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DK0807627T3 - Anilidforbindelser som ACAT-inhibitorer - Google Patents

Anilidforbindelser som ACAT-inhibitorer

Info

Publication number
DK0807627T3
DK0807627T3 DK97108154T DK97108154T DK0807627T3 DK 0807627 T3 DK0807627 T3 DK 0807627T3 DK 97108154 T DK97108154 T DK 97108154T DK 97108154 T DK97108154 T DK 97108154T DK 0807627 T3 DK0807627 T3 DK 0807627T3
Authority
DK
Denmark
Prior art keywords
compounds
group
oxygen
optionally
pharmaceutical compositions
Prior art date
Application number
DK97108154T
Other languages
English (en)
Inventor
Katsumi Kawamine
Yukihiro Sato
Toshiyuki Edano
Kimiyuki Shibuya
Souhei Tanabe
Masami Shiratsuchi
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Application granted granted Critical
Publication of DK0807627T3 publication Critical patent/DK0807627T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97108154T 1996-05-17 1997-05-20 Anilidforbindelser som ACAT-inhibitorer DK0807627T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15874396 1996-05-17
JP08866097A JP4191269B2 (ja) 1996-05-17 1997-03-25 新規なアニリド化合物及びこれを含有する医薬

Publications (1)

Publication Number Publication Date
DK0807627T3 true DK0807627T3 (da) 2006-04-10

Family

ID=26430018

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97108154T DK0807627T3 (da) 1996-05-17 1997-05-20 Anilidforbindelser som ACAT-inhibitorer

Country Status (7)

Country Link
US (2) US6204278B1 (da)
EP (1) EP0807627B1 (da)
JP (1) JP4191269B2 (da)
AT (1) ATE314352T1 (da)
DE (1) DE69734952T2 (da)
DK (1) DK0807627T3 (da)
ES (1) ES2252765T3 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4647726B2 (ja) * 1997-03-25 2011-03-09 興和株式会社 新規なアニリド化合物及びこれを含有する医薬
DE69828276T2 (de) * 1997-05-26 2005-12-15 Kowa Co., Ltd., Nagoya Neue cyclische Diaminverbindungen und Heilmittel das diese enthält
US6969711B2 (en) 1997-05-26 2005-11-29 Kowa Company, Ltd. Cyclic diamine compounds and medicine containing the same
HUP0000729A3 (en) * 1997-11-14 2001-06-28 Kowa Co Novel amide compounds and drugs containing the same
US6849647B1 (en) 1999-07-21 2005-02-01 Kowa Company, Ltd. Amide compounds and medications containing the same technical field
JP4592130B2 (ja) * 1999-08-05 2010-12-01 大塚化学株式会社 チオ酢酸アミド化合物及び農園芸用殺菌剤
US6622484B2 (en) 2001-02-02 2003-09-23 Caterpillar Inc. Hystat/split torque modulation
WO2003018564A1 (fr) * 2001-08-22 2003-03-06 Kowa Company, Ltd Inhibiteur d'acat selectif de la paroi vasculaire
US7163944B2 (en) * 2004-01-26 2007-01-16 Kowa Co., Ltd. Cyclic diamine compound and pharmaceutical containing the same
DK1809759T3 (da) 2004-10-06 2014-01-06 Brigham & Womens Hospital Relevans af opnåede niveauer af markører for systemisk inflammation efter behandling
WO2010017368A2 (en) 2008-08-06 2010-02-11 Hydra Biosciences, Inc. Methods and compositions for treating anxiety
JP5523993B2 (ja) 2010-08-31 2014-06-18 富士フイルム株式会社 酸ハロゲン化物の製造方法、及び酸ハロゲン化物
RS56066B2 (sr) 2013-03-15 2018-09-28 Hydra Biosciences Inc Supstituisani ksantini i postupci za njihovu upotrebu

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB921791A (en) * 1960-01-21 1963-03-27 Ici Ltd New dyestuffs
US3720686A (en) 1971-04-01 1973-03-13 Squibb & Sons Inc Mercaptobenzimidazole derivatives
EP0005501B1 (de) * 1978-05-20 1981-11-25 Bayer Ag Heteroaryl-oxyessigsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide
DE2903966A1 (de) 1979-02-02 1980-08-07 Bayer Ag Substituierte carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
AU541738B2 (en) 1979-09-20 1985-01-17 Nippon Chemiphar Co. Ltd. Cyclohexane carboxylic acid derivatives
GB2093835B (en) 1981-01-22 1984-10-31 Nippon Chemiphar Co Novel guanidinocyclohexanecarboxylic acid derivatives and a process for producing the same
DE3419994A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Benzoxazolyl- und benzthiazolyl-aminosaeuren, ihre herstellung und verwendung im pflanzenschutz
CA2003283A1 (en) 1988-12-05 1990-06-05 C. Anne Higley Imidazoles for the treatment of atherosclerosis
WO1991004027A1 (en) 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
US5668136A (en) 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
JPH04139172A (ja) * 1990-10-01 1992-05-13 Sankyo Co Ltd α―スルフィニル置換アセトアミド誘導体
US5362878A (en) 1991-03-21 1994-11-08 Pfizer Inc. Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
US5364875A (en) 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5290801A (en) * 1992-05-29 1994-03-01 The Du Pont Merck Pharmaceutical Company Benzimidazoles for the treatment of atherosclerosis
CA2251368A1 (en) * 1997-02-14 1998-08-20 Bayer Corporation Amide derivatives as selective neuropeptide y receptor antagonists

Also Published As

Publication number Publication date
JP4191269B2 (ja) 2008-12-03
ATE314352T1 (de) 2006-01-15
US20020037910A1 (en) 2002-03-28
EP0807627B1 (en) 2005-12-28
US6825223B2 (en) 2004-11-30
ES2252765T3 (es) 2006-05-16
EP0807627A2 (en) 1997-11-19
DE69734952T2 (de) 2006-07-27
DE69734952D1 (de) 2006-02-02
US6204278B1 (en) 2001-03-20
JPH1029986A (ja) 1998-02-03
EP0807627A3 (en) 1997-12-03

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