DK0646006T3 - Stabile præparater af gastrobeskyttede omeprazolmikrogranuler og fremgangsmåde til opnåelse deraf - Google Patents
Stabile præparater af gastrobeskyttede omeprazolmikrogranuler og fremgangsmåde til opnåelse derafInfo
- Publication number
- DK0646006T3 DK0646006T3 DK93913137.1T DK93913137T DK0646006T3 DK 0646006 T3 DK0646006 T3 DK 0646006T3 DK 93913137 T DK93913137 T DK 93913137T DK 0646006 T3 DK0646006 T3 DK 0646006T3
- Authority
- DK
- Denmark
- Prior art keywords
- gastroprotected
- obtaining
- methods
- omeprazole
- stable preparations
- Prior art date
Links
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000381 omeprazole Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Epoxy Resins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Sampling And Sample Adjustment (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9207249A FR2692146B1 (fr) | 1992-06-16 | 1992-06-16 | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0646006T3 true DK0646006T3 (da) | 1997-10-13 |
Family
ID=9430771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93913137.1T DK0646006T3 (da) | 1992-06-16 | 1993-06-16 | Stabile præparater af gastrobeskyttede omeprazolmikrogranuler og fremgangsmåde til opnåelse deraf |
Country Status (25)
Country | Link |
---|---|
US (1) | US5385739A (da) |
EP (1) | EP0646006B1 (da) |
JP (1) | JP3568950B2 (da) |
KR (1) | KR100193966B1 (da) |
CN (1) | CN1051225C (da) |
AT (1) | ATE149835T1 (da) |
AU (1) | AU669719B2 (da) |
CA (1) | CA2138149C (da) |
CZ (1) | CZ287260B6 (da) |
DE (1) | DE69308849T2 (da) |
DK (1) | DK0646006T3 (da) |
ES (1) | ES2052458B1 (da) |
FI (1) | FI111220B (da) |
FR (1) | FR2692146B1 (da) |
GE (1) | GEP20002015B (da) |
GR (2) | GR1001535B (da) |
MD (1) | MD1472G2 (da) |
MX (1) | MX9303612A (da) |
NZ (1) | NZ253179A (da) |
PL (1) | PL172706B1 (da) |
RU (1) | RU2103995C1 (da) |
SK (1) | SK280198B6 (da) |
TJ (1) | TJ230B (da) |
WO (1) | WO1993025204A1 (da) |
ZA (1) | ZA934266B (da) |
Families Citing this family (95)
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RU2152212C1 (ru) * | 1994-01-14 | 2000-07-10 | Лаборатуар Де Продюи Этик Этифарм | Лекарственная форма производных 5-нитроимидазола |
US5834002A (en) | 1994-05-02 | 1998-11-10 | Josman Laboratories, Inc. | Chewing gum containing colloidal bismuth subcitrate |
US6902738B2 (en) * | 1994-05-02 | 2005-06-07 | Josman Laboratories, Inc. | Topical oral dosage forms containing bismuth compounds |
US6426085B1 (en) | 1994-05-02 | 2002-07-30 | Josman Laboratories Inc. | Use of bismuth-containing compounds in topical oral dosage forms for the treatment of halitosis |
ES2087823B1 (es) * | 1994-07-13 | 1997-02-16 | Estudes Et Richerches Pharma E | Formulacion de microgranulos gastroresistentes de omeprazol y su procedimiento de fabricacion. |
EP0749500B1 (en) * | 1994-10-18 | 1998-05-27 | Koninklijke Philips Electronics N.V. | Method of manufacturing a thin silicon-oxide layer |
ES2094694B1 (es) * | 1995-02-01 | 1997-12-16 | Esteve Quimica Sa | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
US6379651B1 (en) | 1995-02-07 | 2002-04-30 | Josman Laboratories | Oral-topical dosage forms for delivering antibacterials/antibiotics to oral cavity to eradicate H. pylori as a concomitant treatment for peptic ulcers and other gastro-intestinal diseases |
US6372784B1 (en) | 1995-02-07 | 2002-04-16 | Josman Laboratories, Inc. | Bismuth-containing compounds in topical dosage forms for treatment of corneal and dermal wounds |
AU4596796A (en) * | 1995-02-07 | 1996-08-27 | Narayan Krishnarao Athanikar | Concomitant treatment with bismuth and antibacterials |
US5547844A (en) * | 1995-02-23 | 1996-08-20 | The Regents Of The University Of California | Helicobacter pylori bacterial derived factor |
US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
ES2220989T3 (es) * | 1995-09-21 | 2004-12-16 | Pharma Pass Ii Llc | Nueva composicion que contiene benzimidazol labil al acido y procedimiento para su preparacion. |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
