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DE69618601T2 - Herstellung von einer immunantwort gegen prostat-spezifisches antigen (psa) - Google Patents

Herstellung von einer immunantwort gegen prostat-spezifisches antigen (psa)

Info

Publication number
DE69618601T2
DE69618601T2 DE69618601T DE69618601T DE69618601T2 DE 69618601 T2 DE69618601 T2 DE 69618601T2 DE 69618601 T DE69618601 T DE 69618601T DE 69618601 T DE69618601 T DE 69618601T DE 69618601 T2 DE69618601 T2 DE 69618601T2
Authority
DE
Germany
Prior art keywords
psa
host
prostate
cell
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69618601T
Other languages
German (de)
English (en)
Other versions
DE69618601D1 (de
Inventor
Dennis L. Panicali
Jeffrey Schlom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Therion Biologics Corp
US Department of Health and Human Services
Original Assignee
Therion Biologics Corp
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23988841&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69618601(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Therion Biologics Corp, US Department of Health and Human Services filed Critical Therion Biologics Corp
Publication of DE69618601D1 publication Critical patent/DE69618601D1/de
Application granted granted Critical
Publication of DE69618601T2 publication Critical patent/DE69618601T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6445Kallikreins (3.4.21.34; 3.4.21.35)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69618601T 1995-07-10 1996-06-26 Herstellung von einer immunantwort gegen prostat-spezifisches antigen (psa) Expired - Lifetime DE69618601T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/500,306 US6165460A (en) 1995-07-10 1995-07-10 Generation of immune responses to prostate-specific antigen (PSA)
PCT/US1996/010837 WO1997003203A2 (en) 1995-07-10 1996-06-26 Generation of immune responses to prostate-specific antigen (psa)

Publications (2)

Publication Number Publication Date
DE69618601D1 DE69618601D1 (de) 2002-02-21
DE69618601T2 true DE69618601T2 (de) 2002-08-08

Family

ID=23988841

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69637738T Expired - Lifetime DE69637738D1 (de) 1995-07-10 1996-06-26 Herstellung von einer Immunantwort gegen Prostat-spezifisches Antigen (SPA)
DE69618601T Expired - Lifetime DE69618601T2 (de) 1995-07-10 1996-06-26 Herstellung von einer immunantwort gegen prostat-spezifisches antigen (psa)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69637738T Expired - Lifetime DE69637738D1 (de) 1995-07-10 1996-06-26 Herstellung von einer Immunantwort gegen Prostat-spezifisches Antigen (SPA)

Country Status (11)

Country Link
US (2) US6165460A (es)
EP (2) EP0840791B1 (es)
JP (3) JP4633867B2 (es)
AT (2) ATE212058T1 (es)
CA (1) CA2226436C (es)
DE (2) DE69637738D1 (es)
DK (2) DK0840791T3 (es)
ES (2) ES2320089T3 (es)
HK (1) HK1042518B (es)
PT (2) PT1162272E (es)
WO (1) WO1997003203A2 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699475B1 (en) * 1987-09-02 2004-03-02 Therion Biologics Corporation Recombinant pox virus for immunization against tumor-associated antigens
US6165460A (en) * 1995-07-10 2000-12-26 Therion Biologics Corporation Generation of immune responses to prostate-specific antigen (PSA)
US6946133B1 (en) 1996-03-20 2005-09-20 The United States Of America As Represented By The Department Of Health And Human Services Prostate specific antigen oligo-epitope peptide
US20010036928A1 (en) * 1996-04-22 2001-11-01 Chamberlain Ronald S. Heterologous boosting immunizations
EP0954593A1 (en) 1996-07-25 1999-11-10 Therion Biologics Corporation Recombinant pox virus for immunization against tumor-associated antigens
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7816087B2 (en) 2001-11-14 2010-10-19 The United States Of America As Represented By The Department Of Health And Human Services Gene expressed in prostate cancer and methods of use
EP1512004B1 (en) * 2002-06-11 2006-03-15 MERCK PATENT GmbH Method for mapping and eliminating t-cell epitopes
DE10230893A1 (de) * 2002-06-26 2004-01-15 Dr. Fischer Ag Verfahren zur Eigenschaftsbestimmung und/oder Klassifikation von zirkulierenden Macrophagen und/oder peripheren blutmononuclearen Zellen sowie Analyseanordnung zur Durchführung des Verfahrens
US20040170646A1 (en) * 2002-12-13 2004-09-02 Aventis Pasteur, Inc. Production of ALVAC on avian embryonic stem cells
WO2005005465A2 (en) * 2003-07-08 2005-01-20 Board Of Regents, University Of Texas System Methods and compositions to enhance immune responses via recall antigens
US20070196346A1 (en) * 2003-08-21 2007-08-23 Brown Michael P Poxvirus Vector Encoding Prostate Specific Antigens For Treatment Of Prostate Cancer
WO2006101503A2 (en) * 2004-06-15 2006-09-28 Centocor, Inc. Method for screening agents against human prostate disease
JP2008546788A (ja) * 2005-06-21 2008-12-25 サイト パルス サイエンシズ、インコーポレイテッド 前立腺癌に対するワクチンに関する方法及び組成物
BRPI0708865A8 (pt) 2006-03-14 2019-01-22 Univ Oregon Health & Science métodos para produzir uma resposta imune à tuberculose
CN105056226A (zh) 2006-12-27 2015-11-18 埃默里大学 用于治疗传染病和肿瘤的组合物和方法
AU2008221383B2 (en) 2007-02-28 2012-09-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Brachyury polypeptides and methods for use
KR101648087B1 (ko) * 2007-10-18 2016-08-17 버베리안 노딕 에이/에스 전립선 암 치료를 위한 mva의 용도
WO2010050913A1 (en) * 2008-10-31 2010-05-06 The Brigham And Women's Hospital, Inc. Vaccination with poxvirus vectors via mechanical epidermal disruption
US8691502B2 (en) 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
BRPI0921321A2 (pt) 2008-11-28 2018-10-16 Emory University métodos para o tratamento de indwcções e tumores
US8664183B2 (en) 2009-02-27 2014-03-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services SPANX-B polypeptides and their use
WO2011063263A2 (en) 2009-11-20 2011-05-26 Oregon Health & Science University Methods for producing an immune response to tuberculosis
AU2011285534B2 (en) 2010-08-06 2015-12-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biomarkers for prostate cancer and methods for their detection
WO2014043518A1 (en) 2012-09-14 2014-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use
WO2014097762A1 (ja) * 2012-12-20 2014-06-26 国立大学法人熊本大学 高病原性トリインフルエンザに対する抗体
WO2015175340A1 (en) 2014-05-13 2015-11-19 Bavarian Nordic, Inc. Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3
JP5917626B2 (ja) * 2014-07-28 2016-05-18 トレムアールエックス, インコーポレイテッド 機械的表皮破壊を介したポックスウイルスベクターによるワクチン接種
AU2016270428B2 (en) 2015-06-05 2020-11-26 Musc Foundation For Research Development Endostatin fragments and variants for use in treating fibrosis
WO2017024000A1 (en) 2015-08-03 2017-02-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use
US20190183870A1 (en) 2016-01-05 2019-06-20 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Combination of histone deacetylase inhibitor and immunotherapy
WO2017136342A1 (en) 2016-02-02 2017-08-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells
CA3133971A1 (en) * 2019-03-20 2020-09-24 Turnstone Biologics Inc. Sequential heterologous boost oncolytic viral mmunotherapy
WO2023028451A2 (en) 2021-08-25 2023-03-02 Ibio, Inc. Anti-cd-25 antibody

