DE69314041D1 - Cyanoguanidine als kaliumkanalblocker - Google Patents
Cyanoguanidine als kaliumkanalblockerInfo
- Publication number
- DE69314041D1 DE69314041D1 DE69314041T DE69314041T DE69314041D1 DE 69314041 D1 DE69314041 D1 DE 69314041D1 DE 69314041 T DE69314041 T DE 69314041T DE 69314041 T DE69314041 T DE 69314041T DE 69314041 D1 DE69314041 D1 DE 69314041D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- hydrogen
- cyanoguanidine
- potassium channel
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003450 potassium channel blocker Substances 0.000 title abstract 2
- 229940125422 potassium channel blocker Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92979592A | 1992-08-13 | 1992-08-13 | |
| PCT/US1993/006752 WO1994004500A1 (en) | 1992-08-13 | 1993-07-21 | Cyanoguanidines as potassium channel blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69314041D1 true DE69314041D1 (de) | 1997-10-23 |
| DE69314041T2 DE69314041T2 (de) | 1998-02-05 |
Family
ID=25458467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69314041T Expired - Fee Related DE69314041T2 (de) | 1992-08-13 | 1993-07-21 | Cyanoguanidine als kaliumkanalblocker |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5567722A (de) |
| EP (1) | EP0655057B1 (de) |
| JP (1) | JPH08500111A (de) |
| CN (1) | CN1039997C (de) |
| AT (1) | ATE158279T1 (de) |
| AU (2) | AU4530693A (de) |
| DE (1) | DE69314041T2 (de) |
| DK (1) | DK0655057T3 (de) |
| ES (1) | ES2107049T3 (de) |
| GR (1) | GR3025640T3 (de) |
| IL (1) | IL106641A (de) |
| MX (1) | MX9304882A (de) |
| MY (1) | MY110826A (de) |
| TW (1) | TW223017B (de) |
| WO (2) | WO1994004499A1 (de) |
| ZA (1) | ZA935619B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0741708T3 (da) * | 1994-01-28 | 1999-01-18 | Upjohn Co | Cyanoguanidiner som K-kanal-blokkere |
| AUPN193095A0 (en) * | 1995-03-24 | 1995-04-27 | Polychip Pharmaceuticals Pty Ltd | Potassium ion channel blockers |
| AR008290A1 (es) | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios. |
| WO1998006398A1 (en) * | 1996-08-15 | 1998-02-19 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| EP1917244A2 (de) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| CN113683535B (zh) * | 2020-05-18 | 2022-08-30 | 中国药科大学 | 含氰胍结构的化合物及其制备方法与用途 |
| CN112042664B (zh) * | 2020-09-18 | 2022-06-10 | 广州古神生物科技有限公司 | 防霉抗菌剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
| NL8000869A (nl) * | 1979-02-16 | 1980-08-19 | Eisai Co Ltd | Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan. |
| JPH01166119A (ja) * | 1987-12-23 | 1989-06-30 | Hitachi Ltd | データ入力装置の制御方式 |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| PT93033B (pt) * | 1989-02-03 | 1996-03-29 | Lilly Co Eli | Processo para a preparacao de derivados de guanidina |
| US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
-
1993
- 1993-06-11 AU AU45306/93A patent/AU4530693A/en not_active Abandoned
- 1993-06-11 WO PCT/US1993/005458 patent/WO1994004499A1/en active Application Filing
- 1993-07-21 DK DK93917262.3T patent/DK0655057T3/da active
- 1993-07-21 AU AU46831/93A patent/AU4683193A/en not_active Abandoned
- 1993-07-21 EP EP93917262A patent/EP0655057B1/de not_active Expired - Lifetime
- 1993-07-21 ES ES93917262T patent/ES2107049T3/es not_active Expired - Lifetime
- 1993-07-21 WO PCT/US1993/006752 patent/WO1994004500A1/en active IP Right Grant
- 1993-07-21 JP JP6506258A patent/JPH08500111A/ja active Pending
- 1993-07-21 DE DE69314041T patent/DE69314041T2/de not_active Expired - Fee Related
- 1993-07-21 AT AT93917262T patent/ATE158279T1/de not_active IP Right Cessation
- 1993-08-03 TW TW082106192A patent/TW223017B/zh active
- 1993-08-03 ZA ZA935619A patent/ZA935619B/xx unknown
- 1993-08-07 MY MYPI93001565A patent/MY110826A/en unknown
- 1993-08-10 IL IL10664193A patent/IL106641A/en not_active IP Right Cessation
- 1993-08-12 MX MX9304882A patent/MX9304882A/es not_active IP Right Cessation
- 1993-08-13 CN CN93117781A patent/CN1039997C/zh not_active Expired - Fee Related
-
1995
- 1995-02-06 US US08/384,562 patent/US5567722A/en not_active Expired - Fee Related
-
1997
- 1997-12-10 GR GR970403292T patent/GR3025640T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1090575A (zh) | 1994-08-10 |
| DK0655057T3 (da) | 1998-04-14 |
| WO1994004500A1 (en) | 1994-03-03 |
| WO1994004499A1 (en) | 1994-03-03 |
| IL106641A0 (en) | 1993-12-08 |
| AU4530693A (en) | 1994-03-15 |
| DE69314041T2 (de) | 1998-02-05 |
| MX9304882A (es) | 1994-07-29 |
| CN1039997C (zh) | 1998-09-30 |
| EP0655057A1 (de) | 1995-05-31 |
| EP0655057B1 (de) | 1997-09-17 |
| TW223017B (de) | 1994-05-01 |
| GR3025640T3 (en) | 1998-03-31 |
| US5567722A (en) | 1996-10-22 |
| ZA935619B (en) | 1995-02-03 |
| MY110826A (en) | 1999-05-31 |
| JPH08500111A (ja) | 1996-01-09 |
| AU4683193A (en) | 1994-03-15 |
| ATE158279T1 (de) | 1997-10-15 |
| ES2107049T3 (es) | 1997-11-16 |
| IL106641A (en) | 2001-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |