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DK0725790T3 - Substituerede tetra- og pentapeptidinhibitorer af proteinfarnesyltransferase - Google Patents

Substituerede tetra- og pentapeptidinhibitorer af proteinfarnesyltransferase

Info

Publication number
DK0725790T3
DK0725790T3 DK94931425T DK94931425T DK0725790T3 DK 0725790 T3 DK0725790 T3 DK 0725790T3 DK 94931425 T DK94931425 T DK 94931425T DK 94931425 T DK94931425 T DK 94931425T DK 0725790 T3 DK0725790 T3 DK 0725790T3
Authority
DK
Denmark
Prior art keywords
farnesyl transferase
inhibitors
substituted tetra
protein farnesyl
protein
Prior art date
Application number
DK94931425T
Other languages
English (en)
Inventor
John Cooke Hodges
Gary Louis Bolton
Alfred Campbell
Richard Gowan
Donald Hupe
Daniele Leonard
Tomi Sawyer
Judith Sebolt-Leopold
Francis J Tinney
Original Assignee
Parke Davis & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis & Co filed Critical Parke Davis & Co
Application granted granted Critical
Publication of DK0725790T3 publication Critical patent/DK0725790T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK94931425T 1993-10-25 1994-10-21 Substituerede tetra- og pentapeptidinhibitorer af proteinfarnesyltransferase DK0725790T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14275693A 1993-10-25 1993-10-25
US30963594A 1994-09-23 1994-09-23
PCT/US1994/012060 WO1995011917A1 (en) 1993-10-25 1994-10-21 Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase

Publications (1)

Publication Number Publication Date
DK0725790T3 true DK0725790T3 (da) 2001-06-11

Family

ID=26840404

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94931425T DK0725790T3 (da) 1993-10-25 1994-10-21 Substituerede tetra- og pentapeptidinhibitorer af proteinfarnesyltransferase

Country Status (15)

Country Link
EP (1) EP0725790B1 (da)
JP (1) JPH09504295A (da)
KR (1) KR100378615B1 (da)
AT (1) ATE200677T1 (da)
AU (1) AU682906B2 (da)
CA (1) CA2173590A1 (da)
DE (1) DE69427127T2 (da)
DK (1) DK0725790T3 (da)
ES (1) ES2157994T3 (da)
FI (1) FI961621A0 (da)
GR (1) GR3036188T3 (da)
LV (1) LV12771B (da)
NZ (1) NZ275037A (da)
PT (1) PT725790E (da)
WO (1) WO1995011917A1 (da)

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US5578629A (en) * 1995-03-29 1996-11-26 Merck & Co., Inc. Benzamide-containing inhibitors of farnesyl-protein transferase
US5624936A (en) * 1995-03-29 1997-04-29 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5856326A (en) * 1995-03-29 1999-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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US5631280A (en) * 1995-03-29 1997-05-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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US5710171A (en) * 1995-05-24 1998-01-20 Merck & Co., Inc. Bisphenyl inhibitors of farnesyl-protein transferase
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US7226991B1 (en) 1999-03-23 2007-06-05 United States Of America, Represented By The Secretary, Department Of Health And Human Services Phenylalanine derivatives
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Also Published As

Publication number Publication date
LV12771A (lv) 2001-12-20
WO1995011917A1 (en) 1995-05-04
DE69427127T2 (de) 2001-10-04
FI961621A7 (fi) 1996-04-12
DE69427127D1 (de) 2001-05-23
AU682906B2 (en) 1997-10-23
LV12771B (en) 2002-03-20
EP0725790A1 (en) 1996-08-14
AU8051394A (en) 1995-05-22
PT725790E (pt) 2001-08-30
NZ275037A (en) 1998-01-26
FI961621L (fi) 1996-04-12
KR100378615B1 (ko) 2003-10-10
FI961621A0 (fi) 1996-04-12
EP0725790B1 (en) 2001-04-18
JPH09504295A (ja) 1997-04-28
ES2157994T3 (es) 2001-09-01
ATE200677T1 (de) 2001-05-15
CA2173590A1 (en) 1995-05-04
GR3036188T3 (en) 2001-10-31

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