DE69832270D1 - Isoxazolderivate - Google Patents
IsoxazolderivateInfo
- Publication number
- DE69832270D1 DE69832270D1 DE69832270T DE69832270T DE69832270D1 DE 69832270 D1 DE69832270 D1 DE 69832270D1 DE 69832270 T DE69832270 T DE 69832270T DE 69832270 T DE69832270 T DE 69832270T DE 69832270 D1 DE69832270 D1 DE 69832270D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- formula
- represented
- solid line
- single bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 150000002545 isoxazoles Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11887197 | 1997-04-21 | ||
| JP11887197 | 1997-04-21 | ||
| JP36715497 | 1997-12-24 | ||
| JP36715497 | 1997-12-24 | ||
| PCT/JP1998/001770 WO1998047880A1 (en) | 1997-04-21 | 1998-04-17 | Isoxazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69832270D1 true DE69832270D1 (de) | 2005-12-15 |
| DE69832270T2 DE69832270T2 (de) | 2006-07-13 |
Family
ID=26456721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69832270T Expired - Lifetime DE69832270T2 (de) | 1997-04-21 | 1998-04-17 | Isoxazolderivate |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0979226B1 (de) |
| KR (1) | KR100512087B1 (de) |
| CN (1) | CN1138764C (de) |
| AT (1) | ATE309228T1 (de) |
| AU (1) | AU733091B2 (de) |
| CA (1) | CA2235298C (de) |
| DE (1) | DE69832270T2 (de) |
| DK (1) | DK0979226T3 (de) |
| ES (1) | ES2248894T3 (de) |
| ID (1) | ID22897A (de) |
| NZ (1) | NZ330244A (de) |
| RU (1) | RU2196770C2 (de) |
| TW (1) | TW442476B (de) |
| WO (1) | WO1998047880A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2377527A1 (en) * | 1999-07-15 | 2001-01-25 | Sumitomo Pharmaceuticals Co., Ltd. | Heteroaromatic ring compounds |
| WO2001047895A1 (fr) * | 1999-12-28 | 2001-07-05 | Sumitomo Pharmaceuticals Company, Limited | Nouveaux composes comprenant des cycles heteroaromatiques a cinq chainons |
| WO2002092094A1 (fr) * | 2001-03-27 | 2002-11-21 | Sumitomo Pharmaceuticals Co., Ltd. | Derive d'isoxazole cristallin et preparation medicale associee |
| JPWO2003068239A1 (ja) * | 2002-02-12 | 2005-06-02 | 住友製薬株式会社 | 新規外用剤 |
| ITMI20040019A1 (it) * | 2004-01-12 | 2004-04-12 | Univ Bari | Derivati isossazolici e loro impiego come inibitori della ciclossigenasi |
| DE102004008141A1 (de) * | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
| WO2006049215A1 (ja) * | 2004-11-02 | 2006-05-11 | Dainippon Sumitomo Pharma Co., Ltd. | 自己免疫疾患を治療するための併用薬 |
| US7989450B2 (en) | 2008-01-11 | 2011-08-02 | Universita' Degli Studi Di Bari | Functionalized diarylisoxazoles inhibitors of ciclooxygenase |
| PH12013501574A1 (en) * | 2011-01-28 | 2013-09-30 | 4Sc Discovery Gmbh | Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation |
| DE102014201651A1 (de) | 2014-01-30 | 2015-07-30 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Isoxazolderivate zur Verwendung bei der Behandlung und/oder Prophylaxe von Herzerkrankungen |
| CN111269149B (zh) * | 2020-04-08 | 2022-04-15 | 南京优氟医药科技有限公司 | 一种5-(3,3-二甲基胍基)-2-氧代戊酸的生产工艺 |