CO4771151A1 (es) * | 1996-01-19 | 1999-04-30 | Rachitzky Falicman Pablo Alberto | Procedimiento para la elaboracion de una preparacion farmace utica que contiene nifedipina y la preparacion farmaceutica obtenida mediante el mismo |
US6623759B2 (en) | 1996-06-28 | 2003-09-23 | Astrazeneca Ab | Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof |
FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
SE9702000D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Ab | New pharmaceutical formulation |
SI9700186B (sl) | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
ES2137862B1 (es) * | 1997-07-31 | 2000-09-16 | Intexim S A | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
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FR2771291B1 (fr) * | 1997-11-21 | 2000-02-25 | Ethypharm Lab Prod Ethiques | Spheroides, procede de preparation et compositions pharmaceutiques |
FR2774288B1 (fr) * | 1998-01-30 | 2001-09-07 | Ethypharm Sa | Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques |
DK173431B1 (da) | 1998-03-20 | 2000-10-23 | Gea Farmaceutisk Fabrik As | Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs |
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JP4988088B2 (ja) * | 1998-08-12 | 2012-08-01 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピリジン−2−イルメチルスルフィニル−1h−ベンズイミダゾール、もしくはピリジン−2−イルメチルスルフィニル−1h−ベンズイミダゾールの骨格を有する化合物、またはその薬学的に許容される塩の経口投与形組成物を固定的に組み合わせた組成物 |
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FR2793688B1 (fr) | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
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US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
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SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
SE457326B (sv) * | 1986-02-14 | 1988-12-19 | Lejus Medical Ab | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
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ES2024993A6 (es) * | 1990-12-31 | 1992-03-01 | Genesis Para La Investigacion | Procedimiento de obtencion de un preparado farmaceutico oral conteniendo omeprazol. |
-
1992
- 1992-06-16 FR FR9207249A patent/FR2692146B1/fr not_active Expired - Lifetime
- 1992-07-16 KR KR1019920012770A patent/KR100193966B1/ko not_active Expired - Lifetime
- 1992-10-08 GR GR920100433A patent/GR1001535B/el not_active IP Right Cessation
-
1993
- 1993-06-15 ES ES09301319A patent/ES2052458B1/es not_active Expired - Fee Related
- 1993-06-16 AU AU43321/93A patent/AU669719B2/en not_active Ceased
- 1993-06-16 MD MD96-0332A patent/MD1472G2/ro not_active IP Right Cessation
- 1993-06-16 US US08/078,548 patent/US5385739A/en not_active Expired - Lifetime
- 1993-06-16 ZA ZA934266A patent/ZA934266B/xx unknown
- 1993-06-16 JP JP50119994A patent/JP3568950B2/ja not_active Expired - Fee Related
- 1993-06-16 PL PL93306773A patent/PL172706B1/pl not_active IP Right Cessation
- 1993-06-16 AT AT93913137T patent/ATE149835T1/de active
- 1993-06-16 RU RU94046268A patent/RU2103995C1/ru not_active IP Right Cessation
- 1993-06-16 MX MX9303612A patent/MX9303612A/es not_active IP Right Cessation
- 1993-06-16 EP EP93913137A patent/EP0646006B1/fr not_active Expired - Lifetime
- 1993-06-16 DE DE69308849T patent/DE69308849T2/de not_active Expired - Lifetime
- 1993-06-16 CZ CZ19943165A patent/CZ287260B6/cs not_active IP Right Cessation
- 1993-06-16 WO PCT/FR1993/000582 patent/WO1993025204A1/fr active IP Right Grant
- 1993-06-16 CA CA002138149A patent/CA2138149C/fr not_active Expired - Lifetime
- 1993-06-16 NZ NZ253179A patent/NZ253179A/xx not_active IP Right Cessation
- 1993-06-16 DK DK93913137.1T patent/DK0646006T3/da active
- 1993-06-16 TJ TJ96000409A patent/TJ230B/xx unknown
- 1993-06-16 SK SK1551-94A patent/SK280198B6/sk not_active IP Right Cessation
- 1993-06-16 CN CN93108926A patent/CN1051225C/zh not_active Expired - Fee Related
- 1993-06-16 GE GEAP19932604A patent/GEP20002015B/en unknown
-
1994
- 1994-12-15 FI FI945904A patent/FI111220B/fi not_active IP Right Cessation
-
1997
- 1997-05-09 GR GR970401044T patent/GR3023391T3/el unknown
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