DK0587799T3 - Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning - Google Patents

Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning

Info

Publication number: DK0587799T3
Authority: DK; Denmark
Prior art keywords: cathepsin; connective tissue; elastase; inhibitors; tissue degradation
Prior art date: 1991-05-23

Application number

DK92914209T

Other languages

English (en)

Inventor

Philippe Bey

Norton P Peet

Michael R Angelastro

Niall S Doherty

Michael J Janusz

Shujaath Mehdi

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-23

Filing date

1992-04-21

Publication date

1999-11-22

1992-04-21 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1999-11-22 Application granted granted Critical

1999-11-22 Publication of DK0587799T3 publication Critical patent/DK0587799T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Dental Preparations (AREA)
Transceivers (AREA)
Mobile Radio Communication Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Vehicle Body Suspensions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK92914209T 1991-05-23 1992-04-21 Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning DK0587799T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70449991A	1991-05-23	1991-05-23
PCT/US1992/003288 WO1992020357A1 (en)	1991-05-23	1992-04-21	Inhibitors of cathepsin g and elastase for preventing connective tissue degradation

Publications (1)

Publication Number	Publication Date
DK0587799T3 true DK0587799T3 (da)	1999-11-22

Family

ID=24829789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92914209T DK0587799T3 (da)	1991-05-23	1992-04-21	Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning

Country Status (17)

