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DE69534421D1 - Cytoplasmatische Inhibition des Genexpression - Google Patents

Cytoplasmatische Inhibition des Genexpression

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Publication number
DE69534421D1
DE69534421D1 DE69534421T DE69534421T DE69534421D1 DE 69534421 D1 DE69534421 D1 DE 69534421D1 DE 69534421 T DE69534421 T DE 69534421T DE 69534421 T DE69534421 T DE 69534421T DE 69534421 D1 DE69534421 D1 DE 69534421D1
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Germany
Prior art keywords
gene expression
invention concerns
plant cell
plant
cytoplasmic inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69534421T
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English (en)
Other versions
DE69534421T2 (de
Inventor
Jonathan Donson
Guy Della-Cioppa
Monto Kumagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Large Scale Biology Corp
Original Assignee
Large Scale Biology Corp
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Filing date
Publication date
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Application granted granted Critical
Publication of DE69534421D1 publication Critical patent/DE69534421D1/de
Publication of DE69534421T2 publication Critical patent/DE69534421T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922602A (en) * 1988-02-26 1999-07-13 Biosource Technologies, Inc. Cytoplasmic inhibition of gene expression
US20030150019A1 (en) * 1988-02-26 2003-08-07 Large Scale Biology Corporation Monopartite RNA virus transformation vectors
US6054566A (en) * 1988-02-26 2000-04-25 Biosource Technologies, Inc. Recombinant animal viral nucleic acids
GB9611981D0 (en) * 1996-06-07 1996-08-07 Zeneca Ltd Enhancement of gene expression
AU4058497A (en) * 1996-08-09 1998-03-06 Calgene Llc Methods for producing carotenoid compounds and speciality oils in plant seeds
US6429356B1 (en) 1996-08-09 2002-08-06 Calgene Llc Methods for producing carotenoid compounds, and specialty oils in plant seeds
GB9703146D0 (en) 1997-02-14 1997-04-02 Innes John Centre Innov Ltd Methods and means for gene silencing in transgenic plants
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
GB9720148D0 (en) * 1997-09-22 1997-11-26 Innes John Centre Innov Ltd Gene silencing materials and methods
US6632980B1 (en) 1997-10-24 2003-10-14 E. I. Du Pont De Nemours And Company Binary viral expression system in plants
US6077992A (en) * 1997-10-24 2000-06-20 E. I. Du Pont De Nemours And Company Binary viral expression system in plants
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
US20020164585A1 (en) * 1998-01-16 2002-11-07 Sean Chapman Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
US6468745B1 (en) * 1998-01-16 2002-10-22 Large Scale Biology Corporation Method for expressing a library of nucleic acid sequence variants and selecting desired traits
US20030027173A1 (en) * 1998-01-16 2003-02-06 Della-Cioppa Guy Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
US6300133B1 (en) 1998-01-16 2001-10-09 Large Scale Biology Corporation RNA transformation vectors derived from an uncapped single-component RNA virus
WO2001007600A1 (en) * 1999-07-21 2001-02-01 Large Scale Biology Corporation Method of correlating sequence function by transfecting a nucleic acid sequence of a donor organism into a plant host in an anti-sense or positive sense orientation
US6700040B2 (en) 1998-01-16 2004-03-02 Large Scale Biology Corporation Cytoplasmic gene inhibition or gene expression in transfected plants by a tobraviral vector
WO1999036516A2 (en) * 1998-01-16 1999-07-22 Biosource Technologies, Inc. Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
US6300134B1 (en) 1998-01-16 2001-10-09 Large Scale Biology Corporation RNA transformation vectors derived from a single-component RNA virus and contain an intervening sequence between the cap and the 5′ end
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US6653530B1 (en) 1998-02-13 2003-11-25 Calgene Llc Methods for producing carotenoid compounds, tocopherol compounds, and specialty oils in plant seeds
CN101818145A (zh) 1998-03-20 2010-09-01 联邦科学和工业研究组织 控制基因表达
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6759571B1 (en) 1998-04-01 2004-07-06 North Carolina State University Method of suppressing gene expression in plants
EP1068311B2 (de) 1998-04-08 2020-12-09 Commonwealth Scientific and Industrial Research Organisation Verfahren und mittel zum erhalt von veränderten phänotypen
US6600089B1 (en) 1998-04-24 2003-07-29 E. I. Du Pont De Nemours And Company Carotenoid biosynthesis enzymes
WO1999055887A2 (en) * 1998-04-24 1999-11-04 E.I. Du Pont De Nemours And Company Carotenoid biosynthesis enzymes
FR2784688B1 (fr) * 1998-10-20 2002-12-13 Univ Grenoble 1 SEQUENCE D'ADNc DECRITE PAR SEQ ID N°1 TRANSCRIVANT UN ARNm CODANT POUR L'OXYDASE TERMINALE ASSOCIEE A LA BIOSYNTHESE DES CAROTENOIDES
WO2000044914A1 (en) * 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
BR0010616A (pt) 1999-04-15 2002-05-07 Calgene Llc Sequências de ácido nucléico a proteìnas envolvidas em sìntese de isoprenóide
ES2316363T3 (es) * 1999-04-20 2009-04-16 Bayer Bioscience N.V. Metodos para administracion de rna inhibidor a las plantas y aplicaciones de los mismos.
