DK0585986T3 - Anvendelse af bismuth-213-konjugater til behandling af mikrometastaser - Google Patents

Anvendelse af bismuth-213-konjugater til behandling af mikrometastaser

Info

Publication number: DK0585986T3
Authority: DK; Denmark
Prior art keywords: conjugates; therapy; micrometastases; bismuth; treatment
Prior art date: 1992-07-27

Application number

DK93202174T

Other languages

English (en)

Inventor

Maurits Willem Geerlings

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-27

Filing date

1993-07-22

Publication date

2002-01-14

1993-07-22 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

2002-01-14 Application granted granted Critical

2002-01-14 Publication of DK0585986T3 publication Critical patent/DK0585986T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Optics & Photonics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Dispersion Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
High Energy & Nuclear Physics (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Electrotherapy Devices (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Fats And Perfumes (AREA)
Compounds Of Unknown Constitution (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Massaging Devices (AREA)
Tents Or Canopies (AREA)

DK93202174T 1992-07-27 1993-07-22 Anvendelse af bismuth-213-konjugater til behandling af mikrometastaser DK0585986T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP92202301		1992-07-27
EP93200388		1993-02-11

Publications (1)

Publication Number	Publication Date
DK0585986T3 true DK0585986T3 (da)	2002-01-14

Family

ID=26131590

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93202174T DK0585986T3 (da)	1992-07-27	1993-07-22	Anvendelse af bismuth-213-konjugater til behandling af mikrometastaser

Country Status (15)

Country	Link
US (2)	US5641471C1 (da)
EP (1)	EP0585986B1 (da)
JP (1)	JP3959431B2 (da)
KR (1)	KR100304155B1 (da)
AT (1)	ATE206622T1 (da)
AU (1)	AU676162B2 (da)
CA (1)	CA2100709C (da)
DE (1)	DE69330899T2 (da)
DK (1)	DK0585986T3 (da)
ES (1)	ES2165361T3 (da)
FI (1)	FI118676B (da)
MX (1)	MX9304499A (da)
NO (1)	NO312009B1 (da)
NZ (1)	NZ248235A (da)
PT (1)	PT585986E (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6403771B1 (en)	1991-02-19	2002-06-11	Actinium Pharmaceuticals, Limited	Method and means for site directed therapy
CA2100709C (en) *	1992-07-27	2004-03-16	Maurits W. Geerlings	Method and means for site directed therapy
ES2183904T3 (es) *	1996-11-15	2003-04-01	Euratom	Metodo extracorporeo para el tratamiento de celulas sanguineas.
US5749042A (en) *	1997-01-28	1998-05-05	Battelle Memorial Institute	Bismuth generator method
US5854968A (en) *	1997-06-09	1998-12-29	Arch Development Corporation	Process and apparatus for the production of BI-213 cations
US6603127B1 (en) *	1998-03-30	2003-08-05	Sloan-Kettering Institute For Cancer Research	Bismuth-213 generator and uses thereof
US7736651B1 (en)	2000-11-24	2010-06-15	Sloan-Kettering Institute For Cancer Research	Alpha emitting constructs and uses thereof
ATE381345T1 (de) *	1998-05-26	2008-01-15	Sloan Kettering Inst Cancer	Alpha-emittierende konstrukte sowie deren verwendung
ATE246395T1 (de)	1998-06-22	2003-08-15	Europ Economic Community	Verfahren und vorrichtung zur erzeugung von bi- 213 für menschliche therapeutische verwendung
JP2004510683A (ja) *	1999-06-07	2004-04-08	センター・フォー・モレキュラー・メディシン・アンド・イムノロジー	放射免疫療法において断片に付着されるα線エミッタまたはβ線エミッタ
US6852296B2 (en) *	2001-06-22	2005-02-08	Pg Research Foundation	Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine
US7087206B2 (en) *	2002-04-12	2006-08-08	Pg Research Foundation	Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
WO2004001767A1 (en) *	2002-06-21	2003-12-31	Lynntech, Inc.	Ion exchange materials for use in a bi-213 generator
EP1479399A1 (en) *	2003-05-22	2004-11-24	European Atomic Energy Community (Euratom)	Method of loading a radioelement generator with mother radionuclide
US20050105666A1 (en) *	2003-09-15	2005-05-19	Saed Mirzadeh	Production of thorium-229
CA2768658C (en)	2009-07-22	2018-04-03	Actinium Pharmaceuticals, Inc.	Methods for generating radioimmunoconjugates
EP3302560A4 (en)	2015-06-05	2019-01-09	Panacea Pharmaceuticals, Inc.	RADIOIMAGING AND RADIATION THERAPY OF CANCER USING ANTIBODIES AGAINST HAAH
EP3409297A1 (en)	2017-05-30	2018-12-05	AlfaRim Medial Holding B.V.	The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy
WO2019057598A1 (en)	2017-09-20	2019-03-28	Alfarim Medical Holding B.V.	OPTIMAL 225ACTINIUM - 213BISMUTH GENERATOR FOR ALPHA PARTICLE RADIO IMMUNOTHERAPY

