DE69919361D1 - Pyridyl-ether und -thioether als nikotin-acetylcholin-rezeptorliganden und ihre therapeutische anwendung - Google Patents
Pyridyl-ether und -thioether als nikotin-acetylcholin-rezeptorliganden und ihre therapeutische anwendungInfo
- Publication number
- DE69919361D1 DE69919361D1 DE69919361T DE69919361T DE69919361D1 DE 69919361 D1 DE69919361 D1 DE 69919361D1 DE 69919361 T DE69919361 T DE 69919361T DE 69919361 T DE69919361 T DE 69919361T DE 69919361 D1 DE69919361 D1 DE 69919361D1
- Authority
- DE
- Germany
- Prior art keywords
- acetylcholine receptor
- thioether
- therapeutic use
- receptor ligands
- sup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- POPPVIRYGJQIOF-UHFFFAOYSA-N 2-acetyloxyethyl(trimethyl)azanium;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CC(=O)OCC[N+](C)(C)C.CN1CCCC1C1=CC=CN=C1 POPPVIRYGJQIOF-UHFFFAOYSA-N 0.000 title 1
- JMTMWFZXOIWTLX-UHFFFAOYSA-N 2-pyridin-2-yloxypyridine Chemical compound C=1C=CC=NC=1OC1=CC=CC=N1 JMTMWFZXOIWTLX-UHFFFAOYSA-N 0.000 title 1
- 108010009685 Cholinergic Receptors Proteins 0.000 title 1
- 102000034337 acetylcholine receptors Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000003568 thioethers Chemical class 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006984 memory degeneration Effects 0.000 abstract 1
- 208000023060 memory loss Diseases 0.000 abstract 1
- 230000007659 motor function Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9785398P | 1998-08-25 | 1998-08-25 | |
| US97853P | 1998-08-25 | ||
| PCT/US1999/018954 WO2000010997A1 (en) | 1998-08-25 | 1999-08-25 | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69919361D1 true DE69919361D1 (de) | 2004-09-16 |
| DE69919361T2 DE69919361T2 (de) | 2005-09-08 |
Family
ID=22265449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69919361T Expired - Fee Related DE69919361T2 (de) | 1998-08-25 | 1999-08-25 | Pyridyl-ether und -thioether als nikotin-acetylcholin-rezeptorliganden und ihre therapeutische anwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6562847B1 (de) |
| EP (1) | EP1107965B1 (de) |
| JP (1) | JP2002523413A (de) |
| AT (1) | ATE273298T1 (de) |
| AU (1) | AU5574799A (de) |
| CA (1) | CA2341989A1 (de) |
| DE (1) | DE69919361T2 (de) |
| DK (1) | DK1107965T3 (de) |
| ES (1) | ES2226427T3 (de) |
| PT (1) | PT1107965E (de) |
| WO (1) | WO2000010997A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE247104T1 (de) * | 1997-11-05 | 2003-08-15 | Neurosearch As | Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren |
| WO2001019817A2 (en) * | 1999-09-14 | 2001-03-22 | Abbott Laboratories | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| JP2001302643A (ja) * | 2000-04-21 | 2001-10-31 | Suntory Ltd | 環状アミジン化合物 |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| JP2005516927A (ja) * | 2001-12-13 | 2005-06-09 | アボット・ラボラトリーズ | 癌治療用のキナーゼ阻害剤としての３−（フェニル−アルコキシ）−５−（フェニル）−ピリジン誘導体および関連化合物 |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| EP2270006A1 (de) * | 2002-08-08 | 2011-01-05 | Amgen, Inc | Pyridazin-Derivate zur Verwendung als Vanilloidrezeptorliganden |
| WO2004113297A2 (en) * | 2003-06-24 | 2004-12-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP4735261B2 (ja) * | 2003-06-27 | 2011-07-27 | Ｍｓｄ株式会社 | ヘテロアリールオキシ含窒素飽和ヘテロ環誘導体 |
| EP1775295A1 (de) * | 2003-09-30 | 2007-04-18 | Amgen Inc. | Vanilloidrezeptorliganden und deren Verwendung in Behandlungen |
| AU2004278382B2 (en) | 2003-09-30 | 2008-09-18 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| MY139645A (en) * | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
| EP1745034A1 (de) * | 2004-02-11 | 2007-01-24 | Amgen Inc. | Vanilloidrezeptorliganden und deren verwendung bei behandlungen |
| WO2006031856A2 (en) | 2004-09-13 | 2006-03-23 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
| US7547698B2 (en) * | 2004-09-20 | 2009-06-16 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD) |
| EP1799664A1 (de) * | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Heterozyklische derivate und ihre verwendung als stearoyl-coa-desaturase-inhibitoren |
