DE69822814D1 - Zusammensetzung enthalten Cyclsoporin in einem hydrophilen Träger - Google Patents

Zusammensetzung enthalten Cyclsoporin in einem hydrophilen Träger

Info

Publication number: DE69822814D1
Authority: DE; Germany
Prior art keywords: propylene glycol; hydrophilic carrier; cyclsoporin; cyclosporin; composition contain
Prior art date: 1998-08-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69822814T

Other languages

English (en)

Other versions

DE69822814T2 (de

Inventor

Amarjit Singh

Rajesh Jain

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Panacea Biotec Ltd

Original Assignee

Panacea Biotec Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-18

Filing date

1998-08-18

Publication date

2004-05-06

1998-08-18 Application filed by Panacea Biotec Ltd filed Critical Panacea Biotec Ltd

2004-05-06 Application granted granted Critical

2004-05-06 Publication of DE69822814D1 publication Critical patent/DE69822814D1/de

2005-01-27 Publication of DE69822814T2 publication Critical patent/DE69822814T2/de

2018-08-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000012052 hydrophilic carrier Substances 0.000 title abstract 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 12
-1 C12 fatty acids Chemical class 0.000 abstract 4
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 3
229930105110 Cyclosporin A Natural products 0.000 abstract 3
108010036949 Cyclosporine Proteins 0.000 abstract 3
229960001265 ciclosporin Drugs 0.000 abstract 3
229930182912 cyclosporin Natural products 0.000 abstract 3
229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 2
239000004359 castor oil Substances 0.000 abstract 2
235000014113 dietary fatty acids Nutrition 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
239000000194 fatty acid Substances 0.000 abstract 2
229930195729 fatty acid Natural products 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dispersion Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Compositions Of Macromolecular Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69822814T 1998-08-18 1998-08-18 Zusammensetzung enthaltend Cyclosporin in einem hydrophilen Träger Expired - Lifetime DE69822814T2 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP98306607A EP0982035B1 (de)	1998-08-18	1998-08-18	Zusammensetzung enthalten Cyclsoporin in einem hydrophilen Träger
RU98115892/14A RU2178293C2 (ru)	1998-08-18	1998-08-18	Фармацевтическая композиция, содержащая циклоспорин, способ получения мягких желатиновых капсул
CNB981185851A CN1199642C (zh)	1998-08-18	1998-09-04	含环孢菌素的新型药物组合物
CA002249675A CA2249675A1 (en)	1998-08-18	1998-10-06	A novel composition containing cyclosporin

Publications (2)

Publication Number	Publication Date
DE69822814D1 true DE69822814D1 (de)	2004-05-06
DE69822814T2 DE69822814T2 (de)	2005-01-27

Family

ID=31999277

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69822814T Expired - Lifetime DE69822814T2 (de)	1998-08-18	1998-08-18	Zusammensetzung enthaltend Cyclosporin in einem hydrophilen Träger
DE69921409T Expired - Lifetime DE69921409T2 (de)	1998-08-18	1999-08-16	Cyclosporin enthaltende Zusammensetzungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69921409T Expired - Lifetime DE69921409T2 (de)	1998-08-18	1999-08-16	Cyclosporin enthaltende Zusammensetzungen

Country Status (9)

