DE69627006D1 - 2-substituierte aryl-pyrrolen, zusammensetzungen solche verbindungen enthaltend und deren verwendung - Google Patents

2-substituierte aryl-pyrrolen, zusammensetzungen solche verbindungen enthaltend und deren verwendung

Info

Publication number: DE69627006D1
Authority: DE; Germany
Prior art keywords: compounds; substituted aryl; compositions containing; pyrrols; interleukin
Prior art date: 1995-08-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69627006T

Other languages

English (en)

Other versions

DE69627006T2 (de

Inventor

Laszlo E De

B Mantlo

S Ponticello

G Selnick

J Liverton

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-10

Filing date

1996-08-08

Publication date

2003-04-30

1996-04-04 Priority claimed from GBGB9607254.1A external-priority patent/GB9607254D0/en

1996-05-02 Priority claimed from GBGB9609264.8A external-priority patent/GB9609264D0/en

1996-08-08 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2003-04-30 Publication of DE69627006D1 publication Critical patent/DE69627006D1/de

2004-01-15 Application granted granted Critical

2004-01-15 Publication of DE69627006T2 publication Critical patent/DE69627006T2/de

2016-08-09 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
102000004127 Cytokines Human genes 0.000 abstract 3
108090000695 Cytokines Proteins 0.000 abstract 3
102000000589 Interleukin-1 Human genes 0.000 abstract 2
108010002352 Interleukin-1 Proteins 0.000 abstract 2
102000004889 Interleukin-6 Human genes 0.000 abstract 2
108090001005 Interleukin-6 Proteins 0.000 abstract 2
102000004890 Interleukin-8 Human genes 0.000 abstract 2
108090001007 Interleukin-8 Proteins 0.000 abstract 2
108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
229940100601 interleukin-6 Drugs 0.000 abstract 2
229940096397 interleukin-8 Drugs 0.000 abstract 2
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 2
102000003390 tumor necrosis factor Human genes 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

DE69627006T 1995-08-10 1996-08-08 2-substituierte aryl-pyrrolen, zusammensetzungen solche verbindungen enthaltend und deren verwendung Expired - Fee Related DE69627006T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US209395P	1995-08-10	1995-08-10
US1418196P	1996-03-26	1996-03-26
GBGB9607254.1A GB9607254D0 (en)	1996-04-04	1996-04-04	2-Substituted aryl pyrroles, compositions containing such compounds and methods of use
GBGB9609264.8A GB9609264D0 (en)	1996-05-02	1996-05-02	2-Substituted aryl pyrroles,compositions containing such compounds and methods of use
PCT/US1996/012917 WO1997005877A1 (en)	1995-08-10	1996-08-08	2-substituted aryl pyrroles, compositions containing such compounds and methods of use

Publications (2)

Publication Number	Publication Date
DE69627006D1 true DE69627006D1 (de)	2003-04-30
DE69627006T2 DE69627006T2 (de)	2004-01-15

Family

ID=27451431

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69627006T Expired - Fee Related DE69627006T2 (de)	1995-08-10	1996-08-08	2-substituierte aryl-pyrrolen, zusammensetzungen solche verbindungen enthaltend und deren verwendung

Country Status (8)

Country	Link
EP (1)	EP0863757B1 (de)
JP (1)	JP3294616B2 (de)
AT (1)	ATE235239T1 (de)
AU (1)	AU705082B2 (de)
CA (1)	CA2228136A1 (de)
DE (1)	DE69627006T2 (de)
ES (1)	ES2193256T3 (de)
WO (1)	WO1997005877A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5916891A (en)	1992-01-13	1999-06-29	Smithkline Beecham Corporation	Pyrimidinyl imidazoles
US6046208A (en) *	1996-01-11	2000-04-04	Smithkline Beecham Corporation	Substituted imidazole compounds
AU3044197A (en)	1996-07-11	1998-02-09	Pfizer Inc.	Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
CA2293436C (en)	1997-06-12	2010-10-26	Rhone-Poulenc Rorer Limited	Imidazolyl-cyclic acetals as tnf inhibitors
US7301021B2 (en)	1997-07-02	2007-11-27	Smithkline Beecham Corporation	Substituted imidazole compounds
US6022884A (en)	1997-11-07	2000-02-08	Amgen Inc.	Substituted pyridine compounds and methods of use
AR017219A1 (es)	1997-12-19	2001-08-22	Smithkline Beecham Corp	Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
US6174901B1 (en)	1998-12-18	2001-01-16	Amgen Inc.	Substituted pyridine and pyridazine compounds and methods of use
WO1999032448A1 (en) *	1997-12-19	1999-07-01	Amgen Inc.	Substituted pyridine and pyridazine compounds and their pharmaceutical use
US6858617B2 (en)	1998-05-26	2005-02-22	Smithkline Beecham Corporation	Substituted imidazole compounds
US6649617B1 (en)	1998-10-07	2003-11-18	Smithkline Beecham Corporation	Treatment for stroke management
WO2000025791A1 (en)	1998-11-04	2000-05-11	Smithkline Beecham Corporation	Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
AU2871900A (en) *	1999-02-04	2000-08-25	Millennium Pharmaceuticals, Inc.	G-protein coupled heptahelical receptor binding compounds and methods of use thereof
CO5170501A1 (es) *	1999-04-14	2002-06-27	Novartis Ag	AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO
AU4315100A (en) *	1999-04-28	2000-11-17	Sankyo Company Limited	Preventive or inhibitory agents for hepatopathy
AU777702B2 (en) *	1999-05-14	2004-10-28	Ortho-Mcneil Pharmaceutical, Inc.	Substituted 3-pyridyl-4-arylpyrroles, and related therapeutic and prophylactic methods
IL137365A0 (en) *	1999-07-21	2001-07-24	Sankyo Co	Heteroaryl-substituted pyrrole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US7122666B2 (en)	1999-07-21	2006-10-17	Sankyo Company, Limited	Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
EP1278520B1 (de) *	1999-11-12	2006-03-01	Merck & Co., Inc.	Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel
DE60023025T2 (de)	1999-11-23	2006-07-13	Smithkline Beecham Corp.	3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
US6759410B1 (en)	1999-11-23	2004-07-06	Smithline Beecham Corporation	3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7053098B1 (en)	1999-11-23	2006-05-30	Smithkline Beecham Corporation	3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CN1525968A (zh) *	2001-01-18	2004-09-01	三共株式会社	预防或治疗肝病的组合物
WO2002057255A1 (fr) *	2001-01-22	2002-07-25	Sankyo Company, Limited	Derives du pyrrole substitues en 4 ou 5
ES2296910T3 (es) *	2001-01-22	2008-05-01	Sankyo Company, Limited	Compuestos sustituidos con grupo amino biciclicos.
EP1364949A4 (de) *	2001-02-02	2005-11-23	Takeda Pharmaceutical	Jnk inhibitor
WO2002094267A1 (fr) *	2001-05-24	2002-11-28	Sankyo Company, Limited	Preparation pharmaceutique pour prevenir ou traiter l'arthrite
RU2470017C2 (ru)	2007-06-08	2012-12-20	Янссен Фармацевтика Н.В.	Производные пиперидина/пиперазина
WO2008148851A1 (en)	2007-06-08	2008-12-11	Janssen Pharmaceutica N.V.	Piperidine/piperazine derivatives
JO2972B1 (en)	2007-06-08	2016-03-15	جانسين فارماسوتيكا ان. في	Piperidine / piperazine derivatives
WO2008148840A1 (en)	2007-06-08	2008-12-11	Janssen Pharmaceutica N.V.	Piperidine/piperazine derivatives
CA2725933C (en)	2008-06-05	2018-01-16	Janssen Pharmaceutica Nv	Drug combinations comprising a dgat inhibitor and a ppar-agonist
WO2012006068A2 (en) *	2010-06-28	2012-01-12	President And Fellows Of Harvard College	Compounds for the inhibition of cellular proliferation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0300688A1 (de) *	1987-07-21	1989-01-25	FISONS plc	Pyrrol-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammenstellungen, die sie enthalten
AU3994795A (en) *	1994-12-06	1996-06-26	Nippon Soda Co., Ltd.	Pyridylpyrrole compounds, process for production, and agrohorticultural bactericide

1996
- 1996-08-08 ES ES96928097T patent/ES2193256T3/es not_active Expired - Lifetime
- 1996-08-08 EP EP96928097A patent/EP0863757B1/de not_active Expired - Lifetime
- 1996-08-08 DE DE69627006T patent/DE69627006T2/de not_active Expired - Fee Related
- 1996-08-08 JP JP50865997A patent/JP3294616B2/ja not_active Expired - Fee Related
- 1996-08-08 AU AU67689/96A patent/AU705082B2/en not_active Ceased
- 1996-08-08 CA CA002228136A patent/CA2228136A1/en not_active Abandoned
- 1996-08-08 WO PCT/US1996/012917 patent/WO1997005877A1/en active IP Right Grant
- 1996-08-08 AT AT96928097T patent/ATE235239T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0863757B1 (de)	2003-03-26
WO1997005877A1 (en)	1997-02-20
EP0863757A4 (de)	1998-09-16
AU705082B2 (en)	1999-05-13
EP0863757A1 (de)	1998-09-16
CA2228136A1 (en)	1997-02-20
AU6768996A (en)	1997-03-05
ATE235239T1 (de)	2003-04-15
ES2193256T3 (es)	2003-11-01
JPH11510510A (ja)	1999-09-14
DE69627006T2 (de)	2004-01-15
JP3294616B2 (ja)	2002-06-24

Publication	Publication Date	Title
DE69627006T2 (de)	2004-01-15	2-substituierte aryl-pyrrolen, zusammensetzungen solche verbindungen enthaltend und deren verwendung
NO996120L (no)	2000-01-24	Imidazolyl-cykliske acetaler
CY1109328T1 (el)	2012-05-23	Ενωσεις θειενοδιβενζοαζουλενιου ως αναστολεις παραγοντα νεκρωσης ογκου
NO20054959D0 (no)	2005-10-25	Fremgangsmater for behandling av interleukin-6 relaterte sykdommer
DE69836563D1 (de)	2007-01-11	INHIBIERUNG DER p38 KINASE-AKTIVITÄT DURCH DIE VERWENDUNG VON ARYL- UND HETEROARYLSUBSTITUIERTEN HARNSTOFFEN
FI935585A0 (fi)	1993-12-13	Pyrrolopyrimidiner
IL112427A0 (en)	1995-03-30	Production of pharmaceutical compositions comprising anti-tnf antibodies
ATE203159T1 (de)	2001-08-15	Verbindungen zur behandlung von allergischen und entzündlichen erkrankungen
AU2003263552A8 (en)	2004-03-29	Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
MY138373A (en)	2009-05-29	Cytokine inhibitors
DE69839278D1 (de)	2008-04-30	Substituierte pyridin- und pyridazinderivate und ihre pharmazeutische verwendung
DE60027769D1 (de)	2006-06-08	Pyrrolidin-derivate als inhibitoren von cyclischer amp-phosphodiesterase
CY1111912T1 (el)	2015-11-04	Μεθοδος αναστολης της δραστηριοτητας των οστεοκλαστων
CY1110885T1 (el)	2015-06-10	Πεπτιδια που μπορουν να συνδεθουν στον αυξητικο παραγοντα μεταμορφωσης βητα 1 (tgf-beta1)
TR199900318T2 (xx)	1999-05-21	IL-8 resept�r antagonistleri.
RU2008116925A (ru)	2009-11-10	Лечение болезни альцгеймера цитокинами
ATE149353T1 (de)	1997-03-15	Guluronsäurepolymere und ihre verwendung zur hemmung von cytokinen
AU6227899A (en)	2000-05-08	Method for screening compound inhibiting signal transduction of inflammatory cytokine
ATE311853T1 (de)	2005-12-15	Verwendung von krillenzymen zur behandlung von zahnbelag
ATE186641T1 (de)	1999-12-15	Cytokinhemmer
IL129787A0 (en)	2000-02-29	Isolated tumor necrosis factor receptor releasing enzyme compositions comprising the enzyme and methods of the use thereof
ES2189165T3 (es)	2003-07-01	Nuevos compuestos macrociclicos como inhibidores de metaloproteasa.
ATE429434T1 (de)	2009-05-15	6,7-dihydro-5h-pyrazolo 1,2-a pyrazol-1-one zur kontrolle von entzündungsfördernden cytokinen
AU2003265924A1 (en)	2004-04-30	Benzimidazolones and their use as cytokine inhibitors
HUP0100105A2 (hu)	2001-05-28	TNF-antagonisták alkalmazása szeptikus betegségek kezelésére szolgáló gyógyszerként

Legal Events

Date	Code	Title	Description
2005-06-09	8339	Ceased/non-payment of the annual fee