DK0434394T3 - Forbindelser til behandling af inflammatorisk tarmsygdom - Google Patents

Forbindelser til behandling af inflammatorisk tarmsygdom

Info

Publication number: DK0434394T3
Authority: DK; Denmark
Prior art keywords: inflammatory bowel; bowel disease; compounds; treatment; benzyl
Prior art date: 1989-12-21

Application number

DK90313923T

Other languages

Danish (da)

English (en)

Inventor

Jaswant Singh Gidda

Jill Ann Panetta

Michael Leroy Phillips

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-19

Publication date

1998-12-14

1990-12-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1998-12-14 Application granted granted Critical

1998-12-14 Publication of DK0434394T3 publication Critical patent/DK0434394T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Surgical Instruments (AREA)
Nonmetallic Welding Materials (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Eye Examination Apparatus (AREA)

DK90313923T 1989-12-21 1990-12-19 Forbindelser til behandling af inflammatorisk tarmsygdom DK0434394T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45420389A	1989-12-21	1989-12-21

Publications (1)

Publication Number	Publication Date
DK0434394T3 true DK0434394T3 (da)	1998-12-14

Family

ID=23803709

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90313923T DK0434394T3 (da)	1989-12-21	1990-12-19	Forbindelser til behandling af inflammatorisk tarmsygdom

Country Status (22)

Country	Link
EP (1)	EP0434394B1 (zh)
JP (1)	JP3036853B2 (zh)
KR (1)	KR0176243B1 (zh)
CN (1)	CN1029846C (zh)
AT (1)	ATE169294T1 (zh)
AU (1)	AU639734B2 (zh)
CA (1)	CA2032330C (zh)
CY (1)	CY2100B1 (zh)
DE (1)	DE69032537T2 (zh)
DK (1)	DK0434394T3 (zh)
ES (1)	ES2121748T3 (zh)
FI (2)	FI104251B1 (zh)
HU (1)	HU216732B (zh)
IE (1)	IE904633A1 (zh)
IL (3)	IL108962A (zh)
MX (1)	MX23803A (zh)
NO (1)	NO300458B1 (zh)
NZ (1)	NZ236472A (zh)
PT (1)	PT96198B (zh)
RU (2)	RU2036915C1 (zh)
YU (1)	YU240690A (zh)
ZA (1)	ZA9010041B (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU87339A1 (fr) *	1988-09-20	1990-04-06	Oreal	Nouveaux derives de benzylidene-cyclanones,leur procede de preparation,leur utilisation en tant qu'agents anti-oxydants et comme filtres solaires,compositions cosmetiques et pharmaceutiques les contenant
US5143928A (en) *	1990-03-27	1992-09-01	Warner-Lambert Company	3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
IL106877A (en) *	1992-09-10	1998-03-10	Lilly Co Eli	Rodinin derivatives for use as drugs for the treatment of Alzheimer's disease
DE69301894T2 (de) *	1992-10-28	1996-11-07	Shionogi & Co	Benzylidenderivate
US6251928B1 (en)	1994-03-16	2001-06-26	Eli Lilly And Company	Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5563277A (en) *	1994-12-21	1996-10-08	Eli Lilly And Company	Process for preparing benzyl-substituted rhodanine derivatives
ES2153081T3 (es) *	1995-09-07	2001-02-16	Lilly Co Eli	Forma cristalina alternativa de tazofelona((+,-)-5-((3,5-bis(1,1-dimetiletil)-4-hidroxifenil)metil)-4-tiazolidinona).
ATE193284T1 (de) *	1995-09-07	2000-06-15	Lilly Co Eli	Verfahren zur herstellung von benzylsubstituierten rhodaninederivaten
EP0779282A1 (en) *	1995-12-14	1997-06-18	Eli Lilly And Company	Thiomorpholinone compounds for treating multiple sclerosis
US5981523A (en) *	1996-02-05	1999-11-09	Eli Lilly And Company	Compounds and methods for treating multiple sclerosis
US6063799A (en) *	1996-09-03	2000-05-16	Eli Lilly And Company	Alternate crystal form of Tazofelone
US6005142A (en)	1996-09-03	1999-12-21	Eli Lilly And Company	Process for preparing benzyl-substituted rhodanine derivatives
WO2000018748A1 (en) *	1998-09-30	2000-04-06	Roche Diagnostics Gmbh	Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
WO2000018746A1 (en) *	1998-09-30	2000-04-06	Roche Diagnostics Gmbh	Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
WO2000018747A1 (en) *	1998-09-30	2000-04-06	Roche Diagnostics Gmbh	Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
BR0314943A (pt) *	2002-09-30	2005-08-02	Univ California	Inibidores da proteìna reguladora da condutância transmembrana da fibrose cìstica e usos destes
US7235573B2 (en)	2002-09-30	2007-06-26	The Regents Of The University Of California	Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
AU2002953533A0 (en) *	2002-12-24	2003-01-16	Arthron Limited	Fc receptor modulating compounds and compositions
JP5778755B2 (ja) *	2010-04-15	2015-09-16	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	ヒドロキノンの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR862081B (en) *	1985-08-09	1986-12-24	Lilly Co Eli	Di-t-butylphenol compounds
IE940525L (en) *	1988-05-25	1989-11-25	Warner Lambert Co	Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
CA2013599C (en) *	1989-04-07	1999-11-16	Jill A. Panetta	Aryl-substituted rhodanine derivatives