US7148400B1 (en) 1999-04-20 2006-12-12 Bayer Bioscience N.V. Methods and means for delivering inhibitory RNA to plants and applications thereof
DE19926216A1 (de) * 1999-06-09 2001-02-22 Metallgesellschaft Ag Verfahren zur Herstellung von Bariumsulfat, Bariumsulfat und Verwendung des Bariumsulfats
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
ATE447017T1 (de) 2000-08-07 2009-11-15 Monsanto Technology Llc Am methyl-d-erythriol phosphat reaktionsweg beteiligte gene
US7192771B2 (en) * 2000-08-30 2007-03-20 North Carolina State University Plant promoter sequence
DE10049587A1 (de) * 2000-10-06 2002-05-02 Icon Genetics Ag Vektorsystem für Pflanzen
EP1368467B1 (de) 2000-11-07 2007-04-25 North Carolina State University Putrescin-n-methyltransferasepromotor
DE10061150A1 (de) 2000-12-08 2002-06-13 Icon Genetics Ag Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen
DE10102389A1 (de) 2001-01-19 2002-08-01 Icon Genetics Ag Verfahren und Vektoren zur Plastidentransformation höherer Pflanzen
US6800748B2 (en) 2001-01-25 2004-10-05 Large Scale Biology Corporation Cytoplasmic inhibition of gene expression and expression of a foreign protein in a monocot plant by a plant viral vector
US20020132257A1 (en) 2001-01-31 2002-09-19 Tony Giordano Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
DE10114209A1 (de) 2001-03-23 2002-12-05 Icon Genetics Ag Ortsgerichtete Transformation durch Verwendung von Amplifikationsvektoren
DE10115507A1 (de) 2001-03-29 2002-10-10 Icon Genetics Ag Verfahren zur Kodierung von Information in Nukleinsäuren eines genetisch veränderten Organismus
DE10121283B4 (de) 2001-04-30 2011-08-11 Icon Genetics GmbH, 80333 Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
ES2318004T3 (es) 2001-05-09 2009-05-01 Monsanto Technology Llc Genes tyra y usos de los mismos.