| EP2316458A1 (de) * | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazin-Derivate zur Verhinderung menschlicher Stearoyl-coa-desaturas |
| AU2005329423A1 (en) * | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| US20060183763A1 (en) * | 2004-12-31 | 2006-08-17 | Pfizer Inc | Novel pyrrolidyl derivatives of heteroaromatic compounds |
| WO2006089311A1 (en) * | 2005-02-15 | 2006-08-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| EP1877400A1 (de) * | 2005-04-15 | 2008-01-16 | Amgen, Inc | Vanilloidrezeptorliganden und deren verwendung bei behandlungen |
| WO2007130075A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US7879913B2 (en) * | 2005-06-28 | 2011-02-01 | Catholic Healthcare West | Iptakalim hydrochloride for decreasing nicotine use |
| ES2521494T3 (es) | 2007-04-02 | 2014-11-12 | Parkinson's Institute | Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos |
| AU2011256287B2 (en) | 2010-05-17 | 2016-11-10 | Envivo Pharmaceuticals, Inc. | A crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate |
| WO2013071097A1 (en) * | 2011-11-11 | 2013-05-16 | Georgetown University | 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof |
| RU2635522C2 (ru) | 2012-05-08 | 2017-11-13 | Форум Фармасьютикалз, Инк. | Способы поддержания, лечения или улучшения когнитивной функции |
| CN105431146B (zh) * | 2013-03-27 | 2019-05-28 | 乔治敦大学 | 2-卤代-5-炔基-吡啶基烟碱性配体 |
| AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| US11285306B2 (en) | 2017-01-06 | 2022-03-29 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
| AU2019279884B2 (en) | 2018-05-29 | 2025-01-30 | Morningside Venture Investments Limited | Drug delivery methods and systems |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0107930B1 (de) | 1982-09-30 | 1990-11-28 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Kondensierte aromatische Oxazepinone und Sulphuranaloge, ihrer Herstellung und Verwendung als Histamin-Antagonist |
| ZA836994B (en) * | 1982-09-30 | 1984-05-30 | Robins Co Inc A H | Fused aromatic oxazepinones and sulfur analogs thereof |
| US4667031A (en) * | 1985-10-15 | 1987-05-19 | Ethyl Corporation | Process for preparing oxazepinones |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| ATE247104T1 (de) * | 1997-11-05 | 2003-08-15 | Neurosearch As | Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren |
| WO2001019817A2 (en) | 1999-09-14 | 2001-03-22 | Abbott Laboratories | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
-
1999
- 1999-08-25 DK DK99942347T patent/DK1107965T3/da active
- 1999-08-25 CA CA002341989A patent/CA2341989A1/en not_active Abandoned
- 1999-08-25 EP EP99942347A patent/EP1107965B1/de not_active Expired - Lifetime
- 1999-08-25 US US09/383,142 patent/US6562847B1/en not_active Expired - Lifetime
- 1999-08-25 AT AT99942347T patent/ATE273298T1/de not_active IP Right Cessation
- 1999-08-25 JP JP2000566270A patent/JP2002523413A/ja active Pending
- 1999-08-25 WO PCT/US1999/018954 patent/WO2000010997A1/en active IP Right Grant
- 1999-08-25 DE DE69919361T patent/DE69919361T2/de not_active Expired - Fee Related
- 1999-08-25 ES ES99942347T patent/ES2226427T3/es not_active Expired - Lifetime
- 1999-08-25 PT PT99942347T patent/PT1107965E/pt unknown
- 1999-08-25 AU AU55747/99A patent/AU5574799A/en not_active Abandoned
-
2003
- 2003-04-02 US US10/405,250 patent/US6888001B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69919361T2 (de) | 2005-09-08 |
| US6562847B1 (en) | 2003-05-13 |
| US20030207858A1 (en) | 2003-11-06 |
| EP1107965A1 (de) | 2001-06-20 |
| WO2000010997A1 (en) | 2000-03-02 |
| CA2341989A1 (en) | 2000-03-02 |
| AU5574799A (en) | 2000-03-14 |
| PT1107965E (pt) | 2004-10-29 |
| US6888001B2 (en) | 2005-05-03 |
| ATE273298T1 (de) | 2004-08-15 |
| JP2002523413A (ja) | 2002-07-30 |
| ES2226427T3 (es) | 2005-03-16 |
| EP1107965B1 (de) | 2004-08-11 |
| DK1107965T3 (da) | 2004-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN |
|
| 8339 | Ceased/non-payment of the annual fee |