| CN114478350B (zh) * | 2022-01-25 | 2023-08-11 | 苏州大学 | 一种c3-烷基化吲哚的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2068418A1 (en) * | 1969-10-27 | 1971-08-27 | Innothera Lab Sa | 2-substd-5-amino isoxazole derivs |
| US3720685A (en) * | 1970-07-15 | 1973-03-13 | Squibb & Sons Inc | 3-amino-5-benzyl-1,2,4-oxadiazoles |
| GB1338169A (en) * | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
| DE2341507A1 (de) * | 1973-08-16 | 1975-02-27 | Thomae Gmbh Dr K | Neue biphenylderivate und verfahren zur herstellung |
| JPS54144347A (en) * | 1978-05-02 | 1979-11-10 | Nikken Kagaku Kk | 3-(2-fluoro-4-biphenylyl)-2-butanone |
| HU180567B (en) * | 1980-03-19 | 1983-03-28 | Egyt Gyogyszervegyeszeti Gyar | Method for producing derivatives of isooxazole |
| JPS58150576A (ja) * | 1982-03-03 | 1983-09-07 | Sumitomo Chem Co Ltd | 新規な１，２，４−オキサジアゾ−ル誘導体 |
| US4680300A (en) * | 1985-01-10 | 1987-07-14 | Syntex (U.S.A.) Inc. | Anti-inflammatory guanidines |
| US4914112A (en) * | 1986-06-03 | 1990-04-03 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
| JP2719742B2 (ja) * | 1991-04-30 | 1998-02-25 | 株式会社大塚製薬工場 | フェニルチアゾール誘導体 |
-
1998
- 1998-04-17 KR KR10-1999-7009591A patent/KR100512087B1/ko not_active Expired - Fee Related
- 1998-04-17 EP EP98914071A patent/EP0979226B1/de not_active Expired - Lifetime
- 1998-04-17 CN CNB98804398XA patent/CN1138764C/zh not_active Expired - Fee Related
- 1998-04-17 DE DE69832270T patent/DE69832270T2/de not_active Expired - Lifetime
- 1998-04-17 AT AT98914071T patent/ATE309228T1/de active
- 1998-04-17 ID IDW991245A patent/ID22897A/id unknown
- 1998-04-17 DK DK98914071T patent/DK0979226T3/da active
- 1998-04-17 ES ES98914071T patent/ES2248894T3/es not_active Expired - Lifetime
- 1998-04-17 WO PCT/JP1998/001770 patent/WO1998047880A1/en active IP Right Grant
- 1998-04-17 AU AU61934/98A patent/AU733091B2/en not_active Ceased
- 1998-04-20 TW TW087106014A patent/TW442476B/zh not_active IP Right Cessation
- 1998-04-20 CA CA002235298A patent/CA2235298C/en not_active Expired - Fee Related
- 1998-04-20 RU RU98107337/04A patent/RU2196770C2/ru not_active IP Right Cessation
- 1998-04-21 NZ NZ330244A patent/NZ330244A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0979226T3 (da) | 2006-03-06 |
| CA2235298A1 (en) | 1998-10-21 |
| ATE309228T1 (de) | 2005-11-15 |
| KR100512087B1 (ko) | 2005-09-05 |
| CN1252794A (zh) | 2000-05-10 |
| AU6193498A (en) | 1998-10-22 |
| KR20010006501A (ko) | 2001-01-26 |
| CN1138764C (zh) | 2004-02-18 |
| EP0979226A1 (de) | 2000-02-16 |
| CA2235298C (en) | 2008-05-13 |
| EP0979226B1 (de) | 2005-11-09 |
| ID22897A (id) | 1999-12-16 |
| AU733091B2 (en) | 2001-05-03 |
| NZ330244A (en) | 2000-01-28 |
| TW442476B (en) | 2001-06-23 |
| WO1998047880A1 (en) | 1998-10-29 |
| DE69832270T2 (de) | 2006-07-13 |
| RU2196770C2 (ru) | 2003-01-20 |
| ES2248894T3 (es) | 2006-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD., OSAKA, JP |
|
| 8364 | No opposition during term of opposition |