DK0628569T3 - Triterpenderivater og endothelinreceptorantagonister indeholdende samme - Google Patents
Triterpenderivater og endothelinreceptorantagonister indeholdende sammeInfo
- Publication number
- DK0628569T3 DK0628569T3 DK94304165.7T DK94304165T DK0628569T3 DK 0628569 T3 DK0628569 T3 DK 0628569T3 DK 94304165 T DK94304165 T DK 94304165T DK 0628569 T3 DK0628569 T3 DK 0628569T3
- Authority
- DK
- Denmark
- Prior art keywords
- same
- receptor antagonists
- endothelin receptor
- triterpene derivatives
- hydrogen
- Prior art date
Links
- 150000003648 triterpenes Chemical class 0.000 title abstract 2
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004185 ester group Chemical group 0.000 abstract 2
- 230000002503 metabolic effect Effects 0.000 abstract 2
- 102000002045 Endothelin Human genes 0.000 abstract 1
- 108050009340 Endothelin Proteins 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14041693 | 1993-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0628569T3 true DK0628569T3 (da) | 1996-09-30 |
Family
ID=15268217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94304165.7T DK0628569T3 (da) | 1993-06-11 | 1994-06-09 | Triterpenderivater og endothelinreceptorantagonister indeholdende samme |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5463107A (da) |
| EP (2) | EP0682009B1 (da) |
| JP (1) | JP2724114B2 (da) |
| KR (1) | KR100201015B1 (da) |
| CN (2) | CN1041938C (da) |
| AT (2) | ATE165811T1 (da) |
| DE (2) | DE69410081T2 (da) |
| DK (1) | DK0628569T3 (da) |
| ES (2) | ES2094622T3 (da) |
| GR (1) | GR3021952T3 (da) |
| TW (1) | TW272974B (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69410081T2 (de) | 1993-06-11 | 1998-10-08 | Shionogi & Co | Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten |
| ATE245447T1 (de) * | 1995-06-02 | 2003-08-15 | Shionogi & Co | Inhibitor von gehirnödemen |
| WO1997027314A1 (fr) * | 1996-01-23 | 1997-07-31 | Shionogi & Co., Ltd. | Processus de production d'analogues d'acide oleanolique par la culture de racine pileuse |
| TWI232102B (en) * | 2001-07-17 | 2005-05-11 | Shionogi & Co | A pharmaceutical formulation for injection |
| JP2007217438A (ja) * | 2001-07-17 | 2007-08-30 | Shionogi & Co Ltd | 注射用医薬製剤 |
| MXPA04008944A (es) * | 2002-03-22 | 2004-11-26 | Shionogi & Co | Procedimiento para derivados de triterpeno. |
| WO2004108163A1 (ja) * | 2003-06-04 | 2004-12-16 | Shionogi & Co., Ltd. | 低帯電性粉末の製造方法 |
| TWI335335B (en) * | 2004-03-24 | 2011-01-01 | Shionogi & Co | A novel crystal of a triterpene derivative |
| US8017793B2 (en) | 2004-05-14 | 2011-09-13 | Shionogi & Co., Ltd. | Oxidation of alcohol with use of hydrogen peroxide and tungsten catalyst |
| WO2006077801A1 (ja) * | 2005-01-18 | 2006-07-27 | Shionogi & Co., Ltd. | ミリセロン誘導体の製造方法 |
| TW200731966A (en) * | 2005-12-21 | 2007-09-01 | Shionogi & Co | A pharmaceutical composition or a method for treating ischemic stroke |
| US20070207989A1 (en) * | 2006-03-03 | 2007-09-06 | Savipu Pharmaceuticals | Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases |
| US7795306B2 (en) * | 2006-03-03 | 2010-09-14 | Inderjit Kumar Dev | Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of NF-κB |