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833975A (en) * 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
WO1989001973A2 (en) * 1987-09-02 1989-03-09 Applied Biotechnology, Inc. Recombinant pox virus for immunization against tumor-associated antigens
US5093258A (en) * 1988-08-26 1992-03-03 Therion Biologics Corporation Recombinant fowlpox virus and recombination vector
GB9105383D0 (en) * 1991-03-14 1991-05-01 Immunology Ltd An immunotherapeutic for cervical cancer
ATE248924T1 (de) * 1991-05-06 2003-09-15 Us Gov Health & Human Serv Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendung
ATE342356T1 (de) * 1992-11-05 2006-11-15 Sloan Kettering Inst Cancer Prostata-spezifisches membranantigen
ATE303160T1 (de) * 1993-08-11 2005-09-15 Jenner Technologies Impfstoff gegen prostatakrebs
FR2710536B1 (fr) * 1993-09-29 1995-12-22 Transgene Sa Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire.
EP0652014A1 (en) * 1993-11-10 1995-05-10 National Institute Of Immunology Treatment of prostatic hypertrophy
ZA941645B (en) * 1994-03-09 1995-01-13 South To South Co Operation In Antibodies specifically reactive against human prostate specific antigen.
EP0725139A3 (en) * 1995-02-03 1997-11-26 Bayer Corporation Recombinant prostate-specific antigen and its use as an immunoassay calibrator
US6165460A (en) * 1995-07-10 2000-12-26 Therion Biologics Corporation Generation of immune responses to prostate-specific antigen (PSA)

Also Published As

Publication number Publication date
EP1162272A2 (en) 2001-12-12
JP2006197938A (ja) 2006-08-03
JP2008285492A (ja) 2008-11-27
DE69618601D1 (de) 2002-02-21
WO1997003203A3 (en) 1997-04-17
EP1162272B1 (en) 2008-11-05
PT840791E (pt) 2002-06-28
ES2320089T3 (es) 2009-05-19
EP0840791B1 (en) 2002-01-16
EP1162272A3 (en) 2004-07-14
DK1162272T3 (da) 2009-03-09
DE69637738D1 (de) 2008-12-18
ATE212058T1 (de) 2002-02-15
HK1042518A1 (en) 2002-08-16
ATE413459T1 (de) 2008-11-15
US7598225B1 (en) 2009-10-06
WO1997003203A2 (en) 1997-01-30
EP0840791A2 (en) 1998-05-13
ES2172669T3 (es) 2002-10-01
JP4633867B2 (ja) 2011-02-16
US6165460A (en) 2000-12-26
JPH11509199A (ja) 1999-08-17
EP1162272B8 (en) 2010-03-10
PT1162272E (pt) 2009-02-16
HK1042518B (zh) 2009-04-17
CA2226436C (en) 2006-11-07
CA2226436A1 (en) 1997-01-30
DK0840791T3 (da) 2002-03-18

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