Country	Link
US (1)	US5510333A (da)
EP (1)	EP0587799B1 (da)
JP (1)	JP3442075B2 (da)
AT (1)	ATE181925T1 (da)
AU (1)	AU655301B2 (da)
DE (1)	DE69229552T2 (da)
DK (1)	DK0587799T3 (da)
ES (1)	ES2136091T3 (da)
FI (1)	FI935172L (da)
GR (1)	GR3031005T3 (da)
HU (1)	HU217612B (da)
IL (1)	IL101925A (da)
NO (1)	NO934218D0 (da)
NZ (1)	NZ242807A (da)
PT (1)	PT100517B (da)
WO (1)	WO1992020357A1 (da)
ZA (1)	ZA923602B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5714470A (en) *	1991-08-22	1998-02-03	Merrell Pharmaceuticals, Inc.	Orally-active elastase inhibitors
ES2192190T3 (es) *	1992-04-10	2003-10-01	Abbott Lab	Fragmentos proteicos tensioactivos pulmonares.
CA2137832C (en) *	1992-06-12	2000-09-26	Dennis J. Hoover	Inhibitors of angiotensin i chymase(s) including human heart chymase
KR100367389B1 (ko) *	1994-06-02	2003-07-18	메렐 파마슈티칼스 인크.	엘라스타제억제제의프로드러그로서아실화에놀유도체
CN1152048C (zh) *	1994-06-02	2004-06-02	默里尔药物公司	弹性蛋白酶的全氟烷基酮抑制剂及其制备方法
US5804560A (en) *	1995-01-06	1998-09-08	Sibia Neurosciences, Inc.	Peptide and peptide analog protease inhibitors
US5872101A (en) *	1995-01-06	1999-02-16	Sibia Neurosciences, Inc.	Methods of treating neurodegenerative disorders using protease inhibitors
US5693515A (en) *	1995-04-28	1997-12-02	Arris Pharmaceutical Corporation	Metal complexed serine protease inhibitors
DE19543750C2 (de) *	1995-11-24	1997-10-23	Crinos Industria Farmaco	Cathepsin G inhibierende Aptamere
US6172044B1 (en)	1995-12-01	2001-01-09	Aventis Pharmaceuticals Inc.	Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) *	1996-11-20	1999-09-07	Hoechst Marion Roussel, Inc.	Acylated enol derivatives of α-ketoesters and α-ketoamides
PT912601E (pt)	1996-04-22	2004-04-30	Massachusetts Inst Technology	Supressao da resposta imune via inibicao da catepsina s
JP2002047256A (ja) *	2000-07-26	2002-02-12	Kanegafuchi Chem Ind Co Ltd	α−アミノ−α´，α´，α´−トリハロケトン誘導体、α−アミノ−α´，α´，α´−トリハロアルコ−ル誘導体、及び、α−ヒドロキシ−β−アミノカルボン酸誘導体の製造法
WO2008054144A1 (en) *	2006-11-03	2008-05-08	Amorepacific Corporation	Skin external composition containing cathepsin g inhibitors for preventing skin aging and the screening method for development of antiaging materials
US8883857B2 (en)	2012-12-07	2014-11-11	Baylor College Of Medicine	Small molecule xanthine oxidase inhibitors and methods of use
EP4031138A1 (en)	2019-09-17	2022-07-27	Mereo Biopharma 4 Limited	Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
PL4106757T3 (pl)	2020-04-16	2024-01-22	Mereo Biopharma 4 Limited	Sposoby z udziałem inhibitora elastazy neutrofilowej, alwelestatu, do leczenia choroby układu oddechowego, w której pośredniczy niedobór alfa-1 antytrypsyny
WO2021252491A1 (en)	2020-06-10	2021-12-16	Aligos Therapeutics, Inc.	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
KR20240035513A (ko)	2021-07-09	2024-03-15	알리고스 테라퓨틱스 인코포레이티드	항바이러스 화합물
US12065428B2 (en)	2021-09-17	2024-08-20	Aligos Therapeutics, Inc.	Anti-viral compounds
KR20240090272A (ko)	2021-10-20	2024-06-21	메레오 바이오파마 4 리미티드	섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3230275A1 (de) *	1982-08-14	1984-02-16	Bayer Ag, 5090 Leverkusen	Elastaseinhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel
DE3324534A1 (de) *	1983-07-07	1985-01-17	Ciba-Geigy Ag, Basel	Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
US4629724A (en) *	1984-12-03	1986-12-16	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitors
US4643991A (en) *	1984-12-18	1987-02-17	The University Of Kentucky Research Foundation	Peptide elastase inhibitors and methods
US5055450A (en) *	1985-01-22	1991-10-08	Ici Americas Inc.	Peptide derivatives
GB8600263D0 (en) *	1985-01-22	1986-02-12	Ici America Inc	Peptide derivatives
AU600226B2 (en) *	1985-02-04	1990-08-09	Merrell Pharmaceuticals Inc.	Novel peptidase inhibitors
ATE71934T1 (de) *	1985-06-07	1992-02-15	Ici America Inc	Selektionierte difluorverbindungen.
GB8613703D0 (en) *	1986-06-05	1986-07-09	Ici America Inc	Difluoro peptide compounds
NZ223148A (en) *	1987-01-16	1989-10-27	Merrell Dow Pharma	Peptide derivatives having peptidase inhibition activity
EP0307662A3 (en) *	1987-08-24	1990-07-25	Kabushiki Kaisha Vitamin Kenkyusyo	Enkephalin analogs
EP0356595A1 (en) *	1988-09-01	1990-03-07	Merrell Dow Pharmaceuticals Inc.	Novel peptidase inhibitors
ZA897515B (en) *	1988-10-07	1990-06-27	Merrell Dow Pharma	Novel peptidase inhibitors
CA2021660A1 (en) *	1989-07-26	1991-01-27	Philippe Bey	Peptidase inhibitors
DE3938971A1 (de) *	1989-11-24	1991-05-29	Biotechnolog Forschung Gmbh	Leukozytenelastase und kathepsin g blockierendes peptid, dna, vektor, wirtsorganismus und verfahren zu seiner gewinnung sowie pharmazeutisches praeparat