Country	Link
EP (2)	EP0982035B1 (de)
CN (1)	CN1199642C (de)
AT (1)	ATE262916T1 (de)
CA (1)	CA2249675A1 (de)
DE (2)	DE69822814T2 (de)
DK (1)	DK0982035T3 (de)
ES (1)	ES2215277T3 (de)
PT (1)	PT982035E (de)
RU (1)	RU2178293C2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ512287A (en) *	1998-12-11	2002-12-20	Pharmasolutions Inc	Pharmaceutical compositions comprising a lipophilic drug in a propylene glycol ester of a higher fatty acid carrier, where 60% of the ester is a monoester
ATE297217T1 (de)	1999-10-27	2005-06-15	Alexandra Lucas	Zusammensetzung zur vorbeugung und behandlung von transplantatabstossung
GB2362573A (en) *	2000-05-25	2001-11-28	Cipla Ltd	Cyclosporin formulation
DK1151755T3 (da) *	2000-05-04	2005-06-27	Panacea Biotec Ltd	Farmaceutisk præparat indeholdende cyclosporin som aktiv bestanddel
PT1333851E (pt)	2000-09-18	2007-11-26	Rpg Life Sciences Ltd	Formulação auto-emulsionável que tem actividades de bioabsorção e de imunossupressão aumentadas
AU2001291579B2 (en)	2000-09-29	2006-08-31	Viron Therapeutics Inc.	Use of serp- 1 in combination with an immunosuppressant for influencing inflammatory and immune reactions
RU2207870C2 (ru) *	2000-11-10	2003-07-10	Панацея Биотек Лимитед	Фармацевтическая композиция, включающая циклоспорин в качестве активного ингредиента
JP2005506990A (ja)	2001-10-19	2005-03-10	アイソテクニカインコーポレーテッド	新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート
US7842791B2 (en)	2002-12-19	2010-11-30	Nancy Jean Britten	Dispersible pharmaceutical compositions
RU2285511C2 (ru) *	2004-10-13	2006-10-20	НИИ ГБ им. Гельмгольца	Средство для лечения синдрома сухого глаза
US7285530B2 (en)	2004-10-21	2007-10-23	Viron Therapeutics, Inc.	Use of SERP-1 as an antiplatelet agent
CN105169369B (zh) *	2005-09-30	2019-10-18	中美华世通生物医药科技（武汉）有限公司	治疗和预防丙型肝炎感染的方法和药物组合物
US20090130198A1 (en) *	2007-11-21	2009-05-21	Innopharmax Inc.	Pharmaceutical composition with enhanced bioavailability
AU2013257608B2 (en) *	2012-05-10	2017-12-14	Painreform Ltd.	Depot formulations of a hydrophobic active ingredient and methods for preparation thereof
CN103301068B (zh) *	2013-07-08	2014-09-10	广东彼迪药业有限公司	一种头孢克肟干混悬剂剂及其制备方法
CN103462914B (zh) *	2013-09-04	2015-12-09	南京正宽医药科技有限公司	一种头孢克肟片剂及其制备方法
CN111789943B (zh) *	2019-04-08	2024-01-19	洛阳赛威生物科技有限公司	一种水包油佐剂组合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en) *	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
GB9113872D0 (en) *	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
ES2308955T5 (es) *	1993-09-28	2012-04-03	R.P. Scherer Gmbh	Fabricación de cápsulas de gelatina blanda
IT1277338B1 (it) *	1995-07-25	1997-11-10	Poli Ind Chimicia S P A	Composizioni farmaceutiche di ciclosporina o altre sostanze peptidiche
SK285019B6 (sk) *	1997-01-30	2006-04-06	Novartis Ag	Tvrdá želatínová tobolka