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4001387A (en) *	1973-07-30	1977-01-04	Medi-Physics, Inc.	Process for preparing radiopharmaceuticals
US4305922A (en) *	1978-10-04	1981-12-15	University Patents, Inc.	Labeling proteins with 99m-Tc by ligand exchange
US4296785A (en) *	1979-07-09	1981-10-27	Mallinckrodt, Inc.	System for generating and containerizing radioisotopes
US4454106A (en) *	1982-06-07	1984-06-12	Gansow Otto A	Use of metal chelate conjugated monoclonal antibodies
US4472509A (en) *	1982-06-07	1984-09-18	Gansow Otto A	Metal chelate conjugated monoclonal antibodies
CA1225930A (en) *	1982-06-07	1987-08-25	Otto A. Gansow	Metal chelate conjugated monoclonal antibodies
GB8308235D0 (en) *	1983-03-25	1983-05-05	Celltech Ltd	Polypeptides
US4732864A (en) *	1983-10-06	1988-03-22	E. I. Du Pont De Nemours And Company	Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
US4828991A (en) *	1984-01-31	1989-05-09	Akzo N.V.	Tumor specific monoclonal antibodies
US4663129A (en) *	1985-01-30	1987-05-05	The United States Of America As Represented By The United States Department Of Energy	Isotopic generator for bismuth-212 and lead-212 from radium
AU2068588A (en) *	1987-08-12	1989-02-16	Immunomedics Inc.	Preparation of radiolabeled conjugates
US4833329A (en) *	1987-11-20	1989-05-23	Mallinckrodt, Inc.	System for generating and containerizing radioisotopes
US4871352A (en) *	1987-12-07	1989-10-03	Controlled Release Technologies, Inc.	Self-regulated therapeutic agent delivery system and method
US4923985A (en) *	1988-05-25	1990-05-08	The United States Of America As Represented By The Department Of Health & Human Services	Process for synthesizing macrocyclic chelates
JPH0720989B2 (ja) *	1988-05-25	1995-03-08	アメリカ合衆国	大環状キレート化合物の抱合体と診断的テスト方法
DK0429624T3 (da) *	1989-06-19	1994-05-30	Akzo Nobel Nv	Radioimmunterapi under anvendelse af alfa-partikelemission
EP0484460B1 (en) *	1989-07-12	1996-01-17	Mallinckrodt Medical, Inc.	Method for preparing radiodiagnostic gaseous radionuclide and apparatus
LU87684A1 (de) *	1990-02-23	1991-10-08	Euratom	Verfahren zur erzeugung von aktinium-225 und wismut-213
US5038046A (en) *	1990-07-10	1991-08-06	Biotechnetics	Method and generator for producing radioactive lead-212
CA2100709C (en) *	1992-07-27	2004-03-16	Maurits W. Geerlings	Method and means for site directed therapy

