DE69400506D1 - Triterpenderivate und diese enthaltende Endothelinrezeptor Antagonisten - Google Patents

Triterpenderivate und diese enthaltende Endothelinrezeptor Antagonisten

Info

Publication number: DE69400506D1
Authority: DE; Germany
Prior art keywords: receptor antagonists; endothelin receptor; triterpene derivatives; hydrogen; antagonists containing
Prior art date: 1993-06-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69400506T

Other languages

English (en)

Other versions

DE69400506T2 (de

Inventor

Toshiro Konoike

Yoshitaka Araki

Tetsuyoshi Hayashi

Kensuke Sakurai

Takehiko Tozyo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shionogi and Co Ltd

Original Assignee

Shionogi and Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-11

Filing date

1994-06-09

Publication date

1996-10-17

1994-06-09 Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd

1996-10-17 Publication of DE69400506D1 publication Critical patent/DE69400506D1/de

1997-02-13 Application granted granted Critical

1997-02-13 Publication of DE69400506T2 publication Critical patent/DE69400506T2/de

2014-06-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000003648 triterpenes Chemical class 0.000 title abstract 2
229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
239000002308 endothelin receptor antagonist Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004185 ester group Chemical group 0.000 abstract 2
230000002503 metabolic effect Effects 0.000 abstract 2
102000002045 Endothelin Human genes 0.000 abstract 1
108050009340 Endothelin Proteins 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE69400506T 1993-06-11 1994-06-09 Triterpenderivate und diese enthaltende Endothelinrezeptor Antagonisten Expired - Lifetime DE69400506T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP14041693		1993-06-11

Publications (2)

Publication Number	Publication Date
DE69400506D1 true DE69400506D1 (de)	1996-10-17
DE69400506T2 DE69400506T2 (de)	1997-02-13

Family

ID=15268217

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69410081T Expired - Lifetime DE69410081T2 (de)	1993-06-11	1994-06-09	Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten
DE69400506T Expired - Lifetime DE69400506T2 (de)	1993-06-11	1994-06-09	Triterpenderivate und diese enthaltende Endothelinrezeptor Antagonisten

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69410081T Expired - Lifetime DE69410081T2 (de)	1993-06-11	1994-06-09	Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten

Country Status (11)

Country	Link
US (2)	US5463107A (de)
EP (2)	EP0682009B1 (de)
JP (1)	JP2724114B2 (de)
KR (1)	KR100201015B1 (de)
CN (2)	CN1041938C (de)
AT (2)	ATE165811T1 (de)
DE (2)	DE69410081T2 (de)
DK (1)	DK0628569T3 (de)
ES (2)	ES2094622T3 (de)
GR (1)	GR3021952T3 (de)
TW (1)	TW272974B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69410081T2 (de)	1993-06-11	1998-10-08	Shionogi & Co	Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten
ATE245447T1 (de) *	1995-06-02	2003-08-15	Shionogi & Co	Inhibitor von gehirnödemen
WO1997027314A1 (fr) *	1996-01-23	1997-07-31	Shionogi & Co., Ltd.	Processus de production d'analogues d'acide oleanolique par la culture de racine pileuse
TWI232102B (en) *	2001-07-17	2005-05-11	Shionogi & Co	A pharmaceutical formulation for injection
JP2007217438A (ja) *	2001-07-17	2007-08-30	Shionogi & Co Ltd	注射用医薬製剤
MXPA04008944A (es) *	2002-03-22	2004-11-26	Shionogi & Co	Procedimiento para derivados de triterpeno.
WO2004108163A1 (ja) *	2003-06-04	2004-12-16	Shionogi & Co., Ltd.	低帯電性粉末の製造方法
TWI335335B (en) *	2004-03-24	2011-01-01	Shionogi & Co	A novel crystal of a triterpene derivative
US8017793B2 (en)	2004-05-14	2011-09-13	Shionogi & Co., Ltd.	Oxidation of alcohol with use of hydrogen peroxide and tungsten catalyst
WO2006077801A1 (ja) *	2005-01-18	2006-07-27	Shionogi & Co., Ltd.	ミリセロン誘導体の製造方法
TW200731966A (en) *	2005-12-21	2007-09-01	Shionogi & Co	A pharmaceutical composition or a method for treating ischemic stroke
US20070207989A1 (en) *	2006-03-03	2007-09-06	Savipu Pharmaceuticals	Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US7795306B2 (en) *	2006-03-03	2010-09-14	Inderjit Kumar Dev	Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of NF-κB
US7323476B2 (en) *	2006-03-03	2008-01-29	Savipu Pharmaceuticals	Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070243273A1 (en) *	2006-04-12	2007-10-18	Savipu Pharmaceuticals	Reduction of the Deleterious Effects of Tobacco Smoking
US20080017207A1 (en) *	2006-07-18	2008-01-24	Savipu Pharmaceuticals	Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) *	2007-02-05	2008-08-07	Savipu Pharmaceuticals	Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) *	2007-07-17	2009-01-22	Inderjit Kumar Dev	Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2115665T3 (es)	1991-01-29	1998-07-01	Shionogi & Co	Derivado de triterpeno.
DE69410081T2 (de)	1993-06-11	1998-10-08	Shionogi & Co	Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten

1994
- 1994-06-09 DE DE69410081T patent/DE69410081T2/de not_active Expired - Lifetime
- 1994-06-09 ES ES94304165T patent/ES2094622T3/es not_active Expired - Lifetime
- 1994-06-09 TW TW083105247A patent/TW272974B/zh not_active IP Right Cessation
- 1994-06-09 JP JP6127420A patent/JP2724114B2/ja not_active Expired - Fee Related
- 1994-06-09 ES ES95112524T patent/ES2116663T3/es not_active Expired - Lifetime
- 1994-06-09 EP EP95112524A patent/EP0682009B1/de not_active Expired - Lifetime
- 1994-06-09 AT AT95112524T patent/ATE165811T1/de not_active IP Right Cessation
- 1994-06-09 DK DK94304165.7T patent/DK0628569T3/da active
- 1994-06-09 DE DE69400506T patent/DE69400506T2/de not_active Expired - Lifetime
- 1994-06-09 EP EP94304165A patent/EP0628569B1/de not_active Expired - Lifetime
- 1994-06-09 AT AT94304165T patent/ATE142640T1/de not_active IP Right Cessation
- 1994-06-10 US US08/258,392 patent/US5463107A/en not_active Expired - Lifetime
- 1994-06-10 CN CN94102805A patent/CN1041938C/zh not_active Expired - Fee Related
- 1994-06-10 KR KR1019940013068A patent/KR100201015B1/ko not_active IP Right Cessation
1995
- 1995-07-26 US US08/507,211 patent/US5587505A/en not_active Expired - Lifetime
1996
- 1996-12-10 GR GR960403369T patent/GR3021952T3/el unknown
1998
- 1998-05-20 CN CN98109227A patent/CN1070183C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2116663T3 (es)	1998-07-16
ATE142640T1 (de)	1996-09-15
KR100201015B1 (ko)	1999-06-15
US5463107A (en)	1995-10-31
EP0682009A2 (de)	1995-11-15
CN1070183C (zh)	2001-08-29
EP0682009A3 (de)	1997-02-05
US5587505A (en)	1996-12-24
DE69410081D1 (de)	1998-06-10
DE69410081T2 (de)	1998-10-08
EP0682009B1 (de)	1998-05-06
CN1041938C (zh)	1999-02-03
CN1215725A (zh)	1999-05-05
ATE165811T1 (de)	1998-05-15
EP0628569A1 (de)	1994-12-14
JPH0753484A (ja)	1995-02-28
JP2724114B2 (ja)	1998-03-09
DK0628569T3 (da)	1996-09-30
ES2094622T3 (es)	1997-01-16
EP0628569B1 (de)	1996-09-11
TW272974B (de)	1996-03-21
CN1106368A (zh)	1995-08-09
DE69400506T2 (de)	1997-02-13
KR950000663A (ko)	1995-01-03
GR3021952T3 (en)	1997-03-31

Publication	Publication Date	Title
DE69400506D1 (de)	1996-10-17	Triterpenderivate und diese enthaltende Endothelinrezeptor Antagonisten
ES2086270T5 (es)	2001-02-01	Metabolitos de terfenadina y sus isomeros opticamente puros para tratar trastornos alergicos.
MX9102407A (es)	1994-05-31	4 arilpiperazinas y 4-arilpiperidinas novedosas.
DK1920764T3 (da)	2012-07-02	Fluprostenolisopropylester til anvendelse i behandling af glaukom og okulær hypertension
EP0896533A4 (de)	1999-04-28	Pentafluorobenzensulfonamiden und analoge
ES2172580T3 (es)	2002-10-01	1,3-oxatiolanos sustituidos con propiedades antiviricas.
ES2087038A1 (es)	1996-07-01	Nuevas piperidinas con actividad antagonista del paf.
ES2106531T3 (es)	1997-11-01	Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.
BR8902929A (pt)	1990-03-20	Artigo vendavel
DK0573218T3 (da)	2001-06-18	4-carboxyimidazolderivater som angiotensin-II antagonister og deres terapeutiske anvendelse
NO915021D0 (no)	1991-12-19	Nye metylenbisfosfonsyrederivater
ZA894397B (en)	1990-02-28	Analgesic phenothiazine derivatives
HU9400908D0 (en)	1994-06-28	Pharmaceutical compositions for treatng skin disorders
ATE110569T1 (de)	1994-09-15	Pharmazeutische zusammensetzung zur verbesserung von dysuria.
FI923662A0 (fi)	1992-08-14	Terapeutiska medel.
ZA922625B (en)	1992-11-25	Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients
ES472208A1 (es)	1979-03-16	Procedimiento para la obtencion de nuevos derivados de 2- bencimidazol.
DE59504374D1 (de)	1999-01-14	Verwendung von Deoxyspergualin zur Herstellung eines Arzneimittels zur Behandlung von entzündlich-hyperreaktiven Erkrankungen
IT1313583B1 (it)	2002-09-09	Derivati 2-amminotetralinici per la terapia del glaucoma.
ATE92461T1 (de)	1993-08-15	Gegen die zerebrale insuffizienz wirksame verbindungen.
ITMI911095A1 (it)	1992-10-19	COMPOSIZIONI FARMACEUTICHE CONTENENTI L'ESTERE 4-(2 METILAMMINOETIL)1, 2- FENILENICODELLyACIDO 2-METILPROPANOICO PER IL TRATTAMENTO DELLA NEUROOTTICOPATIA GLAUCOMATOSA
ITMI932285A1 (it)	1995-04-27	Disolfuro chinolonico antibatterico
IT1244696B (it)	1994-08-08	Derivato chinolonico ad attivita' antibatterica e mucolitica

Legal Events

Date	Code	Title	Description
1997-10-09	8364	No opposition during term of opposition