1990
- 1990-12-13 IL IL10896290A patent/IL108962A/en not_active IP Right Cessation
- 1990-12-13 ZA ZA9010041A patent/ZA9010041B/xx unknown
- 1990-12-13 IL IL9665490A patent/IL96654A/en not_active IP Right Cessation
- 1990-12-14 NZ NZ236472A patent/NZ236472A/xx unknown
- 1990-12-14 PT PT96198A patent/PT96198B/pt active IP Right Grant
- 1990-12-14 CA CA002032330A patent/CA2032330C/en not_active Expired - Fee Related
- 1990-12-19 NO NO905478A patent/NO300458B1/no not_active IP Right Cessation
- 1990-12-19 AU AU68266/90A patent/AU639734B2/en not_active Ceased
- 1990-12-19 DE DE69032537T patent/DE69032537T2/de not_active Expired - Fee Related
- 1990-12-19 KR KR1019900021001A patent/KR0176243B1/ko not_active Expired - Fee Related
- 1990-12-19 AT AT90313923T patent/ATE169294T1/de not_active IP Right Cessation
- 1990-12-19 ES ES90313923T patent/ES2121748T3/es not_active Expired - Lifetime
- 1990-12-19 EP EP90313923A patent/EP0434394B1/en not_active Expired - Lifetime
- 1990-12-19 DK DK90313923T patent/DK0434394T3/da active
- 1990-12-19 MX MX2380390A patent/MX23803A/es unknown
- 1990-12-19 FI FI906273A patent/FI104251B1/fi not_active IP Right Cessation
- 1990-12-20 JP JP2413313A patent/JP3036853B2/ja not_active Expired - Fee Related
- 1990-12-20 CN CN90109846A patent/CN1029846C/zh not_active Expired - Fee Related
- 1990-12-20 HU HU908368A patent/HU216732B/hu not_active IP Right Cessation
- 1990-12-20 RU SU904894177A patent/RU2036915C1/ru active
- 1990-12-20 YU YU240690A patent/YU240690A/sh unknown
- 1990-12-20 IE IE463390A patent/IE904633A1/en not_active Application Discontinuation
1991
- 1991-12-24 RU SU915010352A patent/RU2050355C1/ru active
1994
- 1994-03-14 IL IL10896294A patent/IL108962A0/xx unknown
1998
- 1998-09-07 CY CY9800024A patent/CY2100B1/xx unknown
1999
- 1999-08-10 FI FI991698A patent/FI19991698L/fi unknown

