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DE69921409D1 - Cyclosporin enthaltende Zusammensetzungen - Google Patents

Cyclosporin enthaltende Zusammensetzungen

Info

Publication number
DE69921409D1
DE69921409D1 DE69921409T DE69921409T DE69921409D1 DE 69921409 D1 DE69921409 D1 DE 69921409D1 DE 69921409 T DE69921409 T DE 69921409T DE 69921409 T DE69921409 T DE 69921409T DE 69921409 D1 DE69921409 D1 DE 69921409D1
Authority
DE
Germany
Prior art keywords
cyclosporin
propylene glycol
containing compositions
esters
fatty acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69921409T
Other languages
English (en)
Other versions
DE69921409T2 (de
Inventor
Amarjit Singh
Rajesh Jain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panacea Biotec Ltd
Original Assignee
Panacea Biotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd filed Critical Panacea Biotec Ltd
Publication of DE69921409D1 publication Critical patent/DE69921409D1/de
Application granted granted Critical
Publication of DE69921409T2 publication Critical patent/DE69921409T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69921409T 1998-08-18 1999-08-16 Cyclosporin enthaltende Zusammensetzungen Expired - Lifetime DE69921409T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP98306607A EP0982035B1 (de) 1998-08-18 1998-08-18 Zusammensetzung enthalten Cyclsoporin in einem hydrophilen Träger
RU98115892/14A RU2178293C2 (ru) 1998-08-18 1998-08-18 Фармацевтическая композиция, содержащая циклоспорин, способ получения мягких желатиновых капсул
EP98306607 1998-08-18
CNB981185851A CN1199642C (zh) 1998-08-18 1998-09-04 含环孢菌素的新型药物组合物
CA002249675A CA2249675A1 (en) 1998-08-18 1998-10-06 A novel composition containing cyclosporin

Publications (2)

Publication Number Publication Date
DE69921409D1 true DE69921409D1 (de) 2004-12-02
DE69921409T2 DE69921409T2 (de) 2006-03-09

Family

ID=31999277

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69822814T Expired - Lifetime DE69822814T2 (de) 1998-08-18 1998-08-18 Zusammensetzung enthaltend Cyclosporin in einem hydrophilen Träger
DE69921409T Expired - Lifetime DE69921409T2 (de) 1998-08-18 1999-08-16 Cyclosporin enthaltende Zusammensetzungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69822814T Expired - Lifetime DE69822814T2 (de) 1998-08-18 1998-08-18 Zusammensetzung enthaltend Cyclosporin in einem hydrophilen Träger

Country Status (9)

Country Link
EP (2) EP0982035B1 (de)
CN (1) CN1199642C (de)
AT (1) ATE262916T1 (de)
CA (1) CA2249675A1 (de)
DE (2) DE69822814T2 (de)
DK (1) DK0982035T3 (de)
ES (1) ES2215277T3 (de)
PT (1) PT982035E (de)
RU (1) RU2178293C2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100602725B1 (ko) * 1998-12-11 2006-07-20 파마솔루션스, 인코포레이티드 물에서 불충분하게 용해되는 약제를 위한 자가-유화용조성물
WO2001030379A2 (en) 1999-10-27 2001-05-03 Alexandra Lucas Compositions and methods for preventing and treating transplant rejection
GB2362573A (en) * 2000-05-25 2001-11-28 Cipla Ltd Cyclosporin formulation
PT1151755E (pt) * 2000-05-04 2005-05-31 Panacea Biotec Ltd Composicoes farmaceuticas compreendendo a ciclosporina como substancia activa
ES2292496T3 (es) * 2000-09-18 2008-03-16 Rpg Life Sciences Limited Formulacion autoemulsionable con elevada actividad inmunosupresora y bioabsorbente.
DE60140960D1 (de) 2000-09-29 2010-02-11 Viron Therapeutics Inc Verwendung von serp-1 in kombination mit einem immunosuppressor zur behandlung von arthritis
MEP89008A (en) 2001-10-19 2011-12-20 Novel cyclosporin analog microemulsion preconcentrates
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US7285530B2 (en) 2004-10-21 2007-10-23 Viron Therapeutics, Inc. Use of SERP-1 as an antiplatelet agent
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
WO2013168167A1 (en) * 2012-05-10 2013-11-14 Painreform Ltd. Depot formulations of a hydrophobic active ingredient and methods for preparation thereof
CN103301068B (zh) * 2013-07-08 2014-09-10 广东彼迪药业有限公司 一种头孢克肟干混悬剂剂及其制备方法
CN103462914B (zh) * 2013-09-04 2015-12-09 南京正宽医药科技有限公司 一种头孢克肟片剂及其制备方法
CN111789943B (zh) * 2019-04-08 2024-01-19 洛阳赛威生物科技有限公司 一种水包油佐剂组合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
EP0649651B1 (de) * 1993-09-28 2000-12-13 R.P. Scherer GmbH Herstellung von Weichgelatinekapseln
IT1277338B1 (it) * 1995-07-25 1997-11-10 Poli Ind Chimicia S P A Composizioni farmaceutiche di ciclosporina o altre sostanze peptidiche
KR20050084502A (ko) * 1997-01-30 2005-08-26 노파르티스 아게 오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물

Also Published As

Publication number Publication date
EP0982035B1 (de) 2004-03-31
DE69921409T2 (de) 2006-03-09
RU2178293C2 (ru) 2002-01-20
CN1199642C (zh) 2005-05-04
CN1247060A (zh) 2000-03-15
DE69822814D1 (de) 2004-05-06
CA2249675A1 (en) 2000-04-06
EP0985412A3 (de) 2001-05-02
ATE262916T1 (de) 2004-04-15
DE69822814T2 (de) 2005-01-27
EP0985412A2 (de) 2000-03-15
EP0982035A1 (de) 2000-03-01
PT982035E (pt) 2004-08-31
DK0982035T3 (da) 2004-06-28
ES2215277T3 (es) 2004-10-01
EP0985412B1 (de) 2004-10-27

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Legal Events

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