NO930731D0 - Kininogenaseinhibitorer - Google Patents
KininogenaseinhibitorerInfo
- Publication number
- NO930731D0 NO930731D0 NO930731A NO930731A NO930731D0 NO 930731 D0 NO930731 D0 NO 930731D0 NO 930731 A NO930731 A NO 930731A NO 930731 A NO930731 A NO 930731A NO 930731 D0 NO930731 D0 NO 930731D0
- Authority
- NO
- Norway
- Prior art keywords
- kininogenase inhibitor
- kininogenase
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909019558A GB9019558D0 (en) | 1990-09-07 | 1990-09-07 | Enzyme inhibitors |
| PCT/GB1991/001479 WO1992004371A1 (en) | 1990-09-07 | 1991-09-02 | Kininogenase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO930731D0 true NO930731D0 (no) | 1993-02-26 |
| NO930731L NO930731L (no) | 1993-05-07 |
Family
ID=10681831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93930731A NO930731L (no) | 1990-09-07 | 1993-02-26 | Kininogenaseinhibitorer |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0652893A1 (no) |
| JP (1) | JPH06501461A (no) |
| AU (1) | AU8438791A (no) |
| CA (1) | CA2090858A1 (no) |
| FI (1) | FI930946A (no) |
| GB (1) | GB9019558D0 (no) |
| HU (1) | HUT64084A (no) |
| IE (1) | IE913120A1 (no) |
| MC (1) | MC2313A1 (no) |
| NO (1) | NO930731L (no) |
| PT (1) | PT98885A (no) |
| WO (1) | WO1992004371A1 (no) |
| ZA (1) | ZA917096B (no) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| US5374623A (en) * | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| SE9301911D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptide derivatives |
| US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
| US5780631A (en) * | 1993-06-03 | 1998-07-14 | Astra Aktiebolag | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
| GB9318637D0 (en) * | 1993-09-08 | 1993-10-27 | Ferring Res Ltd | Enzyme inhibitors |
| US5486623A (en) | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
| SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
| US5696231A (en) * | 1994-12-21 | 1997-12-09 | Corvas International, Inc. | N-substituted glycine derivatives as enzyme inhibitors |
| US6025472A (en) * | 1994-12-21 | 2000-02-15 | Corvas International, Inc. | N-substituted glycine derivatives as enzyme inhibitors |
| US6586466B2 (en) | 1995-10-30 | 2003-07-01 | Smithkline Beecham Corporation | Carbohydrazide-protease inhibitors |
| AU1118097A (en) | 1995-10-30 | 1997-05-22 | Smithkline Beecham Corporation | Protease inhibitors |
| AR005245A1 (es) | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
| JP2003529528A (ja) | 1998-04-24 | 2003-10-07 | ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド | プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン |
| YU42401A (sh) | 1998-12-14 | 2003-12-31 | Ortho-Mcneil Pharmaceuticals Inc. | Supstituisani heterociklični acil-tripeptidi korisni kao modulatori receptora trombina |
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| EP1930021A3 (en) | 1999-02-18 | 2008-06-18 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
| JP2003513972A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテアーゼ阻害剤 |
| AU1474801A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2001034599A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| MXPA02009305A (es) | 2000-03-21 | 2003-03-12 | Smithkline Beecham Corp | Inhibidores de proteasa. |
| GB0205527D0 (en) * | 2002-03-08 | 2002-04-24 | Ferring Bv | Inhibitors |
| JP2006511452A (ja) | 2002-07-03 | 2006-04-06 | バイオ サイエンス インターナショナル インコーポレイテッド | 芳香族ｄ−アミノ酸を含むペプチドおよびその利用方法 |
| FR2846969A1 (fr) * | 2002-11-08 | 2004-05-14 | Salles Jean Pierre | Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical |
| EP1736465A4 (en) | 2004-03-31 | 2009-06-17 | Ajinomoto Kk | ANILINE DERIVATIVES |
| GB0918922D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
| GB0918923D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminothiazole derivatives |
| GB0918924D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Azaindole derivatives |
| GB2494851A (en) | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
| GB201212081D0 (en) | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
| IL239682B (en) | 2013-01-08 | 2018-10-31 | Kalvista Pharmaceuticals Ltd | History of benzylamine and 2-(aminomethyl)pyridine |
| GB201300304D0 (en) | 2013-01-08 | 2013-02-20 | Kalvista Pharmaceuticals Ltd | Benzylamine derivatives |
| GB2510407A (en) | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
