FI104251B1 - Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi - Google Patents

Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi

Info

Publication number: FI104251B1
Authority: FI; Finland
Prior art keywords: inflammatory bowel; compounds; preparation; treatment; benzyl
Prior art date: 1989-12-21

Application number

FI906273A

Other languages

English (en)

Swedish (sv)

Other versions

FI104251B (fi

FI906273L (fi

FI906273A0 (fi

Inventor

Jaswant Singh Gidda

Jill Ann Panetta

Michael Leroy Phillips

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-19

Publication date

1999-12-15

1990-12-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1990-12-19 Publication of FI906273A0 publication Critical patent/FI906273A0/fi

1991-06-22 Publication of FI906273L publication Critical patent/FI906273L/fi

1999-12-15 Application granted granted Critical

1999-12-15 Publication of FI104251B publication Critical patent/FI104251B/fi

1999-12-15 Publication of FI104251B1 publication Critical patent/FI104251B1/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Surgical Instruments (AREA)
Nonmetallic Welding Materials (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Eye Examination Apparatus (AREA)

FI906273A 1989-12-21 1990-12-19 Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi FI104251B1 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45420389A	1989-12-21	1989-12-21
US45420389		1989-12-21

Publications (4)

Publication Number	Publication Date
FI906273A0 FI906273A0 (fi)	1990-12-19
FI906273L FI906273L (fi)	1991-06-22
FI104251B FI104251B (fi)	1999-12-15
FI104251B1 true FI104251B1 (fi)	1999-12-15

Family

ID=23803709

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI906273A FI104251B1 (fi)	1989-12-21	1990-12-19	Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi
FI991698A FI19991698L (fi)	1989-12-21	1999-08-10	Menetelmä selektiivisesti eristää, oleellisesti puhtaassa enantiomeerisessä muodossa, raseemisten bentsyylisubstituoitujen rodaniinijohdannaisten enantiomeerejä

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI991698A FI19991698L (fi)	1989-12-21	1999-08-10	Menetelmä selektiivisesti eristää, oleellisesti puhtaassa enantiomeerisessä muodossa, raseemisten bentsyylisubstituoitujen rodaniinijohdannaisten enantiomeerejä

Country Status (22)

Country	Link
EP (1)	EP0434394B1 (fi)
JP (1)	JP3036853B2 (fi)
KR (1)	KR0176243B1 (fi)
CN (1)	CN1029846C (fi)
AT (1)	ATE169294T1 (fi)
AU (1)	AU639734B2 (fi)
CA (1)	CA2032330C (fi)
CY (1)	CY2100B1 (fi)
DE (1)	DE69032537T2 (fi)
DK (1)	DK0434394T3 (fi)
ES (1)	ES2121748T3 (fi)
FI (2)	FI104251B1 (fi)
HU (1)	HU216732B (fi)
IE (1)	IE904633A1 (fi)
IL (3)	IL108962A (fi)
MX (1)	MX23803A (fi)
NO (1)	NO300458B1 (fi)
NZ (1)	NZ236472A (fi)
PT (1)	PT96198B (fi)
RU (2)	RU2036915C1 (fi)
YU (1)	YU240690A (fi)
ZA (1)	ZA9010041B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU87339A1 (fr) *	1988-09-20	1990-04-06	Oreal	Nouveaux derives de benzylidene-cyclanones,leur procede de preparation,leur utilisation en tant qu'agents anti-oxydants et comme filtres solaires,compositions cosmetiques et pharmaceutiques les contenant
US5143928A (en) *	1990-03-27	1992-09-01	Warner-Lambert Company	3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
IL106877A (en) *	1992-09-10	1998-03-10	Lilly Co Eli	Rodinin derivatives for use as drugs for the treatment of Alzheimer's disease
DE69301894T2 (de) *	1992-10-28	1996-11-07	Shionogi & Co	Benzylidenderivate
US6251928B1 (en)	1994-03-16	2001-06-26	Eli Lilly And Company	Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5563277A (en) *	1994-12-21	1996-10-08	Eli Lilly And Company	Process for preparing benzyl-substituted rhodanine derivatives
ES2153081T3 (es) *	1995-09-07	2001-02-16	Lilly Co Eli	Forma cristalina alternativa de tazofelona((+,-)-5-((3,5-bis(1,1-dimetiletil)-4-hidroxifenil)metil)-4-tiazolidinona).
ATE193284T1 (de) *	1995-09-07	2000-06-15	Lilly Co Eli	Verfahren zur herstellung von benzylsubstituierten rhodaninederivaten
EP0779282A1 (en) *	1995-12-14	1997-06-18	Eli Lilly And Company	Thiomorpholinone compounds for treating multiple sclerosis
US5981523A (en) *	1996-02-05	1999-11-09	Eli Lilly And Company	Compounds and methods for treating multiple sclerosis
US6063799A (en) *	1996-09-03	2000-05-16	Eli Lilly And Company	Alternate crystal form of Tazofelone
US6005142A (en)	1996-09-03	1999-12-21	Eli Lilly And Company	Process for preparing benzyl-substituted rhodanine derivatives
WO2000018748A1 (en) *	1998-09-30	2000-04-06	Roche Diagnostics Gmbh	Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
WO2000018746A1 (en) *	1998-09-30	2000-04-06	Roche Diagnostics Gmbh	Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
WO2000018747A1 (en) *	1998-09-30	2000-04-06	Roche Diagnostics Gmbh	Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
BR0314943A (pt) *	2002-09-30	2005-08-02	Univ California	Inibidores da proteìna reguladora da condutância transmembrana da fibrose cìstica e usos destes
US7235573B2 (en)	2002-09-30	2007-06-26	The Regents Of The University Of California	Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
AU2002953533A0 (en) *	2002-12-24	2003-01-16	Arthron Limited	Fc receptor modulating compounds and compositions
JP5778755B2 (ja) *	2010-04-15	2015-09-16	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	ヒドロキノンの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR862081B (en) *	1985-08-09	1986-12-24	Lilly Co Eli	Di-t-butylphenol compounds
IE940525L (en) *	1988-05-25	1989-11-25	Warner Lambert Co	Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
CA2013599C (en) *	1989-04-07	1999-11-16	Jill A. Panetta	Aryl-substituted rhodanine derivatives