1998
- 1998-08-18 PT PT98306607T patent/PT982035E/pt unknown
- 1998-08-18 DE DE69822814T patent/DE69822814T2/de not_active Expired - Lifetime
- 1998-08-18 ES ES98306607T patent/ES2215277T3/es not_active Expired - Lifetime
- 1998-08-18 DK DK98306607T patent/DK0982035T3/da active
- 1998-08-18 EP EP98306607A patent/EP0982035B1/de not_active Expired - Lifetime
- 1998-08-18 AT AT98306607T patent/ATE262916T1/de not_active IP Right Cessation
- 1998-08-18 RU RU98115892/14A patent/RU2178293C2/ru not_active IP Right Cessation
- 1998-09-04 CN CNB981185851A patent/CN1199642C/zh not_active Expired - Fee Related
- 1998-10-06 CA CA002249675A patent/CA2249675A1/en not_active Abandoned
1999
- 1999-08-16 EP EP99202660A patent/EP0985412B1/de not_active Expired - Lifetime
- 1999-08-16 DE DE69921409T patent/DE69921409T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1247060A (zh)	2000-03-15
ES2215277T3 (es)	2004-10-01
DE69921409T2 (de)	2006-03-09
EP0982035B1 (de)	2004-03-31
EP0985412A2 (de)	2000-03-15
DE69822814T2 (de)	2005-01-27
DE69921409D1 (de)	2004-12-02
PT982035E (pt)	2004-08-31
EP0985412B1 (de)	2004-10-27
CA2249675A1 (en)	2000-04-06
DK0982035T3 (da)	2004-06-28
EP0982035A1 (de)	2000-03-01
CN1199642C (zh)	2005-05-04
EP0985412A3 (de)	2001-05-02
RU2178293C2 (ru)	2002-01-20
ATE262916T1 (de)	2004-04-15

Publication	Publication Date	Title
ATE262916T1 (de)	2004-04-15	Zusammensetzung enthalten cyclsoporin in einem hydrophilen träger
HK57196A (en)	1996-04-12	Cyclosporin compositions for oral administration
CA2200966A1 (en)	1996-05-09	Pharmaceutical compositions
CA2117957A1 (en)	1995-04-16	Pour point depressants for industrial lubricants containing mixtures of fatty acid esters and vegetable oils
ES2153686T3 (es)	2001-03-01	Composiciones liquidas de limpieza para multiples usos en microemulsion.
DE59505676D1 (de)	1999-05-20	Synthetische ester aus alkoholen und fettsäuregemischen aus ölsäurereichen, stearinsäurearmen pflanzenölen
IL142535A0 (en)	2002-03-10	Pharmaceutical compositions for the treatment of inflammation
ES2159893T3 (es)	2001-10-16	Composiciones para bastoncillos de gel solido contra la transpiracion
CA2362932A1 (en)	2000-08-31	Pharmaceutical composition containing proton pump inhibitors
DE60018715D1 (de)	2005-04-21	Pharmazeutische Zusammensetzung enthaltend Cyclosprin als aktiven Bestandteil
JP2004503480A (ja)	2004-02-05	ヘアオイル
CA2380951A1 (en)	2001-02-22	Pharmaceutical compositions for oral and topical administration
CA2306628A1 (en)	1999-04-29	Cosmetic formulations for the prevention and therapy of hair loss
WO2001091587A3 (en)	2002-08-01	Oil compositions comprising short, medium and long chain triglycerides and use thereof in reducing weight gain
AU692801B2 (en)	1998-06-18	Pharmaceutical compositions comprising a staurosporine as active ingredient.
WO1999016410A3 (en)	1999-06-17	Low residue solid antiperspirant
MY133026A (en)	2007-10-31	Cosmetic pit emulsions
ATE279199T1 (de)	2004-10-15	Zubereitungen zur anwendung als penetrationförderer in transdermalen arzneimitteln die hoch-lipophile wirkstoffe enthalten
DE60135927D1 (en)	2008-11-06	Nd
EP1043015A3 (de)	2001-01-24	Homogene flüssige Duftstoff-Zusammensetzung auf Basis von flüchtigen Silikonen
EP0393748A3 (de)	1991-07-03	Gegen Rost schützende und korrosionsinhibierende Schmieröladditive und dieses Öl enthaltende Schmiermittelzusammensetzungen
DE69809743D1 (de)	2003-01-09	An omega-3 ungesättigten fettsäuren angereicherte wachsester, ihre herstellung und verwendung
CA2197413A1 (en)	1997-09-30	A pharmaceutical or veterinary composition
RU2002116010A (ru)	2004-01-27	Антисептическое средство "АХДЕЗ 3000"
RU96109684A (ru)	1998-07-10	Косметическое средство

Legal Events

Date	Code	Title	Description
2005-04-28	8364	No opposition during term of opposition