| US7323476B2 (en) * | 2006-03-03 | 2008-01-29 | Savipu Pharmaceuticals | Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases |
| US20070243273A1 (en) * | 2006-04-12 | 2007-10-18 | Savipu Pharmaceuticals | Reduction of the Deleterious Effects of Tobacco Smoking |
| US20080017207A1 (en) * | 2006-07-18 | 2008-01-24 | Savipu Pharmaceuticals | Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2 |
| US20080187608A1 (en) * | 2007-02-05 | 2008-08-07 | Savipu Pharmaceuticals | Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases |
| US20090022821A1 (en) * | 2007-07-17 | 2009-01-22 | Inderjit Kumar Dev | Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2115665T3 (es) | 1991-01-29 | 1998-07-01 | Shionogi & Co | Derivado de triterpeno. |
| DE69410081T2 (de) | 1993-06-11 | 1998-10-08 | Shionogi & Co | Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten |
-
1994
- 1994-06-09 DE DE69410081T patent/DE69410081T2/de not_active Expired - Lifetime
- 1994-06-09 ES ES94304165T patent/ES2094622T3/es not_active Expired - Lifetime
- 1994-06-09 TW TW083105247A patent/TW272974B/zh not_active IP Right Cessation
- 1994-06-09 JP JP6127420A patent/JP2724114B2/ja not_active Expired - Fee Related
- 1994-06-09 ES ES95112524T patent/ES2116663T3/es not_active Expired - Lifetime
- 1994-06-09 EP EP95112524A patent/EP0682009B1/en not_active Expired - Lifetime
- 1994-06-09 AT AT95112524T patent/ATE165811T1/de not_active IP Right Cessation
- 1994-06-09 DK DK94304165.7T patent/DK0628569T3/da active
- 1994-06-09 DE DE69400506T patent/DE69400506T2/de not_active Expired - Lifetime
- 1994-06-09 EP EP94304165A patent/EP0628569B1/en not_active Expired - Lifetime
- 1994-06-09 AT AT94304165T patent/ATE142640T1/de not_active IP Right Cessation
- 1994-06-10 US US08/258,392 patent/US5463107A/en not_active Expired - Lifetime
- 1994-06-10 CN CN94102805A patent/CN1041938C/zh not_active Expired - Fee Related
- 1994-06-10 KR KR1019940013068A patent/KR100201015B1/ko not_active IP Right Cessation
-
1995
- 1995-07-26 US US08/507,211 patent/US5587505A/en not_active Expired - Lifetime
-
1996
- 1996-12-10 GR GR960403369T patent/GR3021952T3/el unknown
-
1998
- 1998-05-20 CN CN98109227A patent/CN1070183C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2116663T3 (es) | 1998-07-16 |
| ATE142640T1 (de) | 1996-09-15 |
| KR100201015B1 (ko) | 1999-06-15 |
| US5463107A (en) | 1995-10-31 |
| EP0682009A2 (en) | 1995-11-15 |
| CN1070183C (zh) | 2001-08-29 |
| EP0682009A3 (en) | 1997-02-05 |
| US5587505A (en) | 1996-12-24 |
| DE69410081D1 (de) | 1998-06-10 |
| DE69410081T2 (de) | 1998-10-08 |
| EP0682009B1 (en) | 1998-05-06 |
| CN1041938C (zh) | 1999-02-03 |
| CN1215725A (zh) | 1999-05-05 |
| ATE165811T1 (de) | 1998-05-15 |
| EP0628569A1 (en) | 1994-12-14 |
| DE69400506D1 (de) | 1996-10-17 |
| JPH0753484A (ja) | 1995-02-28 |
| JP2724114B2 (ja) | 1998-03-09 |
| ES2094622T3 (es) | 1997-01-16 |
| EP0628569B1 (en) | 1996-09-11 |
| TW272974B (da) | 1996-03-21 |
| CN1106368A (zh) | 1995-08-09 |
| DE69400506T2 (de) | 1997-02-13 |
| KR950000663A (ko) | 1995-01-03 |
| GR3021952T3 (en) | 1997-03-31 |
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