| KR102276700B1 (ko) | 2013-05-23 | 2021-07-12 | 칼비스타 파마슈티컬즈 리미티드 | 헤테로사이클릭 유도체 |
| GB2517908A (en) | 2013-08-14 | 2015-03-11 | Kalvista Pharmaceuticals Ltd | Bicyclic inhibitors |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| MX366498B (es) | 2013-08-14 | 2019-07-11 | Kalvista Pharmaceuticals Ltd | Inhibidores de calicreina plasmatica. |
| RU2728785C2 (ru) | 2014-10-06 | 2020-07-31 | Кортексим, Инк. | Ингибиторы лизинспецифичного гингипаина |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421088D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| CA3004095A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| BR112018074395A2 (pt) | 2016-05-31 | 2019-03-06 | Kalvista Pharmaceuticals Limited | derivados de pirazol como inibidores de calicreína plasmática |
| GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| AU2017326466B2 (en) | 2016-09-16 | 2021-11-11 | Lighthouse Pharmaceuticals, Inc. | Ketone inhibitors of lysine gingipain |
| CN107011217B (zh) * | 2017-03-24 | 2018-08-14 | 东华大学 | 一类脂溶性5-氨基酮戊酸衍生物及其制备方法和应用 |
| CN107043338B (zh) * | 2017-03-24 | 2018-09-25 | 东华大学 | 一类5-氨基酮戊酸衍生物及其制备方法和应用 |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| SMT202200112T1 (it) | 2017-11-29 | 2022-05-12 | Kalvista Pharmaceuticals Ltd | Forme di dosaggio comprendenti un inibitore della callicreina plasmatica |
| GB201910125D0 (en) | 2019-07-15 | 2019-08-28 | Kalvista Pharmaceuticals Ltd | Treatments of angioedema |
| GB201910116D0 (en) | 2019-07-15 | 2019-08-28 | Kalvista Pharmaceuticals Ltd | Treatments of hereditary angioedema |
| EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| GB2591730A (en) | 2019-12-09 | 2021-08-11 | Kalvista Pharmaceuticals Ltd | New polymorphs |
| GB201918994D0 (en) | 2019-12-20 | 2020-02-05 | Kalvista Pharmaceuticals Ltd | Treatments of diabetic macular edema and impaired visual acuity |
| WO2022079446A1 (en) | 2020-10-15 | 2022-04-21 | Kalvista Pharmaceuticals Limited | Treatments of angioedema |
| WO2022084693A1 (en) | 2020-10-23 | 2022-04-28 | Kalvista Pharmaceuticals Limited | Treatments of angioedema |
| US20240122909A1 (en) | 2021-02-09 | 2024-04-18 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
| WO2023002219A1 (en) | 2021-07-23 | 2023-01-26 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
| CN119095589A (zh) | 2022-04-27 | 2024-12-06 | 卡尔维斯塔制药有限公司 | 血浆激肽释放酶抑制剂的制剂 |
| WO2024180100A1 (en) | 2023-02-27 | 2024-09-06 | Kalvista Pharmaceuticals Limited | New solid form of a plasma kallikrein inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0009010B1 (en) * | 1978-07-18 | 1983-03-02 | Kabi AB | Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them |
| US4563305A (en) * | 1981-01-07 | 1986-01-07 | University Of Miami | Radiolabelled substrates for assaying mammalian enzymes |
| US4835253A (en) * | 1987-04-03 | 1989-05-30 | The University Hospital | Specific inhibitors of tissue kallikrein |
| ZA897514B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
-
1990
- 1990-09-07 GB GB909019558A patent/GB9019558D0/en active Pending
-
1991
- 1991-09-02 AU AU84387/91A patent/AU8438791A/en not_active Abandoned
- 1991-09-02 HU HU93610A patent/HUT64084A/hu unknown
- 1991-09-02 JP JP3514802A patent/JPH06501461A/ja active Pending
- 1991-09-02 MC MC912313D patent/MC2313A1/xx unknown
- 1991-09-02 WO PCT/GB1991/001479 patent/WO1992004371A1/en not_active Application Discontinuation
- 1991-09-02 CA CA002090858A patent/CA2090858A1/en not_active Abandoned
- 1991-09-02 EP EP91915557A patent/EP0652893A1/en not_active Withdrawn
- 1991-09-05 IE IE312091A patent/IE913120A1/en unknown
- 1991-09-06 ZA ZA917096A patent/ZA917096B/xx unknown
- 1991-09-06 PT PT98885A patent/PT98885A/pt not_active Application Discontinuation
-
1993
- 1993-02-26 NO NO93930731A patent/NO930731L/no unknown
- 1993-03-03 FI FI930946A patent/FI930946A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992004371A1 (en) | 1992-03-19 |
| ZA917096B (en) | 1992-04-29 |
| NO930731L (no) | 1993-05-07 |
| PT98885A (pt) | 1992-08-31 |
| IE913120A1 (en) | 1992-03-11 |
| MC2313A1 (fr) | 1993-09-27 |
| HU9300610D0 (en) | 1993-05-28 |
| AU8438791A (en) | 1992-03-30 |
| FI930946A (fi) | 1993-04-26 |
| HUT64084A (en) | 1993-11-29 |
| FI930946A0 (fi) | 1993-03-03 |
| CA2090858A1 (en) | 1992-03-08 |
| EP0652893A1 (en) | 1995-05-17 |
| GB9019558D0 (en) | 1990-10-24 |
| JPH06501461A (ja) | 1994-02-17 |
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