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DE69535031D1 - Selektive Acylierung von Epsilon-Aminogruppen in Insulin - Google Patents

Selektive Acylierung von Epsilon-Aminogruppen in Insulin

Info

Publication number
DE69535031D1
DE69535031D1 DE69535031T DE69535031T DE69535031D1 DE 69535031 D1 DE69535031 D1 DE 69535031D1 DE 69535031 T DE69535031 T DE 69535031T DE 69535031 T DE69535031 T DE 69535031T DE 69535031 D1 DE69535031 D1 DE 69535031D1
Authority
DE
Germany
Prior art keywords
epsilon
insulin
amino groups
selective acylation
acylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535031T
Other languages
English (en)
Other versions
DE69535031T2 (de
Inventor
Jeffrey Clayton Baker
Victor John Chen
Aidas Vladas Kriauciunas
Brian Allen Moser
Jose Michael Hanquier
Robert Theodore Shuman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69535031D1 publication Critical patent/DE69535031D1/de
Application granted granted Critical
Publication of DE69535031T2 publication Critical patent/DE69535031T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69535031T 1994-11-17 1995-11-14 Selektive Acylierung von Epsilon-Aminogruppen in Insulin Expired - Lifetime DE69535031T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups
US341231 1994-11-17

Publications (2)

Publication Number Publication Date
DE69535031D1 true DE69535031D1 (de) 2006-07-20
DE69535031T2 DE69535031T2 (de) 2006-12-28

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535031T Expired - Lifetime DE69535031T2 (de) 1994-11-17 1995-11-14 Selektive Acylierung von Epsilon-Aminogruppen in Insulin

Country Status (28)

Country Link
US (2) US5646242A (de)
EP (2) EP0712862B1 (de)
JP (1) JP4312828B2 (de)
CN (1) CN1171742A (de)
AR (1) AR003915A1 (de)
AT (1) ATE328902T1 (de)
AU (2) AU691066B2 (de)
BR (1) BR9509652A (de)
CA (1) CA2205061A1 (de)
CO (1) CO4520285A1 (de)
CZ (1) CZ287731B6 (de)
DE (1) DE69535031T2 (de)
DK (1) DK0712862T3 (de)
ES (1) ES2264124T3 (de)
HK (1) HK1014007A1 (de)
HU (2) HU217585B (de)
IL (1) IL115972A (de)
IN (1) IN179820B (de)
NO (1) NO972185D0 (de)
NZ (1) NZ297256A (de)
PL (1) PL320556A1 (de)
PT (1) PT712862E (de)
RU (1) RU2155773C2 (de)
SI (1) SI0712862T1 (de)
TR (1) TR199501421A2 (de)
WO (1) WO1996015803A1 (de)
YU (1) YU71495A (de)
ZA (1) ZA959680B (de)