NZ530238A (en) * 2001-06-08 2004-08-27 Vector Tobacco Ltd Modifying nicotine and nitrosamine levels in tobacco
DE10132780A1 (de) 2001-07-06 2003-01-16 Icon Genetics Ag Plastidäre Genexpression über autonom replizierende Vektoren
US7244877B2 (en) 2001-08-17 2007-07-17 Monsanto Technology Llc Methyltransferase from cotton and uses thereof
DE10143238A1 (de) 2001-09-04 2003-03-20 Icon Genetics Ag Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente
DE10143237A1 (de) 2001-09-04 2003-03-20 Icon Genetics Ag Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente)
DE60235252D1 (de) 2001-10-25 2010-03-18 Monsanto Technology Llc Aromatische methyltransferasen und ihre verwendung
AU2002361997B2 (en) * 2001-12-18 2007-10-04 Bayer Bioscience N.V. Improved methods and means for delivering inhibitory RNA to plants and applications thereof
WO2003078604A2 (en) * 2002-03-14 2003-09-25 Yale University Tobacco rattle virus vectors and related compositions and methods
US7112717B2 (en) 2002-03-19 2006-09-26 Monsanto Technology Llc Homogentisate prenyl transferase gene (HPT2) from arabidopsis and uses thereof
DE10212892A1 (de) 2002-03-20 2003-10-09 Basf Plant Science Gmbh Konstrukte und Verfahren zur Regulation der Genexpression
BR0308977A (pt) * 2002-04-09 2005-01-11 Vector Tobacco Ltd Métodos de redução da quantidade de nicotina numa planta de tabaco e em folhas de tabaco curadas, da quantidade de tsna em tabaco curado, de tratamento de cessação do uso de tabaco, de redução dos efeitos tóxicos da nicotina, da exposição de um consumidor de tabaco aos efeitos tóxicos de tsna, de tratamento de uma planta de tabaco, produtos de tabaco, planta de tabaco de usos de uma auxina, um análogo de auxina ou um antagonista de jasmonato
US20060005282A1 (en) * 2002-04-23 2006-01-05 Activx Biosciences, Inc Production and use of salt tolerant and culture density tolerant organisms
US20040180438A1 (en) * 2002-04-26 2004-09-16 Pachuk Catherine J. Methods and compositions for silencing genes without inducing toxicity
WO2003093449A2 (en) * 2002-05-06 2003-11-13 Nucleonics, Inc. Methods for delivery of nucleic acids
US20040126823A1 (en) * 2002-05-31 2004-07-01 Tsichlis Philip N. Modulation of prostaglandin synthesis and cancer growth
US7786344B2 (en) 2002-07-26 2010-08-31 Basf Plant Science Gmbh Selection method
EP1540004A4 (de) * 2002-07-31 2007-10-03 Nucleonics Inc Doppelstrang-rna-strukturen und -konstrukte sowie verfahren zur erzeugung und verwendung davon
US20050255086A1 (en) * 2002-08-05 2005-11-17 Davidson Beverly L Nucleic acid silencing of Huntington's Disease gene
US20080274989A1 (en) * 2002-08-05 2008-11-06 University Of Iowa Research Foundation Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
US20050042646A1 (en) * 2002-08-05 2005-02-24 Davidson Beverly L. RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US20040023390A1 (en) * 2002-08-05 2004-02-05 Davidson Beverly L. SiRNA-mediated gene silencing with viral vectors
US7230165B2 (en) 2002-08-05 2007-06-12 Monsanto Technology Llc Tocopherol biosynthesis related genes and uses thereof
US20080176812A1 (en) * 2002-08-05 2008-07-24 Davidson Beverly L Allele-specific silencing of disease genes
US20040241854A1 (en) 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20050106731A1 (en) * 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
WO2004044161A2 (en) * 2002-11-06 2004-05-27 Fraunhofer Usa Expression of foreign sequences in plants using trans-activation system
US7692063B2 (en) * 2002-11-12 2010-04-06 Ibio, Inc. Production of foreign nucleic acids and polypeptides in sprout systems
US7683238B2 (en) * 2002-11-12 2010-03-23 iBio, Inc. and Fraunhofer USA, Inc. Production of pharmaceutically active proteins in sprouted seedlings
US20040248299A1 (en) * 2002-12-27 2004-12-09 Sumedha Jayasena RNA interference
EP2192172B1 (de) 2003-02-03 2014-12-03 iBio, Inc. System zur Expression von Genen in Pflanzen
WO2004113573A2 (en) * 2003-06-19 2004-12-29 The Samuel Roberts Noble Foundation, Inc. Methods and compositions for analysis of plant gene function
US7696406B2 (en) * 2003-07-03 2010-04-13 Board Of Trustees Operating Michigan State University Expression of a recombinant transgene
