DE60223904D1 - Benzylaminanalogen - Google Patents

Benzylaminanalogen

Info

Publication number: DE60223904D1
Authority: DE; Germany
Prior art keywords: represent; different; same; alkyl group; sulfur
Prior art date: 2001-01-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60223904T

Other languages

English (en)

Other versions

DE60223904T2 (de

Inventor

Kazuo Koyama

Shinji Marumoto

Narihiro Toda

Hiroshi Kogen

Keiko Suzuki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BTG International Ltd

Original Assignee

BTG International Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-26

Filing date

2002-01-22

Publication date

2008-01-17

2002-01-22 Application filed by BTG International Ltd filed Critical BTG International Ltd

2008-01-17 Application granted granted Critical

2008-01-17 Publication of DE60223904D1 publication Critical patent/DE60223904D1/de

2008-11-27 Publication of DE60223904T2 publication Critical patent/DE60223904T2/de

2022-01-23 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C219/30—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Quinoline Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)

DE60223904T 2001-01-26 2002-01-22 Benzylaminanalogen Expired - Fee Related DE60223904T2 (de)

Applications Claiming Priority (12)

Application Number	Priority Date	Filing Date	Title
JP2001018386		2001-01-26
JP2001018386		2001-01-26
JP2001305182		2001-10-01
JP2001305182		2001-10-01
PCT/JP2002/000400 WO2002059074A1 (fr)	2001-01-26	2002-01-22	Analogue de benzylamine
JP2002015136A JP4176997B2 (ja)	2001-01-26	2002-01-24	ヒドロキシベンジルアミン誘導体
TW91101231		2002-01-25
JP2002214641		2002-07-24
JP2003200434A JP2004107322A (ja)	2001-01-26	2003-07-23	ヒドロキシベンジルアミン誘導体を含有する医薬
US10/629,108 US7504437B2 (en)	2001-01-26	2003-07-28	Benzylamine analogues
US11/583,499 US7514475B2 (en)	2001-01-26	2006-10-19	Benzylamine analogues
US11/820,218 US20080255095A1 (en)	2001-01-26	2007-06-18	Benzylamine analogues

Publications (2)

Publication Number	Publication Date
DE60223904D1 true DE60223904D1 (de)	2008-01-17
DE60223904T2 DE60223904T2 (de)	2008-11-27

Family

ID=32300480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60223904T Expired - Fee Related DE60223904T2 (de)	2001-01-26	2002-01-22	Benzylaminanalogen

Country Status (11)