Also Published As

Publication number	Publication date
FI104251B (fi)	1999-12-15
NO905478D0 (no)	1990-12-19
AU639734B2 (en)	1993-08-05
IL96654A (en)	1995-06-29
FI906273L (fi)	1991-06-22
CY2100B1 (en)	2002-04-05
HU908368D0 (en)	1991-07-29
ZA9010041B (en)	1992-08-26
IL108962A0 (en)	1994-06-24
FI19991698L (fi)	1999-08-10
EP0434394B1 (en)	1998-08-05
CN1052668A (zh)	1991-07-03
KR910011812A (ko)	1991-08-07
NO300458B1 (no)	1997-06-02
PT96198A (pt)	1991-09-30
IE904633A1 (en)	1991-07-17
FI906273A0 (fi)	1990-12-19
MX23803A (es)	1994-02-28
IL108962A (en)	1996-12-05
CA2032330C (en)	2001-05-08
EP0434394A3 (en)	1992-01-08
HUT59915A (en)	1992-07-28
CN1029846C (zh)	1995-09-27
AU6826690A (en)	1991-06-27
FI104251B1 (fi)	1999-12-15
JPH04279573A (ja)	1992-10-05
EP0434394A2 (en)	1991-06-26
DE69032537T2 (de)	1999-01-21
RU2050355C1 (ru)	1995-12-20
DE69032537D1 (de)	1998-09-10
HU216732B (hu)	1999-08-30
ES2121748T3 (es)	1998-12-16
PT96198B (pt)	1998-05-29
RU2036915C1 (ru)	1995-06-09
YU240690A (sh)	1992-12-21
CA2032330A1 (en)	1991-06-22
KR0176243B1 (ko)	1999-03-20
NO905478L (no)	1991-06-24
ATE169294T1 (de)	1998-08-15
NZ236472A (en)	1993-03-26
JP3036853B2 (ja)	2000-04-24

Publication	Publication Date	Title
DK0434394T3 (da)	1998-12-14	Forbindelser til behandling af inflammatorisk tarmsygdom
IS4638A (is)	1997-12-22	Aðferð við ljósfræðilega hreinsun á bensimidasólafleiðum með hækkað hlutfall enantíómera
DE68913860D1 (de)	1994-04-21	Pressform und Formgebungsverfahren zum Herstellen von optischen Teilen.
HUT49113A (en)	1989-08-28	Process for producing 2-/2-hydroxy-3-phenoxy-propyl-amino/-ethyl-phenoxy-methyl-amido derivatives and pharmaceutical compositions containing them as active components
AT383130B (de)	1987-05-25	Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin
DE3676922D1 (de)	1991-02-21	Neue polyoxygenierte labdan-derivate, verfahren zu ihrer herstellung und ihre anwendung als medikamente.
PT97547A (pt)	1992-01-31	Processo para a preparacao de novas pirido {2,3-f}{1,4}tiazepinas e pirido {3,2-b}{1,5}benzotiazepinas e de composicoes farmaceuticas que as contem
ATE65779T1 (de)	1991-08-15	Verfahren zur herstellung von carbinolderivaten.
DE69527802D1 (de)	2002-09-19	Verfahren zur herstellung von benzyl-substituierten rhodanin derivaten
PL266361A1 (en)	1988-10-13	Method for manufacturing new tetrahydrobenyotiazole derivatives
DK0431305T3 (da)	1995-04-03	Fremgangsmåde til fremstilling af molluskicide 2,4,5-tribrompyrrol-3-carbonitriler
CS53688A2 (en)	1989-04-14	Method of new substituted 3-phenyl-7h-thiazolo/3,2-b//1,2,4/triazine -7-ons production
DK0383316T3 (da)	1994-03-07	Fremgangsmåde til enantiomer-opspaltning af et benzopyranderivat
FR2647959B1 (fr)	1991-09-20	Procede de fabrication simultanee de transistors mos a canal n et de transistors bipolaires verticaux pnp
NO950952D0 (no)	1995-03-13	Fremgangsmåte for fremstilling av pilokarpin
DE3864286D1 (de)	1991-09-26	Herstellungsverfahren von trifluormethylverbindungen.
DK0425980T3 (da)	1994-08-22	Fremgangsmåde til enantiomerspaltning af benzopyranderivater
NO980937D0 (no)	1998-03-04	Fremgangsmåte for fremstilling av benzyl-substituerte rhodaninderivater
HU9203625D0 (en)	1993-01-28	Stereoselective process for producing optical isomers of 1-benzoyl-4-hydroxi-5-(1-phenyl-ethyl)-amino-1,2,2a,3,4,5-hexahydrobenz/cd/-indole
ATE93515T1 (de)	1993-09-15	Neues verfahren zur herstellung von phenylguanidin-derivaten.