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US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
WO1998002460A1 (en) * 1996-07-11 1998-01-22 Novo Nordisk A/S Selective acylation method
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
EA200000453A1 (ru) * 1997-10-24 2000-10-30 Эли Лилли Энд Компани Композиции нерастворимого инсулина
US5985263A (en) * 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US5981709A (en) * 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
AU4904800A (en) 1999-05-27 2000-12-18 Robert Z-T. Luo Identification of compounds for modulating dimeric receptors
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
EP1292324A2 (de) * 2000-05-05 2003-03-19 Novo Nordisk A/S Neuropathien verursacht durch kritischen krankheiten
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US20030054015A1 (en) * 2000-12-25 2003-03-20 Shinichiro Haze Sympathetic-activating perfume composition
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
PL367687A1 (en) * 2001-07-24 2005-03-07 Novo Nordisk A/S Method for making acylated polypeptides
US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
US20030082671A1 (en) * 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
EP1421102A2 (de) * 2001-07-24 2004-05-26 Novo Nordisk A/S Verfahren zur herstellung acylierter polypeptide
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
MY127575A (en) 2001-09-07 2006-12-29 Biocon Ltd Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
WO2003105768A2 (en) 2002-06-13 2003-12-24 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
PL210455B1 (pl) * 2002-09-25 2012-01-31 Novo Nordisk As Sposób otrzymywania acylowanych peptydów
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
MXPA06001283A (es) * 2003-08-05 2006-04-11 Novo Nordisk As Derivados de insulina novedosos.
EP1687428A1 (de) 2003-11-14 2006-08-09 Novo Nordisk A/S Verfahren zur herstellung von acyliertem insulin
AU2005269753B2 (en) 2004-07-19 2011-08-18 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US9056921B2 (en) 2005-08-16 2015-06-16 Novo Nordisk A/S Method for making mature insulin polypeptides
WO2007074133A2 (en) 2005-12-28 2007-07-05 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
EP1991576B1 (de) * 2006-02-27 2010-09-29 Novo Nordisk A/S Insulinderivate
US8927015B2 (en) * 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
US20090306337A1 (en) 2006-07-31 2009-12-10 Novo Nordisk A/S Pegylated, Extended Insulins
BRPI0717098B8 (pt) 2006-09-22 2021-05-25 Novo Nordisk As análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação
EP2069502B1 (de) 2006-09-27 2014-02-26 Novo Nordisk A/S Verfahren zur herstellung gereifter insulinpolypeptide
JP5496082B2 (ja) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
JP5552046B2 (ja) 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
ES2664822T3 (es) 2007-10-16 2018-04-23 Biocon Limited Una composición farmacéutica sólida administrable por vía oral y un proceso de la misma
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
PT2910570T (pt) 2008-03-18 2017-01-24 Novo Nordisk As Análogos de insulina acilados, estabilizados contra proteases
US8637647B2 (en) 2008-09-12 2014-01-28 Novo Nordisk A/S Method of acylating a peptide or protein
MX2011004357A (es) * 2008-10-30 2011-05-23 Novo Nordisk As Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyeccion menor que a diario.
WO2010096188A2 (en) * 2009-02-20 2010-08-26 Ipsen Pharma S.A.S Analogues of neuropeptide y having proline substitution at position 34
WO2011064316A2 (en) 2009-11-25 2011-06-03 Paolo Botti Mucosal delivery of peptides
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
KR20150002777A (ko) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 인슐린 제제
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
CN109715793A (zh) * 2016-05-05 2019-05-03 科德克希思公司 青霉素-g 酰化酶
CN109922835B (zh) 2016-11-07 2023-08-04 诺和诺德股份有限公司 Peg化合物的dchbs活性酯及其用途
HUE060149T2 (hu) 2016-12-16 2023-02-28 Novo Nordisk As Inzulint tartalmazó gyógyászati készítmények
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CN116874585B (zh) * 2023-09-06 2023-12-15 杭州湃肽生化科技有限公司 一种地特胰岛素的合成方法

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Also Published As

Publication number Publication date
JPH10509176A (ja) 1998-09-08
EP0712862B1 (de) 2006-06-07
HU9903007D0 (en) 1999-11-29
EP0712862A2 (de) 1996-05-22
HU217585B (hu) 2000-02-28
IL115972A0 (en) 1996-01-31
PL320556A1 (en) 1997-10-13
NZ297256A (en) 2000-01-28
EP0712862A3 (de) 1998-03-04
CO4520285A1 (es) 1997-10-15
RU2155773C2 (ru) 2000-09-10
BR9509652A (pt) 1997-09-16
MX9703506A (es) 1997-07-31
HK1014007A1 (en) 1999-09-17
YU71495A (sh) 1998-09-18
ES2264124T3 (es) 2006-12-16
ZA959680B (en) 1997-05-14
US5646242A (en) 1997-07-08
DK0712862T3 (da) 2006-09-25
SI0712862T1 (sl) 2006-10-31
CZ287731B6 (en) 2001-01-17
ATE328902T1 (de) 2006-06-15
DE69535031T2 (de) 2006-12-28
JP4312828B2 (ja) 2009-08-12
AU4237296A (en) 1996-06-17
USRE37971E1 (en) 2003-01-28
AR003915A1 (es) 1998-09-30
CN1171742A (zh) 1998-01-28
HUT77737A (hu) 1998-07-28
AU7885498A (en) 1998-11-05
CA2205061A1 (en) 1996-05-30
EP1227107A1 (de) 2002-07-31
AU720820B2 (en) 2000-06-15
WO1996015803A1 (en) 1996-05-30
PT712862E (pt) 2006-08-31
NO972185L (no) 1997-05-13
NO972185D0 (no) 1997-05-13
TR199501421A2 (tr) 1996-06-21
IN179820B (de) 1997-12-13
AU691066B2 (en) 1998-05-07
IL115972A (en) 2000-09-28
CZ145697A3 (en) 1997-12-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN