537B1 (es)
JP (1) JP2799745B2 (es)
KR (1) KR0157976B1 (es)
AT (1) ATE139775T1 (es)
AU (1) AU4140389A (es)
DE (1) DE68926729T2 (es)
DK (1) DK453389A (es)
ES (1) ES2088895T3 (es)
GR (1) GR3020915T3 (es)
IE (1) IE74217B1 (es)
PT (1) PT91715B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE120459T1 (de) * 1988-12-13 1995-04-15 Beecham Group Plc Benzopyran und verwandte verbindungen.
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
US5140031A (en) * 1989-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
CA2015296C (en) * 1989-05-31 2001-08-07 Karnail Atwal Pyranyl cyanoguanidine derivatives
US5185345A (en) * 1989-11-06 1993-02-09 Sanofi 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them
US5061813A (en) * 1990-04-02 1991-10-29 E. R. Squibb & Sons, Inc. Substituted cyanoimino benzopyranes
US5401848A (en) * 1990-11-26 1995-03-28 E. R. Squibb & Sons, Inc. Indane and quinoline derivatives
CA2055376A1 (en) * 1990-12-05 1992-06-06 Gary J. Grover Method of treating shock using a potassium channel activator
US5262419A (en) * 1992-06-11 1993-11-16 E. R. Squibb & Sons, Inc. Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
US5374643A (en) * 1992-09-11 1994-12-20 E. R. Squibb & Sons, Inc. Aryl urea (thiourea) and cyanoguanidine derivatives
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
US5514690A (en) * 1992-11-17 1996-05-07 E. R. Squibb & Sons, Inc. Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
US5393771A (en) * 1993-05-12 1995-02-28 Brisol-Myers Squibb Company 4-substituted benzopyran and related compounds
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5401758A (en) * 1993-10-07 1995-03-28 Bristol-Myers Squibb Company Pyridinyl cyanoguanidine compounds
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
US5354763A (en) * 1993-11-17 1994-10-11 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
CN1126888C (zh) 1999-02-18 2003-11-05 萱场工业株式会社 密封构造
GB9914025D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088785A (en) * 1976-03-25 1978-05-09 William H. Rorer, Inc. Amidinoureas for the treatment of cardinascular disorders
EP0004959A1 (de) * 1978-04-24 1979-10-31 Ciba-Geigy Ag Verfahren zur Herstellung von 3-Oxo-cyclopentenylharnstoffen, die so erhaltenen Verbindungen, sie enthaltende pharmazeutische Präparate und 3-Oxo-cyclopentenylisothioharnstoffe
EP0126367B1 (en) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman and chromene derivatives
GB8414987D0 (en) * 1984-06-12 1984-07-18 Beecham Group Plc Active compounds
EP0205292B1 (en) * 1985-06-08 1991-11-06 Beecham Group Plc Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives

Also Published As

Publication number Publication date
KR0157976B1 (ko) 1998-12-01
PT91715A (pt) 1990-03-30
DE68926729T2 (de) 1997-02-13
IE892943L (en) 1990-03-16
DK453389D0 (da) 1989-09-14
JPH02134357A (ja) 1990-05-23
US5053427A (en) 1991-10-01
EP0359537B1 (en) 1996-06-26
IE74217B1 (en) 1997-07-16
KR900004694A (ko) 1990-04-12
EP0359537A1 (en) 1990-03-21
GR3020915T3 (en) 1996-11-30
DK453389A (da) 1990-03-17
JP2799745B2 (ja) 1998-09-21
ATE139775T1 (de) 1996-07-15
PT91715B (pt) 1995-05-31
AU4140389A (en) 1990-03-22
DE68926729D1 (de) 1996-08-01

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