DK0655057T3 - Cyanoguanidiner som kaliumkanalblokkere - Google Patents
Cyanoguanidiner som kaliumkanalblokkereInfo
- Publication number
- DK0655057T3 DK0655057T3 DK93917262.3T DK93917262T DK0655057T3 DK 0655057 T3 DK0655057 T3 DK 0655057T3 DK 93917262 T DK93917262 T DK 93917262T DK 0655057 T3 DK0655057 T3 DK 0655057T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- hydrogen
- channel blockers
- potassium channel
- cyanoguanidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92979592A | 1992-08-13 | 1992-08-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0655057T3 true DK0655057T3 (da) | 1998-04-14 |
Family
ID=25458467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93917262.3T DK0655057T3 (da) | 1992-08-13 | 1993-07-21 | Cyanoguanidiner som kaliumkanalblokkere |
Country Status (16)
Country | Link |
---|---|
US (1) | US5567722A (es) |
EP (1) | EP0655057B1 (es) |
JP (1) | JPH08500111A (es) |
CN (1) | CN1039997C (es) |
AT (1) | ATE158279T1 (es) |
AU (2) | AU4530693A (es) |
DE (1) | DE69314041T2 (es) |
DK (1) | DK0655057T3 (es) |
ES (1) | ES2107049T3 (es) |
GR (1) | GR3025640T3 (es) |
IL (1) | IL106641A (es) |
MX (1) | MX9304882A (es) |
MY (1) | MY110826A (es) |
TW (1) | TW223017B (es) |
WO (2) | WO1994004499A1 (es) |
ZA (1) | ZA935619B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2116726T3 (es) * | 1994-01-28 | 1998-07-16 | Upjohn Co | Cianoguanidinas utilizadas como bloqueadores del canal k. |
AUPN193095A0 (en) * | 1995-03-24 | 1995-04-27 | Polychip Pharmaceuticals Pty Ltd | Potassium ion channel blockers |
AR008290A1 (es) * | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios. |
WO1998006398A1 (en) * | 1996-08-15 | 1998-02-19 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
EP1917244A2 (de) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
CN113683535B (zh) * | 2020-05-18 | 2022-08-30 | 中国药科大学 | 含氰胍结构的化合物及其制备方法与用途 |
CN112042664B (zh) * | 2020-09-18 | 2022-06-10 | 广州古神生物科技有限公司 | 防霉抗菌剂 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
NL8000869A (nl) * | 1979-02-16 | 1980-08-19 | Eisai Co Ltd | Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan. |
JPH01166119A (ja) * | 1987-12-23 | 1989-06-30 | Hitachi Ltd | データ入力装置の制御方式 |
NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
AU623217B2 (en) * | 1989-02-03 | 1992-05-07 | Eli Lilly And Company | (-)-n"-cyano-n-3-pyridyl-n'-1,2,2-trimethyl- propylguanidine, a process for preparing the compound, and use of the compound as a medicament |
US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
-
1993
- 1993-06-11 AU AU45306/93A patent/AU4530693A/en not_active Abandoned
- 1993-06-11 WO PCT/US1993/005458 patent/WO1994004499A1/en active Application Filing
- 1993-07-21 AU AU46831/93A patent/AU4683193A/en not_active Abandoned
- 1993-07-21 DK DK93917262.3T patent/DK0655057T3/da active
- 1993-07-21 DE DE69314041T patent/DE69314041T2/de not_active Expired - Fee Related
- 1993-07-21 JP JP6506258A patent/JPH08500111A/ja active Pending
- 1993-07-21 ES ES93917262T patent/ES2107049T3/es not_active Expired - Lifetime
- 1993-07-21 AT AT93917262T patent/ATE158279T1/de not_active IP Right Cessation
- 1993-07-21 WO PCT/US1993/006752 patent/WO1994004500A1/en active IP Right Grant
- 1993-07-21 EP EP93917262A patent/EP0655057B1/en not_active Expired - Lifetime
- 1993-08-03 ZA ZA935619A patent/ZA935619B/xx unknown
- 1993-08-03 TW TW082106192A patent/TW223017B/zh active
- 1993-08-07 MY MYPI93001565A patent/MY110826A/en unknown
- 1993-08-10 IL IL10664193A patent/IL106641A/en not_active IP Right Cessation
- 1993-08-12 MX MX9304882A patent/MX9304882A/es not_active IP Right Cessation
- 1993-08-13 CN CN93117781A patent/CN1039997C/zh not_active Expired - Fee Related
-
1995
- 1995-02-06 US US08/384,562 patent/US5567722A/en not_active Expired - Fee Related
-
1997
- 1997-12-10 GR GR970403292T patent/GR3025640T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH08500111A (ja) | 1996-01-09 |
EP0655057B1 (en) | 1997-09-17 |
WO1994004499A1 (en) | 1994-03-03 |
DE69314041D1 (de) | 1997-10-23 |
ES2107049T3 (es) | 1997-11-16 |
ZA935619B (en) | 1995-02-03 |
US5567722A (en) | 1996-10-22 |
CN1039997C (zh) | 1998-09-30 |
AU4530693A (en) | 1994-03-15 |
DE69314041T2 (de) | 1998-02-05 |
IL106641A0 (en) | 1993-12-08 |
EP0655057A1 (en) | 1995-05-31 |
TW223017B (es) | 1994-05-01 |
ATE158279T1 (de) | 1997-10-15 |
IL106641A (en) | 2001-01-11 |
WO1994004500A1 (en) | 1994-03-03 |
CN1090575A (zh) | 1994-08-10 |
MX9304882A (es) | 1994-07-29 |
GR3025640T3 (en) | 1998-03-31 |
MY110826A (en) | 1999-05-31 |
AU4683193A (en) | 1994-03-15 |
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