1992
- 1992-04-21 EP EP92914209A patent/EP0587799B1/en not_active Expired - Lifetime
- 1992-04-21 DE DE69229552T patent/DE69229552T2/de not_active Expired - Fee Related
- 1992-04-21 AT AT92914209T patent/ATE181925T1/de not_active IP Right Cessation
- 1992-04-21 ES ES92914209T patent/ES2136091T3/es not_active Expired - Lifetime
- 1992-04-21 DK DK92914209T patent/DK0587799T3/da active
- 1992-04-21 AU AU21841/92A patent/AU655301B2/en not_active Ceased
- 1992-04-21 JP JP50004493A patent/JP3442075B2/ja not_active Expired - Fee Related
- 1992-04-21 WO PCT/US1992/003288 patent/WO1992020357A1/en active IP Right Grant
- 1992-04-21 HU HU9303314A patent/HU217612B/hu not_active IP Right Cessation
- 1992-05-18 ZA ZA923602A patent/ZA923602B/xx unknown
- 1992-05-19 IL IL10192592A patent/IL101925A/en not_active IP Right Cessation
- 1992-05-20 NZ NZ24280792A patent/NZ242807A/en unknown
- 1992-05-22 PT PT100517A patent/PT100517B/pt not_active IP Right Cessation
1993
- 1993-11-22 FI FI935172A patent/FI935172L/fi unknown
- 1993-11-22 NO NO934218A patent/NO934218D0/no not_active Application Discontinuation
1995
- 1995-06-05 US US08/462,456 patent/US5510333A/en not_active Expired - Fee Related
1999
- 1999-08-18 GR GR990402083T patent/GR3031005T3/el unknown

Also Published As

Publication number	Publication date
HU217612B (hu)	2000-03-28
ZA923602B (en)	1993-02-24
US5510333A (en)	1996-04-23
HUT65140A (en)	1994-04-28
NO934218L (no)	1993-11-22
JP3442075B2 (ja)	2003-09-02
IL101925A (en)	1996-03-31
EP0587799A1 (en)	1994-03-23
EP0587799B1 (en)	1999-07-07
NO934218D0 (no)	1993-11-22
HU9303314D0 (en)	1994-03-28
GR3031005T3 (en)	1999-12-31
FI935172A0 (fi)	1993-11-22
PT100517A (pt)	1993-09-30
WO1992020357A1 (en)	1992-11-26
PT100517B (pt)	1999-06-30
IL101925A0 (en)	1992-12-30
FI935172L (fi)	1993-11-22
JPH06508355A (ja)	1994-09-22
NZ242807A (en)	1994-07-26
ATE181925T1 (de)	1999-07-15
DE69229552D1 (de)	1999-08-12
AU2184192A (en)	1992-12-30
EP0587799A4 (en)	1995-06-14
ES2136091T3 (es)	1999-11-16
AU655301B2 (en)	1994-12-15
DE69229552T2 (de)	1999-12-23

Publication	Publication Date	Title
DK0587799T3 (da)	1999-11-22	Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning
DK0793674T3 (da)	2000-08-14	Inhibitorer af human neutrofil elastase
FI961886L (fi)	1996-07-03	Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit
FI943233L (fi)	1994-07-06	Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos
FI943232L (fi)	1994-07-06	Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos
FI943234L (fi)	1994-07-06	Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos
ATE199090T1 (de)	2001-02-15	Gegenüber eigenen inhibitoren resistente t-pa mutanten
FI944804A0 (fi)	1994-10-12	Pyrimidinyyliasetamideja elastaasin estäjinä
DE59200089D1 (de)	1994-04-21	Hochdruckentladungslampe kleiner Leistung.
NO930731D0 (no)	1993-02-26	Kininogenaseinhibitorer
ATE148130T1 (de)	1997-02-15	Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
FI943231L (fi)	1994-07-06	Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnoksia
DE69103827D1 (de)	1994-10-13	Schraubenverdichter.
EA199800200A1 (ru)	1998-10-29	Ингибиторы пролилэндопептидазы
DK0666755T3 (da)	2003-08-04	Inhibering af HIV-infektion
CA2109516A1 (en)	1992-11-24	Inhibitors of cathepsin g and elastase for preventing connective tissue degradation
KR940027038U (ko)	1994-12-09	압축기의 소음기
KR930010655U (ko)	1993-06-23	파철판의 압축기
ECSP951559A (es)	1997-04-04	Inhibidores de la 5- lipoxigenasa
KR950006808U (ko)	1995-03-21	개량 자바라 펌프
NO931841D0 (no)	1993-05-19	Forbedrede matriksmetallproteasehemmere
NO931844D0 (no)	1993-05-19	Forbedrede matriks metallproteasehemmere