1990
- 1990-12-13 IL IL10896290A patent/IL108962A/en not_active IP Right Cessation
- 1990-12-13 ZA ZA9010041A patent/ZA9010041B/xx unknown
- 1990-12-13 IL IL9665490A patent/IL96654A/en not_active IP Right Cessation
- 1990-12-14 NZ NZ236472A patent/NZ236472A/xx unknown
- 1990-12-14 PT PT96198A patent/PT96198B/pt active IP Right Grant
- 1990-12-14 CA CA002032330A patent/CA2032330C/en not_active Expired - Fee Related
- 1990-12-19 NO NO905478A patent/NO300458B1/no not_active IP Right Cessation
- 1990-12-19 AU AU68266/90A patent/AU639734B2/en not_active Ceased
- 1990-12-19 DE DE69032537T patent/DE69032537T2/de not_active Expired - Fee Related
- 1990-12-19 KR KR1019900021001A patent/KR0176243B1/ko not_active Expired - Fee Related
- 1990-12-19 AT AT90313923T patent/ATE169294T1/de not_active IP Right Cessation
- 1990-12-19 ES ES90313923T patent/ES2121748T3/es not_active Expired - Lifetime
- 1990-12-19 EP EP90313923A patent/EP0434394B1/en not_active Expired - Lifetime
- 1990-12-19 DK DK90313923T patent/DK0434394T3/da active
- 1990-12-19 MX MX2380390A patent/MX23803A/es unknown
- 1990-12-19 FI FI906273A patent/FI104251B1/fi not_active IP Right Cessation
- 1990-12-20 JP JP2413313A patent/JP3036853B2/ja not_active Expired - Fee Related
- 1990-12-20 CN CN90109846A patent/CN1029846C/zh not_active Expired - Fee Related
- 1990-12-20 HU HU908368A patent/HU216732B/hu not_active IP Right Cessation
- 1990-12-20 RU SU904894177A patent/RU2036915C1/ru active
- 1990-12-20 YU YU240690A patent/YU240690A/sh unknown
- 1990-12-20 IE IE463390A patent/IE904633A1/en not_active Application Discontinuation
1991
- 1991-12-24 RU SU915010352A patent/RU2050355C1/ru active
1994
- 1994-03-14 IL IL10896294A patent/IL108962A0/xx unknown
1998
- 1998-09-07 CY CY9800024A patent/CY2100B1/xx unknown
1999
- 1999-08-10 FI FI991698A patent/FI19991698L/fi unknown