ES2532609T3 (es) * 2004-02-20 2015-03-30 Ibio, Inc. Sistemas y métodos para expresión clonales en plantas
US20050260652A1 (en) * 2004-04-15 2005-11-24 The General Hospital Corporation Compositions and methods that modulate RNA interference
US7644624B2 (en) 2004-06-04 2010-01-12 The Board Of Trustees Of The University Of Illinois Artificial lateral line
CN1330756C (zh) * 2005-03-14 2007-08-08 姜国勇 抗番茄花叶病毒基因及其分离方法
US9085774B2 (en) 2005-04-19 2015-07-21 Basf Plant Science Gmbh Methods controlling gene expression
EP1931789B1 (de) 2005-09-20 2016-05-04 BASF Plant Science GmbH VERFAHREN ZUR STEUERUNG DER GENEXPRESSION MITTELS ta- siRNA
US8431080B2 (en) 2006-06-02 2013-04-30 The Board Of Trustees Of The University Of Illinois Soft MEMS
WO2007143123A2 (en) * 2006-06-02 2007-12-13 The Board Of Trustees Of The University Of Illinois Micromachined artificial haircell
WO2008005466A2 (en) * 2006-06-30 2008-01-10 The Board Of Trustees Of The University Of Illinois Artificial lateral line
WO2008095889A1 (en) 2007-02-06 2008-08-14 Basf Plant Science Gmbh Use of alanine racemase genes to confer nematode resistance to plants
BRPI0807428A2 (pt) 2007-02-06 2014-07-22 Basf Plant Science Gmbh Molécula de dsrna, coleção de moléculas dsrna, planta transgênica, métodos para preparar uma planta transgênica, e para conceder resistência a nematódeo a uma planta, e, vetor de expressão
MX2009007926A (es) 2007-02-08 2009-08-07 Basf Plant Science Gmbh Composiciones y metodos que utilizan arn de interferencia del gen tipo opr3 para el control de nematodos.
EP2115148B1 (de) 2007-02-09 2011-09-14 BASF Plant Science GmbH Zusammensetzungen und verfahren, die rna-interferenzen von cdpk-like zur kontrolle von nematoden verwenden
US20100095404A1 (en) 2007-03-15 2010-04-15 Basf Plant Science Gmbh Use of Nematode Chitinase Genes to Control Plant Parasitic Nematodes
WO2009029644A1 (en) * 2007-08-27 2009-03-05 Cornell Research Foundation, Inc. Methods to improve alcohol tolerance of microorganisms
US8097712B2 (en) 2007-11-07 2012-01-17 Beelogics Inc. Compositions for conferring tolerance to viral disease in social insects, and the use thereof
US20090255013A1 (en) * 2008-04-07 2009-10-08 Pioneer Hi-Bred International, Inc. Use of virus induced gene silencing (VIGS) to down-regulate gene use in plants
US20110145945A1 (en) 2008-08-27 2011-06-16 Basf Plant Science Gmbh Nematode-Resistant Transgenic Plants
EP2376635B1 (de) 2008-12-11 2012-09-26 BASF Plant Science GmbH Pflanzenwurzelspezifische nematodenresistenz
BRPI1006273A2 (pt) 2009-03-20 2019-09-24 Basf Plant Science Gmbh " vetor de expressão isolado, vegetal transgênico, método para produção de um vegetal transgênico e método para conferir resistência contra nematoide a um vegetal "
WO2011023571A1 (en) 2009-08-25 2011-03-03 Basf Plant Science Company Gmbh Nematode-resistant transgenic plants
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
CA2782545A1 (en) 2009-12-09 2011-06-16 Basf Plant Science Company Gmbh Methods for increasing the resistance of plants to fungi by silencing the fungal smt1-gene
US20130091598A1 (en) 2010-02-23 2013-04-11 Basf Plant Science Company Gmbh Nematode-Resistant Transgenic Plants
ES2641642T3 (es) 2010-03-08 2017-11-10 Monsanto Technology Llc Moléculas de polinucleótido para regulación génica en plantas
CA2802275A1 (en) 2010-06-16 2011-12-22 Plant Bioscience Limited Control of plant seed shattering
DE112011104462T5 (de) 2010-12-20 2013-09-12 Basf Plant Science Company Gmbh Nematodenresistente transgene Pflanzen
EP2535416A1 (de) 2011-05-24 2012-12-19 BASF Plant Science Company GmbH Entwicklung einer Phytophthora-resistenten Kartoffel mit verbessertem Ertrag
CN103957696B (zh) 2011-09-13 2019-01-18 孟山都技术公司 用于杂草控制的方法和组合物
AU2012308659B2 (en) 2011-09-13 2017-05-04 Monsanto Technology Llc Methods and compositions for weed control
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
PL2755467T4 (pl) 2011-09-13 2018-01-31 Monsanto Technology Llc Sposoby i kompozycje do kontroli chwastów
MX362810B (es) 2011-09-13 2019-02-13 Monsanto Technology Llc Metodos y composiciones para controlar malezas.
