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DK0458959T3 - Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf - Google Patents

Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf

Info

Publication number
DK0458959T3
DK0458959T3 DK91902366.3T DK91902366T DK0458959T3 DK 0458959 T3 DK0458959 T3 DK 0458959T3 DK 91902366 T DK91902366 T DK 91902366T DK 0458959 T3 DK0458959 T3 DK 0458959T3
Authority
DK
Denmark
Prior art keywords
analogs
pdgf
present
growth factor
novel
Prior art date
Application number
DK91902366.3T
Other languages
English (en)
Inventor
Arlen Read Thomason
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/454,794 external-priority patent/US5149792A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0458959T3 publication Critical patent/DK0458959T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DK91902366.3T 1989-12-19 1990-12-17 Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf DK0458959T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/454,794 US5149792A (en) 1989-12-19 1989-12-19 Platelet-derived growth factor B chain analogs
US07/624,451 US5272064A (en) 1989-12-19 1990-12-13 DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof

Publications (1)

Publication Number Publication Date
DK0458959T3 true DK0458959T3 (da) 1995-08-14

Family

ID=27037609

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91902366.3T DK0458959T3 (da) 1989-12-19 1990-12-17 Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf

Country Status (17)

Country Link
US (1) US5272064A (da)
EP (1) EP0458959B1 (da)
JP (1) JPH04504064A (da)
AT (1) ATE123949T1 (da)
AU (1) AU646014B2 (da)
CA (1) CA2032675A1 (da)
DE (1) DE69020335T2 (da)
DK (1) DK0458959T3 (da)
ES (1) ES2073735T3 (da)
FI (1) FI913892A0 (da)
GR (1) GR3017317T3 (da)
IE (1) IE904608A1 (da)
IL (1) IL96723A0 (da)
NO (1) NO913232L (da)
NZ (1) NZ236549A (da)
PT (1) PT96272A (da)
WO (1) WO1991008761A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07507055A (ja) * 1992-02-26 1995-08-03 アラーガン、インコーポレイテッド 眼の創傷の治癒における血小板誘導化成長因子の使用
IL105176A0 (en) * 1992-03-30 1993-07-08 Schering Corp Monomeric platelet-derived growth factor and prevention of stenosis or restenosis
ES2557741T3 (es) 2002-03-27 2016-01-28 Immunex Corporation Procedimientos para incrementar la producción de polipéptidos
EP1594527A2 (en) * 2003-02-04 2005-11-16 Ludwig Institute For Cancer Research Vegf-b and pdgf modulation of stem cells
BR112012000865A2 (pt) 2009-07-17 2019-09-24 T Tabor Aaron "composição e método para a modificação genética cosmética de células substancialmente intactas"
SG187198A1 (en) 2010-08-05 2013-03-28 Amgen Inc Dipeptides to enhance yield and viability from cell cultures
HUE042822T2 (hu) 2011-04-20 2019-07-29 Amgen Inc Automata befecskendezõ szerkezet
WO2012145682A1 (en) 2011-04-21 2012-10-26 Amgen Inc. A method for culturing mammalian cells to improve recombinant protein production
ES2788132T3 (es) 2011-07-01 2020-10-20 Amgen Inc Cultivo de células de mamífero
CN103917458A (zh) 2011-09-02 2014-07-09 安姆根有限公司 药物产品和分析药物产品的光暴露的方法
AR089231A1 (es) 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
WO2014109858A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
MX365501B (es) 2013-03-14 2019-06-05 Amgen Inc Eliminacion de ligandos lixiviados de purificacion de afinidad.
TWI832345B (zh) 2013-03-14 2024-02-11 美商安美基公司 用於增加重組蛋白質之甘露糖含量之方法
TWI592183B (zh) 2013-03-15 2017-07-21 安美基公司 本體輪廓可調適之自動注射器裝置
TWI639453B (zh) 2013-03-15 2018-11-01 美商安美基公司 用於注射器之匣盒
ES2973257T3 (es) 2013-03-15 2024-06-19 Amgen Inc Casete de fármaco, autoinyector y sistema de autoinyector
US9481901B2 (en) 2013-05-30 2016-11-01 Amgen Inc. Methods for increasing mannose content of recombinant proteins
MX2016005572A (es) 2013-10-31 2016-12-09 Amgen Inc Uso de monensina para regular la glicosilacion de proteinas recombinantes.
US10513723B2 (en) 2014-01-13 2019-12-24 Amgen Inc. Decreasing ornithine production to decrease high mannose glycoform content of recombinant proteins
US10106829B2 (en) 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
AU2014380174B2 (en) 2014-01-29 2018-08-30 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
CN106687575B (zh) 2014-06-04 2021-04-30 美国安进公司 用于收获哺乳动物细胞培养物的方法
EP3221465B1 (en) 2014-11-19 2019-03-13 Amgen Inc. Quantitation of glycan moiety in recombinant glycoproteins
EP3227454B1 (en) 2014-12-01 2020-01-29 Amgen Inc. Process for manipulating the level of glycan content of a glycoprotein
JP2021503311A (ja) 2017-11-16 2021-02-12 アムジエン・インコーポレーテツド 失速及び終点検出を有するオートインジェクタ
CA3099163A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Antibodies with modulated glycan profiles
WO2021143699A1 (en) 2020-01-15 2021-07-22 Wuxi Biologics (Shanghai) Co. Ltd. An apparatus and a method for continuously harvesting a biological substance produced by a cultured cell
WO2023079058A1 (en) 2021-11-05 2023-05-11 Yokogawa Insilico Biotechnology Gmbh Cell culture with reduced production of lactate
KR20240128067A (ko) 2021-12-29 2024-08-23 브리스톨-마이어스 스큅 컴퍼니 랜딩 패드 세포주의 생성

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479896A (en) * 1981-12-11 1984-10-30 Antoniades Harry N Method for extraction localization and direct recovery of platelet derived growth factor
EP0487116B1 (en) * 1984-10-12 1999-12-29 ZymoGenetics, Inc. Biologically active PDGF analogs in eucaryotic cells
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4801542A (en) * 1984-10-12 1989-01-31 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4769328A (en) * 1984-10-12 1988-09-06 Zymogenetics Inc. Expression of biologically active PDGF analogs in yeast
DE3751632T2 (de) * 1986-08-13 1996-06-13 Zymogenetics Inc Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen
DE3834079A1 (de) * 1988-10-06 1990-04-12 Biotechnolog Forschung Gmbh Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren
IL96682A0 (en) * 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems

Also Published As

Publication number Publication date
DE69020335D1 (de) 1995-07-27
FI913892A0 (fi) 1991-08-16
PT96272A (pt) 1991-09-30
CA2032675A1 (en) 1991-06-20
EP0458959A4 (en) 1993-06-16
AU646014B2 (en) 1994-02-03
ES2073735T3 (es) 1995-08-16
GR3017317T3 (en) 1995-12-31
IE904608A1 (en) 1991-06-19
JPH04504064A (ja) 1992-07-23
ATE123949T1 (de) 1995-07-15
NO913232D0 (no) 1991-08-19
EP0458959A1 (en) 1991-12-04
NO913232L (no) 1991-08-19
US5272064A (en) 1993-12-21
AU7153491A (en) 1991-07-18
WO1991008761A1 (en) 1991-06-27
NZ236549A (en) 1993-03-26
IL96723A0 (en) 1991-09-16
DE69020335T2 (de) 1995-11-02
EP0458959B1 (en) 1995-06-21

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