Also Published As

Publication number	Publication date
FI104251B (fi)	1999-12-15
NO905478D0 (no)	1990-12-19
AU639734B2 (en)	1993-08-05
IL96654A (en)	1995-06-29
FI906273L (fi)	1991-06-22
CY2100B1 (en)	2002-04-05
HU908368D0 (en)	1991-07-29
ZA9010041B (en)	1992-08-26
IL108962A0 (en)	1994-06-24
FI19991698L (fi)	1999-08-10
EP0434394B1 (en)	1998-08-05
CN1052668A (zh)	1991-07-03
KR910011812A (ko)	1991-08-07
NO300458B1 (no)	1997-06-02
PT96198A (pt)	1991-09-30
IE904633A1 (en)	1991-07-17
FI906273A0 (fi)	1990-12-19
MX23803A (es)	1994-02-28
IL108962A (en)	1996-12-05
CA2032330C (en)	2001-05-08
EP0434394A3 (en)	1992-01-08
HUT59915A (en)	1992-07-28
CN1029846C (zh)	1995-09-27
AU6826690A (en)	1991-06-27
JPH04279573A (ja)	1992-10-05
EP0434394A2 (en)	1991-06-26
DE69032537T2 (de)	1999-01-21
RU2050355C1 (ru)	1995-12-20
DE69032537D1 (de)	1998-09-10
HU216732B (hu)	1999-08-30
ES2121748T3 (es)	1998-12-16
DK0434394T3 (da)	1998-12-14
PT96198B (pt)	1998-05-29
RU2036915C1 (ru)	1995-06-09
YU240690A (sh)	1992-12-21
CA2032330A1 (en)	1991-06-22
KR0176243B1 (ko)	1999-03-20
NO905478L (no)	1991-06-24
ATE169294T1 (de)	1998-08-15
NZ236472A (en)	1993-03-26
JP3036853B2 (ja)	2000-04-24

Publication	Publication Date	Title
FI104251B1 (fi)	1999-12-15	Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi
DE69130570D1 (de)	1999-01-14	Heterozyklische verbindungen, ihre herstellung und anwendung
HUT45247A (en)	1988-06-28	Process for producing thiazolidinediones with hypolycaemic effect and pharmaceutical compositions comprising the same
NO874350L (no)	1988-04-21	Fremgangsmaate for fremstilling av antibakterielle forbindelser.
HUT49113A (en)	1989-08-28	Process for producing 2-/2-hydroxy-3-phenoxy-propyl-amino/-ethyl-phenoxy-methyl-amido derivatives and pharmaceutical compositions containing them as active components
NO302414B1 (no)	1998-03-02	Analogifremgangsmåte for fremstilling av heterocykliske forbindelser
HUT56356A (en)	1991-08-28	Process for producing thiazolidin-4-ones and 1,3-oxathiolan-5-one derivatives
DE3676922D1 (de)	1991-02-21	Neue polyoxygenierte labdan-derivate, verfahren zu ihrer herstellung und ihre anwendung als medikamente.
DE69130679D1 (de)	1999-02-04	Die herstellung von zusammensetzungen zur behandlung von krankheiten der zellproliferation
ATA900589A (de)	1993-06-15	Stereospezifisches verfahren fuer die herstellung von enantiomeren des 3-substituierten furo (3,4-c) pyridins, so erhaltene enantiomere oder mischungen davon sowie diese enthaltene therapeutische mittel
HUT35680A (en)	1985-07-29	Process for preparing purine derivatives
DE3775496D1 (de)	1992-02-06	Benzhydryloxyaethyl-piperidine-derivate, verfahren zur herstellung und pharmazeutische zusammenstellungen, die diese enthalten.
DK0405442T3 (da)	1996-09-23	4,5-Dihydro-6H-imidazo 4,5,1-ij quinolin-6-on-6-oxim-O-sulfonsyrederivater
DE69527802D1 (de)	2002-09-19	Verfahren zur herstellung von benzyl-substituierten rhodanin derivaten
FR2623501B1 (fr)	1990-03-16	Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FI873843A (fi)	1987-09-04	Menetelmä uusien terapeuttisesti käyttökelpoisten 4-C-hydroksi-2-r-(substituoitu)kromaani-4-etikkahappojohdannaisten valmistamiseksi
ATE13676T1 (de)	1985-06-15	Delta-1,3,5-3-chlor-11-beta,16-alpha,17-alpha,2 - tetra-(hydroxy)-pregnan-20-on-16,17acetonidderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
ATE160568T1 (de)	1997-12-15	Spiro-oxetane, verfahren zu ihrer herstellung und arzneimittel
NO834759L (no)	1984-06-25	Fremgangsmaate ved fremstilling av nye 6alfa-methylprednisolonderivater
DE3578065D1 (de)	1990-07-12	3-mercapto-2-oxo-1-pyrrolidinessigsaeurederivate, verfahren zur herstellung und pharmazeutische zusammensetzungen die sie enthalten.

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: ELI LILLY AND COMPANY