WO2013050593A1 (en) 2011-10-07 2013-04-11 Basf Plant Science Company Gmbh Method of producing plants having increased resistance to pathogens
WO2013050611A1 (en) 2011-10-07 2013-04-11 Basf Plant Science Company Gmbh Method of producing plants having increased resistance to pathogens
WO2013050318A1 (en) 2011-10-07 2013-04-11 Basf Plant Science Company Gmbh Method of producing plants having increased resistance to pathogens
WO2013053686A1 (en) 2011-10-10 2013-04-18 Basf Plant Science Company Gmbh Method of producing plants having increased resistance to pathogens
WO2013053711A1 (en) 2011-10-10 2013-04-18 Basf Plant Science Company Gmbh Method of producing plants having increased resistance to pathogens
WO2013175480A1 (en) 2012-05-24 2013-11-28 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
US10077451B2 (en) 2012-10-18 2018-09-18 Monsanto Technology Llc Methods and compositions for plant pest control
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
CN105358695B (zh) 2013-01-01 2019-07-12 A.B.种子有限公司 将dsRNA引入植物种子以调节基因表达的方法
US20150342192A1 (en) 2013-01-15 2015-12-03 Monsanto Technology Llc Methods and Compositions for Plant Pest Control
US10000767B2 (en) 2013-01-28 2018-06-19 Monsanto Technology Llc Methods and compositions for plant pest control
CA2897482A1 (en) 2013-01-29 2014-08-07 Basf Plant Science Company Gmbh Fungal resistant plants expressing hcp7
US10435705B2 (en) 2013-01-29 2019-10-08 Basf Plant Science Company Gmbh Fungal resistant plants expressing HCP6
CA2891424A1 (en) 2013-01-29 2014-08-07 Basf Plant Science Company Gmbh Fungal resistant plants expressing ein2
CN105008542B (zh) 2013-03-08 2020-02-07 巴斯夫植物科学有限公司 表达MybTF的抗真菌性植物
CN105074008A (zh) 2013-03-13 2015-11-18 孟山都技术有限公司 用于杂草控制的方法和组合物
UA121846C2 (uk) 2013-03-13 2020-08-10 Монсанто Текнолоджи Ллс Спосіб та гербіцидна композиція для контролю видів рослини роду lolium
US20140283211A1 (en) 2013-03-14 2014-09-18 Monsanto Technology Llc Methods and Compositions for Plant Pest Control
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
EP3010329B1 (de) 2013-06-17 2019-11-20 Bayer CropScience Aktiengesellschaft Verfahren zur identifizierung von substanzen, die zellen für eine stressreaktion vorbereiten, sowie zellen zur verwendung mit diesem verfahren
WO2015004174A1 (en) 2013-07-10 2015-01-15 Basf Se Rnai for the control of phytopathogenic fungi and oomycetes by inhibiting the expression of cyp51 genes
WO2015010026A2 (en) 2013-07-19 2015-01-22 Monsanto Technology Llc Compositions and methods for controlling leptinotarsa
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
BR112016003152A2 (pt) 2013-08-14 2017-11-21 Inst Of Genetics And Developmental Biology métodos para modular o tamanho de órgãos e sementes em plantas
EP3066200B1 (de) 2013-11-04 2024-12-04 Greenlight Biosciences, Inc. Zusammensetzungen und verfahren zur bekämpfung eines befalls durch arthropoden und andere schädlinge
UA119253C2 (uk) 2013-12-10 2019-05-27 Біолоджикс, Інк. Спосіб боротьби із вірусом у кліща varroa та у бджіл
AU2015206585A1 (en) 2014-01-15 2016-07-21 Monsanto Technology Llc Methods and compositions for weed control using EPSPS polynucleotides
CN106413390B (zh) 2014-04-01 2019-09-27 孟山都技术公司 用于控制虫害的组合物和方法
EP3158067B1 (de) 2014-06-23 2020-08-12 Monsanto Technology LLC Zusammensetzungen und verfahren zur regulierung der genexpression durch rna-interferenz
EP3161138A4 (de) 2014-06-25 2017-12-06 Monsanto Technology LLC Verfahren und zusammensetzungen zur zuführung von nukleinsäuren an pflanzenzellen und regulierung der genexpression
RU2021123470A (ru) 2014-07-29 2021-09-06 Монсанто Текнолоджи Ллс Композиции и способы борьбы с насекомыми-вредителями
MX2017009521A (es) 2015-01-22 2018-11-09 Monsanto Technology Llc Composiciones y métodos para controlar leptinotarsa.
