[go: up one dir, main page]

DE69704235D1 - Benzothiophenverbindungen, ihre Anwendungen und Zusammensetzungen - Google Patents

Benzothiophenverbindungen, ihre Anwendungen und Zusammensetzungen

Info

Publication number
DE69704235D1
DE69704235D1 DE69704235T DE69704235T DE69704235D1 DE 69704235 D1 DE69704235 D1 DE 69704235D1 DE 69704235 T DE69704235 T DE 69704235T DE 69704235 T DE69704235 T DE 69704235T DE 69704235 D1 DE69704235 D1 DE 69704235D1
Authority
DE
Germany
Prior art keywords
compositions
phenyl
benzothiophene compounds
oco
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69704235T
Other languages
English (en)
Other versions
DE69704235T2 (de
Inventor
David Thompson Berg
George Joseph Cullinan
Brian William Grinnell
Mark Alan Richardson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69704235D1 publication Critical patent/DE69704235D1/de
Application granted granted Critical
Publication of DE69704235T2 publication Critical patent/DE69704235T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69704235T 1996-07-15 1997-07-11 Benzothiophenverbindungen, ihre Anwendungen und Zusammensetzungen Expired - Fee Related DE69704235T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2178896P 1996-07-15 1996-07-15

Publications (2)

Publication Number Publication Date
DE69704235D1 true DE69704235D1 (de) 2001-04-19
DE69704235T2 DE69704235T2 (de) 2001-09-06

Family

ID=21806155

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69704235T Expired - Fee Related DE69704235T2 (de) 1996-07-15 1997-07-11 Benzothiophenverbindungen, ihre Anwendungen und Zusammensetzungen

Country Status (10)

Country Link
US (2) US5948795A (de)
EP (1) EP0819687B1 (de)
JP (1) JPH1067774A (de)
AT (1) ATE199717T1 (de)
CA (1) CA2207141A1 (de)
DE (1) DE69704235T2 (de)
DK (1) DK0819687T3 (de)
ES (1) ES2155655T3 (de)
GR (1) GR3035981T3 (de)
PT (1) PT819687E (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094268A1 (en) * 2001-05-22 2002-11-28 Eli Lilly And Company Tetrahydroquinolin derivatives for the inhibition of diseases associated with estrogen deprivation or with an aberrant physiological response to endogenous estrogen
WO2002094788A1 (en) * 2001-05-22 2002-11-28 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
TWI240723B (en) * 2001-06-20 2005-10-01 Wyeth Corp Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
TWI224101B (en) * 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7163954B2 (en) * 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
ES2291981T3 (es) * 2003-11-20 2008-03-01 Eli Lilly And Company Moduladores del receptor de la vitamina d.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE339235B (de) * 1965-06-01 1971-10-04 Haessle Ab
US3598839A (en) * 1969-06-30 1971-08-10 Parke Davis & Co Phenylbenzothiophene compounds
US3935231A (en) * 1972-10-17 1976-01-27 Sandoz Ltd., (Sandoz Ag) Novel benzothiophene derivatives as stabilizers for organic compounds
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
PH18628A (en) * 1981-04-03 1985-08-23 Lilly Co Eli "6-hydroxy-2-(4-hydroxyphenyl)-3 4-(2- piperidine or 3-methylpyrollidine -benzo b thiophene compounds
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US5175184A (en) * 1982-10-19 1992-12-29 Kotobuki Seiyaku Company Limited Benzothiophene derivatives and antihyperuricemia thereof
GB8417559D0 (en) * 1984-07-10 1984-08-15 Pfizer Ltd Anti-diarrhoeal agents
JPH04312526A (ja) * 1991-04-09 1992-11-04 Fujisawa Pharmaceut Co Ltd 骨疾患治療剤
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5466810A (en) * 1994-06-10 1995-11-14 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
US5532382A (en) * 1995-03-13 1996-07-02 Eli Lilly And Company Benzothiophenes substituted at the 3-carbonyl
US5731328A (en) * 1995-10-10 1998-03-24 Eli Lilly And Company Methods of inhibiting plasminogen activator inhibitor 1

Also Published As

Publication number Publication date
GR3035981T3 (en) 2001-08-31
EP0819687B1 (de) 2001-03-14
DE69704235T2 (de) 2001-09-06
JPH1067774A (ja) 1998-03-10
PT819687E (pt) 2001-06-29
EP0819687A1 (de) 1998-01-21
US5962698A (en) 1999-10-05
CA2207141A1 (en) 1998-01-15
DK0819687T3 (da) 2001-04-17
ATE199717T1 (de) 2001-03-15
ES2155655T3 (es) 2001-05-16
US5948795A (en) 1999-09-07

Similar Documents

Publication Publication Date Title
ATE251150T1 (de) Benzothiophenverbindungen, ihre anwendungen und zusammensetzungen
BE2018C008I2 (de)
DK0792641T3 (da) Anvendelse af estrogenantagonister og estrogenagonister til hæmning af patologiske tilstande
IL160304A (en) Compounds and composition for activating peroxisome proliferators-responsive receptor ??
DE60006216D1 (de) Chinolinderivate und chinazolinderivate
FI943561A0 (fi) Uudet ainekoostumukset
DE60014043D1 (de) Flouride von 4-substituierten piperidin-derivaten
ATE232528T1 (de) Pyrimidinylpyrazolderivate
DE69704235D1 (de) Benzothiophenverbindungen, ihre Anwendungen und Zusammensetzungen
DE60223904D1 (de) Benzylaminanalogen
AU755654C (en) Novel amide compounds and drugs containing the same
DK1209151T3 (da) 4-substituerede piperidinderivativer
ES2055867T3 (es) Derivados de dibenzotiazepina utiles como agentes antiespasmodicos.
DK0807627T3 (da) Anilidforbindelser som ACAT-inhibitorer
DK1559714T3 (da) Fremgangsmåde til fremstilling af 2-alkyl-3-aminothiophenderivater og 3-aminothiophenderivater
BR0207966A (pt) Composição farmacêutica contendo derivados 1,3-tiazina
DE69828087D1 (de) Aminderivate
FI944207A (fi) Cyclohexane derivatives
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee