CY1109328T1 - Ενωσεις θειενοδιβενζοαζουλενιου ως αναστολεις παραγοντα νεκρωσης ογκου - Google Patents
Ενωσεις θειενοδιβενζοαζουλενιου ως αναστολεις παραγοντα νεκρωσης ογκουInfo
- Publication number
- CY1109328T1 CY1109328T1 CY20091100888T CY091100888T CY1109328T1 CY 1109328 T1 CY1109328 T1 CY 1109328T1 CY 20091100888 T CY20091100888 T CY 20091100888T CY 091100888 T CY091100888 T CY 091100888T CY 1109328 T1 CY1109328 T1 CY 1109328T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- tumor
- thienodibenzoazulenium
- necrosion
- factor inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Η παρούσα εφεύρεση αφορά τις νέες ενώσεις διβενζοαζουλενίου που αντιπροσωπεύονται από τον τύπο I, καθώς και τα φαρμακευτικά παρασκευάσματα αυτών για την αναστολή του άλφα παράγοντα νέκρωσης όγκου (TNF-α) και της ιντερλευκίνης 1 (IL-1) σε θηλαστικά σε όλες τις ασθένειες και καταστάσεις όπου αυτοί οι μεσολαβητές εκκρίνονται υπερβολικά. Οι ενώσεις της παρούσας εφεύρεσης επίσης παρουσιάζουν αναλγητική δράση και μπορεί να χρησιμοποιούνται για την ανακούφιση πόνου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR20000310A HRP20000310A2 (en) | 2000-05-17 | 2000-05-17 | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
PCT/HR2001/000027 WO2001087890A1 (en) | 2000-05-17 | 2001-05-16 | Thienodibenzoazulene compounds as tumor necrosis factor inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109328T1 true CY1109328T1 (el) | 2012-05-23 |
Family
ID=10947110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100888T CY1109328T1 (el) | 2000-05-17 | 2009-08-20 | Ενωσεις θειενοδιβενζοαζουλενιου ως αναστολεις παραγοντα νεκρωσης ογκου |
Country Status (37)
Country | Link |
---|---|
US (2) | US6897211B2 (el) |
EP (1) | EP1284977B1 (el) |
JP (1) | JP2003533528A (el) |
KR (1) | KR100823064B1 (el) |
CN (1) | CN1194976C (el) |
AR (1) | AR030562A1 (el) |
AT (1) | ATE434619T1 (el) |
AU (2) | AU5656001A (el) |
BG (1) | BG65967B1 (el) |
BR (1) | BR0111202A (el) |
CA (1) | CA2409090C (el) |
CR (1) | CR6860A (el) |
CY (1) | CY1109328T1 (el) |
CZ (1) | CZ301770B6 (el) |
DE (1) | DE60139070D1 (el) |
DK (1) | DK1284977T3 (el) |
DZ (1) | DZ3357A1 (el) |
EA (1) | EA006069B1 (el) |
EE (1) | EE200200636A (el) |
ES (1) | ES2328335T3 (el) |
GE (1) | GEP20043304B (el) |
HK (1) | HK1056719A1 (el) |
HR (1) | HRP20000310A2 (el) |
HU (1) | HUP0302295A3 (el) |
IL (1) | IL152809A0 (el) |
IS (1) | IS6621A (el) |
MA (1) | MA27125A1 (el) |
MX (1) | MXPA02011269A (el) |
NO (1) | NO20025510L (el) |
NZ (1) | NZ522553A (el) |
PL (1) | PL204849B1 (el) |
PT (1) | PT1284977E (el) |
RS (1) | RS50893B (el) |
SI (1) | SI1284977T1 (el) |
SK (1) | SK17702002A3 (el) |
WO (1) | WO2001087890A1 (el) |
ZA (1) | ZA200209180B (el) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20020303B8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | Benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
HRP20020304B1 (en) | 2002-04-10 | 2008-04-30 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof |
HRP20020305A8 (en) * | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
HRP20020440B1 (en) * | 2002-05-21 | 2008-02-29 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof |
HRP20020441A2 (en) * | 2002-05-21 | 2003-12-31 | Pliva D D | 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
HRP20020452A2 (en) * | 2002-05-23 | 2004-02-29 | Pliva D D | 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
HRP20020451A2 (en) * | 2002-05-23 | 2003-12-31 | Pliva D D | 1-tia-3-aza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
HRP20020453A2 (en) | 2002-05-23 | 2003-12-31 | Pliva D D | 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
HRP20030160A2 (en) * | 2003-03-06 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | 1-thiadibenzoazulene derivatives and biological action thereof |
HRP20030324A2 (en) | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
CA2575975A1 (en) * | 2003-11-12 | 2005-05-26 | Dr. Reddy's Laboratories, Inc. | Preparation of escitalopram |
HRP20030954A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva D.D. | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030955A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20040104A2 (en) * | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
KR20070083811A (ko) | 2004-10-27 | 2007-08-24 | 글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오. | 항-염증 활성을 가진 접합체 |
WO2006061392A2 (en) * | 2004-12-07 | 2006-06-15 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
WO2006075255A2 (en) * | 2005-01-13 | 2006-07-20 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Anti-inflamatory macrolide conjugates |
EP2026651B1 (en) | 2006-03-08 | 2013-04-17 | Cortria Corporation | Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries |
WO2008094275A1 (en) | 2007-01-30 | 2008-08-07 | New York University | Peptides for treatment of conditions associated with nitric oxide |
WO2008096755A1 (ja) * | 2007-02-07 | 2008-08-14 | Nippon Suisan Kaisha, Ltd. | バニロイド受容体(vr1)阻害剤及びその用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3711489A (en) * | 1971-03-31 | 1973-01-16 | Pfizer | Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles |
JPS53116385A (en) * | 1977-03-19 | 1978-10-11 | Hokuriku Pharmaceutical | Pyrazin derivative and method for its production |
US4198421A (en) * | 1978-11-30 | 1980-04-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles |
EE03612B1 (et) * | 1996-04-12 | 2002-02-15 | Janssen Pharmaceutica N.V. | Asendatud tetratsüklilised tetrahüdrofuraanderivaadid |
GB9713368D0 (en) * | 1997-06-25 | 1997-08-27 | Weston Medical Ltd | Flame control |
EP0887339A1 (de) * | 1997-06-27 | 1998-12-30 | Roche Diagnostics GmbH | Neue Azulenderivate und diese enthaltende Arzneimittel |
-
2000
- 2000-05-17 HR HR20000310A patent/HRP20000310A2/hr not_active Application Discontinuation
-
2001
- 2001-05-16 KR KR1020027015567A patent/KR100823064B1/ko not_active IP Right Cessation
- 2001-05-16 IL IL15280901A patent/IL152809A0/xx unknown
- 2001-05-16 CN CNB018115896A patent/CN1194976C/zh not_active Expired - Fee Related
- 2001-05-16 EA EA200201223A patent/EA006069B1/ru not_active IP Right Cessation
- 2001-05-16 SI SI200130930T patent/SI1284977T1/sl unknown
- 2001-05-16 JP JP2001584284A patent/JP2003533528A/ja active Pending
- 2001-05-16 CZ CZ20024090A patent/CZ301770B6/cs not_active IP Right Cessation
- 2001-05-16 AU AU5656001A patent/AU5656001A/xx active Pending
- 2001-05-16 BR BR0111202-3A patent/BR0111202A/pt not_active Application Discontinuation
- 2001-05-16 CA CA2409090A patent/CA2409090C/en not_active Expired - Fee Related
- 2001-05-16 AT AT01929882T patent/ATE434619T1/de not_active IP Right Cessation
- 2001-05-16 WO PCT/HR2001/000027 patent/WO2001087890A1/en active IP Right Grant
- 2001-05-16 NZ NZ522553A patent/NZ522553A/en unknown
- 2001-05-16 PT PT01929882T patent/PT1284977E/pt unknown
- 2001-05-16 DE DE60139070T patent/DE60139070D1/de not_active Expired - Lifetime
- 2001-05-16 RS YUP-841/02A patent/RS50893B/sr unknown
- 2001-05-16 HU HU0302295A patent/HUP0302295A3/hu unknown
- 2001-05-16 SK SK1770-2002A patent/SK17702002A3/sk unknown
- 2001-05-16 EP EP01929882A patent/EP1284977B1/en not_active Expired - Lifetime
- 2001-05-16 ES ES01929882T patent/ES2328335T3/es not_active Expired - Lifetime
- 2001-05-16 AU AU2001256560A patent/AU2001256560B2/en not_active Ceased
- 2001-05-16 GE GE5019A patent/GEP20043304B/en unknown
- 2001-05-16 EE EEP200200636A patent/EE200200636A/xx unknown
- 2001-05-16 DK DK01929882T patent/DK1284977T3/da active
- 2001-05-16 PL PL365054A patent/PL204849B1/pl not_active IP Right Cessation
- 2001-05-16 DZ DZ013357A patent/DZ3357A1/fr active
- 2001-05-16 MX MXPA02011269A patent/MXPA02011269A/es active IP Right Grant
- 2001-05-17 AR ARP010102339A patent/AR030562A1/es active IP Right Grant
-
2002
- 2002-11-11 MA MA26901A patent/MA27125A1/fr unknown
- 2002-11-12 ZA ZA200209180A patent/ZA200209180B/en unknown
- 2002-11-14 IS IS6621A patent/IS6621A/is unknown
- 2002-11-15 NO NO20025510A patent/NO20025510L/no not_active Application Discontinuation
- 2002-11-18 US US10/298,217 patent/US6897211B2/en not_active Expired - Fee Related
- 2002-12-17 CR CR6860A patent/CR6860A/es not_active Application Discontinuation
- 2002-12-17 BG BG107399A patent/BG65967B1/bg unknown
-
2003
- 2003-12-11 HK HK03109004A patent/HK1056719A1/xx not_active IP Right Cessation
-
2005
- 2005-03-25 US US11/090,743 patent/US20050171091A1/en not_active Abandoned
-
2009
- 2009-08-20 CY CY20091100888T patent/CY1109328T1/el unknown
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