US10570412B2 (en) 2015-02-04 2020-02-25 Basf Plant Science Company Gmbh Method of increasing resistance against soybean rust in transgenic plants by increasing the scopoletin content
WO2016196738A1 (en) 2015-06-02 2016-12-08 Monsanto Technology Llc Compositions and methods for delivery of a polynucleotide into a plant
CN108024517A (zh) 2015-06-03 2018-05-11 孟山都技术公司 用于将核酸引入到植物中的方法和组合物
EP3054014A3 (de) 2016-05-10 2016-11-23 BASF Plant Science Company GmbH Benutzung einer fungizids auf transgenen pflanzen
GB201721600D0 (en) 2017-12-21 2018-02-07 Plant Bioscience Ltd Metabolic engineering
GB201808617D0 (en) 2018-05-25 2018-07-11 Plant Bioscience Ltd Scaffold modification
GB201908431D0 (en) 2019-06-12 2019-07-24 Plant Bioscience Ltd Biosynthetic genes and polypeptides
GB201909104D0 (en) 2019-06-25 2019-08-07 Plant Bioscience Ltd Transferase enzymes
EP4508189A1 (de) 2022-04-14 2025-02-19 Institute of Agricultural Resources and Regional Planning of the Chinese Academy of Agricultural Sciences Modifizierte mikroalgen für verbesserte phosphatuptade mit überexpression von psrr1 und optional unterexpression von ptc1
GB202209501D0 (en) 2022-06-29 2022-08-10 Plant Bioscience Ltd Biosynthetic enzymes
LU503053B1 (en) 2022-11-14 2024-05-14 Univ Birmingham Somaclonal Variation

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59216245A (ja) 1983-05-25 1984-12-06 Nec Corp 正規化回路
US5272065A (en) * 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US5190931A (en) * 1983-10-20 1993-03-02 The Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US5107065A (en) * 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
US5453566A (en) * 1986-03-28 1995-09-26 Calgene, Inc. Antisense regulation of gene expression in plant/cells
DE3751393T2 (de) * 1986-04-02 1996-02-22 Pioneer Hi Bred Int Pflanzen, resistent gegen den Anti-sens RNS aufweisenden Virus.
US5922602A (en) * 1988-02-26 1999-07-13 Biosource Technologies, Inc. Cytoplasmic inhibition of gene expression
US5316931A (en) * 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US5231020A (en) * 1989-03-30 1993-07-27 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US5034323A (en) * 1989-03-30 1991-07-23 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
WO1990012107A1 (en) * 1989-03-31 1990-10-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Recombinant expression system based on satellite tobacco mosaic virus
SE466123B (sv) 1989-04-25 1991-12-16 Kvaser Consultant Ab Anordning foer att synkonisera data i ett datoriserat system, som innefattar en gemensam seriell datakommunikationskanal
NL9001711A (nl) * 1989-10-03 1991-05-01 Clovis Matton N V Genetische manipulaties met recombinant dna, dat van rna virus afgeleide sequenties omvat.
GB8928179D0 (en) * 1989-12-13 1990-02-14 Ici Plc Dna,constructs,cells and plants derived therefrom
EP0471056B1 (de) * 1990-03-02 2001-10-17 BP Corporation North America Inc. Biosynthese von carotinoiden in genetisch hergestellten wirtszellen
WO1991013994A1 (en) * 1990-03-13 1991-09-19 Commonwealth Scientific And Industrial Research Organisation Gene expression
DK0596979T3 (da) * 1991-08-01 2002-05-13 Large Scale Biology Corp Rekombinante nucleinsyrer fra plantevirus
GB9210273D0 (en) * 1992-05-13 1992-07-01 Ici Plc Dna
US5539093A (en) * 1994-06-16 1996-07-23 Fitzmaurice; Wayne P. DNA sequences encoding enzymes useful in carotenoid biosynthesis

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