Country	Link
US (5)	US7504437B2 (de)
EP (1)	EP1362844B1 (de)
JP (2)	JP4176997B2 (de)
AT (1)	ATE380172T1 (de)
AU (1)	AU2002226687B9 (de)
CA (1)	CA2435883A1 (de)
DE (1)	DE60223904T2 (de)
DK (1)	DK1362844T3 (de)
ES (1)	ES2299561T3 (de)
PT (1)	PT1362844E (de)
WO (1)	WO2002059074A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60144284D1 (de)	2000-11-01	2011-05-05	Millennium Pharm Inc	Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
AU2004285893B2 (en) *	2003-10-21	2011-12-15	Colucid Pharmaceuticals, Inc.	Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
AT500143A1 (de) *	2004-04-22	2005-11-15	Sanochemia Pharmazeutika Ag	Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
TW200829171A (en)	2006-11-17	2008-07-16	Nihon Nohyaku Co Ltd	Haloalkyl sulfonanilide derivatives or salts thereof, herbicide using it as effective constituent and use-method thereof
US8101782B2 (en)	2007-02-02	2012-01-24	Colucid Pharmaceuticals, Inc.	Compounds that inhibit cholinesterase
CA2679039A1 (en) *	2007-03-05	2008-09-12	F. Hoffmann-La Roche Ag	Aminoamides as orexin antagonists
CN102762554A (zh)	2010-02-16	2012-10-31	辉瑞大药厂	5-ht4受体的部分激动剂(r)-4-((4-((4-(四氢呋喃-3-基氧基)苯并[d]异*唑-3-基氧基)甲基)哌啶-1-基)甲基)四氢-2h-吡喃-4-醇
CN102850318A (zh) *	2011-07-01	2013-01-02	中国人民解放军军事医学科学院毒物药物研究所	新的选择性5-羟色胺重摄取抑制剂及其医药用途
CN103131747A (zh) *	2013-03-15	2013-06-05	康化（上海）新药研发有限公司	利用生物酶手性拆分合成(s)-3-(4-羟基苯基)-3-甲氨基丙酸的方法
CN107141266B (zh) *	2017-06-28	2019-04-09	佳木斯大学附属第一医院	一种用于治疗阿尔茨海默病的杂环化合物及其制备方法
CN109225653B (zh) *	2018-07-19	2020-11-06	昆明理工大学	一种高磷赤褐铁矿石除磷的选矿方法
CN118239868A (zh) *	2019-07-18	2024-06-25	华夏生生药业(北京)有限公司	氨基甲酸酯取代的苯乙烯基砜类化合物及其制备方法和用途
CN114522707B (zh) *	2022-02-22	2023-07-21	中南大学	一种碱土金属碳酸盐负载纳米钌复合材料及其制备方法和应用
CN115215769B (zh) *	2022-06-28	2024-01-30	黄淮学院	一种用于检测乙酰胆碱酯酶的荧光探针及其制备方法与应用
CN118184601B (zh) *	2024-03-15	2024-10-25	安徽医科大学	一种可用于实时监测体内/外乙酰胆碱酯酶的小分子生物发光探针及制法和应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3217007A (en)		1965-11-09		Halo- and nitro-substituted phenethyl-z- methyl tetrahydroisoquinolsnes
JPS4318547Y1 (de)	1965-04-13	1968-07-31
US3557122A (en)	1968-10-10	1971-01-19	Warner Lambert Pharmaceutical	5,6,7a,8,11,11a,12,12a-octahydroindolo (2,1-a)isoquinolin-9(10h)-ones
IL33480A (en)	1968-12-10	1973-03-30	Tanabe Seiyaku Co	6,7-diacyloxy-tetrahydro-isoquinolines and their preparation
JPS4714108U (de)	1971-03-17	1972-10-19
JPS5734275B2 (de)	1973-07-30	1982-07-22
JPS5246232B2 (de) *	1973-07-31	1977-11-22
JPS5148677A (en)	1974-10-22	1976-04-26	Hokuriku Pharmaceutical	00 ashiruhaigenaminno seizohoho
JPS5247474B2 (de)	1974-11-20	1977-12-02
JPS5170772A (ja)	1974-11-27	1976-06-18	Tanabe Seiyaku Co	Tetorahidoroisokinorinjudotaino seiho
JPS5170774A (ja)	1974-12-05	1976-06-18	Tanabe Seiyaku Co	Tetorahidoroisokinorinjudotaino seiho
JPS5186478A (en)	1975-01-17	1976-07-29	Fujisawa Pharmaceutical Co	123*44 tetorahidoroisokinorinruio seizosuruhoho
JPS52102281A (en)	1976-02-24	1977-08-27	Tanabe Seiyaku Co Ltd	Tetrahydroisoquinoline derivatives
US4207343A (en)	1978-06-22	1980-06-10	Eli Lilly And Company	1-Phenyl-3-(substituted phenoxy)propylamines
JPS57139066A (en)	1981-02-20	1982-08-27	Fujisawa Pharmaceut Co Ltd	Isoquinoline derivative and its preparation
JPS62265266A (ja)	1986-05-13	1987-11-18	Takasago Corp	Ｎ−アシル−テトラヒドロイソキノリン類の製造法
US5135947A (en)	1987-04-09	1992-08-04	Eli Lilly And Company	1-phenyl-3-naphthalenyloxypropanamines and their use as selective serotonin reuptake inhibitors
US4920132A (en)	1987-11-03	1990-04-24	Rorer Pharmaceutical Corp.	Quinoline derivatives and use thereof as antagonists of leukotriene D4
NO880840L (no)	1988-02-26	1989-08-28	Jan Saelensminde	Fremgangsmaate til behandling av betong.
US5187168A (en)	1991-10-24	1993-02-16	American Home Products Corporation	Substituted quinazolines as angiotensin II antagonists
GB9205505D0 (en)	1992-03-13	1992-04-29	Ici Plc	Cyclic compounds
JP3457669B2 (ja)	1992-10-28	2003-10-20	富山化学工業株式会社	新規な１，２−ベンゾイソオキサゾール誘導体またはその塩，それらからなる脳保護剤
KR950704228A (ko)	1992-12-02	1995-11-17	알렌 제이. 스피겔	선택적 포스포디에스테르가수분해효소 iv형(pde_iv) 저해제로서의 카테콜 디에테르(catecol diethers as selective pde_iv inhibitors)
US5292962A (en)	1992-12-11	1994-03-08	Eli Lilly And Company	Intermediates to 1-phenyl-3-naphthalenyloxy-propanamines
US5589489A (en)	1993-12-15	1996-12-31	Zeneca Limited	Cyclic amide derivatives for treating asthma
JPH0841008A (ja)	1994-07-29	1996-02-13	Ono Pharmaceut Co Ltd	一酸化窒素合成酵素阻害剤
US6743902B1 (en)	1994-11-02	2004-06-01	Valeant Pharmaceuticals International	Sugar modified nucleosides
US5681940A (en)	1994-11-02	1997-10-28	Icn Pharmaceuticals	Sugar modified nucleosides and oligonucleotides
WO1996022276A1 (fr) *	1995-01-20	1996-07-25	Nippon Shinyaku Co., Ltd.	Derives d'ethylamine et medicaments
IL117149A0 (en)	1995-02-23	1996-06-18	Schering Corp	Muscarinic antagonists
GB9508748D0 (en)	1995-04-28	1995-06-14	British Biotech Pharm	Benzimidazole derivatives
DE19643048A1 (de)	1996-10-18	1998-04-23	Daimler Benz Ag	Verbindungen und deren Verwendung sowie Verfahren zur Herstellung von flüssigkristallinen Polymeren daraus
DE19651099A1 (de)	1996-12-09	1998-06-10	Consortium Elektrochem Ind	Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung
AU5727798A (en)	1996-12-23	1998-07-17	Texas A & M University, The	Anti-amyloidogenic agents
HUP0004151A3 (en)	1997-10-27	2001-12-28	Isk Americas Inc Concord	Herbicidal substituted benzene derivatives, intermediates, preparation and use thereof
JP4907817B2 (ja)	1999-11-03	2012-04-04	エーエムアールテクノロジーインコーポレイテッド	ノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するための、４−フェニル置換テトラヒドロイソキノリン類およびその利用
TWI284639B (en)	2000-01-24	2007-08-01	Shionogi & Co	A compound having thrombopoietin receptor agonistic effect
AU2002341034B2 (en)	2001-03-21	2007-06-14	Molteni Therapeutics S.R.L.	Metal substituted non centrosimmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostic
DE10211597A1 (de)	2002-03-15	2003-10-02	Merck Patent Gmbh	Verfahren zur Herstellung von Ringverbindungen