1993
- 1993-07-16 CA CA002100709A patent/CA2100709C/en not_active Expired - Lifetime
- 1993-07-22 DE DE69330899T patent/DE69330899T2/de not_active Expired - Lifetime
- 1993-07-22 AT AT93202174T patent/ATE206622T1/de active
- 1993-07-22 ES ES93202174T patent/ES2165361T3/es not_active Expired - Lifetime
- 1993-07-22 PT PT93202174T patent/PT585986E/pt unknown
- 1993-07-22 EP EP93202174A patent/EP0585986B1/en not_active Expired - Lifetime
- 1993-07-22 DK DK93202174T patent/DK0585986T3/da active
- 1993-07-23 AU AU42154/93A patent/AU676162B2/en not_active Expired
- 1993-07-23 NZ NZ248235A patent/NZ248235A/en not_active IP Right Cessation
- 1993-07-26 MX MX9304499A patent/MX9304499A/es active IP Right Grant
- 1993-07-26 NO NO19932687A patent/NO312009B1/no not_active IP Right Cessation
- 1993-07-26 KR KR1019930014146A patent/KR100304155B1/ko not_active Expired - Lifetime
- 1993-07-26 FI FI933350A patent/FI118676B/fi not_active IP Right Cessation
- 1993-07-27 JP JP18506693A patent/JP3959431B2/ja not_active Expired - Lifetime
1995
- 1995-09-12 US US08527296 patent/US5641471C1/en not_active Expired - Lifetime
1998
- 1998-01-05 US US09/002,848 patent/US6127527A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ248235A (en)	1995-04-27
NO932687L (no)	1994-01-28
AU4215493A (en)	1994-02-03
KR940005295A (ko)	1994-03-21
US5641471C1 (en)	2001-05-15
CA2100709C (en)	2004-03-16
JPH06157350A (ja)	1994-06-03
DE69330899D1 (de)	2001-11-15
MX9304499A (es)	1994-04-29
AU676162B2 (en)	1997-03-06
US5641471A (en)	1997-06-24
JP3959431B2 (ja)	2007-08-15
NO312009B1 (no)	2002-03-04
KR100304155B1 (ko)	2001-11-22
FI933350L (fi)	1994-01-28
EP0585986B1 (en)	2001-10-10
DE69330899T2 (de)	2002-04-25
CA2100709A1 (en)	1994-01-28
EP0585986A1 (en)	1994-03-09
PT585986E (pt)	2002-03-28
FI933350A0 (fi)	1993-07-26
ES2165361T3 (es)	2002-03-16
ATE206622T1 (de)	2001-10-15
US6127527A (en)	2000-10-03
FI118676B (fi)	2008-02-15
NO932687D0 (no)	1993-07-26

Publication	Publication Date	Title
DK0585986T3 (da)	2002-01-14	Anvendelse af bismuth-213-konjugater til behandling af mikrometastaser
NO891896L (no)	1990-10-22	Fremgangsmaate og innretning for behandling av medisinsk spesialavfall.
EP0724467A4 (en)	2000-01-05	RADIOACTIVE WIRE-SHAPED SOURCE, DEVICE AND HEALING METHODS
NO971015D0 (no)	1997-03-05	Forbindelser og metoder for behandling av cancer
DE69133567D1 (de)	2007-05-16	Vakuumbehandlungsvorrichtung und Arbeitsverfahren dafür
NO883540L (no)	1989-02-13	Fremgangsmaate og anlegg for behandling av slam.
NO901882D0 (no)	1990-04-27	Fremgangsmaate og anordning for kjemisk behandling av borehull.
DE3854540D1 (de)	1995-11-09	Behandlungsapparat und Verfahren.
NO875252D0 (no)	1987-12-16	Fremgangsmaate og system for behandling av partikkelboreslam.
ATE279216T1 (de)	2004-10-15	Schichtförmige gemischte metallhydroxide zur stabilisierung von radioaktiven kolloiden
DE69314860D1 (de)	1997-12-04	Mammographiemethode und Mammographieröntgenröhre
DE69012647D1 (de)	1994-10-27	Halbleiterbehandlungsvorrichtung und Verfahren.
DE69115150D1 (de)	1996-01-18	Verfahren und Gerät zur Bestrahlung mittels niederenergetischer Elektronen.
FI960658L (fi)	1996-02-14	Uudet bis-naftalimidit syövän hoitamiseksi
EA199800864A1 (ru)	1999-02-25	Способ лечения при боли, вызванной мигренью
NO306262B1 (no)	1999-10-11	FremgangsmÕte for hydrogenbehandling
DK0693912T3 (da)	1999-02-08	Apparat til medicinsk behandling
DK0588873T3 (da)	1997-09-15	Behandling af levercancer
DE3789958D1 (de)	1994-07-07	Verfahren und Apparat zur Bestrahlungsbehandlung, angepasst an das Frequenzspektrum des menschlichen Körpers.
DK0796232T3 (da)	2000-06-05	Fremgangsmåde til behandling af organisk affald og indretning til udøvelse af fremgangsmåden
ITTO920561A0 (it)	1992-07-03	Dispositivo infusore di farmaci, particolarmente per terapie ferrochelanti
NO904873L (no)	1991-05-13	Fremgangsmaate og anordning for behandling av sinkslig.
DE69217221D1 (de)	1997-03-13	Hydrochinonderivate und diese enthaltende Antioxydantien sowie Tumorinhibitoren
DE68909750D1 (de)	1993-11-11	Vorrichtung zur therapeutischen behandlung von lumbago sowie lumbago/ischias.
DK0673902T3 (da)	1998-09-07	Middel til behandling af bioaffald