2002
- 2002-01-22 WO PCT/JP2002/000400 patent/WO2002059074A1/ja active IP Right Grant
- 2002-01-22 CA CA002435883A patent/CA2435883A1/en not_active Abandoned
- 2002-01-22 EP EP02716323A patent/EP1362844B1/de not_active Expired - Lifetime
- 2002-01-22 ES ES02716323T patent/ES2299561T3/es not_active Expired - Lifetime
- 2002-01-22 AU AU2002226687A patent/AU2002226687B9/en not_active Ceased
- 2002-01-22 DE DE60223904T patent/DE60223904T2/de not_active Expired - Fee Related
- 2002-01-22 DK DK02716323T patent/DK1362844T3/da active
- 2002-01-22 AT AT02716323T patent/ATE380172T1/de not_active IP Right Cessation
- 2002-01-22 PT PT02716323T patent/PT1362844E/pt unknown
- 2002-01-24 JP JP2002015136A patent/JP4176997B2/ja not_active Expired - Fee Related
2003
- 2003-07-23 JP JP2003200434A patent/JP2004107322A/ja not_active Withdrawn
- 2003-07-28 US US10/629,108 patent/US7504437B2/en not_active Expired - Fee Related
2006
- 2006-10-19 US US11/583,404 patent/US7504393B2/en not_active Expired - Fee Related
- 2006-10-19 US US11/583,499 patent/US7514475B2/en not_active Expired - Fee Related
2007
- 2007-06-18 US US11/820,218 patent/US20080255095A1/en not_active Abandoned
2009
- 2009-01-29 US US12/322,173 patent/US20090149444A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1362844A4 (de)	2004-05-26
US20070037795A1 (en)	2007-02-15
US20090149444A1 (en)	2009-06-11
DK1362844T3 (da)	2008-04-14
AU2002226687B2 (en)	2005-08-25
US20070037793A1 (en)	2007-02-15
JP4176997B2 (ja)	2008-11-05
US7514475B2 (en)	2009-04-07
US20080255095A1 (en)	2008-10-16
ATE380172T1 (de)	2007-12-15
US20040067981A1 (en)	2004-04-08
JP2004107322A (ja)	2004-04-08
DE60223904T2 (de)	2008-11-27
AU2002226687B9 (en)	2005-10-20
WO2002059074A1 (fr)	2002-08-01
EP1362844A1 (de)	2003-11-19
EP1362844B1 (de)	2007-12-05
US7504393B2 (en)	2009-03-17
CA2435883A1 (en)	2002-08-01
ES2299561T3 (es)	2008-06-01
PT1362844E (pt)	2008-03-10
US7504437B2 (en)	2009-03-17
JP2003176256A (ja)	2003-06-24

Publication	Publication Date	Title
DK1424330T3 (da)	2012-01-16	Aktivator for peroxisom proliferator-responsiv receptor delta
DE60315265D1 (de)	2007-09-13	Stickstoffhaltige heterocyclische verbindung und arzneimittel davon
PT976748E (pt)	2004-03-31	Derivados de pirrolidina com actividade inibidora de fosfolipase a2
NO20021528D0 (no)	2002-03-26	Kinuklidinforbindelser og medikamenter inneholdende de samme som den aktive bestanddel
DE60223904D1 (de)	2008-01-17	Benzylaminanalogen
AU3599801A (en)	2001-09-12	Reagents for the quantitation of active oxygen
DK0916651T3 (da)	2003-12-01	Phenylalkylcarboxylsyrederivater
ATE279411T1 (de)	2004-10-15	Fluorszierende marker
ATE537158T1 (de)	2011-12-15	M-stage-kinesin-inhibitor
DK0807627T3 (da)	2006-04-10	Anilidforbindelser som ACAT-inhibitorer
ATE284884T1 (de)	2005-01-15	Triazolderivate mit amidbindungen
DK1433480T3 (da)	2011-04-11	Lægemiddel indeholdende pyrimidin-derivat
ATE171622T1 (de)	1998-10-15	Antiallergische zusammensetzung enthaltend eine phosphorsäurediester-verbindung
ATE311877T1 (de)	2005-12-15	Lp(a)-mindernde mittel und inhibitoren der apoprotein (a) produktion
EP1607390A4 (de)	2008-03-26	Pyrazolverbindung

Legal Events

Date	Code	Title	Description
2009-01-02	8364	No opposition during term of opposition
2010-11-18	8339	Ceased/non-payment of the annual fee